8 research outputs found
The sacred choral music of Alberto Ginastera
No full text"The noted Argentine composer, Alberto Ginastera is remembered primarily for operas, Don Rodrigo, Bomarzo, and Beatrix Cenci. Stuart Pope, editor of Ginastera's works and personal friend, has written in the preface of his catalogue: ""As with his (Ginastera's) contemporary Benjamin Britten, the human voice is perhaps Alberto Ginastera's greatest influence: the operas, the cantatas, the chamber music with voice and not least the choral writing."" Ginastera composed three choral works and, notably, all three appear in the sacred genre. These three sacred choral works were written at the beginning of his ouevre, Psalm 150 (Op. 5, 1938), the middle years, Hieremiae Prophetae Lamentationes (Op. 14, 1946), and Turbae ad Passionem Gregroianam, (Op. 43, 1974). From a musical and historical view, this study will show not only his choral compositional techniques but also yield in-sights into the development of Ginastera as a composer in general."Made available in DSpace on 2011-05-07T12:08:54Z (GMT). No. of bitstreams: 2
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Methane oxidation and emission in Lake Lugano (Southern Switzerland) : a lipid biomarker and isotopic approach
No full textMethane is an important greenhouse gas in Earth's atmosphere. The sources of atmospheric methane are largely biogenic, being produced under anoxic conditions by methanogenic Archaea. Wetlands, which include lakes, are important contributors to the atmospheric methane budget, since they commonly feature anoxic sediments or bottom water. Methane oxidising bacteria at the interface between oxic and anoxic sediments and water limit the efflux of methane. Furthermore, in the oceans, methane is oxidised anaerobically by Archaea, in a process coupled to sulfate reduction. In freshwater environments, where sulfate concentrations are orders of magnitude lower, this process is not thermodynamically favourable, and archaeal anaerobic oxidation of methane is often absent. It has been proposed in certain lake environments, however, that anaerobic oxidation of methane does take place.
One lake in which anaerobic oxidation of methane was proposed is the northern basin of Lake Lugano, southern Switzerland. Anaerobic oxidation of methane in this basin is explored in chapter 2 of this PhD thesis. Indeed we found methane concentration and carbon isotopic composition profiles characteristic of methane oxidation in the anoxic hypolimnion, more than 30 m below the interface between the oxic and anoxic waters. In addition, microbial biomass at these depths showed carbon isotope signatures of methane-derived carbon (d13C-values as low as -70‰ in C16:1 fatty acids), indicating that methane is used as a carbon source. However, no methane oxidation took place in incubation experiments under anoxic conditions. Addition of alternative potential electron acceptors did not stimulate methane oxidation, and methane oxidation was only observed in the presence of oxygen. Instead, we propose that episodic introduction of oxygenated water into the anoxic hypolimnion sustains a community of aerobic methanotrophs.
Carbon derived from methane oxidation has been shown in several studies to constitute an important carbon input to aquatic ecosystems. In the studies reported in chapters 2 and 3, compound specific stable carbon isotope analysis of lipid biomarkers was used to trace methane-derived carbon through the ecosystems at redox interfaces and in the anoxic hypolimnion of Lake Lugano. In the monomictic southern basin (chapter 3), an anoxic benthic nepheloid layer develops during the period of water column stratification. This layer was found to be derived from microbial production in the hypolimnion. Methane oxidising bacteria constituted up to 30% of total microbial cell numbers in the nepheloid layer, and 77% to 96% of the organic carbon in this layer was methane-derived. High rates of aerobic methane oxidation at the top of the anoxic nepheloid layer led to an oxygen consumption that was greater than the downward diffusion, causing the anoxic nepheloid layer to expand. Bacterial aerobic methanotrophs migrate upwards through the water column with the interface between the oxic hypolimnion and the anoxic nepheloid layer.
