8 research outputs found
System-related errors associated with the long-term use of electronic medication management
No full textBackground: Electronic medication management (EMM) systems can facilitate system-related errors; errors that were less likely with the use of paper-based medication charts. Little is known about the types of system-related errors that persist or emerge with routine system use. This thesis aimed to identify and classify long-term system-related errors, determine contributing factors and compare errors over time. Methods: Research was conducted at three hospitals with the same EMM system in place for different durations. A narrative review was followed by mixed methods research, including an analysis of EMM-related incident reports, interviews with stakeholders and a review of documents detailing EMM system enhancements at the three sites. Long-term system-related errors were examined in terms of error types, contributing factors, consequences, and strategies for detection and mitigation. Analysis of each data source considered the element of time since EMM system implementation. Results: System-related errors were found to persist with long-term EMM system use. Factors related to the EMM system design, user and organisation contributed to system-related errors in varying degrees over time, however certain factors were consistently associated with errors. System-related errors resulted in medication errors, but also impacted the user, and documentation within the EMM system. Detection of system-related errors relied heavily on clinicians, while mitigation strategies targeted the EMM system and the context in which the system was used. Conclusion: This program of research highlighted how system-related errors develop over time. The findings emphasise that system-related errors result from a combination of different factors, and therefore mitigation strategies should be multilayered. Future research should investigate the effectiveness of interventions aimed at minimising system-related errors, particularly as EMM systems are increasingly implemented and improved
Building parent-school partnerships that improve kindergarten readiness for immigrant and English learner students
No full textThe research question addressed in this capstone is: how can educators effectively partner with parents and guardians to exchange information and resources that improve kindergarten readiness in English learners and immigrant students? This capstone documents interviews with immigrant and/or English learner families on the topic of increasing kindergarten readiness. The author outlines ways to boost kindergarten readiness by addressing two main methods: increasing access of formal preschool programs and improving the quality of learning that occurs in family, friend, and neighbor care. The capstone includes analysis of six parent perspectives on the issue. Finally, the author compares the parent perspectives with the existing body of research about kindergarten readiness, access of formal preschool and quality of family friend and neighbor care programs, and ways to build parent-school partnerships. The capstone concludes with suggestions for the school of study and further research to bring new voices to academic and policy decisions
Strategies used to detect and mitigate system-related errors over time: A qualitative study in an Australian health district
No full textAbstract Background Electronic medical record (EMR) systems provide timely access to clinical information and have been shown to improve medication safety. However, EMRs can also create opportunities for error, including system-related errors or errors that were unlikely or not possible with the use of paper medication charts. This study aimed to determine the detection and mitigation strategies adopted by a health district in Australia to target system-related errors and to explore stakeholder views on strategies needed to curb future system-related errors from emerging. Methods A qualitative descriptive study design was used comprising semi-structured interviews. Data were collected from three hospitals within a health district in Sydney, Australia, between September 2020 and May 2021. Interviews were conducted with EMR users and other key stakeholders (e.g. clinical informatics team members). Participants were asked to reflect on how system-related errors changed over time, and to describe approaches taken by their organisation to detect and mitigate these errors. Thematic analysis was conducted iteratively using a general inductive approach, where codes were assigned as themes emerged from the data. Results Interviews were conducted with 25 stakeholders. Participants reported that most system-related errors were detected by front-line clinicians. Following error detection, clinicians either reported system-related errors directly to the clinical informatics team or submitted reports to the incident information management system. System-related errors were also reported to be detected via reports run within the EMR, or during organisational processes such as incident investigations or system enhancement projects. EMR redesign was the main approach described by participants for mitigating system-related errors, however other strategies, like regular user education and minimising the use of hybrid systems, were also reported. Conclusions Initial detection of system-related errors relies heavily on front-line clinicians, however other organisational strategies that are proactive and layered can improve the systemic detection, investigation, and management of errors. Together with EMR design changes, complementary error mitigation strategies, including targeted staff education, can support safe EMR use and development
Errors resulting from the use of electronic systems – stakeholder perceptions on how to reduce them
