229 research outputs found
Dopaminergic and Behavioral Deficits Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1
No full textThe manifestations of Parkinson's disease are caused by reduced dopaminergic innervation of the striatum. Loss-of-function mutations in the DJ-1 gene cause early-onset familial parkinsonism. To investigate a possible role for DJ-1 in the dopaminergic system, we generated a mouse model bearing a germline disruption of DJ-1. Although DJ-1(-/-) mice had normal numbers of dopaminergic neurons in the substantia nigra, evoked dopamine overflow in the striatum was markedly reduced, primarily as a result of increased reuptake. Nigral neurons lacking DJ-1 were less sensitive to the inhibitory effects of D2 autoreceptor stimulation. Corticostriatal long-term potentiation was normal in medium spiny neurons of DJ-1(-/-) mice, but long-term depression (LTD) was absent. The LTD deficit was reversed by treatment with D2 but not D1 receptor agonists. Furthermore, DJ-1(-/-) mice displayed hypoactivity in the open field. Collectively, our findings suggest an essential role for DJ-1 in dopaminergic physiology and D2 receptor-mediated functions
Asymmetric Vinylogous Nitro-Michael Reaction of Furanones Catalyzed by Cinchona Alkaloid Derivatives
No full textCurrent Advances in the Research of RNA Regulatory Enzymes
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Current Advances in the Research of RNA Regulatory Enzymes
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Lie Algebras Attached to Clifford Modules and Simple Graded Lie Algebras
No full textThe author is partially supported by the Grant-in-aid for Scientific Research (C) No. 26400124, Japan Society for the Promotion of Science and grant SPIRE 710022 from the University of Bergen.; The author is partially supported by Grants Fondecyt1181084 from the Chilean Research Council and DI17-0147 of Universidad de La Frontera, Chile.; The authors are partially supported by the grant of the Norwegian Research Council239033/F20.; The author is partially supported by JSPS KAKENHI Grant Number 17K05232.; The authors are partially supported by the grant of the Chilean Research Council Anillo ACT 1415 PIA CONICYT and EU FP7 IRSES program STREVCOMS, grant no. PIRSES-GA-2013-612669
OBSERVATION ON PSOLUS SQUAMATUS (KOREN) FROM THE OKHOTSK SEA (DENDROCHIROTA : PSOLIDAE)
No full textRecently, the author had a chance of making some close observations on two specimens of Psolus collected from the Okhotsk Sea off the northeastern coast of Hokkaido Island, Japan. These specimens were easily identified with P. squamatus (Koren) on their general morphology. This is a well-known species found rather commonly in the seas of higher latitudes in both hemispheres. Therefore, little doubts remained about this identifications at first. However, the feature of ossicles seems to differ somewhat significantly between these two specimens, and these differences remind the author of two type of the species, mentioned in detail by Ekman (1923 and 1925). Moreover, some features of ossicles in the present specimens seem to be out of the trends supposed by previous researchers on this species. Thus, it seems to the author that the present only two specimens might give a clue to make clear the morphological range of this species, and this has made the author repeat the morphological descriptions of the specimens, in the present paper, but always keeping the two types of the species and the morphological trends so far proposed by previous researchers in his mind. Prior to enter the description, the author wishes to express his hearty thanks to Mr. Goro Osagawa for his generosity in submitting the specimens to the author's examination and to the Seto Marine Biological Laboratory for every facility in carrying on his studies. Further, the author's gratitudes are due to Dr. Takasi Tokioka for his kindness in reading the manuscript
Studies on Drug Metabolism. XIII. Possible Role of Liver Microsomal Cytochrome P-450 in the Oxidative N-Demethylation of <I>p</I>-Substituted Dimethylaniline, N-Methyl-N-alkylaniline and N-Methyl-N-acylaniline Derivatives
No full textA comparison of Landau-Ginzburg models for odd-dimensional Quadrics
No full textIn [Rie08], the second author defined a Landau-Ginzburg model for homogeneous spaces G/P, as a regular function on an affine subvariety of the Langlands dual group. In this paper, we reformulate this LG model (X^, W_t) in the case of the odd-dimensional quadric, as a rational function on a Langlands dual projective space, in the spirit of work by R. Marsh and the second author for type A Grassmannians and by both authors for Lagrangian Grassmannians. We also compare this LG model with the one obtained independently by Gorbounov and Smirnov, and we use this comparison to deduce part of a conjecture of the second author for odd-dimensional quadrics
- …
