1,720,963 research outputs found
Numerical study of transient response in amperometric and potentiometric glucose biosensors
No full textBiosensors are indispensable tools for continuous monitoring of key analytes, such as glucose, in chronic disease management. This thesis focuses on enzyme-immobilized redox polymer biosensors, leveraging reaction-diffusion partial differential equations (PDEs) to bridge the gap between theory and practical applications for biosensor design.A transient numerical scheme in MATLAB was used to solve coupled non-linear PDEs, capturing the dynamic behavior of enzyme-membrane systems. Verification was achieved by comparing steady-state analytical solutions with numerical outputs, while Case diagrams were used to identify different kinetic and transport regimes. Experiments with deflavinated enzymes provided a means to validate our model by systematically manipulating key parameters. Simulation results were compared with experimental data, revealing key insights into transient enzyme-membrane interactions.The study also investigated tubular flow electrodes, revealing the dependence of steady-state amperometric responses on solution viscosity under flow conditions. Experimentally obtained chronoamperograms were fitted to numerically solved dynamic simulations, confirming the model's predictive capabilities. Novel boundary conditions were also proposed to simulate potentiometric biosensors, broadening the scope of this work beyond amperometric sensing.Animations visualizing concentration profiles and system responses offer a deeper understanding of transient and steady-state behaviors. These insights can contribute to the optimization of biosensor performance, including sensitivity, dynamic range, and response time, advancing the development of robust and accurate glucose monitoring technologies
Dataset in support of thesis titled "Numerical Study of Transient Response in Amperometric and Potentiometric Glucose Biosensors"
No full textThis dataset contains:
1-.gif files containing animations for the reaction-diffusion simulations for different input variables. Animation Created in MATLAB R2022a.
2-.gif files containing animations for the 3D Case diagram created in Wolfram Mathematica 13.1.
3-.m files containing MATLAB code for the readers to reproduce the simulations. Files titled "ND_PS_EK_PencilE_SubStep_v3.mlx" and "Fit_PS_PencilE_Caller.mlx" are associated with Chapter 4. </span
Optimization of amperometric biosensor design using mathematical modelling and simulation
No full text425 million adults suffered from diabetes globally in 2017 with a predicted increase of 50 % by 2045. One good way to reduce the impact of this disease is by continuously monitoring the glucose levels of the patient using analytical devices. We are trying to research a specific case of such analytical devices i.e., enzyme immobilized redox polymer layered biosensors for continuous glucose monitoring using mathematical models. We have applied a transient numerical scheme using the commercial software MATLAB to solve the mathematical model. Mathematical verification of the system has been carried out by comparing our numerical results to steady state analytical solutions. We are trying to understand the transient regimes before the system reaches steady state. A novel validation procedure has been devised using the deflavinated enzyme to change the kinetic parameters in the physical system. The response will be compared with the simulated results.We also present an optimization of the physical system by using engineering constraints. This work has the potential to better explain the working of analytical devices and improve their working. <br/
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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