147 research outputs found
Sammy Cowan
No full textThis 1961 photograph, taken by Asheville Citizen-Times photographer Ewart McKinley Ball, Jr. (1918-1966), shows Sammy Cowan singing. Founder and director of the Mountain Youth Jamboree, Hubert H. Hayes (1901-1964) auditioned and directed youth to perform in folk dance, music, and folk and ballad singing. The jamboree was held in the Asheville City Auditorium (now known as Thomas Wolfe Auditorium) from 1948 to 1973, and Hayes’ wife, Leona Trantham Hayes (1913-1989) continued to direct the program after his death in 1964. Hubert Hayes was an author, playwright, and alumni of Duke University
Role of skeletal muscle cells-specific mitochondrial DNA deletions in the development of aging sarcopenia
Get PDFHematological Changes in Newly Diagnosed Pulmonary Tuberculosis Patients on Standard Anti-TB Treatment Regimen and their Influence on Smear Conversion
Get PDFPulmonary tuberculosis (PTB) mortality remains high despite the availability of effective anti-TB therapy. Disease and treatment-associated hematological derangements at diagnosis and during therapy might contribute to this high TB mortality rate. This paper aims to determine hematological changes in newly diagnosed pulmonary tuberculosis patients on standard anti-TB treatment regimen and their influence on smear conversion. The study adopted a longitudinal design in which 55 newly diagnosed HIV negative PTB patients were followed up to the fifth month of anti-TB therapy. Blood samples (5ml) were collected for diagnosis during the second and fifth months and analyzed using automated HumaCount 5D hematology analyzer. Data was analyzed using Kruskal-wallis test with Dunn’s multiple comparisons test in Graph-Pad prism version 6.0. Throughout therapy, there was a statistically significant time-dependent decrease in median total white blood cell counts from 6.82x103/ uL at diagnosis to 5.87x103/ uL at the fifth month (P=0.0358). This decrease in total WBC count was majorly driven by significant decrease in the neutrophil numbers from 4.31x103/ uL at diagnosis to 2.97x103/ uL at the fifth month. The proportion of patients who had anemia at the fifth month of treatment increased compared to the second month post intensive phase. There was also a significant decrease in MCV, MCH and MCHC at the second month compared to diagnosis. Moreover, the median platelet count, MPV, PDW and PCT% decreased from 314x103/ uL, 8.9 fL, 10.4 fL and 0.273 at diagnosis to 232x103/ uL, 10.15 fL, 12.5 fL and 0.235 at the fifth month, respectively. High WBC count, high platelet count, low lymphocyte count and low HGB at the end of month two of therapy were shown to increase the likelihood of sputum non-conversion (OR-2.42 (95% Ci 2.07-2.82)), (OR-1.5 (95% Ci 1.01-2.22)), (OR-1 (95% Ci 1-1)) and (OR-2.58 (95% Ci 1.68-3.95)), respectively (P<0.05). A significant number of PTB patients presented with anemia, thrombocytosis and leukocytosis. The proportion of patients with anemia increased over time. The study recommends screening for hematological abnormalities in patients for tailored patient interventions for better clinical outcomes
Potential Role of Plasmodium falciparum-derived Ammonia in the Pathogenesis of Cerebral Malaria
No full textCerebral malaria (CM) is the most severe complication associated with Plasmodium falciparum infection. The exact pathogenic mechanisms leading to the development CM remains poorly understood and the mortality rates remain high. Several potential mechanisms including mechanical obstruction of brain microvasculature, inflammation, oxidative stress and hemostatic dysfunction have been suggested to play a role in CM pathogenesis. However, these proposed mechanisms, even when considered together, do not fully explain the pathogenesis and clinicopathological features of human CM. This necessitates consideration of alternative pathogenic mechanisms. P. falciparum generates substantial amounts of ammonia as a catabolic byproduct, but lacks detoxification mechanisms. Whether or not this parasite-derived ammonia plays a pathogenic role in CM is yet to be considered, despite its potential to cause localized brain ammonia elevation and subsequent neurotoxic effects. This article therefore, explores and proposes a potential role of parasite-derived ammonia in the pathogenesis and neuropathology of CM. A consideration of parasite-derived ammonia as a factor in CM pathogenesis provides plausible explanations of the various features observed in CM patients including how a largely intravascular parasite can cause neuronal dysfunction. It also provides a framework for rational development and testing of novel drugs targeting parasite’s ammonia handling
IBPP Research Associates: Kenya
No full textThe article discussed - It\u27s Goodbye to Personality Cults and Songs of Praise, by Wambua Sammy - was posted on the December 30, 2002 - January 5, 2003 issue of The East African (Kenya). Copyright permissions were not available for posting the article in Scholarly Commons, but the article is available online as part of The Mail Archive.
