1,720,960 research outputs found
Kamerabevakning utan tillståndskrav på platser där allmänheten inte äger tillträde – ett hot mot den personliga integriteten?
No full textIn Sweden, camera surveillance in places where the public own access is regulated by a permit. This entails a lack of permit requirement for camera surveillance in places where the public does not own access. Such places can consist of a privacy-sensitive character. Surveillance constitutes processing of personal data whereupon the General Data Protection Regulation (GDPR) must be complied with. Article 6 of the GDPR stipulates various legal bases that must be met in the processing of personal data. The ones who conduct surveillance in places where the public does not own access often fails to make correct legal assessments of Article 6(1)(e) and 6(1)(f) of the GDPR, as displayed by various supervisory decisions issued by the Swedish Authority for Privacy Protection. In this light, the purpose of the thesis is to examine and analyze how the ones who conduct surveillance and the Swedish Authority for Privacy Protection consider the personal integrity of the camera monitored individual in the assessments of Article 6(1)(e) and 6(1)(f) of the GDPR during camera surveillance without permit requirement in places where the public does not own access. Because of the differences between the legal assessments made by the ones who conduct camera surveillance and the Swedish Authority for Privacy Protection, the thesis also intends to shed light on the consequences that arise for the camera monitored individual by the fact that their personal integrity is assessed in different ways. The thesis also aims to evaluate the Swedish Authority for Privacy Protections’ supervisory work in relation to both personal integrity and the compliance with Article 6(1)(e) and 6(1)(f) of the GDPR during camera surveillance without permit requirement in places where the public does not own access. The Swedish Authority for Privacy Protections’ supervisory work is important as most of the camera surveillance takes place without a permit requirement and the fact that there is a lack of knowledge prevailing to the number of cameras in use. It is important that the Swedish Authority for Privacy Protections’ supervisory work is well-functioning since the ones who conduct surveillance carry out the legal assessments incorrectly. The risk with insufficient supervisory work is that personal integrity is violated and that the GDPR is ineffectual in the long run. In general, it can be said that the legal assessments of Article 6(1)(e) and 6(1)(f) of the GDPR are poorly carried out by both the ones who conduct surveillance and the Swedish Authority for Privacy Protection. This primarily affects the camera monitored individuals’ personal integrity. Because of the indications of shortcomings in the supervisory work, there are several improvement measures that can be taken to maintain personal integrity and ensure that the Swedish Authority for Privacy Protection continue to constitute an important function
Structural and Functional Studies of Human E3 Ubiquitn Ligase HUWE1
No full textUbiquitin (Ub) acts as an intracellular signal once tagged covalently to the target proteins and regulates a myriad of cellular processes. Ubiquitin is attached to the target protein by the concerted action of E1, E2, and E3 Ub ligase enzymes, in the presence of ATP. During this process, E3 Ub ligases are responsible for the final step of protein ubiquitination and play crucial roles in substrate selectivity and specificity. Therefore, understanding the structure and function of E3 Ub ligases provides valuable mechanistic information regarding their specific roles in Ub-mediated regulatory processes. In this dissertation, we aimed to investigate the structure and function of the human E3 Ub ligase, HUWE1. HUWE1 regulates multiple cellular pathways, including DNA damage response, apoptosis, and transcriptional regulation through controlling the stability and fate of various proteins involved in these pathways. Using multidisciplinary approaches, we studied the functional domains, the regulation, and the new cellular substrates of HUWE1. We report that HUWE1 harbors a previously uncharacterized tandem ubiquitin-binding motif (UBM). It contains three independently folded unique UBMs, and as a tandem, it binds three different Ub chains. Most significantly, this tandem UBM enhances HUWE1-mediated ubiquitination. We also uncovered the mechanism of a X-linked mental retardation mutation, R2981H, of HUWE1. Our results show this mutation disrupts the structure of the UBM that attenuates HUWE1 function.
We also investigated the molecular mechanism of the HUWE1 inhibition by ARF. We identified an 8mer ARF peptide that binds HUWE1 and p53 in vivo to inhibit HUWE1-mediated p53 ubiquitination, which results in p53 transcriptional activation. Moreover, this peptide inhibited cancer cell growth in a p53-dependent manner.
Finally, we found that HUWE1 directly binds and ubiquitinates -catenin, a master signal transducer in the canonical WNT signaling pathway. Overall, these findings identify a new HUWE1 substrate that provides new knowledge of HUWE1 function in cell regulation and development
Camera surveillance without permit requirement in places where the public does not own access – a threat against personal integrity?