The extent of emission of methane to the atmosphere depends on the totality of sinks and sources in the lake basin. In both the northern and the southern basin of Lake Lugano, large amounts of methane are emitted from the sediments into the bottom water. However, consumption by aerobic methanotrophs at the oxic-anoxic redoxcline is near complete, and during stratified conditions, no methane escapes to the epilimnion. On the other hand, methane super-saturation in the surface water was observed throughout the year. Chapter 4 describes the results of three mapping campaigns of surface water methane concentrations in the northern basin of Lake Lugano, in spring and autumn. Additionally, methane concentration and carbon isotopic composition were measured on depth profiles down to 40 m depth in transects across the lake basin. Methane fluxes to the atmosphere were calculated from surface water concentration and wind speed. At a standardised wind speed of 1.6 m s-1 (average wind speed during the period from May until October) fluxes to the atmosphere were significantly higher in autumn (44 and 97 micromol m-2 d-1 in October 2011 and October 2012, respectively) than in spring (7 micromol m-2 d-1, May 2012). This difference is in part due to higher concentrations in autumn than in spring, and in part a result of a stronger dependence of the transfer velocity on buoyancy flux when the surface water cools. The source of methane in the surface water could not be determined with certainty. It is possible that internal waves at the thermocline induce friction at the sediment-water interface in the littoral zone, which leads to increased outgassing of sedimentary methane. However, the northern basin of Lake Lugano has steep shores along large parts of the basin, which offer little space for deposition of sediments, and the possibility of in situ production of methane in the water column must be considered
Writing and Reading in the Circle of Sir John Fastolf (d. 1459)
No full textThis thesis is a study of all aspects of writing and reading connected with Sir John Fastolf, a military captain and steward of the household of John Duke of Bedford, who returned to England from the later battles of the Hundred Years War in 1438. Using the circumstantial, palaeographical, and codicological evidence contained in
the letters, documents, and literary texts associated with Fastolf, the thesis performs a survey of the men who wrote for Fastolf, their interactions with him and with each other, and their positions in what might be deemed a ‘readership community’. The thesis takes a detailed look at letter and document composition, delivery, and storage,
then relates this administrative writing to the production and reception of texts in manuscript books. It argues that there was a close relationship between these two types of work, finding that the administrators of the Fastolf circle were also the scribes of literary texts. The thesis consistently reinforces the importance of oral communication within this circle, emphasising that though there is a substantial amount of surviving written material associated with this circle, the written word was
not the sole form of communication within it.
The first section of the thesis is an introduction to the circle of Sir John Fastolf,since it is necessary to comprehend this complex and multitudinous group before
considering reading and writing within it. Chapter One gives biographical information about Fastolf and the associates who were most involved with writing and reading. It then reconsiders the highly-contended issue of Fastolf's relations with these men: was Fastolf a harsh master, or badly-served by his men? Chapter Two explains the choice of the word ‘circle’ to describe this group, and considers potential subdivisions within it according to responsibilities or linguistic descriptions. It emphasises the individuality within the master-servant relationship, as is indicated by the evidence that Fastolf’s servants maintained various levels of proximity and permanence of service.
In the second section, Chapter Three is a detailed examination of the writing of letters and administrative documents. It opens with a discussion of the interplay between oral conversation and written correspondence. It then looks at the evidence for the way in which Fastolf’s letters (none of which were autograph) were composed, and argues that they were not dictated. It progresses to examine the practicalities of correspondence and administration: drafting, copying, letter delivery,
and storage. Finally, there is a look at the watermarks of paper associated with Fastolf. This leads into Chapter Four, which is a study of interactions between the men who wrote for Fastolf. It shows that there was consistent co-operation between Fastolf’s scribes, and suggests that collaboration had an effect upon the linguistic features of their work. Finally, Chapter Five looks at Fastolf’s collection of literary manuscript books, and considers the evidence about who read literary texts, as indicated by circumstantial evidence, as well codicological evidence such as annotations within the books themselves. It provides case studies of the men who can be shown to have written these books, and a focused study of one of these books in particular, the hitherto under-studied manuscript, College of Arms, MS. Arundel 48.
Finally, there is an overview of the formation of a sub-section of Fastolf’s readership community in the west country, especially in Bristol, Glastonbury and Wells, which
was facilitated by Fastolf’s Bristol-born secretary William Worcester
The representation of the English in French literature between 1450 and 1530
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Determinism and organization. Foundations and limits of Claude Bernard’s program
No full textComo lo afirma el autor de este perspicazlibro: el presente de una ciencia no solamente se define por su éxito y su proyección, también hacen parte de su imagen más completa -aunque precisamente por eso jamás acabada- los problemas y polémicas de dicha ciencia; asuntos que la mantienen activa, creativa y avanzando.
Este libro se constituye en una franca imagen del presente de una ciencia como la Biología. Magistralmente Gustavo Caponi examina, a la luz de los problemas y tensiones actuales de la Filosofía de la Biología, la historia del programa de la Fisiología Experimental conformado en el siglo XIX por el médico y biólogo francés Claude Bernard. Así, el objeto de este libro es al menos doble: por un lado, examinar con detalle y ofrecer claridad de los presupuestos y consecuencias epistemológicas de la Fisiología Experimental de Claude Bernard; por otro, valerse de las discusiones históricas de la Biología para traer nuevas respuestas y precisiones al actual debate presente en la Filosofía de la Biología.The present of a science is not only defined by its success and projection; the problems and controversies that keep it moving forward are also part of its complete image. This book constitutes a frank image of the present of Biology. The author examines, in light of the current problems of the philosophy of biology, the history of the program of experimental physiology elaborated in the 19th century by the French scientist Claude Bernard
Innovative approaches to monitor mutant huntingtin and to facilitate its degradation in Huntington's disease models
No full textHuntington’s disease (HD) is a dominant genetic neurodegenerative disease caused by a mutation in the exon 1 of the huntingtin gene. The clinical symptoms, such as motor disturbances (chorea), cognitive decline and psychiatric impairments are usually developed by the patients in mid-life. Mutant huntingtin protein presents an amplification of a polyglutamine repeat at its N-terminus, which induces conformational changes and leads to neurotoxicity, impairment of cell homeostasis and neuronal cell death. The neuropathology of HD is characterized by a progressive degeneration of the brain starting from the striatum and spreading to other regions such as cortex, hypothalamus and cerebellum. In addition to the diffused brain atrophy, HD patients are also affected by multiple peripheral symptoms which contribute to worsening disease progression and eventually lead to death approximately two decades after onset.
