1,721,001 research outputs found
Impact of cannula size on clinical outcomes in peripheral venoarterial extracorporeal membrane oxygenation
No full textBackground: Venoarterial extracorporeal membrane oxygenation (VA ECMO) is an effective mechanical circulatory support for cardiopulmonary failure. Conventionally, an arterial cannula over 15Fr is inserted for full circulatory support in peripheral VA ECMO. However, limited data are available regarding the impact of cannula size on clinical and procedural outcomes.
Methods: Between January 2014 and April 2016, 165 patients underwent peripheral VA ECMO with femoral artery cannulation were enrolled in a single-center registry. We classified patients into 2 groups according to the arterial cannula’s size: ‘Small cannula group’ (14-15Fr, n = 87) and ‘Large cannula group’ (16-21Fr, n = 78). We compared the clinical outcomes and procedural-related complications between the two groups.
Results: Neither the in-hospital mortality (48.3% in the small cannula group vs. 42.3% in the large cannula group; p = 0.44) nor the weaning success rate (70.1% in the small cannula group vs. 64.1% in the large cannula group; p = 0.41) were significantly different between the two groups. The small cannula group showed significantly lower initial pump flow (3.2 [2.5-3.7] vs. 3.5 [3.0-4.0] L/min; p = 0.02) and shorter ECMO duration time (2.6 [0.7-5.2] vs. 4.0 [1.3-7.8] day; p < 0.01). Also, lower limb ischemia was significantly lower in the small cannula group than in large cannula group (4.6% vs. 15.4%; p = 0.02). But other complications (including cannula site or non-cannula site bleeding, thrombotic events, coagulopathy, or sepsis) were not significantly different between the two groups.
Conclusions: In peripheral VA ECMO, as compared with the large cannula strategy, the small arterial cannula strategy showed similar clinical outcomes and a decrease in lower limb ischemia
Impact of cannula size on clinical outcomes in peripheral venoarterial extracorporeal membrane oxygenation
No full textBackground: Venoarterial extracorporeal membrane oxygenation (VA ECMO) is an effective mechanical circulatory support for cardiopulmonary failure. Conventionally, an arterial cannula over 15Fr is inserted for full circulatory support in peripheral VA ECMO. However, limited data are available regarding the impact of cannula size on clinical and procedural outcomes.
Methods: Between January 2014 and April 2016, 165 patients underwent peripheral VA ECMO with femoral artery cannulation were enrolled in a single-center registry. We classified patients into 2 groups according to the arterial cannula’s size: ‘Small cannula group’ (14-15Fr, n = 87) and ‘Large cannula group’ (16-21Fr, n = 78). We compared the clinical outcomes and procedural-related complications between the two groups.
Results: Neither the in-hospital mortality (48.3% in the small cannula group vs. 42.3% in the large cannula group; p = 0.44) nor the weaning success rate (70.1% in the small cannula group vs. 64.1% in the large cannula group; p = 0.41) were significantly different between the two groups. The small cannula group showed significantly lower initial pump flow (3.2 [2.5-3.7] vs. 3.5 [3.0-4.0] L/min; p = 0.02) and shorter ECMO duration time (2.6 [0.7-5.2] vs. 4.0 [1.3-7.8] day; p < 0.01). Also, lower limb ischemia was significantly lower in the small cannula group than in large cannula group (4.6% vs. 15.4%; p = 0.02). But other complications (including cannula site or non-cannula site bleeding, thrombotic events, coagulopathy, or sepsis) were not significantly different between the two groups.
Conclusions: In peripheral VA ECMO, as compared with the large cannula strategy, the small arterial cannula strategy showed similar clinical outcomes and a decrease in lower limb ischemia
Impact of cannula size on clinical outcomes in peripheral venoarterial extracorporeal membrane oxygenation
No full textBackground: Venoarterial extracorporeal membrane oxygenation (VA ECMO) is an effective mechanical circulatory support for cardiopulmonary failure. Conventionally, an arterial cannula over 15Fr is inserted for full circulatory support in peripheral VA ECMO. However, limited data are available regarding the impact of cannula size on clinical and procedural outcomes.
Methods: Between January 2014 and April 2016, 165 patients underwent peripheral VA ECMO with femoral artery cannulation were enrolled in a single-center registry. We classified patients into 2 groups according to the arterial cannula’s size: ‘Small cannula group’ (14-15Fr, n = 87) and ‘Large cannula group’ (16-21Fr, n = 78). We compared the clinical outcomes and procedural-related complications between the two groups.
Results: Neither the in-hospital mortality (48.3% in the small cannula group vs. 42.3% in the large cannula group; p = 0.44) nor the weaning success rate (70.1% in the small cannula group vs. 64.1% in the large cannula group; p = 0.41) were significantly different between the two groups. The small cannula group showed significantly lower initial pump flow (3.2 [2.5-3.7] vs. 3.5 [3.0-4.0] L/min; p = 0.02) and shorter ECMO duration time (2.6 [0.7-5.2] vs. 4.0 [1.3-7.8] day; p < 0.01). Also, lower limb ischemia was significantly lower in the small cannula group than in large cannula group (4.6% vs. 15.4%; p = 0.02). But other complications (including cannula site or non-cannula site bleeding, thrombotic events, coagulopathy, or sepsis) were not significantly different between the two groups.
Conclusions: In peripheral VA ECMO, as compared with the large cannula strategy, the small arterial cannula strategy showed similar clinical outcomes and a decrease in lower limb ischemia
Impact of cannula size on clinical outcomes in peripheral venoarterial extracorporeal membrane oxygenation
No full textBackground: Venoarterial extracorporeal membrane oxygenation (VA ECMO) is an effective mechanical circulatory support for cardiopulmonary failure. Conventionally, an arterial cannula over 15Fr is inserted for full circulatory support in peripheral VA ECMO. However, limited data are available regarding the impact of cannula size on clinical and procedural outcomes.
