66 research outputs found
New detection of a 30-year-old population of introduced mongoose Herpestes auropunctatus on Kyushu Island, Japan
No full textA method for estimation of kinship based on the tooth measurements and its application to the ancient human skeletal remains.
No full textTooth Development and Replacement in the Japanese Greater Horseshoe Bat, Rhinolophus ferrumequinum nippon(COMMUNICATION)(Developmental Biology)
No full textVolume: 9Start Page: 445End Page: 45
Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice
No full textAbstractA number of studies have shown that CD8+ T cells mediate protective anti-malaria immunity in a mouse model. However, whether human CD8+ T cells play a role in protection against malaria remains unknown. We recently established human immune system (HIS) mice harboring functional human CD8+ T cells (HIS-CD8 mice) by transduction with HLA-A∗0201 and certain human cytokines using recombinant adeno-associated virus-based gene transfer technologies. These HIS-CD8 mice mount a potent, antigen-specific HLA-A∗0201-restricted human CD8+ T-cell response upon immunization with a recombinant adenovirus expressing a human malaria antigen, the Plasmodium falciparum circumsporozoite protein (PfCSP), termed AdPfCSP. In the present study, we challenged AdPfCSP-immunized HIS-CD8 mice with transgenic Plasmodium berghei sporozoites expressing full-length PfCSP and found that AdPfCSP-immunized (but not naïve) mice were protected against subsequent malaria challenge. The level of the HLA-A∗0201-restricted, PfCSP-specific human CD8+ T-cell response was closely correlated with the level of malaria protection. Furthermore, depletion of human CD8+ T cells from AdPfCSP-immunized HIS-CD8 mice almost completely abolished the anti-malaria immune response. Taken together, our data show that human CD8+ T cells mediate protective anti-malaria immunity in vivo
Maximum longevity of the Ussurian tube-nosed bat, Murina ussuriensis
No full textLocal population of the Ussurian tube-nosed bats, Murina ussuriensis, was studied from 2006 to 2018 using dead-leaf Mallotus japonicas traps in warm-tem- perate forests of Miike in Miyazaki Prefecture, Japan. A total number of 446 bats were captured and 233 bats were recaptured on the survey of bat-banding. The maximaum longevity records were five years in males and six years in females. Murina ussuriensis was rela- tively short-lived species among Chiroptera.journal articl
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