The mechanisms leading to the toxicity induced by mutant huntingtin are not well understood. However the acquisition of a misfolded conformation and the formation of intracellular inclusions constituted by shorter fragments of the mutant protein are considered important in the neurodegenerative process.
In my thesis project I have investigated mechanisms to enhance the cellular degradation of mutant huntingtin. A second focus was on the development of an immunoassay to detect and quantify aggregates in HD models.
I analyzed the data obtained form a high through-put screen aimed to identify small molecular weight compounds decreasing mutant huntingtin levels in cells. Among all compounds screened, only inhibitors of heat shock protein 90 (Hsp90) showed a significant effect on mutant huntingtin clearance. I therefore investigated the mechanisms of Hsp90 chaperone inhibition and the reduction of soluble mutant huntigtin levels. Data from biochemical assays demonstrated that mutant huntingtin degradation is enhanced upon compound treatment and that the protein is cleared through the ubiquitin-proteasome system. This was independent from the heat shock response induced after pharmacological Hsp90 inhibition. Co-immunoprecipitation experiments suggested that mutant huntingtin is a client protein of Hsp90. The results were replicated in different cellular models including full length mutant huntingtin expressed from the endogenous locus, thus highlighting the importance of Hsp90 in stabilizing soluble mutant huntingtin and suggesting the possible application of Hsp90 inhibitors as therapies in HD.
In the second project I developed a sensitive method to detect mutant protein aggregates in HD models. To this purpose I implemented the already established time resolved fluorescence resonance energy transfer (TR-FRET) based immunoassay for the detection of soluble mutant and wild-type huntingtin. A mixture of either donor or acceptor fluorophore labeled single monoclonal antibody directed against an epitope exposed on the huntingtin aggregate surface was used. This strategy allowed for energy transfer and therefore a measurable TR-FRET signal, only in presence of mutant aggregated protein. I could demonstrate the sensitivity of the bioassay on a microtiter set up both as a single assay and in a duplex combination with the previously developed TR-FRET assay for soluble huntingtin.
I applied the TR-FRET for aggregated huntingtin to samples from R6/2 and HdhQ150 mice, expressing exon 1 and full length mutant huntingtin, respectively. In brain homogenates from both models there was an age-dependent, inverse correlation between soluble and aggregated mutant huntingtin. These findings supported the importance of the relation between aggregated and soluble protein in disease progression. Furthermore, I detected the inverse correlation also in peripheral tissues of R6/2 mice where the presence of aggregates was previously demonstrated with other methods. An in-depth analysis of R6/2 samples in a combination of TR-FRET and size exclusion chromatography suggested a differential specificity of the two antibody combinations used for different aggregate populations. The TR-FRET method provides a new means to characterize the aggregation process as well as to test the efficacy of possible disease modifying treatments for HD
On the Problem of the Island of Earth: Introducing a Universal Theory of Value in an Open Letter to The President of the United States
No full textThis paper introduces a unified theory of value.theory of value; evolutionary stable solution; economic power; military power; national security; global threat mitigation; extinction; human evolution; ideological environmentalism; the problem of induction; karl popper; F.A. von Hayek; austrian economics
Proceedings of the Frontiers of Retrovirology Conference 2016
