176,571 research outputs found
Mr. William C. Kirkpatrick
No full textMr. William C. Kirkpatrick, gerente de la Andian National Corporation, 1952 - 1954
Determining the effectiveness of the HERS-SA Academy using the Kirkpatrick framework of training evaluation
No full textIncludes bibliographical references (leaves 76-86).The research evaluated the outcomes of Higher Education Resource Service South Africa (HERS-SA) Academy using the Kirkpatrick (1996a) framework of training evaluation. The study used a three-stage research design to evaluate Academy outcomes in tenns of the reactions, learning and behaviour levels of the Kirkpatrick (1996a) framework. Two main findings emerged from the research: (1) the reactions and learning outcomes of the Academy are successful while the behaviour outcomes are only partially successful, and (2) increased confidence and increased understanding of HE are by far the strongest outcomes of the Academy. Based on the major findings of the research, a number of recommendations were made primarily to improve the behaviour outcomes of the Academy
Marriage record of Kirkpatrick, John Owen and McKay, Mary C.
No full textMarriage license for John Owen Kirkpatrick and Mary C. McKay. William F. Orhorue was the officiant
Study of jet precession, recirculation and vortex breakdown in turbulent swirling jets using LES.
No full textLarge eddy simulations (LES) are used to investigate turbulent isothermal swirling flows with a strong emphasis on vortex breakdown, recirculation and instability behaviour. The Sydney swirl burner configuration is used for all simulated test cases from low to high swirl and Reynolds numbers. The governing equations for continuity and momentum are solved on a structured Cartesian grid, and a Smagorinsky eddy viscosity model with the localised dynamic procedure is used as the sub-grid scale turbulence model. The LES successfully predicts both the upstream first recirculation zone generated by the bluff body and the downstream vortex breakdown bubble. The frequency spectrum indicates the presence of low frequency oscillations and the existence of a central jet precession as observed in experiments. The LES calculations well captured the distinct precession frequencies. The results also highlight the precession mode of instability in the center jet and the oscillations of the central jet precession, which forms a precessing vortex core. The study further highlights the predictive capabilities of LES on unsteady oscillations of turbulent swirling flow fields and provides a good framework for complex instability investigations
Motuporamines A−C, Cytotoxic Alkaloids Isolated from the Marine Sponge <i>Xestospongia exigua</i> (Kirkpatrick)
No full textMotuporamines A−C, Cytotoxic Alkaloids
Isolated from the Marine Sponge
Xestospongia exigua (Kirkpatrick
Elmer E. Kirkpatrick, Jr.
No full textPhotograph that was taken around 1940s. Elmer E. Kirkpatrick, Jr. was in Washington, D. C where he was responsible for emergency construction of cantonments, hospitals and POW facilities throughout the nation
William Bess, Mrs. Robert C. Harrison, Mrs. Monroe Kirkpatrick
No full textWilliam Bess is one of the first men to sign up for membership in Opera Guild of Fort Worth under its new policy of admitting male members. Mrs. Robert C. Harrison (center), and Mrs. Monroe Kirkpatrick accept his check. Fort Worth Star-Telegram Morning edition September 24, 1967.https://mavmatrix.uta.edu/specialcollections_startelegram1960s/5250/thumbnail.jp
John E. Kirkpatrick, Leo H. Bostwick, and Richard C. "Dick" Walker
No full textPhotograph depicting John E. Kirkpatrick (far right), Leo H. Bostwick (center), and Richard C. "Dick" Walker (far left) at the Kirkpatrick Center Naval Gallery, February 1988. Bostwick and Walker were former shipmates of John where they all served aboard the USS North Carolina. The three men are standing in front of a model of that ship. Mr. Kirkpatrick's friends were attending the celebration of his 80th birthday and the 10th anniversary of the center
Rossella podagrosa Kirkpatrick, 1907 — A valid species after all
No full textGöcke, Christian, Janussen, Dorte, Reiswig, Henry M., Jarrell, Shannon C., Dayton, Paul K. (2015): Rossella podagrosa Kirkpatrick, 1907 — A valid species after all. Zootaxa 4021 (1): 169-177, DOI: 10.11646/zootaxa.4021.1.
There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer
No full textBackground
Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation. The hTERT (human telomerase reverse transcriptase) subunit seems to be the rate-limiting determinant of telomerase and knowledge of factors controlling hTERT transcription may be useful in therapeutic strategies. The hTERT promoter contains binding sites for c-Myc and there is experimental and in vitro evidence that c-Myc may increase hTERT expression.
Materials and methods
RNA was extracted from 18 breast carcinomas and c-Myc mRNA expression was estimated by quantitative reverse transcriptase-PCR (RT-PCR) with Taqman methodology. These tumours had already been analysed for ER and PgR status using ligand-binding assays and had had their DNA ploidy and S-phase fractions measured by flow cytometry. Telomerase activity had already been determined by using a modified telomeric repeat and amplification protocol (TRAP) assay.
Results
Telomerase activity ranged from 0 to 246 units of Total Protein Generated (TPG), where one unit of TPG was equal to 600 molecules of telomerase substrate primers extended by at least three telomeric repeats. Median levels of TPG were 60 and mean levels 81. There was no significant correlation between levels of c-Myc mRNA expression, telomerase activity, S phase fraction or PgR. There was a significant negative correlation with ER status.
Conclusion
Although the hTERT promoter contains potential binding sites for c-Myc oncoprotein, we have found no correlation between c-Myc mRNA levels and telomerase activity
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