53 research outputs found
Therapeutic Potential of Amyloid‐β Interactors in Rapidly Progressive Alzheimer's Disease—An In Silico Study
No full textRapidly progressive Alzheimer's disease (rpAD) is a rare but severe form of Alzheimer's disease characterized by accelerated cognitive decline and limited therapeutic options. Conventional anti–amyloid‐β interventions have shown little success due to poor target specificity, neurotoxicity, and lack of efficacy, underscoring the need for novel therapeutic strategies. This study aimed to identify and prioritize molecular targets associated with rpAD by investigating the protein interactome of amyloid‐β (Aβ 42 ) using integrative computational approaches. Functional enrichment, protein–protein interaction network analysis, and community clustering revealed that rpAD‐specific Aβ 42 interactors were predominantly involved in mitochondrial bioenergetics, redox regulation, and cytoskeletal stability, pathways central to neuronal survival and synaptic function. Molecular docking identified fumarate hydratase, carbonyl reductase 1, and the F‐actin capping protein as high‐affinity interactors of Aβ 42 , linking these proteins to energy failure, oxidative stress, and synaptic dysfunction. Virtual screening of a therapeutic drug library against fumarate hydratase identified several compounds with strong binding affinities, among which quinestrol, estradiol benzoate, norethindrone, tamibarotene, drospirenone, and ketanserin emerged as lead candidates. Pharmacokinetic profiling, including ADMET modeling, confirmed their blood–brain barrier permeability and drug‐likeness, supporting their potential as central nervous system active agents. Together, this work highlights key molecular targets in rpAD and proposes repurposed, pharmacologically diverse compounds with multitarget neuroprotective potential. By utilizing in silico analysis, the study provides a rational framework for target discovery and drug prioritization in rpAD, offering a foundation for future experimental validation and the development of translational research
Prevention of Chronic Diabetic Neuropathy and Diabetes-Associated Cognitive Impairment Using Medicinal Herbs (Cassia Angustifolia and Nigella Sativa)
No full textTherapeutic Potential of Nitrogen-Doped Rutin-Bound Glucose Carbon Dots for Alzheimer’s Disease
No full textCareer Fair\u2724 Panel Discussion: Respect for Human, Significance of Diversity and Insclusion at Work place
No full textconversation on Diversity and Inclusion in the workplace.
From embracing differences to fostering belonging, our panelists shared invaluable insights on how organizations promote inclusion and gender diversity.
Moderator: Mr. Rehan Naeem(head of culture enablement)
Panelists: Mr. Emran Assad Khan(head- of branch banking operations), Ms. Aneeqa Kayani(head of premier proposition), and Ms. Taniya Zaffar Khan
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Exploring the Concept of Feminism among Young Urban women
No full textAurat March is held every year to highlight the issues of women. The present research was conducted to see how much women know about feminism along with Aurat March. A quantitative method with survey design was used for the present research and a semi-structured questionnaire was developed to collect data from 350 young women of Lahore, Pakistan and15 to 24 years age range was selected. Standpoint theory by Dorothy E. Smith was taken as a theoretical framework to study the results. This research mainly covered the concept of feminism, its growth over time, how ‘Aurat March’ had played its role in the development of feminism, and how it was contributing to shaping the identity of young women. Content analysis was used for open-ended questions and one-way ANOVA along with descriptive statistics was used for closed-ended ones. Results showed that education plays no role in the increment of knowledge and in its quality. This study will help in filling the gaps in Pakistani literature and be base of future studies
STUDY TO EVALUATE ANXIETY AND DEPRESSION AMONG STUDENTS OF A MEDICAL COLLEGE IN LAHORE, PAKISTAN
Get PDFObjective : To evaluate predominance of uneasiness and dejection among restorative understudies in a Services Institute Of Medical Sciences lahore Techniques : A cross-sectional investigation was done on premedical, first, second and third year understudies of Services Institute of Medical Sciences Lahore, The instrument used to survey the tension and despondency was Self managed poll, The Aga Khan University Anxiety and Depression Scale (AKUADS). AKUADS is a screening instrument, and at a cut off purpose of 19, it has a Specificity of 81%, Sensitivity of 74%, a Positive Predictive Value of 63% and Negative Predictive Value of 88%. Information examination was done on Epi Info form 6.
Results : At the season of the investigation there were a sum of 288 male understudies and 105 female understudies tried out the school. The general reaction rate among the guys and females were 68.7% and 99.0% individually. In general the pervasiveness of nervousness and discouragement in females were 66.6% and guys 44.4% (p-esteem 0.01). In the first year the commonness in females were 89.7% and guys 60% (P-Value = 0.006). No self-destructive ideation was accounted for by either guys or females.
End : Almost comparative dimension of nervousness and dejection was found in another investigation utilizing a similar instrument in a comparative educational modules model therapeutic school in Pakistan. Our discoveries are likewise predictable with the discoveries from different investigations from western therapeutic schools just as other Asian and African medicinal schools utilizing distinctive screening devices
ANALYSIS OF KNOWLEDGE AND AWARENESS OF HEPATITIS B VIRUS INFECTION AMONG PREGNANT WOMEN OF PAKISTAN
No full textIntroduction: Hepatitis B virus (HBV) infection remains a serious global public health problem. Globally, there are an estimated 240 million people chronically infected with HBV, with more than 686,000 deaths annually due to complications of hepatitis B, including cirrhosis and hepatocellular carcinoma. Objectives of the study: The main objective of the study is to find the Knowledge and awareness of Hepatitis B virus infection among pregnant women of Pakistan. Material and methods: This study was conducted at Bahawal Victoria hospital, Bahawalpur during Dec 2017 to May 2018. The group of participants comprised both genders and inclusion criteria required participants to be 18 years of age and provide signed, informed consent. A sample size of 100 individuals for each location was targeted. Results: Independent factors associated with insufficient reduced HBV knowledge include women outside the healthcare sector, lower education level, and no previous HBV testing. The majority of respondents could provide correct responses about the common aspects of HBV infection, including screening, blood-borne and perinatal transmissions, prevention by vaccination, and sequelae of HBV infection. Conclusion: It is concluded that pregnant women of Pakistan had insufficient knowledge regarding HBV infection
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