No full textTable of contentsOral presentationsSession 1: Entry & uncoatingO1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replicationIrena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk LindemannO2 A novel entry/uncoating assay reveals the presence of at least two species of viral capsids during synchronized HIV-1 infectionClaire Da Silva Santos, Kevin Tartour, Andrea CimarelliO3 Dynamics of nuclear envelope association and nuclear import of HIV-1 complexesRya Burdick, Jianbo Chen, Jaya Sastri, Wei-Shau Hu, Vinay PathakO4 Human papillomavirus protein E4 potently enhances the susceptibility to HIV infectionOliver T. KepplerSession 2: Reverse transcription & integrationO5 Structure and function of HIV-1 integrase post translational modificationsKarine Pradeau, Sylvia Eiler, Nicolas Levy, Sarah Lennon, Sarah Cianferani, Stéphane Emiliani, Marc RuffO6 Regulation of retroviral integration by RNA polymerase II associated factors and chromatin structureVincent ParissiSession 3: Transcription and latencyO7 A novel single-cell analysis pipeline to identify specific biomarkers of HIV permissivenessSylvie Rato, Antonio Rausell, Miguel Munoz, Amalio Telenti, Angela CiuffiO8 A capsid-dependent integration program linking T cell activation to HIV-1 gene expressionAlexander Zhyvoloup, Anat Melamed, Ian Anderson, Delphine Planas, Janos Kriston-Vizi, Robin Ketteler, Chen-Hsuin Lee, Andy Merritt, Petronela Ancuta, Charles Bangham, Ariberto FassatiO9 Characterisation of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genomeAnthony Rodari, Benoit Van Driessche, Mathilde Galais, Nadége Delacourt, Sylvain Fauquenoy, Caroline Vanhulle, Anna Kula, Arsène Burny, Olivier Rohr, Carine Van LintO10 Tissue-specific dendritic cells differentially modulate latent HIV-1 reservoirsThijs van Montfort, Renee van der Sluis, Dave Speijer, Ben BerkhoutSession 4: RNA trafficking & packagingO11 A novel cis-acting element affecting HIV replicationBo Meng, Andrzej Rutkowski, Neil Berry, Lars Dölken, Andrew LeverO12 Tolerance of HIV’s late gene expression towards stepwise codon adaptationThomas Schuster, Benedikt Asbach, Ralf WagnerSession 5: Assembly & releaseO13 Importance of the tax-inducible actin-bundling protein fascin for transmission of human T cell leukemia virus Type 1 (HTLV-1)Christine Gross, Veit Wiesmann, Martina Kalmer, Thomas Wittenberg, Jan Gettemans, Andrea K. Thoma-KressO14 Lentiviral nef proteins antagonize TIM-mediated inhibition of viral releaseMinghua Li, Eric O. Freed, Shan-Lu LiuSession 6: Pathogenesis & evolutionO15 SEVI and semen prolong the half-life of HIV-1Janis Müller, Jan MünchO16 CD169+ macrophages mediate retrovirus trans-infection of permissive lymphocytes to establish infection in vivoXaver Sewald, Pradeep Uchil, Mark Ladinsky, Jagadish Beloor, Ruoxi Pi, Christin Herrmann, Nasim Motamedi, Thomas Murooka, Michael Brehm, Dale Greiner, Thorsten Mempel, Pamela Bjorkman, Priti Kumar, Walther MothesO17 Efficient replication of a vpu containing SIVagm construct in African Green Monkeys requires an HIV-1 nef geneSimone Joas, Erica Parrish, Clement Wesley Gnanadurai, Edina Lump, Christina M. Stürzel, Nicholas F. Parrish, Ulrike Sauermann, Katharina Töpfer, Tina Schultheiss, Steven Bosinger, Guido Silvestri, Cristian Apetrei, Nicholas Huot, Michaela Müller-Trutwin, Daniel Sauter, Beatrice H. Hahn, Christiane Stahl-Hennig, Frank KirchhoffO18 Reprogramming initiates mobilization of endogenous mutagenic LINE-1, Alu and SVA retrotransposons in human induced pluripotent stem cells with consequences for host gene expressionGerald Schumann, Sabine Jung-Klawitter, Nina V. Fuchs, Kyle R. Upton, Martin Muñoz-Lopez, Ruchi Shukla, Jichang Wang, Marta Garcia-Canadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Patricia Gerdes, Sylvia Merkert, Andres Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, J. Garcia-Perez, Geoffrey J. FaulknerO19 NF-κB activation induces expression of human endogenous retrovirus and particle productionTara Hurst, Aris Katzourakis, Gkikas MagiorkinisSession 7a and b: Innate sensing & intrinsic immunityO20 Identification of the phosphatase acting on T592 in SAMHD1 during M/G1 transitionKerstin Schott, Rita Derua, Janna Seifried, Andreas Reuter, Heike Schmitz, Christiane Tondera, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Veerle Janssens, Renate KönigO21 Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cellsHanna-Mari Baldauf, Lena Stegmann, Sarah-Marie Schwarz, Maud Trotard, Margarethe Martin, Gina Lenzi, Manja Burggraf, Xiaoyu Pan, Oliver I. Fregoso, Efrem