1,721,096 research outputs found
Glyoxal Detoxification in Escherichia coli K-12 by NADPH Dependent Aldo-keto Reductases
No full textGlyoxal (GO) and methylglyoxal (MG) are reactive carbonyl compounds that are accumulated in vivo through various pathways. They are presumably detoxified through multiple pathways including glutathione (GSH)-dependent/independent glyoxalase systems and NAD(P)H dependent reductases. Previously, we reported an involvement of aldo-ketoreductases (AKRs) in MG detoxification. Here, we investigated the role of various AKRs (YqhE, YafB, YghZ, YeaE, and YajO) in GO metabolism. Enzyme activities of the AKRs to GO were measured, and GO sensitivities of the corresponding mutants were compared. In addition, we examined inductions of the AKR genes by GO. The results indicate that AKRs efficiently detoxify GO, among which YafB, YghZ, and YeaE are major players
Hsp31 of Escherichia coli K-12 is glyoxalase III
No full textHsp31 encoded by hchA is known as a heat-inducible molecular chaperone. Although structure studies revealed that Hsp31 has a putative catalytic triad consisting of Asp-214, His-186 and Cys-185, its enzymatic function, besides weak amino-peptidase activity, is still unknown. We found that Hsp31 displays glyoxalase activity that catalyses the conversion of methylglyoxal (MG) to D-lactate without an additional cofactor. The glyoxalase activity was completely abolished in the hchA-deficient strain, confirming the relationship between the hchA gene and its enzymatic activity in vivo. Hsp31 exhibits Michaelis-Menten kinetics for substrates MG with K(m) and k(cat) of 1.43 +/- 0.12 mM and 156.9 +/- 5.5 min(-1) respectively. The highest glyoxalase activity was found at 35-40 degrees C and pH of 6.0-8.0, and the activity was significantly inhibited by Cu(2+), Fe(3+) and Zn(2+). Mutagenesis studies based on our evaluation of conserved catalytic residues revealed that the Cys-185 and Glu-77 were essential for catalysis, whereas His-186 was less crucial for enzymatic function, although it participates in the catalytic process. The stationary-phase Escherichia coli cells became more susceptible to MG when hchA was deleted, which was complemented by an expression of plasmid-encoded hchA. Furthermore, an accumulation of intracellular MG was observed in hchA-deficient strains
A Study on the incidence and
No full text치의학과/석사[영문]
[한글]
저자는 한국인에서의 치조골 결손 형태의 빈도 및 분포를 알아보기 위하여 연세 대학교
원주 의과대학 해부학 교실의 해부용 사체에서 적출한 22개의 하악골, 총 210개의 치아
를 대상으로 부위별, 연령별로 조사하여 다음과 같은 결론을 얻었다.
1. 치조골 결손 형태별로 빈도를 보면 furcation involvement 17.8%, inconsistent mar
gin 15.8%, dehiscence 13.8%, fenestration 12,5%의 순으로 나타났다.
2. inconsistent margin, dehiscence, fenestration은 전치부에서 많이 나타났고, thic
kened margin, ledgelike margin, intrabony defect는 구치부에서 많이 나타났다.
3. furcation involvement는 연령이 증가함에 따라 class Ⅰ보다 class Ⅲ의 빈도가 높
게 나타났다.
4. 연령이 증가함에 따라 thickened margin, ledgelike margin은 감소하였고, inconsis
tent margin, interdental crater, intrabony defect, dehiscence , fenestration은 증가
하였다.
5. 같은 형태 치아 좌측과 우측을 비교해 보았을 때 별다른 차이를 보이지 않았다.
A STUDY ON THE INCIDENCE AND DISTRIBUTI0N OF ALVEOLAR BONI DEFECTS IN DRIED
MANDIBLES OF KOREAN
In Sook Kim
Dept. of Dental Science, Graduate School Yonsei University
(Directed by Assistant Prof. Han Pyong Kim, D.D.S., Ph.D.)
In order to observe the Incidence and distribution of alveolar bone defects
according to age, type of tooth, the author had surveyed the 22 mandibles of dry
human jaws of the department of Anatomy, the Wonju Medical College, Yonsei
University.
210 teeth among 22 d교 human mandibles were studies.
The obtained results were as fellows:
1. According to the morphology, the alveolar bone defects most frequenty observed
were furcation involvements (17.8%), inconsistent margins (15.8%), dehiscences
(13.8%), fensetrations(12.5%) in order.
2. Inconsistent margins, dehiscences, fenestrations were much more common in the
anterior segment, thickened margins, ledgelike margins, instrabony defects were
much more common in the posterior segment.
3. As the age increases, Class Ⅲ furcation involvements were increased, Class I
furcation involvements were decreased.