In the article, the author discusses and criticizes personality cults as they are associated with government in Kenya
Sammy Slap the Bill Sticker
Get PDFA man pastes bills for different clients.https://egrove.olemiss.edu/kgbsides_uk/1024/thumbnail.jp
Chorismus antarcticus
No full text<i>Chorismus antarcticus</i> (Pfeffer, 1887) <p> A circum-Antarctic benthic shelf species (0–915 m), reaching South Georgia, the Falkland Islands and Southern Patagonia (Holthuis 1952; Garth <i>et al.</i> 1967; Ledoyer 1989; Komai <i>et al.</i> 1996), although possibly confused with <i>C. tuberculatus</i> in sub-Antarctic areas. Biological differences were observed between populations from South Georgia and the Weddell Sea (Gorny <i>et al.</i> 1992). A very common species, with a preference for bottoms rich in epifauna (personal observations of the first author). Synonym: <i>Hippolyte romanchei</i> A. Milne-Edwards, 1891 (type locality: Tierra del Fuego).</p>Published as part of <i>D'Acoz, Cédric D'Udekem & Degrave, Sammy, 2018, A new genus and species of large-bodied caridean shrimp from the Crozet Islands, Southern Ocean (Crustacea, Decapoda, Lipkiidae) with a checklist of Antarctic and sub-Antarctic shrimps, pp. 201-240 in Zootaxa 4392 (2)</i> on page 223, DOI: 10.11646/zootaxa.4392.2.1, <a href="http://zenodo.org/record/1195302">http://zenodo.org/record/1195302</a>
Author Response: K320E-Twinkle skm Mice Are Genetically Heterogeneous for Secondary mtDNA Deletions Impairing Comparison With Controls
No full textInternational audienc
Moon Sammy award goes to Marshall
No full textThis collection comprises newspaper articles, advertisements, images and announcements from newspapers (local and regional) which highlight the activities and the relationship of The University of the West Indies with its key stakeholders. The Marketing & Communications Office of The University of the West Indies, St. Augustine Campus, and Trinidad and Tobago has compiled this collection and the collection should only be used for research and educational purposes. Permission must be sought from the copyright holder (the newspaper publisher) if the article is to be used for other purposes
Association between blood group, CD4, Viral load and opportunistic infections among patients attending Kericho county referral comprehensive care clinic, Kenya
Get PDFErythrocyte antigens bringing about blood groups are considered pathogen receptor sites, including Human Immunodeficiency Virus (HIV), affecting approximately 39.9 million people worldwide, with 3.31% and 3.3% prevalence in Kenya and Kericho County, respectively. Limited studies showing inconsistent results and unpublished perceptions suggest a possible role of blood groups in Human Immunodeficiency Virus disease surveilled by changes in CD4 counts, viral load and opportunistic infections among infected. This study determined the ABO-Rhesus blood group distribution and association with CD4 counts, viral load and opportunistic infections at the Kericho County Referral Hospital Comprehensive Care Clinic in the year 2020. This cross-sectional, retrospective study comprised randomly sampled adults (≥18 years) without bone marrow transplant or transfusion history, with the sample size (n=285) calculated using the Yamane Taro formula. ABO-Rhesus typing was done on venous ethylenediaminetetraacetic acid blood using commercial antisera. Viral load and CD4 counts, determined using Abbott m2000sp/rt and FacsCalibur, respectively, and opportunistic infection data were documented in the data extraction form. Statistical Package for Social Sciences SPSS® version 26 was used to analyse and summarise data as means, standard deviation and prevalence ratios. Z-test, analysis of variance, regression, and chi-square were used to contrast, compare means, assess outcomes among variables, and determine relationships, respectively. Ethical principles were observed during specimens’ and participants’ information handling. Females were the majority, 174 (61.1%), and the mean age was 42.8 (12.8) years. Blood group O was most prevalent at 138 (48.4%), followed by A at 78 (27.4%), B at 59 (20.7%), and the least was AB. The Analysis of Variance showed a statistically non-significant association between blood groups on both viral load (p=0.74) and CD4 counts (p=0.84). Predictors for viral load change on regression analysis found increased viral load improvement in blood group AB-positive compared to blood group A-positive (OR=6.77, 95% CI [1.82-14.33], p=0.01). Most of the participants did not develop opportunistic infections, n=209 (73.3%). Tuberculosis was more prevalent among blood groups on chi-square: A-positive (16.2%), B-positive (16.4%), O-positive (17.7%), O-negative (12.5%) and B-negative. Blood groups A-negative and AB-negative developed no opportunistic infections. The differences were, however, not significant at the 95% level of significance (p=0.91). The study showed a non-significant association between the ABO blood groups and HIV infection based on CD4 counts, viral load and opportunistic infections. However, group AB-positive and those with good adherence were associated with viral load improvement. Increased CD4 count and body mass index were associated with reduced opportunistic infections. Viral load increase was associated with likelihood of opportunistic infection. Further studies need to be conducted for comparison
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