S. Lim, Libin Abraham, Elina Erikson, Laura Nguyen, Ina Ambiel, Frank Rutsch, Renate König, Baek Kim, Michael Emerman, Oliver T. Fackler, Oliver T. KepplerO22 The role of SAMHD1 in antiviral restriction and immune sensing in the mouseSabine Wittmann, Rayk Behrendt, Bianca Volkmann, Kristin Eissmann, Thomas GrambergO23 T cells expressing reduced restriction factors are preferentially infected in therapy naïve HIV-1 patientsSebastian Bolduan, Herwig Koppensteiner, Stefanie Regensburg, Ruth Brack-Werner, Rika Draenert, Michael SchindlerO24 cGAS-mediated innate immunity spreads through HIV-1 env-induced membrane fusion sites from infected to uninfected primary HIV-1 target cellsAurélie Ducroux, Shuting Xu, Aparna Ponnurangam, Sergej Franz, Angelina Malassa, Ellen Ewald, Christine GoffinetO25 Perturbation of innate RNA and DNA sensing by human T cell leukemia virus type 1 oncoproteinsSin-Yee Fung, Ching-Ping Chan, Chun-Kit Yuen, Kin-Hang Kok, Chin-Ping Chan, Dong-Yan JinO26 Induction and anti-viral activity of Interferon α subtypes in HIV-1 infectionUlf DittmerO27 Vpu-mediated counteraction of tetherin is a major determinant of HIV-1 interferon resistanceDorota Kmiec, Shilpa Iyer, Christina Stürzel, Daniel Sauter, Beatrice Hahn, Frank KirchhoffO28 DNA repair protein Rad18 restricts HIV-1 and LINE-1 life cycleYasuo Ariumi, Mariko Yasuda-Inoue, Koudai Kawano, Satoshi Tateishi, Priscilla TurelliO29 Natural mutations in IFITM3 allow escape from post-translational regulation and toggle antiviral specificityAlex Compton, Nicolas Roy, Françoise Porrot, Anne Billet, Nicoletta Casartelli, Jacob Yount, Chen Liang, Oliver SchwartzSession 8: Adaptive immunity & immune evasionO30 Observing evolution in HIV-1 infection: phylogenetics and mutant selection windows to infer the influence of the autologous antibody response on the viral quasispeciesCarsten Magnus, Lucia Reh, Penny Moore, Therese Uhr, Jacqueline Weber, Lynn Morris, Alexandra TrkolaO31 Dose and subtype specific analyses of the anti-HIV effects of IFN-alpha family membersRashel V. Grindberg, Erika Schlaepfer, Gideon Schreiber, Viviana Simon, Roberto F. SpeckSession 9: Novel antiviral strategiesO32 LEDGIN-mediated inhibition of the integrase-LEDGF/p75 interaction reduces reactivation of residual latent HIVZeger Debyser, Lenard Vranckx, Jonas Demeulemeester, Suha Saleh, Eric Verdin, Anna Cereseto, Frauke Christ, Rik GijsbersO33 NKG2D-mediated clearance of reactivated viral reservoirs by natural killer cellsO34 Inhibition of HIV reactivation in brain cells by AAV-mediated delivery of CRISPR/Cas9O35 CRISPR-Cas9 as antiviral: potent HIV-1 inhibition, but rapid virus escape and the subsequent design of escape-proof antiviral strategiesBen Berkhout, Gang Wang, Na Zhao, Atze T. DasSession 10: Recent advances in HIV vaccine developmentO36 Priming with a potent HIV-1 DNA vaccine frames the quality of T cell and antibody responses prior to a poxvirus and protein boostBenedikt Asbach, Josef Köstler, Beatriz Perdiguero, Mariano Esteban, Bertram L. Jacobs, David C. Montefiori, Celia C. LaBranche, Nicole L. Yates, Georgia D. Tomaras, Guido Ferrari, Kathryn E. Foulds, Mario Roederer, Gary Landucci, Donald N. Forthal, Michael S. Seaman, Natalie Hawkins, Steven G. Self, Sanjay Phogat, James Tartaglia, Susan W. Barnett, Brian Burke, Anthony D. Cristillo, Song Ding, Jonathan L. Heeney, Giuseppe Pantaleo, Ralf WagnerO37 Passive immunisation with a neutralising antibody against HIV-1 Env prevents infection of the first cells in a mucosal challenge rhesus monkey modelChristiane Stahl-Hennig, Viktoria Stab, Armin Ensser, Ulrike Sauermann, Bettina Tippler, Dennis Burton, Matthias Tenbusch, Klaus ÜberlaO38 HIV antibody Fc-glycoforms drive B cell affinity maturationGalit Alter, Giuseppe Lofano, Anne-Sophie Dugast, Viraj Kulkarni, Todd SuscovichPoster presentationsTopic 1: Entry & uncoatingP1 Dynein light chain is required for murine leukemia virus infectionTatiana Opazo, Felipe Barraza, Diego Herrera, Andrea Garces, Tomas Schwenke, Diego Tapia, Jorge Cancino, Gloria ArriagadaP2 Peptide paratope mimics of the broadly neutralising HIV-1 antibody b12Christina Haußner, Dominik Damm, Anette Rohrhofer, Barbara Schmidt, Jutta EichlerP3 Investigating