1,720,961 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
"mosque" : shaping an architecture for the Muslim community of Northern Ontario
No full textThe role of a mosque in a minority
community, such as Northern Ontario, shifts from
its common role as solely a sacred place. There is
a consistent conflict that arises in western mosque
architecture: western mosques have become isolated
entities, located on the edges of cities and disconnected
from the communities that need them.01 In a minority
community the mosque must transcend the singular
program of prayer/religious practice and begin to serve
the secular along with the religious communities.02
This integration of community allows the mosque to
become a more integral part of the society as a whole.
Beyond the traditional roles they play in Muslim
majority communities, mosques become places for
both secular and non-secular programs through secular
spaces, such as, educational, cultural, art, and social
places.
Thus, this thesis will re-investigate western
contemporary mosques to understand how these
mosques could be able to provide for both the secular
and religious communities in Northern Ontariowhile still maintaining the sacred qualities that make
these spaces unique.
The thesis will tackle this issue
through three different categories of communities:
non-Muslim community, current community, and new
community. In this discussion, the three categories
represent the following demographics. Non-Muslim
communities refer to the secular society of the
region along with the indigenous population. Current
community is the first, second, and third generation
of Muslims who are currently navigating their own
identities and require a place to learn and grow in a
healthy environment. New community refers to the
population of people who have recently immigrated
or been displaced to the region; for example refugees,
or converted Muslims, the communities who are in
transition and need help establishing their new lives.
The key to this thesis is taking
agency in the approach as a first generation MuslimCanadian and tackling tackling the issues through this
particular perspectiv
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Impact of CYP2C8 single nucleotide polymorphisms on in-vitro metabolism of imatinib to N-desmethyl imatinib
Get PDFImatinib is a first line therapy for the treatment of chronic myeloid leukaemia (CML). Treatment with imatinib must be continuous and indefinite for most patients to maintain disease control. Despite excellent efficacy and tolerability, up to 50% of CML patients discontinue imatinib due to lack of efficacy and adverse events. Imatinib is metabolised to its main metabolite N-desmethyl imatinib by CYP3A4 and CYP2C8. In vitro human liver microsome (HLM) studies indicate imatinib autoinhibition of CYP3A4-mediated metabolism, suggesting a more significant role for CYP2C8 upon chronic dosing. CYP2C8 is polymorphic and functional effects of the major CYP2C8 polymorphisms CYP2C8*3 and CYP2C8*4 on N-desmethyl imatinib formation are unknown. It was hypothesised that CYP2C8*3 and CYP2C8*4 genetic polymorphisms will decrease imatinib metabolism to N-desmethyl imatinib in HLM. Therefore the aim of this study was to examine the impact of CYP2C8*3 and CYP2C8*4 on N-demethylation of imatinib in HLMs genotyped for CYP2C8*1/*1 (n=5), CYP2C8*1/*3 (n=4), CYP2C8*1/*4 (n=2), in CYP2C8*3/*3 pooled HLM, and in expressed CYP2C8 and CYP3A4 enzymes. Effects of CYP-selective chemical and antibody inhibitors on N-demethylation were also determined. A single enzyme Michaelis-Menten model with substrate inhibition best fitted wild-type CYP2C8*1/*1 HLM kinetic data (median ± SD K = 139 ± 61 μM). Three of four CYP2C8*1/*3 HLMs showed single enzyme but no substrate inhibition kinetics. Binding affinity (K) was approximately 2-fold higher in CYP2C8*1/*3 HLMs as compared to CYP2C8*1/*1 (median ± SD K = 6 ± 2 vs 11 ± 2 μM, p=0.04). Intrinsic clearance (Cl) was higher in CYP2C8*1/*3 HLMs compared to CYP2C8*1/*1 (median ± SD Cl = 19 ± 8 vs 13 ± 2 μl/min/mg, p = 0.25). CYP2C8*3/*3 (pooled HLM) showed highest binding affinity (K = 3.6 μM) and weak autoinhibition (K = 449 μM) kinetics. N-desmethyl imatinib formation was below the limit of quantification in one CYP2C8*1/*4 HLM, whereas the other CYP2C8*1/*4 HLM showed lower intrinsic clearance (Cl = 7 vs 11 ± 2 μl/min/mg) due to 2-fold lower catalytic activity (V) compared to the wild-type (V = 73 vs 140 ± 31 pmol/min/mg). A single enzyme model with substrate inhibition best fitted expressed CYP2C8 kinetic data (K = 149 μM). Expressed CYP3A4 showed two site enzyme kinetics with no evidence of autoinhibition. CYP2C8 inhibitors reduced N-demethylation in HLM by 47-75%, compared to 0-30% for CYP3A4 inhibitors. Two unidentified peaks M1 and M2 were found in expressed CYP3A4, whereas they were absent in expressed CYP2C8. These results indicate that CYP2C8*3 may enhance CYP2C8 activity by influencing autoinhibition, and that in vitro the metabolism and autoinhibition of imatinib N-demethylation appears mainly mediated by CYP2C8 and not CYP3A4. CYP2C8*4 appears a reduced functional allele for imatinib N-demethylation.Thesis (M.Phil.) (Research by Publication) -- University of Adelaide, School of Medicine, 2015
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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