2,064 research outputs found

    Kitchener, HC

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    Observation of hc radiative decay hc › ??' and evidence for hc › ??

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    Kolcu, Onur Buğra (Arel Author) --- Makale 69 yazarlıdır.A search for radiative decays of the P-wave spin singlet charmonium resonance hc is performed based on 4.48 × 108 ? events collected with the BESIII detector operating at the BEPCII storage ring. Events of the reaction channels hc › ??' and ?? are observed with a statistical significance of 8.4? and 4.0?, respectively, for the first time. The branching fractions of hc › ??' and hc › ?? are measured to be B(hc › ??' ) = (1.52±0.27±0.29)×10-3 and B(hc › ??) = (4.7±1.5±1.4)×10-4 , respectively, where the first errors are statistical and the second are systematic uncertainties

    HPV testing as a triage for borderline or mild dyskaryosis on cervical cytology: results from the Sentinel Sites study

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    background: Earlier pilot studies of human papillomavirus (HPV) triage concluded that HPV triage was feasible and cost-effective. The aim of the present study was to study the impact of wider rollout of HPV triage for women with low-grade cytology on colposcopy referral and outcomes.methods: Human papillomavirus testing of liquid-based cytology (LBC) samples showing low-grade abnormalities was used to select women for colposcopy referral at six sites in England. Samples from 10 051 women aged 25–64 years with routine call or recall cytology reported as borderline or mild dyskaryosis were included.results: Human papillomavirus-positive rates were 53.7% in women with borderline cytology and 83.9% in those with mild dyskaryosis. The range between sites was 34.8–73.3% for borderline cytology, and 73.4–91.6% for mild dyskaryosis. In the single site using both LBC technologies there was no difference in rates between the two technologies. The positive predictive value of an HPV test was 16.3% for CIN2 or worse and 6.1% for CIN3 or worse, although there was considerable variation between sites.conclusion: Triaging women with borderline cytological abnormalities and mild dyskaryosis with HPV testing would allow approximately a third of these women to be returned immediately to routine recall, and for a substantial proportion to be referred for colposcopy without repeat cytology. Variation in HPV-positive rates results in differing colposcopy workload

    Cost and logistics of alternative roll-out options for implementing human papillomavirus testing as a triage in cervical screening: results of the sentinel sites study.

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    BACKGROUND: Previous studies have indicated that human papillomavirus (HPV) testing as a triage for managing equivocal cytology is cost-effective. The aim of this study was to assess the costs of alternative roll-out options. METHODS: Detailed cost estimates were collected from six laboratories where HPV triage had been implemented. Costs were assessed for the two different service delivery models that were implemented; a 'hub and spoke model' of central HPV testing in a microbiology laboratory with separate cytology laboratories, and an 'integrated model' where HPV testing was conducted within the cytology laboratory. RESULTS: Comparison of alternative delivery models indicated that setting up HPV processing within existing cytology laboratory, i.e., an 'integrated cytology/HPV laboratory' generated savings in staff time amounting to between £2.54 and 4.86 per sample processed. Running full HPV testing batches was also an important consideration. For full batches to be run on a twice weekly basis requires having no more than two laboratories per Strategic Health Authority. CONCLUSIONS: To be cost-efficient, and to meet turn-around times, HPV testing needs to be conducted at integrated cytology/HPV testing centres with sufficient throughput to run full batches of HPV tests

    Genital virus infection and cervical neoplasia

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    Financial analysis and evaluation of company HC Betons Ltd

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    Diplomdarba nosaukums: Uzņēmuma SIA HC Betons finanšu analīze un novērtējums Diplomdarba mērķis ir uz finanšu analīzes pamata izvērtēt uzņēmuma SIA HC Betons esošo finansiālo situāciju un izstrādāt priekšlikumus finansiālā stāvokļa uzlabošanai. Teorētiskajā daļā apskatīti finanšu analīzes teorētiskie aspekti. Praktiskajā daļā autore veica uzņēmuma SIA HC Betons finanšu analīzi par 2009., 2010., un 2011.gadu. Analītiskajā daļā autore salīdzina rādītājus ar konkurējošo uzņēmumu SIA Cemex. Autore secinājusi, ka uzņēmumam ir finansiālas grūtības, bet pēc autores domām, uzņēmums tuvāko gadu laikā nebankrotēs. Diplomdarba apjoms ir 78 lapaspuses, tas sastāv no 3 daļām, 12 tabulām, 5 attēliem un 12 pielikumiem. Atslēgvārdi: analīze, likviditāte, bankrots, koeficienti.Diploma thesis: Financial Analysis and Evaluation of Company HC Betons Ltd. The aim of the diploma paper is to evaluate company’s HC Betons Ltd current financial situation based on financial analysis and make suggestions for improvement of the financial position. Theoretical aspects of financial analysis are discussed in the theoretical part of the paper. In the practical part author has performed company’s HC Betons Ltd financial analysis of the years 2009, 2010 and 2011. In the analytical part author compares ratios of a competing company Cemex Ltd. The author concludes that the company is in financial difficulties, but according to the author’s thoughts, the company will not bankrupt in the coming years. The volume of the diploma paper is 78 pages; it consists of 3 parts, 12 tables, 5 images and 12 appendices. Keywords: analysis, liquidity, bankruptcy, ratios

    Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies

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    The application of a 1H nuclear magnetic resonance (NMR) spectroscopy-based screening method for determining the use of two widely available analgesics (acetaminophen and ibuprofen) in epidemiologic studies has been investigated. We used samples and data from the cross-sectional INTERMAP Study involving participants from Japan (n = 1145), China (n = 839), U.K. (n = 501), and the U.S. (n = 2195). An orthogonal projection to latent structures discriminant analysis (OPLS-DA) algorithm with an incorporated Monte Carlo resampling function was applied to the NMR data set to determine which spectra contained analgesic metabolites. OPLS-DA preprocessing parameters (normalization, bin width, scaling, and input parameters) were assessed systematically to identify an optimal acetaminophen prediction model. Subsets of INTERMAP spectra were examined to verify and validate the presence/absence of acetaminophen/ibuprofen based on known chemical shift and coupling patterns. The optimized and validated acetaminophen model correctly predicted 98.2%, and the ibuprofen model correctly predicted 99.0% of the urine specimens containing these drug metabolites. The acetaminophen and ibuprofen models were subsequently used to predict the presence/absence of these drug metabolites for the remaining INTERMAP specimens. The acetaminophen model identified 415 out of 8436 spectra as containing acetaminophen metabolite signals while the ibuprofen model identified 245 out of 8604 spectra as containing ibuprofen metabolite signals from the global data set after excluding samples used to construct the prediction models. The NMR-based metabolic screening strategy provides a new objective approach for evaluation of self-reported medication data and is extendable to other aspects of population xenometabolome profiling

    Specific and fitness testing of goalies HC Motor Czech Budejovice\\

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    The aim of this bachelor thesis is to test specific and fitness abilities of goalkeepers of HC Motor Czech Budejovice. In the theoretical part of this thesis, based on content analysis of literature research, the author presents motoric abilities, development patterns and overview of most frequently used tests. In the practical part of thesis, the author deals with creating and verifying tested battery. It was designed using the knowledge gained from books reference and self- experience of a player and a coach as well. To obtain the results of performance of particular motoric abilities the author used testing method. The outcomes were subsequently compared with the evaluation of given motoric abilities on ice. The author acquired the evaluation from goalkeeper's coaches of HC Motor Czech Budejovice. Final results are described and thereafter tabularly presented

    VIBRATIONAL RELAXATION IN THE BINARY GASEOUS MIXTURES HCCO2HC\ell-CO_{2} AND HCN2OHC\ell-N_{2}O

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    Author Institution: Laboratoire de Spectronomie Moleculaire, Universit\'e de Paris VI, 4, Place Jussieu - Tour 13Vibrational relaxation rates for gaseous mixtures MHCM-HC\ell, with M=CO2M = CO_{2} or N2ON_{2}O, in which vibrational energy transfer can occur from the (001)(00^{\circ} 1) level of M to the v = 1 level of HCHC\ell, has been measured as a function of the temperature using the laser-induced vibrational fluorescence technique. The relaxation processes which must be considered are: - the V-V transfer process: \begin{eqnarray*} &&M(00^{\circ }1)+ HC (v=0)\begin{array}{c}^{k}M-HC\ell\\ \rightleftharpoons\\ ^{k}HC\ell-M\end{array}M(00^{\circ}0)+ HC\ell(v=1)+ \Delta E=he\Delta\nu\\ &&with\ \Delta\nu=-537\, cm^{-1} for\ CO_{2}, -663\, cm ^{-1}\ for\ N_{2}O \end{eqnarray*} - the V-TR de-excitation processes: \begin{eqnarray*} M(00^{\circ}1)+ HC\ell(or M)\stackrel{k^{HC\ell}_{M}}{(o\vec{r}\; k_{M})}M(mn^{\ell}0)+HC\ell (or \; M)\\ HC\ell(v=1)+ M(or\; HC\ell)\stackrel{k^{M}_{HC\ell}}{(o\vec{r}\; k_{HC\ell})}HC\ell(v=0)+M(or \; HC\ell) \end{eqnarray*} For most of the systems in which near-resonant V-V transfers occur, the V-TR de-excitation rates are negligible compared to the V-V transfer rates. But this is not the case for the M-HC\ell systems considered in this work. The de-excitation rates kHCMk^{M}_{HC\ell} and kMHCk^{HC\ell}_{M} are of the same order of magnitude as the V-V transfer rates kHCMk_{HC\ell-M} and kMHCk_{M-HC\ell} respectively. In order to determine separately all these rates, relaxation measurements have been performed by exciting either H to the (001)(00^{\circ} 1) level or HCHC\ell to the v = 1 level, and measuring the relaxation rates versus the molar fraction of the gas excited by laser. The results are discussed and compared with the values of the rates calculated by using a Morse potential as the intermolecular potential, and according to a semi-classical method in which a vibration-rotation exchange is assumed
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