1,776 research outputs found
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
Hydrogen from Radiolysis of Aqueous Fluid Inclusions during Diagenesis
No full textAcknowledgments We are grateful to J. Bowie and J. Still for skilled technical support and the staff at ICL-UK’s Boulby mine (especially Thomas Edwards), STFC’s Boulby underground Laboratory and the UK Centre for Astrobiology MINAR programme team (especially Sean Paling) for their support and supervised access to the site. The critical comments of two reviewers helped to improve the manuscript. Author Contributions John Parnell undertook the sampling. Nigel Blamey performed all analytical work. John Parnell wrote the manuscript.Peer reviewe
L’assurance-vie face aux nouveaux instruments financiers et à la déréglementation
No full textDeregulation is the outcome of the unification of the industry throughout Europe. Insurance companies have been slow to react to
the sweeping change we are witnessing. This is partly owing to the
legislation in force in each of the member countries. But, with the
emergence of a single European market, the situation is beginning to
change.
According to the author, Nigel J. Sedgewick, insurers, while
remaining competitive, should adopt a more offensive stance by not
only gaining more control over general expenses, but also by
broadening their range of products to include caps, floors, swaps
and others
Expression of interleukin 3 and granulocyte-macrophage colony-stimulating factor receptor common chain βc, β<sub>IT</sub> in normal haematopoiesis: lineage specificity and proliferation-independent induction
No full textInterleukin 3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 5 (IL-5) exert their biological activities through interaction with cell-surface receptors that consist of two subunits, a specific α subunit and a common β transducing subunit (βc). We have evaluated the expression of βc on purified haematopoietic progenitor cells (HPCs) induced to unilineage differentiation/maturation through the erythroid (E), granulocytic (G), megakaryocytic (Mk) or monocytic (Mo) lineage, HPCs displayed low βc expression, which increased during the initial stages of HPC differentiation along the E, G, Mo or Mk lineages. At later stages of differentiation, βc chain expression increased in both G and Mo lineages, was expressed at low levels in the Mk lineage and declined to undetectable levels in the E lineage. Analysis of the full-length βc and intracytoplasmically truncated βc (βIT) mRNAs showed that the former was predominant in the G and Mo lineages, whereas the latter was prevalent in the E and Mk lineages. The βc induction takes place even in the absence of cell cycling. Thus, incubation of HPCs with graded amounts of IL-3 showed that the initial induction of βc expression is unrelated to cell proliferation. Furthermore, circulating monocytes and granulocytes exhibit a low level of βc expression that is greatly stimulated following incubation with either IL-3 or GM-CSF.</p
Mannose-binding lectin enhances phagocytosis and killing of Neisseria meningitidis by human macrophages
No full textDeficiency of mannose-binding lectin (MBL) is probably the most common human immunodeficiency and is associated with an increased risk of mucosally acquired infections including meningococcal disease. Tissue macrophages are an important component of mucosal defense, and so we determined the effect of MBL on uptake of meningococci by human monocyte-derived macrophages. Opsonization with MBL significantly increased the capture and doubled the amount of internalization of Neisseria meningitidis. Inhibition of f-actin polymerization indicated that MBL exerted this effect by a dose-dependent acceleration of uptake into phagosomes, which was maximal within the normal physiological concentration of MBL (1.5 microg/ml) and was independent of scavenger receptors. MBL accelerated the acquisition and subsequent loss of the early endosome marker, early endosomal antigen-1, and enhanced the acquisition of the late endosomal marker, lysosome-associated membrane protein-1. MBL reduced the survival of meningococci within macrophages by more than half, despite the increased uptake of organisms, and significantly reduced the number of viable extracellular bacteria by 80%. We conclude that MBL is a dependent opsonin able to accelerate microbial uptake and killing. These results suggest that MBL could modify disease susceptibility by modulating macrophage interactions with mucosal organisms at the site of initial acquisition.</p
A standing ovation for Nigel: An informal study
No full textThis article analyses a series of emails thanking Nigel for his stewardship of JASSS and the characteristics of their authors. It identifies a correlation between two measures of author activity in social simulation research, but no pattern between these activity measures and the email timing. Instead, the sequence suggests a classic standing ovation effect.</p
Distributed human computation framework for linked data co-reference resolution