cellular pathways involved in the transmission of HIV-1 between dendritic cells and T cells using RNAi screening techniquesRebecca Midgley, James Wheeldon, Vincent PiguetP4 Co-receptor tropism in HIV-1, HIV-2 monotypic and dual infectionsPriyanka Khopkar, Megha Rohamare, Smita KulkarniP5 Characterisation of the role of CIB1 and CIB2 as HIV-1 helper factorsAna Godinho-Santos, Allan Hance, Joao Goncalves, Fabrizio MammanoP6 Buffering deleterious polymorphisms in the highly constrained C2 region of HIV-1 envelope by the flexible V3 domainRomain Gasser, Meriem Hamoudi, Martina Pellicciotta, Zhicheng Zhou, Clara Visdeloup, Philippe Colin, Martine Braibant, Bernard Lagane, Matteo NegroniP7 Entry inhibition of HERV-K(HML-2) by an Env-IgG fusion proteinJula Wamara, Norbert BannertTopic 2: Reverse transcription & integrationP8 The R263K/H51Y resistance substitutions in HIV integrase decreases levels of integrated HIV DNA over timeThibault Mesplede, Nathan Osman, Kaitlin Anstett, Jiaming Calvin Liang, Hanh Thi Pham, Mark WainbergP9 The Retrovirus Integration Database (RID)Wei Shao, Jigui Shan, Mary Kearney, Xiaolin Wu, Frank Maldarelli, John Mellors, Brian Luke, John Coffin, Stephen HughesP10 The small molecule 3G11 inhibits HIV-1 reverse transcriptionThomas Fricke, Silvana Opp, Caitlin Shepard, Dmitri Ivanov, Baek Kim, Jose Valle-Casuso, Felipe Diaz-GrifferoP11 Dual and opposite regulation of HIV-1 integration by hRAD51: impact on therapeutical approaches using homologous DNA repair modulatorsVincent ParissiP12 A flexible motif essential for integration by HIV-1 integraseMarine Kanja, Pierre Cappy, Matteo Negroni, Daniela LenerP13 Interaction between HIV-1 integrase and the host protein Ku70: identification of the binding site and study of the influence on integrase-proteasome interplayEkaterina Knyazhanskaya, Andrey Anisenko, Timofey Zatsepin, Marina GottikhP14 Normalisation based method for deep sequencing of somatic retroelement integrations in human genomeAlexander Komkov, Anastasia Minervina, Gaiaz Nugmanov, Vadim Nazarov, Konstantin Khodosevich, Ilgar Mamedov, Yuri LebedevTopic 3: Transcription and latencyP15 BCA2/RABRING7 restricts HIV-1 transcription by preventing the nuclear translocation of NF-κBMarta Colomer-Lluch, Ruth Serra-MorenoP16 MATR3 post-transcriptional regulation of HIV-1 transcription during latencyAmbra Sarracino, Anna Kula, Lavina Gharu, Alexander Pasternak, Carine Van Lint, Alessandro MarcelloP17 HIV-1 tat intersects the SUMO pathway to regulate HIV-1 promoter activityAnn Marie McCartin, Anurag Kulkarni, Valentin Le Douce, Virginie GautierP18 Conservation in HIV-1 Vpr guides tertiary gRNA folding and alternative splicingAnn Baeyens, Evelien Naessens, Anouk Van Nuffel, Karin Weening, Anne-Marie Reilly, Eva Claeys, Wim Trypsteen, Linos Vandekerckhove, Sven Eyckerman, Kris Gevaert, Bruno VerhasseltP19 The majority of reactivatable latent HIV are genetically distinctHoi Ping Mok, Nicholas Norton, Axel Fun, Jack Hirst, Mark Wills, Andrew LeverP20 Do mutations in the tat exonic splice enhancer contribute to HIV-1 latency?Nicholas Norton, Hoi Ping Mok, Jack Hirst, Andrew LeverP21 Culture-to-Ct: A fast and direct RT-qPCR HIV gene reactivation screening method using primary T cell cultureValentin Le Douce, Ann Marie McCartin, Virginie GautierP22 A novel approach to define populations of early silenced provirusesDalibor Miklik, Filip Senigl, Jiri HejnarTopic 4: RNA trafficking & packagingP23 Functional analysis of the structure and conformation of HIV-1 genome RNA DISJun-ichi Sakuragi, Sayuri Sakuragi, Masaru Yokoyama, Tatsuo Shioda, Hironori SatoP24 Regulation of foamy viral env splicing controls gag and pol expressionJochen Bodem, Rebecca Moschall, Sarah Denk, Steffen Erkelenz, Christian Schenk, Heiner SchaalTopic 5: Assembly & releaseP25 Transfer of HTLV-1 p8 to target T cells depends on VASP: a novel interaction partner of p8Norbert Donhauser, Ellen Socher, Sebastian Millen, Heinrich Sticht, Andrea K. Thoma-KressP26 COL4A1 and COL4A2 are novel HTLV-1 tax targets with a putative role in virus transmissionChristine Gross, Sebastian Millen, Melanie Mann, Klaus Überla, Andrea K. Thoma-KressP27 The C terminus of foamy virus gag protein is