4. As the age increases, thickened margins and ledgelike margins were decreased,
whereas inconsistent margins, interdental craters, intrabony defects, dehiscences
and fenestrations were increased.
5. As to the type and incidence of bone defect, there were no significant
differences between left and right side of mandible.restrictio
The Narrative Strategies of Nationalism in Returning to Haifa by Ghassan Kanafani
No full text이 글에서는 갓산 카나파니의 소설 ｢하이파에 돌아와서｣(Returning to Haifa)에 나타난 내셔널리즘 서사 전략을 분석하고자 한다. 1969년의 팔레스타인 상황에서 소설을 통해 내셔널리즘을 강화하고자 한 작가의 기획이 성공적으로 드러나는 면과 실패하는 국면을 함께 살펴봄으로써 내셔널리즘의 한계를 고찰하려는 것이 이 글의 목적이다. 이를 위해 이 글에서는 다음의 두 가지에 초점을 맞추었다. 첫 번째는 내셔널리즘을 강화하고자 한 이야기 형식을 살펴보는 것이고, 두 번째는 내셔널리즘의 타자들이 소설에서 어떤 방식으로 그려지는가 하는 점이다.
갓산 카나파니의 이력은 조국에서의 추방과 인접 아랍국들을 전전하는 피난생활 등 팔레스타인 인민들의 운명과 그 궤를 함께 한다. 1948년에 그는 12세의 나이로 다른 팔레스타인 사람들과 똑같이 피난길에 오르
게 되어, 레바논, 시리아, 쿠웨이트, 베이루트 순으로 옮겨다녔다. 문학저술 외에도 교사, 언론인, 정치가로 활동해 온 그는 PELP(팔레스타인 인민 해방전선) 대변인으로 활동하던 중 자동차 폭파 사고로 목숨을 잃었다. 뚜렷한 정치적 이력과 함께 그는 장편소설 세 편, 희곡 한 편, 그리고 50편이 넘는 단편소설을 남겼다.
This thesis deals with the narrative strategies of Nationalism in Returning to Haifa written by Ghassan Kanafani. He intended to strengthen Nationalism by dealing with the Palestinian situation in 1969 in his novel. The objective of this thesis is to understand the limitations
of Nationalism by looking into the successes and failures of what he intended to.
In this novel who we can see a narrator, who assimilated with a character in the novel, who considers the others as his enemies and suppress them in an authoritative manner, which implies what Nationalism is. In addition, we can see a unique structure where the Nationalism that the author
intended to highlight is reinforced, while three returning narratives are overlapped. However, the irony is, we can notice that the authors messages with the monophonic voice become weaker when we pay attention
to the otherness that is eventually exposed. The narrative strategies of Nationalism start to rupture at this point where the imagination to resolve the Israeli Palestinian issue can newly created
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A Study oÍl the History of English Preposition Stranding
No full textPreposition Stranding was not possible in OE Topiclaization unless the prepositional
object was a pronoun. In the case of a pronoun, the Preposition Stranding could be attributed to the effects of an independently motivated rule permitting pronominal object of prepositions and their prepositions, after which the pronoun and the preposition could split up freely. Passivization of the object of a preposition was not possible, either.
Preposition stranding was obligatory in þe relatives, but non-existent in se and se þe relatives. Apparent counterexamples to this generalization involving pronouns were accounted for by an independently motivated rule permitting objects of prepositions with those prepositions, in conjunction with the PP-Split rule.
While preposition stranding 'was possible in free relatives of the sort in which the
pronoun independently must be analyzed as being the head of the relative clause, it was not possible in free relatives which must be analyzed as involving movement of the pronoun.
In ME, Preposition Stranding came about in all ψh-relatives, questions, and passives of the sort he was laughed at. This change can be accounted. for as folloing In OE, Prepostion Stranding was possible in free relatives which were hypothesized there to ìnvolve deletìon under ìdentity to the head, which was the wh-pfonoun. Since Prepositìon Strandìng was 'possìble ìn these relatives, and since these relatives were now superficially much similar to ordinary ψh-relatives, it would be easy for a language learner; hearìng Prepositìon Strnading in one constructìon with ψh-pronouns, to extend Preposition Strandìng to other constructions, such as ordinary relatives involvìng wh-movement. Once this step was taken, there was no longer any. evìdenc for a prohibitìon against movement out of PP (Prepositional Phrase). And when this prohibition was dropped, we would expect Preposition Straning in not only relatìve clauses and questions, which used tνhwords, but also ìn. other constructions ìnvolving movement, such as Topìcalization an Passivization
(A) study on the decisive factors in personal health maintenance practice of housewives living in Younhi area apartments
No full text간호학과/석사[한글]
현대과학의 발전과 인간수명의 연장, 인구의 급증, 경제수준의 향상 등으로 말미암아 건강에 대한 인간의 요구는 증가하였고, 우리는 이 건강요구를 충족시켜주기 위하여 건강인권운동을 더욱 적극적으로 전개할 계획을 세워야한다.