Methods: Between January 2014 and April 2016, 165 patients underwent peripheral VA ECMO with femoral artery cannulation were enrolled in a single-center registry. We classified patients into 2 groups according to the arterial cannula’s size: ‘Small cannula group’ (14-15Fr, n = 87) and ‘Large cannula group’ (16-21Fr, n = 78). We compared the clinical outcomes and procedural-related complications between the two groups.
Results: Neither the in-hospital mortality (48.3% in the small cannula group vs. 42.3% in the large cannula group; p = 0.44) nor the weaning success rate (70.1% in the small cannula group vs. 64.1% in the large cannula group; p = 0.41) were significantly different between the two groups. The small cannula group showed significantly lower initial pump flow (3.2 [2.5-3.7] vs. 3.5 [3.0-4.0] L/min; p = 0.02) and shorter ECMO duration time (2.6 [0.7-5.2] vs. 4.0 [1.3-7.8] day; p < 0.01). Also, lower limb ischemia was significantly lower in the small cannula group than in large cannula group (4.6% vs. 15.4%; p = 0.02). But other complications (including cannula site or non-cannula site bleeding, thrombotic events, coagulopathy, or sepsis) were not significantly different between the two groups.
Conclusions: In peripheral VA ECMO, as compared with the large cannula strategy, the small arterial cannula strategy showed similar clinical outcomes and a decrease in lower limb ischemia
Simple methods to determine the dissociation constant, Kd
No full textThe determination of the dissociation constant (K-d) is pivotal in biochemistry and pharmacology for understanding binding affinities in chemical reactions, which is crucial for drug development and comprehending biological systems. Here, we introduce a single-molecule fluorescence resonance energy transfer-based method for determining K-d, alongside the conventional electrophoretic mobility shift assay method of K-d, offering insights into thermodynamic interactions between proteins and substrates. The single-molecule fluorescence resonance energy transfer approach is highlighted for its ability to accurately measure binding and dissociation kinetics through fluorescence labeling and the intrinsic nature of protein-DNA interactions, representing a significant advancement in the fields of molecular biology and pharmacology. (c) 2024 The Author(s). Published by Elsevier Inc. on behalf of Korean Society for Molecular and Cellular Biology.
Economic evaluation of small-scale LNG production system for shale gas recovery considering life cycle cost with availability
No full textThis study propose a novel liquefaction system for the recovery of shale gas using cryogenic liquid nitrogen and conducts a Life Cycle Cost (LCC) analysis while considering the availability estimation. The system directly liquefies shale gas using the latent heat of liquid nitrogen and consisted of heat exchangers and expansion valves without compression and expansion engines. To verify the economics of the system compared to that of a conventional liquefaction system based on compression expansion cooling, the LCCs of the two systems are estimated. Because the two systems are subject to a significant difference in reliability and availability, the production loss caused by equipment failure is also reflected in the LCC. The result of LCC showed that the novel system is attractive when the price of liquid nitrogen is less than $60/ton. In addition, the absence of turbo-machines in the system results in less frequent and shorter repair times, which leads to significantly less production loss compared with the conventional system
Nanoscale Visualization and Contact Angle Analysis of Water Droplets on Ferroelectric Materials
No full textUnderstanding wetting phenomena at the nanoscale is essential for evaluating interfacial properties of functional materials. However, conventional contact angle measurements lack the resolution required to capture nanoscopic features, while existing nanoscale approaches remain technically complex or indirect. Here, we present a direct visualization method using noncontact atomic force microscopy (AFM) combined with temperature-controlled condensation and pixel-wise contact angle mapping. By inducing the spontaneous formation of stable water droplets on hydrophilic surfaces through controlled stage cooling, we achieve high-resolution imaging and quantitative analysis of contact angles. Applying this method to ferroelectric lithium tantalate (LiTaO3), we reveal a polarization-dependent contact angle difference at the nanoscale, undetectable by conventional macroscopic sessile methods. We further demonstrate the broader applicability of this approach by visualizing nanoscale water droplets on individual submicron nickel-iron layered double hydroxide (NiFeLDH) catalyst particles. This methodology enhances the precision and generalizability of nanoscale wetting characterization and opens further possibilities for interfacial analysis across a wide range of functional materials.
IPLFS: Log-Structured File System without Garbage Collection
No full textIn this work, we develop the log-structured filesystem that is free from garbage collection. There are two key technical ingredients: IPLFS, a log-structured filesystem for infinite partition, and Interval Mapping, a spaceefficient LBA-to-PBA mapping for infinite filesystem partition. In IPLFS, we separate the filesystem partition size from the physical storage size and set the size of the logical partition large enough so that there is no lack of free segments in the logical partition during SSD's lifespan. This allows the filesystem to write the updates in append-only fashion without reclaiming the invalid filesystem blocks. We revise the metadata structure of the baseline filesystem, F2FS, so that it can efficiently handle the storage partition with 264 sectors. We develop Interval Mapping to minimize the memory requirement for the LBA-to-PBA translation in FTL. Interval Mapping is a three level mapping tree. It maintains mapping only for actively used filesystem region. With Interval Mapping, the FTL can maintain the mapping for the 264 sector range with almost identical memory requirement with the page mapping whose LBA range is limited by the size of the storage capacity. We implement the IPLFS on Linux kernel 5.11.0 and prototype the Interval Mapping in OpenSSD. By eliminating the filesystem level garbage collection, IPLFS outperforms F2FS by up to 12.8× (FIO) and 3.73× (MySQL YCSB A), respectively
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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