5,531 research outputs found
Ordering of simultaneous events in distributed DEVS simulation
No full textSimultaneous events are the events scheduled to occur at the same simulation time. This paper proposes a new event ordering mechanism for handling simultaneous events of DEVS models in distributed simulation. The DEVS formalism provides a formal framework for specifying discrete event models in a modular, hierarchical form. Thus, the formalism can ease the model verification and validation problems of distributed simulation. Also, the formalism separates models from underlying simulation algorithms. Hence, DEVS models can be simulated in both sequential and distributed environments without any modification. One important issue for such framework is to obtain the same results in both simulation environments. However, in distributed simulation of DEVS models, the processing order of simultaneous events may affect the simulation results. Thus, some ordering mechanism of events is required for well-defined simulation results. The proposed mechanism orders simultaneous events correctly with respect to their causal relationships in distributed DEVS simulation. Also, the mechanism guarantees the same ordering of simultaneous events in both sequential and distributed simulation environments. ？ 1997 Elsevier Science B.V
Analysis of Boundary Layers in Transient Buoyant Convection in a Differentially Heated Porous Cavity
No full textSpectroscopic analysis of charge transport characteristics in wide-band-gap semiconductor detectors
No full textTwo-Photon Microscopy of the Mouse Peripheral Cornea Ex Vivo
No full textPurpose: To investigate the 3-dimensional (3D) cell and extracellular matrix (ECM) structure of mouse peripheral corneas in normal and corneal neovascularization tissues using 2-photon microscopy (TPM) based on both intrinsic and extrinsic moxifloxacin contrasts.
Methods: Peripheral corneas in freshly enucleated mouse eyes were imaged by TPM based on both intrinsic and extrinsic contrasts. Intrinsic autofluorescence and second harmonic generation were used to image cells and ECM collagen, respectively. Moxifloxacin ophthalmic solution was applied to image cells. The peripheral cornea, limbus, and sclera were imaged in 3D. In addition to normal mice, mouse models of suture-induced corneal neovascularization were imaged to visualize changes in the microstructure.
Results: Complex 3D cell and ECM structures in the cornea, limbus, and sclera were visualized by TPM. TPM images based on intrinsic contrasts visualized both cell and ECM structures, and TPM images based on moxifloxacin visualized cell structures with enhanced contrast. On the limbus side of the mouse peripheral cornea, TPM images visualized the vasculature in the limbus, the trabecular meshwork/Schlemm canal, iris, and ciliary body. On the scleral side, TPM images visualized cell and ECM structures in the sclera and multiple cell layers below the sclera. TPM images of the peripheral cornea in the corneal neovascularization condition visualized the extension of vasculature from the limbus to the cornea.
Conclusions: TPM imaging based on both intrinsic and external moxifloxacin contrasts visualized detailed 3D cell and ECM microstructures in the mouse peripheral cornea. TPM based on moxifloxacin might be advantageous for studying cell structures by enhancing image contrast.1100sciescopu
Clinically Compatible Fluorescence Microscopy Based on Moxifloxacin Antibiotic
No full textHigh-resolution fluorescence tissue imaging with the application of moxifloxacin as a cell-labelling agent is described. Moxifloxacin is an antibiotic used in the clinic to both treat and prevent bacterial infections, and it has both good pharmacokinetic properties for tissue penetration and intrinsic fluorescence under ultraviolet (UV) excitation. Alternative usage of moxifloxacin as the cell-labelling agent was discovered and its imaging applications have been explored. With moxifloxacin administration, fluorescence microscopy could visualize cells within tissues either in enhanced contrasts or at high imaging speeds. Both linear and nonlinear fluorescence microscopies could be used for moxifloxacin-based tissue imaging. High-contrast cellular imaging was demonstrated in various tissues including the cornea, skin, small and large intestines, and brain. Moxifloxacin-based fluorescence microscopy can be clinically compatible by using the FDA-approved moxifloxacin and it could be used for both diagnosis and surgery guidance. Moxifloxacin-based fluorescence microscopy has been tested in several preclinical studies, including the detection of infecting pathogens in fungal keratitis, and the delineation of tumor margin in brain tumor and skin cancer.11Nsciescopu
Discrimination of Invasive Human Skin Tumor Using an Ultrafast ATP-Proton AND-Gate Probe