건강교육은 개인과 단체를 접촉하여 개인 및 지역사회의 보건형태를 변화시키기 위한 접근법의 하나이며, 효율적인 건강교육을 위하여서는 표적집단의 특성을 올바로 파악하고, 지역사회주민들로 하여금 자신들의 보건계획을 개발함에 참여토록 해야한다.
본 연구는 건강관리실천에 대한 대상자의 반응과 건강관리실천에 영향을 미칠 결정요인과의 관계를 검토함으로써, 효과적인 건강교육을 시행할 수 있고 주민의 건강관리실천에 변화를 가져올 수 있도록 하기 위하여 건강교육계획의 기틀을 마련하는데 도움이 되고자 시도되었다.
연구대상은 서울시 연희3동 B지구 아파트지역에 거주하는 600명의 주부를 모집단으로 하여 계통적 표집에 의하여 120명을 선정하고, 자료수집은 본 연구조사를 위하여 훈련된 면접자가 1978년 5월16일부터 19일까지 4일동안 질문지를 가지고 대상주부를 직접면접하여 타기식(他記式) 방법으로 기록하였고, 통계적 분석방법으로는 전자계산조작을 이용하여 백분율, t-test, 단계적 중회귀분석을 이 용하였다.
연구결과를 요약하면 다음과 같다.
1. 대상자의 일반적 특성,
연령분포를 보면 20세이상 39세이하가 전대상자의 62.5%이었고, 40세이상이 37.5%를 차지하고 있었으며, 자녀수는 3명이하가 76.7%, 4명이상이 19.1%이었고, 교육정도는 중학교이하의 교육 이수자가 43.7 %. 고등학교과정이상의 교육 이수자가 51.3%이었다.
2. 건강관리실천에 대한 대상자의 반응
영역별 건강관리실험의 평점의 최대평점에 대한 비율을 보면, 인구 및 가족계획에 관한 영역에서 84.1%로 가장 높았고, 그다음은 사고예방에 관한 영역에서 82.4%, 전염병관리에 관한 영역에서 68.0%, 개인위생 및 일상생활습관에 관한 영역에서 67.8%, 정신건강에 관한 영역에서 64.3%, 기생충 관리에 관한 영역에서 52.5%로 기생충 관리가 가장 낮은 비율을 보였다.
3. 건강관리실천의 결정요인에 대한 대상자의 반응.
결정요인별 실평점의 산술평균은 가족원 상호관계가 18.33점으로 최대평점의 73.3%에 해당하는 것으로 가장 높았고, 다음은 건강에 대한 관심도가 34.48점으로 70.0%, 의료기관이용 및 의료요구도가 25.79점으로 64.5%, 가족의 건강관리가 11.58점으로 43.6%를 나타내어 가족의 건강관리가 가장 낮은 반응을 보였다.
4. 건강관리실천과 일반적 특성간의 유의성.
1) 건강관리실천에 대해서 자녀수간에는 유의한 차가 있었다. (t=1.83, d.f.=117. p<0.1)
2) 건강관리실천에 대해서 메스미디아 접촉도간에는 유의한 차가 있었다. (t=-0.52,d.f.=118, p<0.05)
3) 건강관리 실천에 대해서 생활정도간에는 유의한 차가 있었다.(t=-3.33, d.f.=118, p<0.05)
4) 그 이외의 특성, 즉 연령, 가족형태, 1인당 주거면적, 거주기간, 남편의 직업, 부인의 직업유무, 단체참여도, 부인의 종교, 교육정도등에 대해선 유의한 차가 나타나지 않았다. (t=-0.68∼1.95, d.f.=118, p>0.05)
5. 건강관리실천과 결정요인간의 상관성
1) 건강관리실천과 건강에 대한 관심도, 가족의 건강관리, 의료기관이용 및 의료요구도와는 유의한 상관이 있음이 나타났다. (p<0.005)
2) 건강에 대한 관심도와 의료기관이용 및 의료요구도, 가족의 건강관리, 가족원 상호관계와는 유의한 상관이 있음이 나타났다. (p<0.005)
3 )가족의 건강관리와 의료기관이용 및 의료요구도와는 유의한 상관이 있음이 나타났다. (p<0.O05)
6. 건강관리실천과 결정요일간의 다변수 상관성
1) 건강에 대한 관심도는 건강관리실천을 43.6% 설명할 수 있었다. (R=0.6602, R**2 =0.4359, F=91.1678, p<0.001)
2) 가족의 건강관리가 더 첨가되면 건강관리실천을 51.2% 설명할 수 있었다. (R=0.7158, R**2= 0.5124, F=61.4653, p<0.001)
3) 가족의 상호관계가 더 첨가되면 건강관리실천을 53.7% 설명할 수 있었다. (R=0.7324, R**2= 0.5365, F=44.7509, p<0.001)
4) 의료기관이용 및 의료요구도가 더 첨가되면 건강관리실천을 55.1% 설명할 수 있었다. (R=O.7421, R**2 =0.5507, F=35.2430, p<0.001)
[영문]
Owing to the development of modern science, prolonging man's life, the sudden increase of population and betterment of the standard of living has increased health needs.