No full textDistributed Human Computation (DHC) is a technique used to solve computational problems by incorporating the collaborative effort of a large number of humans. It is also a solution to AI-complete problems such as natural language processing. The Semantic Web with its root in AI is envisioned to be a decentralised world-wide information space for sharing machine-readable data with minimal integration costs. There are many research problems in the Semantic Web that are considered as AI-complete problems. An example is co-reference resolution, which involves determining whether different URIs refer to the same entity. This is considered to be a significant hurdle to overcome in the realisation of large-scale Semantic Web applications. In this paper, we propose a framework for building a DHC system on top of the Linked Data Cloud to solve various computational problems. To demonstrate the concept, we are focusing on handling the co-reference resolution in the Semantic Web when integrating distributed datasets. The traditional way to solve this problem is to design machine-learning algorithms. However, they are often computationally expensive, error-prone and do not scale. We designed a DHC system named iamResearcher, which solves the scientific publication author identity co-reference problem when integrating distributed bibliographic datasets. In our system, we aggregated 6 million bibliographic data from various publication repositories. Users can sign up to the system to audit and align their own publications, thus solving the co-reference problem in a distributed manner. The aggregated results are published to the Linked Data Cloud
Measure Attractors For Stochastic Navier-Stokes Equations
No full text: We show existence of measure attractors for 2-D stochastic Navier-Stokes equations with general multiplicative noise. Keywords: Stochastic Navier--Stokes equations, measure attractors AMS subject classification: Primary: 35Q30, 60H15, 60G60; Secondary: 35R60, 76D05, 60J25 The research of the first author was supported by an EPSRC Visiting Fellowship at the University of Hull and also partially by the KBN grant 2PO3A 064 08. Submitted to EJP on 15 May, 1997. Final version accepted on May 20, 1998. MEASURE ATTRACTORS FOR STOCHASTIC NAVIER--STOKES EQUATIONS MAREK CAPI ' NSKI AND NIGEL J. CUTLAND Abstract. We show existence of measure attractors for 2-D stochastic Navier-Stokes equations with general multiplicative noise. 1. Introduction This paper is concerned with existence of attractors in connection with stochastic Navier-Stokes equations in dimension 2. For deterministic Navier-Stokes equations, the existence of a global attractor in dimension 2 goes back to the work of Ladyzh..
Combustion and Society: A Fire-Centred History of Energy Use
No full textFire is a force that links everyday human activities to some of the most powerful energetic movements of the Earth. Drawing together the energy-centred social theory of Georges Bataille, the fire-centred environmental history of Stephen Pyne, and the work of a number of ‘pyrotechnology’ scholars, the paper proposes that the generalized study of combustion is a key to contextualizing human energetic practices within a broader ‘economy’ of terrestrial and cosmic energy flows. We examine the relatively recent turn towards fossil-fuelled ‘internal combustion’ in the light of a much longer human history of ‘broadcast’ burning of vegetation and of artisanal pyrotechnologies – the use of heat to transform diverse materials. A combustion-centred analysis, it is argued, brings human collective life into closer contact with the geochemical and geologic conditions of earthly existence, while also pointing to the significance of explorative, experimental and even playful dispositions towards energy and matter. © 2014, SAGE Publications. All rights reserved
Detection of Cognitive Features from Web Resources in Support of Cultural Modeling and Analysis
No full textThe World Wide Web serves as a valuable source of culture-relevant information, which can be used to support cultural modeling and analysis activities. Part of the challenge in exploiting the Web as a source of culture-relevant information relates to the need to detect and extract information about beliefs, attitudes, and values from a variety of different resources. The Web thus features a rich variety of information resources, and these are seldom categorized with respect to the dimensions in which cultural analysts are interested. Exploiting the Web as a source of culture-relevant information therefore requires techniques and approaches that enable cultural analysts to extract relevant information and organize extracted content in various ways. In this paper, we outline an approach to assist cultural analysts in the extraction and organization of relevant information. We show techniques that can be used to extract information about the attitudes, beliefs, and values of individuals, and how this data can, in turn, be used to support cultural modeling and analysis
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