553 research outputs found
Environmental toxicity, redox signaling and lung inflammation:the role of glutathione
No full textGlutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is tightly regulated and has been implicated in redox signaling and also in protection against environmental oxidant-mediated injury. Changes in the ratio of the reduced and disulfide form (GSH/GSSG) can affect signaling pathways that participate in a broad array of physiological responses from cell proliferation, autophagy and apoptosis to gene expression that involve H(2)O(2) as a second messenger. Oxidative stress due to oxidant/antioxidant imbalance and also due to environmental oxidants is an important component during inflammation and respiratory diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and asthma. It is known to activate multiple stress kinase pathways and redox-sensitive transcription factors such as Nrf2, NF-kappaB and AP-1, which differentially regulate the genes for pro-inflammatory cytokines as well as the protective antioxidant genes. Understanding the regulatory mechanisms for the induction of antioxidants, such as GSH, versus pro-inflammatory mediators at sites of oxidant-directed injuries may allow for the development of novel therapies which will allow pharmacological manipulation of GSH synthesis during inflammation and oxidative injury. This article features the current knowledge about the role of GSH in redox signaling, GSH biosynthesis and particularly the regulation of transcription factor Nrf2 by GSH and downstream signaling during oxidative stress and inflammation in various pulmonary diseases. We also discussed the current therapeutic clinical trials using GSH and other thiol compounds, such as N-acetyl-l-cysteine, fudosteine, carbocysteine, erdosteine in environment-induced airways disease
Biswas-Milovic model and its optical solitons
No full textInternational Conference on Numerical Analysis and Applied Mathematics 2018, ICNAAM 2018 -- 13 September 2018 through 18 September 2018 -- -- 149843In this work, optical solitons are obtained for the Biswas - Milovic equation as a generalized model via the extended generalizing Riccati mapping method. This method reveals several optical solitons including traveling wave solutions. The found solutions are identified with two different forms including the hyperbolic functions, the rational functions and the trigonometric functions. Reliability of our solution is given graphical consequens. © 2019 Author(s)
On connections on principal bundles
No full textAbstractA new construction of a universal connection was given in Biswas, Hurtubise and Stasheff (2012). The main aim here is to explain this construction. A theorem of Atiyah and Weil says that a holomorphic vector bundle E over a compact Riemann surface admits a holomorphic connection if and only if the degree of every direct summand of E is zero. In Azad and Biswas (2002), this criterion was generalized to principal bundles on compact Riemann surfaces. This criterion for principal bundles is also explained
Simultaneous linearization of germs of commuting holomorphic diffeomorphisms
No full textAbstractLet α1,…,αn be irrational numbers which are linearly independent over the rationals, and f1,…,fn commuting germs of holomorphic diffeomorphisms in ℂ such that fk(0)=0,f′k(0)=e2πiαk,k=1,…,n. Moser showed that f
1,…,fn are simultaneously linearizable (i.e. conjugate by a germ of holomorphic diffeomorphism h to the rigid rotations Rαk(z)=e2πiαkz) if the vector of rotation numbers (α
1,…,αn) satisfies a Diophantine condition. Adapting Yoccoz’s renormalization to the setting of commuting germs, we show that simultaneous linearization holds in the presence of a weaker Brjuno-type condition ℬ(α1,…,αn)<+∞, where ℬ(α1,…,αn) is a multivariable analogue of the Brjuno function. If there are no periodic orbits for the action of the germs f1,…,fn in a neighbourhood of the origin, then a weaker arithmetic condition ℬ′ (α
1,…,αn)<+∞ analogous to Perez-Marco’s condition for linearization in the absence of periodic orbits is shown to suffice for linearizability. Normalizing the germs to be univalent on the unit disc, in both cases the Siegel discs are shown to contain discs of radii for some universal constant C.</jats:p
Quasi-metric antipodal spaces and maximal Gromov hyperbolic spaces
No full textHyperbolic fillings of metric spaces are a well-known tool for proving results on extending quasi-Moebius maps between boundaries of Gromov hyperbolic spaces to quasi-isometries between the spaces. For a hyperbolic filling Y of the boundary of a Gromov hyperbolic space X, one has a quasi-Moebius identification between the boundaries ∂Y and ∂X. For CAT(-1) spaces, and more generally boundary continuous Gromov hyperbolic spaces, one can refine the quasi-Moebius structure on the boundary to a Moebius structure. It is then natural to ask whether there exists a functorial hyperbolic filling of the boundary by a boundary continuous Gromov hyperbolic space with an identification between boundaries which is not just quasi-Moebius, but in fact Moebius. The filling should be functorial in the sense that a Moebius homeomorphism between boundaries should induce an isometry between there fillings. We give a positive answer to this question for a large class of boundaries satisfying one crucial hypothesis, the antipodal property. This gives a class of compact spaces called quasi-metric antipodal spaces. For any such space Z, we give a functorial construction of a boundary continuous Gromov hyperbolic space M(Z) together with a Moebius identification of its boundary with Z. The space M(Z) is maximal amongst all fillings of Z. These spaces M(Z) give in fact all examples of a natural class of spaces called maximal Gromov hyperbolic spaces. We prove an equivalence of categories between quasi-metric antipodal spaces and maximal Gromov hyperbolic spaces. This is part of a more general equivalence we prove between the larger categories of certain spaces called antipodal spaces and maximal Gromov product spaces. We prove that the injective hull of a Gromov product space X is isometric to the maximal Gromov product space M(Z), where Z is the boundary of X. We also show that a Gromov product space is injective if and only if it is maximal
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