required for particle formation, and virus budding: starting assembly at the C terminus?Guochao Wei, Matthew J. Betts, Yang Liu, Timo Kehl, Robert B. Russell, Martin LöcheltP28 Generation of an antigen-capture ELISA and analysis of Rec and Staufen-1 effects on HERV-K(HML-2) virus particle productionOliver Hohn, Saeed Mostafa, Kirsten Hanke, Stephen Norley, Norbert BannertP29 Antagonism of BST-2/tetherin is a conserved function of primary HIV-2 Env glycoproteinsChia-Yen Chen, Masashi Shingai, Pedro Borrego, Nuno Taveira, Klaus StrebelP30 Mutations in the packaging signal region of the HIV-1 genome cause a late domain mutant phenotypeChris Hellmund, Bo Meng, Andrew LeverP31 p6 regulates membrane association of HIV-1 gagMelanie Friedrich, Friedrich Hahn, Christian Setz, Pia Rauch, Kirsten Fraedrich, Alina Matthaei, Petra Henklein, Maximilian Traxdorf, Torgils Fossen, Ulrich SchubertTopic 6: Pathogenesis & evolutionP32 Molecular and structural basis of protein evolution during viral adaptationAya Khwaja, Meytal Galilee, Akram AlianP33 HIV-1 enhancement and neutralisation by soluble gp120 and its role for the selection of the R5-tropic “best fit”Birco Schwalbe, Heiko Hauser, Michael SchreiberP34 An insertion of seven amino acids in the Env cytoplasmic tail of Human Immunodeficiency Virus type 2 (HIV-2) selected during disease progression enhances viral replicationFrançois Dufrasne, Mara Lucchetti, Patrick Goubau, Jean RuelleP35 Cell-associated HIV-1 unspliced to multiply spliced RNA ratio at 12 weeks ART correlates with markers of immune activation and apoptosis and predicts the CD4 T-cell count at 96 weeks ARTMirte Scherpenisse, Ben Berkhout, Alexander PasternakP36 Faster progression in non-B subtype HIV-1-infected patients than Korean subclade of subtype B is accompanied by higher variation and no induction of gross deletion in non-B nef gene by Korean red ginseng treatmentYoung-Keol Cho, Jungeun Kim, Daeun JeongP37 Aberrant expression of ERVWE1 endogenous retrovirus and overexpression of TET dioxygenases are characteristic features of seminomaKaterina Trejbalova, Martina Benesova, Dana Kucerova, Zdenka Vernerova, Rachel Amouroux, Petra Hajkova, Jiri HejnarP38 Life history of the oldest lentivirus: characterisation of ELVgv integrations and the TRIM5 selection pattern in dermopteraDaniel Elleder, Tomas Hron, Helena Farkasova, Abinash Padhi, Jan PacesP39 Characterisation of a highly divergent endogenous retrovirus in the equine germ lineHenan Zhu, Robert Gifford, Pablo MurciaP40 The emergence of pandemic retroviral infection in small ruminantsMaria Luisa Carrozza, Anna-Maria Niewiadomska, Maurizio Mazzei, Mounir Abi-Said, Joseph Hughes, Stéphane Hué, Robert GiffordP41 Near full-length genome (NFLG) Characterisation of HIV-1 subtype B identified in South AfricaAdetayo Obasa, Graeme Jacobs, Susan EngelbrechtP42 Acquisition of Vpu-mediated tetherin antagonism by an HIV-1 group O strainKatharina Mack, Kathrin Starz, Daniel Sauter, Matthias Geyer, Frederic Bibollet-Ruche, Christina Stürzel, Marie Leoz, Jean Christophe Plantier, Beatrice H. Hahn, Frank KirchhoffP43 The human endogenous retrovirus type K is involved in cancer stem cell markers expression and in human melanoma malignancyAyele Argaw-Denboba, Emanuela Balestrieri, Annalucia Serafino, Ilaria Bucci, Chiara Cipriani, Corrado Spadafora, Paolo Sinibaldi-Vallebona, Claudia MatteucciP44 Natural infection of Indian non-human primates by unique lentivirusesS. Nandi Jayashree, Ujjwal Neogi, Anil K. Chhangani, Shravan Sing Rathore, Bajrang R. J. MathurP45 Free cervical cancer screening among HIV-positive women receiving antiretroviral treatment in NigeriaAdeyemi AbatiP46 Molecular evolutionary status of feline immunodeficiency virus in TurkeyB. Taylan Koç, Tuba Çiğdem OğuzoğluTopic 7: Innate sensing & intrinsic immunityP47 Cell-to-cell contact with HTLV-1-infected T cells reduces dendritic cell immune functions and contributes to infection in trans.Takatoshi Shimauchi, Stephan Caucheteux, Jocelyn Turpin, Katja Finsterbusch, Charles Bangham, Yoshiki Tokura, Vincent PiguetP48 Deciphering the mechanisms of HIV-1 exacerbation induced by Mycobacterium tuberculosis in monocytes/macrophagesShanti Souriant, Luciana