No full textIn Sweden, camera surveillance in places where the public own access is regulated by a permit. This entails a lack of permit requirement for camera surveillance in places where the public does not own access. Such places can consist of a privacy- sensitive character. Surveillance constitutes processing of personal data where- upon the General Data Protection Regulation (GDPR) must be complied with.Article 6 of the GDPR stipulates various legal bases that must be met in the processing of personal data. The ones who conduct surveillance in places where the public does not own access often fails to make correct legal assessments of Article 6(1)(e) and 6(1)(f) of the GDPR, as displayed by various supervisory de- cisions issued by the Swedish Authority for Privacy Protection. In this light, the purpose of the thesis is to examine and analyze how the ones who conduct sur- veillance and the Swedish Authority for Privacy Protection consider the personal integrity of the camera monitored individual in the assessments of Article 6(1)(e) and 6(1)(f) of the GDPR during camera surveillance without permit requirement in places where the public does not own access. Because of the differences be- tween the legal assessments made by the ones who conduct camera surveillance and the Swedish Authority for Privacy Protection, the thesis also intends to shed light on the consequences that arise for the camera monitored individual by the fact that their personal integrity is assessed in different ways.The thesis also aims to evaluate the Swedish Authority for Privacy Protec- tions’ supervisory work in relation to both personal integrity and the compliance with Article 6(1)(e) and 6(1)(f) of the GDPR during camera surveillance without permit requirement in places where the public does not own access. The Swedish Authority for Privacy Protections’ supervisory work is important as most of the camera surveillance takes place without a permit requirement and the fact that there is a lack of knowledge prevailing to the number of cameras in use. It is important that the Swedish Authority for Privacy Protections’ supervisory work is well-functioning since the ones who conduct surveillance carry out the legal assessments incorrectly. The risk with insufficient supervisory work is that per- sonal integrity is violated and that the GDPR is ineffectual in the long run.In general, it can be said that the legal assessments of Article 6(1)(e) and 6(1)(f) of the GDPR are poorly carried out by both the ones who conduct surveillance and the Swedish Authority for Privacy Protection. This primarily affects the cam- era monitored individuals’ personal integrity. Because of the indications of short- comings in the supervisory work, there are several improvement measures that can be taken to maintain personal integrity and ensure that the Swedish Authority for Privacy Protection continue to constitute an important function
Kamerabevakning utan tillståndskrav på platser där allmänheten inte äger tillträde – ett hot mot den personliga integriteten?
No full textIn Sweden, camera surveillance in places where the public own access is regulated by a permit. This entails a lack of permit requirement for camera surveillance in places where the public does not own access. Such places can consist of a privacy-sensitive character. Surveillance constitutes processing of personal data whereupon the General Data Protection Regulation (GDPR) must be complied with. Article 6 of the GDPR stipulates various legal bases that must be met in the processing of personal data. The ones who conduct surveillance in places where the public does not own access often fails to make correct legal assessments of Article 6(1)(e) and 6(1)(f) of the GDPR, as displayed by various supervisory decisions issued by the Swedish Authority for Privacy Protection. In this light, the purpose of the thesis is to examine and analyze how the ones who conduct surveillance and the Swedish Authority for Privacy Protection consider the personal integrity of the camera monitored individual in the assessments of Article 6(1)(e) and 6(1)(f) of the GDPR during camera surveillance without permit requirement in places where the public does not own access. Because of the differences between the legal assessments made by the ones who conduct camera surveillance and the Swedish Authority for Privacy Protection, the thesis also intends to shed light on the consequences that arise for the camera monitored individual by the fact that their personal integrity is assessed in different ways. The thesis also aims to evaluate the Swedish Authority for Privacy Protections’ supervisory work in relation to both personal integrity and the compliance with Article 6(1)(e) and 6(1)(f) of the GDPR during camera surveillance without permit requirement in places where the public does not own access. The Swedish Authority for Privacy Protections’ supervisory work is important as most of the camera surveillance takes place without a permit requirement and the fact that there is a lack of knowledge prevailing to the number of cameras in use. It is important that the Swedish Authority for Privacy Protections’ supervisory work is well-functioning since the ones who conduct surveillance carry out the legal assessments incorrectly. The risk with insufficient supervisory work is that personal integrity is violated and that the GDPR is ineffectual in the long run. In general, it can be said that the legal assessments of Article 6(1)(e) and 6(1)(f) of the GDPR are poorly carried out by both the ones who conduct surveillance and the Swedish Authority for Privacy Protection. This primarily affects the camera monitored individuals’ personal integrity. Because of the indications of shortcomings in the supervisory work, there are several improvement measures that can be taken to maintain personal integrity and ensure that the Swedish Authority for Privacy Protection continue to constitute an important function
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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