In order to fulfill these health needs, more active plans for developing health should be made.
Health education is one of the methods at hand that can improve the health behavior of the community and the individual through the contact of individuals with their groups. Proper understanding of the characteristics of the sampled group and participation of individuals within the community for the development of their health plan are needed for efficient health education.
This study was attempted for the purpose of presenting some data helpful for preparing the fundamentals of a health education plan that can improve personal health maintenance practice of a community through efficient health education by investigating the relationship between the response of subjects to personal health maintenance practice and selected decisive factors in personal health maintenance practice.
The subjects for this study were a systematic sample of 120 housewives selected from 700 housewives from B Zone APt. Younhi-3-Dong in Seoul.
Data was collected for 4 days from May 16th to May 19th, 1978 through personal interviews with questionaires by well trained interviewers. Percentage, t-test and stepwise multiple regression analysis by use of EDPS were employed for statistical analysis.
Resets of this study can be summarized.
1. General characteristics of subjects
Subjects over 20 and below 70 years of age formed 62.5% of the total and the rest were subjects of 40 years and upward. 76.7% of the subjects have less than 4 children. 51.3%of the subjects had completed at least the senior high school course.
2. The response of subjects to personal health maintenance practice.
Ratios of personal health maintenance practice to the maximum score for each category are as follows; 84.1% in the category of population and family planning, which was the highest ratio; 84.4% in the prevention of accidents; 68.0% in control of communicable disease; 67.8% in personal health care and habits of daily life, 64.3% in mental health and 52.5% in control of parasites, which was the lowest.
3. The response of subjects to selected decisive factors in personal health maintenance practice.
The arithmetic mean of the scorer for each decisive factor was as follows; the mutual relatin between family members marked 18.33, which is under 73.3% of the maximum score; the degree of interest in health marked 34.48, 70.0% of the maximum score; the degree of utilization and demand for health care facilities marked 25.79 or 64.5% of the maximum score and health maintenance of the family marked 11.58, 43.6% of the maximum score.
4. The relationship between personal health maintenance practice and general characteristics of subjects.
1) There was a significant difference in the numbers of children. (t=1.83, d.f.=117. p<0.1)
2) There was a significant difference in the contact rates with mass-media. (t=5.02, d.f.=118, p<0.05)
3) There was significant difference in the standard of living. (t=-3.33, d.f.=118, p<0.05)
4) There was no significant difference in the other characteristics, i.e.age, residential space, period of residence, occupations of husbands, occupations of subjects, participating degree for a group, religion of subjects and extent of education. (t=-0.68 -0.95, d.f.=118, p>0.05)
5. The Correlation between personal health maintenance practice and selected decisive factors.
1) There was a significant correlation between personal health maintenance practice and the degree of interest in health, and the degree of utilization and demand for health care facilities. (p<0.005)
2) There was a significant correlation between the degree of interest in health and the degree of utilization and demand for health care facilities, health maintenance of family, and mutual relations between family members. (p<0.005)
3) There was a significant correlation between health maintenance of family and the degree of utilization and demand for heath care facilities. (p<0.005)
6. the multiple correlation between pereonal health maintenance practice and their selected decisive factors.
1) The factor "the degree of interest in health" could account for personal health maintenance practice in 43.6% of the sample.
j73.6? of the sample. (R=0.6602, R**2 =0.4359, F=91.1678, p<0.001)
2) Then the factor, "health maintenance of family" is added to this, it accounts for 51.2% of personal health maintenance practice. (R=0.7158, R**2 =0.5124, F=61.4653, p<0.001)
3) When the factor, "mutual relations between family members" is also included, it accounts for 53.7% of personal health maintenance practice. (R=0.7324, R**2 =0.5365, F=44.7509, p<0.OO1)
4) When the factor, "the degree of utilization and demand for health care facilities" is included, it accounts for 55.1% of personal health maintenance practice. (R=0.7421, R**2 =0.5507, F=35.2430, p<0.001)restrictio
- …
