19,471 research outputs found
Cell-based therapies of liver diseases: age-related challenges
No full textKonstantin N Yarygin, Alexei Y Lupatov, Irina V Kholodenko Laboratory of Cell Biology, Institute of Biomedical Chemistry, Moscow, Russia Abstract: The scope of this review is to revise recent advances of the cell-based therapies of liver diseases with an emphasis on cell donor’s and patient’s age. Regenerative medicine with cell-based technologies as its integral part is focused on the structural and functional restoration of tissues impaired by sickness or aging. Unlike drug-based medicine directed primarily at alleviation of symptoms, regenerative medicine offers a more holistic approach to disease and senescence management aimed to achieve restoration of homeostasis. Hepatocyte transplantation and organ engineering are very probable forthcoming options of liver disease treatment in people of different ages and vigorous research and technological innovations in this area are in progress. Accordingly, availability of sufficient amounts of functional human hepatocytes is crucial. Direct isolation of autologous hepatocytes from liver biopsy is problematic due to related discomfort and difficulties with further expansion of cells, particularly those derived from aging people. Allogeneic primary human hepatocytes meeting quality standards are also in short supply. Alternatively, autologous hepatocytes can be produced by reprogramming of differentiated cells through the stage of induced pluripotent stem cells. In addition, fibroblasts and mesenchymal stromal cells can be directly induced to undergo advanced stage hepatogenic differentiation. Reprogramming of cells derived from elderly people is accompanied by the reversal of age-associated changes at the cellular level manifesting itself by telomere elongation and the U-turn of DNA methylation. Cell reprogramming can provide high quality rejuvenated hepatocytes for cell therapy and liver tissue engineering. Further technological advancements and establishment of national and global registries of induced pluripotent stem cell lines homozygous for HLA haplotypes can allow industry-style production of livers for immunosuppression-free transplantation. Keywords: cell aging, rejuvenation, liver engineering, liver cell therap
Chapter 19: Hydrogen cogeneration with generation IV nuclear power plants
No full textA promising method of clean fuel production in the future is nuclear-based hydrogen production using electrolysis and thermochemical cycles. Hydrogen is a clean energy carrier and potentially major solution to the problem of climate change. Production of hydrogen can also serve the role of energy storage of off-peak nuclear energy and intermittent renewables, such as wind and solar energy, and stabilize the fluctuating load of the electric power grid. This chapter discusses a number of hydrogen production methods, use of hydrogen, and design aspects of hydrogen cogeneration with Generation IV nuclear reactors
Bresgroei - deel IV: Pragmatische modellering breedtegroei
No full textHet voorliggende onderzoek heeft tot doel inzicht te verschaffen in de wijze waarop het verloop van het instroomdebiet en de binnenwaterstand afhangen van de breedtegroei van de bres. De resultaten van deze verkenning geven aan in hoeverre (of en zoja, met welke middelen) nader onderzoek naar het proces van bresgroei gewenst is en wat de optimale invulling ervan is. Na een nadere karakterisering van het breedtegroeiproces is een onderverdeling gegeven in verschillende te onderkennen fasen. Vervolgens is, voor een situatie met constante buitenwaterstand, een analytische oplossing gegeven voor de ontwikkeling van respectievelijk de bresbreedte, het bresdebiet en de binnenwaterstand. Hieruit kan de gevoeligheid van de bresgroeisnelheid op bijvoorbeeld de uiteindelijke breedte van het gat en de totale tijdsduur worden afgeschat. Implementatie van de basisformuleringen in een eenvoudig mathematisch model (BREACHlD) maakt het doorrekenen van de ontwikkelingen voor een niet-constante buitenconditie mogelijk. Hiermee zijn voor het geval van een fictieve polder enkele verkennende berekeningen uitgevoerd waarbij de te verwachte spreiding in het resultaten is gerelateerd aan de onbekendheid met het onderliggende proces van bresgroei. Bij deze interpretatie zijn ook de resultaten van berekeningen met het RAMP-model van de DWW betrokken
KAJIAN LITERATUR : PENERAPAN SLEEP HYGIENE EDUCATION DALAM MENGATASI INSOMNIA
No full textStudi Literatur : Penerapan Sleep Hygiene Education Dalam Mengatasi InsomniaTina Irmadany*, Dwi Ari Murti Widigdo**, Angga Sugiarto**, Bambang Sarwono**Email : [email protected] ABSTRAKLatar Belakang : Insomnia adalah kesuiltan untuk tertidur dan kesulitan untuk mempertahakan tidur bahkan ketika seseorang memiliki kesempatan untuk melakukannya. Insomnia merupakan gangguan tidur yang paling umum pada populasi umum, dan umumnya ditemui dalam praktik medis. Sleep hygiene education merupakan penerapan perilaku kebersihan atau kebiasaan yang dilakukan menjelang tidur. Sleep hygiene education dapat digunakan sebagai alternatif dalam mengatasi insomnia dan dapat digunakan untuk meningkatkan kualitas tidur.Tujuan Penelitian : Membahas topik dengan kajian literatur penerapan sleep hygiene education untuk mengatasi insomnia.Metode Penelitian : Penelitian ini menggunakan metode penelitian kepustakaan. Database yang digunakan adalah artikel terindeks nasional dan internasional di Pubmed, Science Direct, dan Google Scholar. Batas waktu publikasi adalah 5 tahun terakhir (2015-2020). Artikel penelitian yang didapatkan sebanyak 21 artikel, dianalisis dan disintesis dalam format tabel berisi judul, penulis, tahun, metodologi, dan rekomendasi.Hasil Penelitian : Setelah dilakukan penelitian dari 21 kajian literatur terdiri dari 3 artikel RCT, 5 artikel quasy experimental, 2 artikel systematic review, 1 artikel comparative intervention study, 1 artikel qualitative method, 1 artikel longitudinal study, 1 artikel metaanalisis, 5 artikel cross-sectional, 1 artikel