1,064 research outputs found
Study of 47 DNA markers in five populations from four continents
No full textForty seven DNA markers from 30 genes or chromosomal regions were investigated in five populations (Biaka and Mbuti Pygmies, Melanesians, Chinese and Caucasoids). Both the variation between populations (measured by FST) and between markers is highly significant. The average heterozygosity for all markers is .284 and the average FST is .145. There was no significant difference in the FST values, or in the average heterozygosity between known genes and random segments. The FST distance between all populations considered in pairs, and averaged over all loci favours a primary split between Eurasia and Africa, but this conclusion is neither statistically significant nor uncomplicated. Condensing the 47 markers into 30 "genes" where 10 were treated as haplotypes, it was found that the haplotypes always give higher FST's than the separate markers, although similar conclusions can be drawn
KK-DUALITY FOR SELF-SIMILAR GROUPOID ACTIONS ON GRAPHS
No full textWe extend Nekrashevych’s KK-duality for C∗-algebras of regular, recurrent, contracting self-similar group actions to regular, contracting self-similar groupoid actions on a graph, removing the recurrence condition entirely and generalising from a finite alphabet to a finite graph. More precisely, given a regular and contracting self-similar groupoid (G, E) acting faithfully on a finite directed graph E, we associate two C∗-algebras, O(G, E) and Ô(G, E), to it and prove that they are strongly Morita equivalent to the stable and unstable Ruelle C*-algebras of a Smale space arising from a Wieler solenoid of the self-similar limit space. That these algebras are Spanier-Whitehead dual in KK-theory follows from the general result for Ruelle algebras of irreducible Smale spaces proved by Kaminker, Putnam, and the last author
K-theory for group C*-algebras
No full textThese notes are based on a lecture course given by the first author in the Sedano Winter School on K-theory held in Sedano, Spain, on January 22-27th of 2007. They aim at introducing K-theory of C*-algebras, equivariant K-homology and KK-theory in the context of the Baum-Connes conjectur
[[alternative]]Shape and KK Masses
No full text[[abstract]]我們討論在六維時空模型中，額外維度空間的形狀對現象學的影響。兩個以週期性條件緊緻化的維度可以夾角Θ，此角對Kaluza-Klein態的質量有很大影響。我們特別考慮Θ<<1的情況，大部分的KK態質量會比Θ=90°時大很多，但是有一群KK態的質量會相較下小很多，我們討論這些Light KK態的KK數n1、n2滿足哪些條件，並以一個具體Θ為例找出最輕的一些KK態，這些態通常具有蠻大的KK數。如果在Universal Extra Dimension模型中來討論，KK數守恆會造成許多Light KK態無法衰變，而形成穩定粒子，這些粒子可能成為黑物質。
Genotyping of Kell, Duffy, Kidd and RHD in patients with b Thalassemia
No full textDetermination of Rh, Kell, Duffy and Kidd phenotypes in addition to ABO is used to prevent the alloimmunization to red blood cells (RBCs) antigens and as part of the antibody identification process in patients with beta Thalassemia. However, phenotyping in these patients can be time consuming and difficult to interpret. In these situations, it would be valuable to have an alternative to hemagglutination tests to determine the patient's antigen profile. We used PCR-RFLP to genotype such patients. DNA was prepared from 50 patients with beta Thalassemia who had been phenotyped by routine hemagglutination, and tested for Kell, Kidd, Duffy/GATA mutation by PCR-RFLP. RHD/non-D was analysed by PCR product size associated to RHD gene sequence in intron 4 and exon 10/3'UTR. The genotyping assays were performed without knowledge of phenotype results. For RHD/non-D, 47 were RhD+ and RHD+/RHCE+, and 3 were RhD- and RHD-/RHCE+. For Kell, 48 kk were K2K2 and 2 Kk were K1K2. For Duffy, of 44 samples that had normal GATA box, 8 Fy(a+b-) were FYA/FYA, 15 Fy(a+b+) were FYB/FYB, and 19 Fy(a+b+) were FYA/FYB; of the other 4 samples 3 were FYA/FYB and heterozygous GATA