No full textCancer cells undergo unscheduled proliferation resulting from dysregulation of the cell cycle, and hence, evaluation in tumor is of keen interest to examine the invasiveness and recurrence of cancer in the lesion. Molecular probes capable of discriminating actively growing tumor from resting ones remain unexplored despite their vast importance. Here, we describe a novel strategy to visualize invasive areas in tumor with a fluorescence probe that implements synergistic fluorescence response toward the slightly acidic environment of tumor and an ATP-abundant nature of actively growing cells. The probe has been designed for ultrafast detection of ATP with high specificity. We demonstrate its utility in visualizing invasive areas in tumor by distinguishing basal cell carcinomas and squamous cell carcinomas at their early stages by two-photon microscopy. © 2022 American Chemical Society.11Nsciescopu
STUDI KOMPARASI PEMIKIRAN K.H. AHMAD DAHLAN DAN K.H. HASYIM ASY’ARI TENTANGPENDIDIKAN ISLAM
Full text linkThe goal of this study is to develop Islamic education through a series of studies
on the thinking of K.H. Ahmad Dahlan and K.H. Hasyim Asy’ari about Islamic
education. The author brings back the thoughts of the two figures, because both are wellknown
icons of thousands of Muslim intellectual figures, whose lives are preoccupied to
fight for Islamic education. On this basis the author later raised the title of a comparative
study of K.H's thought. Ahmad Dahlan and K.H. Hasyim Asy'ari about Islamic
education. Belong to that basis the title of a comparative study through the through of
K.H. Ahmad Dahlan and K.H. Hasyim Asy’ari about Islamic education. The author hope
that he conception of Islamic education offered by the two figures is able to inspire
elements of education implementers.
The focus of the problem in this study is (1) Islamic education thinking according
to K.H. Ahamd Dahlan, (2) Islamic education thought according to K.H. Hasyim Asy'ari,
and (3) Comparative thinking of K.H. Ahmad Dahlan and K.H. Hasyim Asy’ari about
Islamic education This reseachuses a descriptive qualitative approach to the type of
library research. Data collection is done by exploring the sources of literature conducted
in three stages, namely orientation, exploration, and focused research phase. Data
analysis techniques include determining the theme, looking for a logical relationship
between the thoughts of the character in various fields so that reasons can be found
regarding these thoughts, classifying, looking for generalizations of specific ideas.
The results showed that: (1) K.H. Ahmad Dahlan tried to make a new
breakthrough by creating schools that integrate religious studies and general subjects at
the same time, so that they are expected to become "intellectual scholars and intellectual
scholars". (2) K.H. Hasyim Asy'ari taught the religious sciences, Arabic, and included
general subjects such as mathematics and earth sciences, from the low to the high levels,
as evidenced by the construction of the Tebuireng Islamic Boarding School which
produced great scholars. (3) The concept of education produced by the two figures is
agreed that the basis or foundation of Islamic education must return to the primary
sources of Muslims, namely the Qur'an and Hadith, while the differences seen from the
two figures are about the objectives, curriculum, methods and evaluation of Islamic
education. The concept of Education is K.H. AhmadDahlan and K.H. Hasyim Asy'ari is
still relevant when applied to education today because it contains universal-minded
education
Light sheet microscopy for histopathology applications
No full textLight sheet microscopy (LSM) is an evolving optical imaging technique with a plane illumination for optical sectioning and volumetric imaging spanning cell biology, embryology, and in vivo live imaging. Here, we focus on emerging biomedical applications of LSM for tissue samples. Decoupling of the light sheet illumination from detection enables high-speed and large field-of-view imaging with minimal photobleaching and phototoxicity. These unique characteristics of the LSM technique can be easily adapted and potentially replace conventional histopathological procedures. In this review, we cover LSM technology from its inception to its most advanced technology; in particular, we highlight the human histopathological imaging applications to demonstrate LSM’s rapid diagnostic ability in comparison with conventional histopathological procedures. We anticipate that the LSM technique can become a useful three-dimensional imaging tool for assessing human biopsies in the near future. © 2019, Korean Society of Medical and Biological Engineering.11Nscopuskc
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