case study, dan 1 artikel case control. Semua artikel membahas mengenai sleep hygiene education dalam mengatasi insomnia dengan berbagai kasus.Kesimpulan : Pada semua artikel/jurnal menunjukkan adanya pengaruh sleep hygiene education terhadap derajat insomnia, dibuktikan dengan hasil penelitian.Saran : Untuk penelitian selanjutnya, dapat membahas mengenai teknik yang paling efektif dalam melakukan sleep hygiene education untuk mengatasi insomnia pada pasien tertentu. Penelitian terkait dengan kebutuhan serta persayaratan lain untuk menentukan tipe pasien yang bisa mendapatkan sleep hygiene education.Kata Kunci : Sleep hygiene education, insomnia*Mahasiswa Program Studi D IV Keperawatan Magelang Poltekkes Kemenkes Semarang**Dosen Program Studi D IV Keperawatan Magelang Poltekkes Kemenkes SemarangLiterature Study: Application of Sleep Hygiene Education in Overcoming InsomniaTina Irmadany *, Dwi Ari Murti Widigdo **, Angga Sugiarto **, Bambang Sarwono **Email : [email protected] ABSTRACTBackground : Insomnia is a difficulty to fall asleep and difficulty maintaining sleep even when someone has the opportunity to do so. Insomnia is the most common sleep disorder in the general population and is commonly encountered in medical practice. Sleep hygiene education is the application of hygiene behavior or habits that are carried out before going to sleep. Sleep hygiene education can be used as an alternative in dealing with insomnia and can be used to improve sleep quality.Research purposes : Discuss the topic with the literature review of the application of sleep hygiene education to overcome insomnia.Research methods : This research uses library research methods. The database used is national and international indexed articles in Pubmed, Science Direct, and Google Scholar. The deadline for publication is the past 5 years (2015-2020). The research articles obtained were 21 articles, analyzed and synthesized in a table format containing the title, author, year, methodology, and recommendations.Research result : After researching 21 literature studies consisting of 3 RCT articles, 5 quasi experimental articles, 2 systematic review articles, 1 comparative intervention study article, 1 qualitative method article, 1 longitudinal study article, 1 meta-analysis article, 5 cross-sectional articles, 1 case study articles, and 1 case-control article. All articles discuss sleep hygiene education in dealing with insomnia in various cases.Conclusion : All articles show the effect of sleep hygiene education on the degree of insomnia, evidenced by the results of the study.Suggestion : For further research, it can discuss the most effective techniques in conducting sleep hygiene education to overcome insomnia in certain patients. Research related to the needs and other requirements to determine the type of patient who can get sleep hygiene education.Keywords : Sleep hygiene education, insomnia* Students of Magelang D IV Nursing Study Program, Ministry of Health Polytechnic Semarang** Lecturer of Magelang D IV Nursing Study Program, Ministry of Health Polytechnic Semaran
The form of cruising off Acapulca on the coast of Mexico in the South Seas, in the year 1742 by His Majesty's ships, Centurion, Gloucester, Tryall Prize, Carmila Prize, Carmin Prize [cartographic material].
No full textPl. [18/C] of: A voyage round the world in the years MDCCXL, I, II, III, IV, by George Anson. London : Printed for the author by John and Paul Knapton ... , 1748.; A.E. Nordenskield, v. 3, 326; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an24313870
A plan of the harbour of Chequetan or Seguataneo [cartographic material].
No full textMap of Mexico. Relief shown pictorially and by bathymetric soundings.; Pl. [20/A] of: A voyage round the world in the years MDCCXL, I, II, III, IV, by George Anson. London : Printed for the author by John and Paul Knapton ... , 1748.; A.E. Nordenskield, v. 3, 326; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an24313886
A plan of the town of Payta in the kingdom of Santa-Fee lying in the latitude of 5 d. 12 m. S* [cartographic material].
No full textPlan of the town of Paita, Peru.; Pl. [17/A] of: A voyage round the world in the years MDCCXL, I, II, III, IV, by George Anson. London : Printed for the author by John and Paul Knapton ... , 1748.; A.E. Nordenskield, v. 3, 326; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an24313818
The bay and rocks of Petaplan [cartographic material].
No full textRelief shown pictorially and by bathymetric soundings.; Pl. [19/A] of: A voyage round the world in the years MDCCXL, I, II, III, IV, by George Anson. London : Printed for the author by John and Paul Knapton ... , 1748.; A.E. Nordenskield, v. 3, 326; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an24313876
A plan of Iuan Fernandes Island in the South Sea, lying in the latitude of 33d 40 m South, and West from the continent of Chili 110 leagues [cartographic material] : variation of the compass 10 d 00 m E.
No full textMap of Juan Fernandez Islands. Relief shown pictorially and by soundings.; Pl. [13/B] of: A voyage round the world in the years MDCCXL, I, II, III, IV, by George Anson. London : Printed for the author by John and Paul Knapton ... , 1748.; A.E. Nordenskield, v. 3, 326; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an24313763
A chart of the southern part of South America [cartographic material] : with the track of the Centurion from the Island of St. Catherines to the Island of Juan Fernandes: in which is inserted the variation and soundings observ'd on board her, together with her deviation from her estimated course in passing round Cape Horn, occasioned by the force of the currents.
No full textRelief shown by soundings.; "R.W. Seale sculp."; Pl. no. [11a] of: A voyage round the world in the years MDCCXL, I, II, III, IV, by George Anson. London : Printed for the author by John and Paul Knapton ... , 1748.; A.E. Nordenskield, v. 3, 326; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an24313604
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