mutation, and 1 Fy(a-b-) was FYB/FYB, homozygous GATA mutation. Two samples phenotyped as Fy(a+b-) that had normal GATA , presented the 265T/298A mutations and two samples phenotyped as Fy(a-b+) were genotyped was FYA/FYB.. For Kidd , 15 Jk(a+b) were JKA/JKA, 12 Jk(a-b+) were JKB/JKB, and 20 Jk(a+b+) were JKA/JKB. Three samples phenotyped as JK(a+b+) were genotyped as JKB/JKB. Genotype is more accurate than phenotype for determination of blood groups in polytransfused patients with betaThalassemia. Genotyping in these patients can be helpful to select antigen-negative RBCs for transfusion
Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-Ay mice
No full textFucoxanthin (Fx) isolated from Undaria pinnatifida suppresses the development of hyperglycemia and hyperinsulinemia of diabetic/obese KK-Ay mice after two weeks of feeding 0.2% Fx-containing diet. In the soleus muscle of KK-Ay mice that were fed Fx, glucose transporter 4 (GLUT4) translocation to plasma membranes from cytosol was promoted. On the other hand, Fx increased GLUT4 expression levels in the extensor digitorum longus (EDL) muscle, although GLUT4 translocation tended to increase. The expression levels of insulin receptor (IR) mRNA and phosphorylation of Akt, which are in upstream of the insulin signaling pathway regulating GLUT4 translocation, were also enhanced in the soleus and EDL muscles of the mice fed Fx. Furthermore, Fx induced peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α), which has been reported to increase GLUT4 expression, in both soleus and EDL muscles. These results suggest that in diabetic/obese KK-Ay mice, Fx improves hyperglycemia by activating the insulin signaling pathway, including GLUT4 translocation, and inducing GLUT4 expression in the soleus and EDL muscles, respectively, of diabetic/obese KK-Ay mice
The dietary effect of milk sphingomyelin on the lipid metabolism of obese/diabetic KK-A(y) mice and wild-type C57BL/6J mice
No full textPurified milk sphingomyelin (SM) was obtained from lipid concentrated butter serum (LC-BS) by successive separations involving solvent fractionation, selective saponification, and silicic acid column chromatography. The SM obtained was given to obese/diabetic KK-A(y) mice and wild-type C57BL/6J mice. SM supplementation significantly increased fecal lipids paralleled with a decrease in non-HDL cholesterol levels in the serum and neutral lipids and in cholesterol levels in the livers of KK-A(y) mice. The reduction of liver lipid levels also resulted in a decrease in the total fatty acid content of the KK-A(y) mice livers, while n-3 fatty acids derived from the conversion of a-linolenic acid (18:3n-3) increased due to SM supplementation. In contrast to the KK-A(y) mice, little change in the serum and liver lipids was observed in wild-type C57BL/6J mice. The present study suggests that SM may be effective only in subjects with metabolic disorders
KK-duality for self-similar groupoid actions on graphs
No full textWe extend Nekrashevych’s KK-duality for C∗-algebras of regular, recurrent, contracting self-similar group actions to regular, contracting self-similar groupoid actions on a graph, removing the recurrence condition entirely and generalising from a finite alphabet to a finite graph.
More precisely, given a regular and contracting self-similar groupoid (G, E) acting faithfully on a finite directed graph E, we associate two C∗-algebras, O(G, E) and̂ O(G, E), to it and prove that they are strongly Morita equivalent to the stable and unstable Ruelle C*-algebras of a Smale space arising from a Wieler solenoid of the self-similar limit space. That these algebras are Spanier-Whitehead dual in KK-theory follows from the general result for Ruelle algebras of irreducible Smale spaces proved by Kaminker, Putnam, and the last author
- …