No full textBackground: Electronic medication management (eMeds) systems improve medication safety, but simultaneously introduce new system-related errors; errors that were not possible with the use of paper records. We know very little about strategies used in Australian settings to reduce system-related errors.Aims: To explore stakeholders’ perceptions and experiences of interventions that were implemented to reduce system-related errors associated with the use of eMeds, as well as other changes they believe could further reduce these errors in the future.Methods: Semi-structured interviews were conducted with users of eMeds and stakeholders with eMeds supporting roles in a NSW Local Health District. Discussions focused on interventions which had targeted or reduced system-related errors, in addition to future changes needed to stop these errors from occurring. Interviews were audio-recorded, transcribed verbatim, and analysis was conducted iteratively using an inductive approach.Results: Twenty-five participants took part. Participants described the redesign of eMeds as central to decreasing system-related errors, with examples of system changes described, including pop-up alerts and changes to the visual display. Increased monitoring of system use was also perceived to reduce errors. However, participants indicated that in some cases, redesign at the local level was not possible, so increased training and support was needed. Future recommended changes included more effective alerts, and a more intuitive system, as well as ongoing training.Conclusions: Redesign of eMeds was a frequent strategy used to reduce system-related errors, but not all desired system changes were possible at a local level. Ensuring that users are well-supported in using the system and monitoring how users interact with the system will likely reduce system-related errors
TNFα treated 7SL-a-p50 and TAR-a-p50 transfectants show reduced NFκB-luciferase activity compared with vehicle controls
No full text<p><b>Copyright information:</b></p><p>Taken from "Co-expression of anti-NFκB RNA aptamers and siRNAs leads to maximal suppression of NFκB activity in mammalian cells"</p><p>Nucleic Acids Research 2006;34(5):e36-e36.</p><p>Published online 3 Mar 2006</p><p>PMCID:PMC1390692.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> The 293 cells were co-transfected with NFκB-luciferase reporter and 7SL or 7SL-a-p50 () or TAR or TAR-a-p50 (). Transfectants were treated with TNFα at 20 ng/ml (plus) or medium alone (minus). Substrate and lysis solution was added to cells and fluorescence was measured and reported as relative luciferase units (RLU). Shown experiment is representative of multiple experiments. Error bars generated by Microsoft Excel
NFκB activity is most significantly inhibited in the presence of both p50-specific siRNA and p50-specific aptamer
No full text<p><b>Copyright information:</b></p><p>Taken from "Co-expression of anti-NFκB RNA aptamers and siRNAs leads to maximal suppression of NFκB activity in mammalian cells"</p><p>Nucleic Acids Research 2006;34(5):e36-e36.</p><p>Published online 3 Mar 2006</p><p>PMCID:PMC1390692.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> () Bar graph of results of NFκB-dependent luciferase assay of cells transfected with NFκB-dependent reporter plasmid along with control plasmids for both siRNA and aptamer expressors (siRNA CON + 7SL), p-50 specific siRNA and aptamer control plasmid (siRNA2 + 7SL), p-50 specific aptamer plus siRNA control plasmid (siRNA CON + 7SL-a-p50), and plasmids expressing both p-50 specific siRNA and aptamer (siRNA 2 + 7SL-a-p50). () Bar graph of results of NFκB-dependent luciferase assay of cells transfected with NFκB-dependent reporter plasmid along with control plasmids for both siRNA and aptamer expressors (siRNA CON + TAR), p-50 specific siRNA and aptamer control plasmid (siRNA2 + TAR), p-50 specific aptamer + siRNA control plasmid (siRNA CON + TAR-a-p50), and plasmids expressing both p-50 specific siRNA and aptamer (siRNA 2 + TAR-a-p50) Shown experiments are representative of multiple experiments. Error bars generated by Microsoft Excel
A-p50 retains NFκB-binding activity within the context of 7SL and TAR RNA vehicles
No full text<p><b>Copyright information:</b></p><p>Taken from "Co-expression of anti-NFκB RNA aptamers and siRNAs leads to maximal suppression of NFκB activity in mammalian cells"</p><p>Nucleic Acids Research 2006;34(5):e36-e36.</p><p>Published online 3 Mar 2006</p><p>PMCID:PMC1390692.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> Lysates from TNFα stimulated 293 () or HeLa () cells were incubated with titrations of transcribed a-p50 or control aptamer in the presence of radiolabeled NFκB DNA probe. Samples were run on 6% DNA retardation gels and then visualized after being exposed to phosphoimager plates. Lane 1, no TNF A. Lanes 2–10, with TNFα at 10 ng/ml. Lane 2, no aptamer. Lane 3, 25 µg/ml 7SL a-p50. Lane 4, 12.5 µg/ml 7SL a-p50. Lane 5, 5 µg/ml 7SL a-p50. Lane 6, 2.5 µg/ml 7SL a-p50. Lane 7, 25 µg/ml 7SL. Lane 8, 12.5 µg/ml 7SL. Lane 9, 5 µg/ml 7SL. Lane 10, 2.5 µg/ml 7SL. Shown experiment is representative of multiple experiments. (B) Lanes 2–10, with TNFα at 30 ng/ml. Lane 2, TNFα alone. Lane 3, 90 µg/ml TAR-a-p50. Lane 4, 45 µg/ml TAR-a-p50. Lane 5, 30 µg/ml TAR-a-p50. Lane 6, 10 µg/ml TAR-a-p50. Lane 7, 90 µg/ml TAR transcript. Lane 8, 45 µg/ml TAR. Lane 9, 30 µg/ml TAR. Lane 10, 10 µg/ml TAR. Shown experiment is representative of multiple experiments
Aqui nessa fronteira onde tu vê beira de linha tu vai ver cuento...: tradições orais na fronteira entre Argentina, Brasil e Uruguai
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-Graduação em Antrolopologia Social.Este trabalho aborda o contexto de transmissão das tradições orais da fronteira entre Argentina, Brasil e Uruguai, sob a hipótese de que a circulação de narrativas cria, nas zonas vizinhas destes três países, uma cultura comum. Inicialmente, o referencial etnográfico derivou na realização de um mapeamento das características da oralidade na região: quem são os contadores, como executam suas performances, quais são os temas recorrentes de seus causos, quais são os locais onde ocorrem as "rodas de causo", os horários preferidos para a sua narração e como se caracteriza a participação dos ouvintes. A análise deste material é realizada com base em duas perspectivas, das narrativas como expressão da experiência (com foco sobre os eventos narrados) e das narrativas como performance (com foco sobre os eventos narrativos), a partir das quais são discutidas especificidades do ethos local (gaúcho ou gaucho), tais como o apelo à ruralidade (nas referências à "campanha" e à relação com o cavalo), a mobilidade dos indivíduos através da fronteira, a vivência