Balboa, Karine Pingris, Denise Kviatcowsky, Brigitte Raynaud-Messina, Céline Cougoule, Ingrid Mercier, Marcelo Kuroda, Pablo González-Montaner, Sandra Inwentarz, Eduardo Jose Moraña, Maria del Carmen Sasiain, Olivier Neyrolles, Isabelle Maridonneau-Parini, Geanncarlo Lugo-Villarino, Christel VérolletP49 The SAMHD1-mediated inhibition of LINE-1 retroelements is regulated by phosphorylationAlexandra Herrmann, Sabine Wittmann, Caitlin Shepard, Dominique Thomas, Nerea Ferreirós Bouzas, Baek Kim, Thomas GrambergP50 Activities of nuclear envelope protein SUN2 in HIV infectionXavier Lahaye, Anvita Bhargava, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, Aymeric Silvin, Cécile Conrad, Hakim Ahmed-Belkacem, Elisa C. Rodriguez, Jean-François Guichou, Nathalie Bosquet, Matthieu Piel, Roger Le Grand, Megan King, Jean-Michel Pawlotsky, Nicolas ManelP51 Activation of TLR7/8 with a small molecule agonist induces a novel restriction to HIV-1 infection of monocytesHenning Hofmann, Benedicte Vanwalscappel, Nicolin Bloch, Nathaniel LandauP52 Steady state between the DNA polymerase and Rnase H domain activities of reverse transcriptases determines the sensitivity of retroviruses to inhibition by APOBEC3 proteinsStanislav Indik, Benedikt HagenP53 HIV restriction in mature dendritic cells is related to p21 induction and p21-mediated control of the dNTP pool and SAMHD1 activity.José Carlos Valle-Casuso, Awatef Allouch, Annie David, Françoise Barré-Sinoussi, Michaela Müller-Trutwin, Monsef Benkirane, Gianfranco Pancino, Asier Saez-CirionP54 IFITM protens restrict HIV-1 protein synthesisWing-Yiu Lee, Chen Liang, Richard SloanP55 Characterisation and functional analysis of the novel restriction factor Serinc5Bianca Schulte, Silvana Opp, Felipe Diaz-GrifferoP56 piRNA sequences are common in Human Endogenous Retroviral Sequences (HERVs): An antiretroviral restriction mechanism?Jonas Blomberg, Luana Vargiu, Patricia Rodriguez-Tomé, Enzo Tramontano, Göran SperberP57 Ferroportin restricts HIV-1 infection in sickle cell diseaseNamita Kumari, Tatiana Ammosova, Sharmeen Diaz, Patricia Oneal, Sergei NekhaiP58 APOBEC3G modulates the response to antiretroviral drugs in humanized miceAudrey Fahrny, Gustavo Gers-Huber, Annette Audigé, Roberto F. Speck, Anitha Jayaprakash, Ravi Sachidanandam, Matt Hernandez, Marsha Dillon-White, Viviana SimonP59 High-throughput epigenetic analysis of evolutionarily young endogenous retrovirus presents in the mule deer (Odocoileus hemionus) genomeTomas Hron, Helena Farkasova, Daniel EllederP60 Characterisation of the expression of novel endogenous retroviruses and immune interactions in a macaque modelNeil Berry, Emmanuel Maze, Claire Ham, Neil Almond, Greg Towers, Robert BelshawP61 HIV-1 restriction by orthologs of SERINC3 and SERINC5Patrícia de Sousa-Pereira, Joana Abrantes, Massimo Pizzato, Pedro J. Esteves, Oliver T. Fackler, Oliver T. Keppler, Hanna-Mari BaldaufP62 TRIM19/PML restricts HIV infection in a cell type-dependent mannerBianca Volkmann, Tanja Kahle, Kristin Eissmann, Alexandra Herrmann, Sven Schmitt, Sabine Wittmann, Laura Merkel, Nina Reuter, Thomas Stamminger, Thomas GrambergP63 Recent invasion of the mule deer genome by a retrovirusHelena Farkasova, Tomas Hron, Daniel EllederP64 Does the antiviral protein SAMHD1 influence mitochondrial function?Ilaria Dalla Rosa, Kate Bishop, Antonella Spinazzola, Harriet GroomP65 cGAMP transfers intercellularly via HIV-1 Env-mediated cell–cell fusion sites and triggers an innate immune response in primary target cellsShuting Xu, Aurélie Ducroux, Aparna Ponnurangam, Sergej Franz, Gabrielle Vieyres, Mathias Müsken, Thomas Zillinger, Angelina Malassa, Ellen Ewald, Veit Hornung, Winfried Barchet, Susanne Häussler, Thomas Pietschmann, Christine GoffinetP66 Pre-infection transcript levels of FAM26F in PBMCS inform about overall plasma viral load in acute and postacute phase after SIV-infectionUlrike Sauermann, Aneela Javed, Nicole Leuchte, Gabriela Salinas, Lennart Opitz, Christiane Stahl-Hennig, Sieghart SopperP67 Sequence-function analysis of three T cell receptors targeting the HIV-1 p17 epitope SLYNTVATLChristiane Mummert, Christian Hofmann, Angela G. Hückelhoven, Silke Bergmann, Sandra M. Müller-Schmu
