28 research outputs found
Cervical Health Parameters in Car Drivers: Assessing the Influence of Driving on Neck Pain, Mobility, Proprioception and Craniovertebral Angle – A Cross-Sectional Study
Full text linkAdel Alshahrani,1 Hussain Saleh H Ghulam,1 Raee S Alqhtani,1 Yousef Hamad Hassan Al Sharyah,1 Hashim Ahmed,1 Aafreen Aafreen,2 Abdur Raheem Khan,2 Ashfaque Khan,2 Ausaf Ahmad3 1Department of Medical Rehabilitation Sciences-Physiotherapy Program, College of Applied Medical Sciences, Najran University, Najran, 55461, Saudi Arabia; 2Department of Physiotherapy, Integral University, Lucknow, India; 3Department of Community Medicine, IIMSR, Integral University, Lucknow, IndiaCorrespondence: Abdur Raheem Khan, Department of Physiotherapy, Integral University, Lucknow, India, Tel +9616739965, Email [email protected]: Prolonged sitting during driving is linked to neck pain, uncomfortable body positions, and repetitive motions. Recognizing these challenges, this study aimed to investigate Cervical Health Parameters in Car Drivers.Methods: The sample consisted of 160 car drivers between 25 and 45 years. This subject was then divided into two groups based on neck pain. Participants met the required criteria, such as being between 25– 45 years of age, maintaining a BMI of 18– 24, and driving for at least 2 hours each day for at least 3– 5 years. To evaluate the results, we employed a clinometer and compass app on a smartphone to measure the Cervical Range of Motion (CROM). We used Surgimap software to estimate the Craniovertebral Angle (CVA), and a (Cervical range of motion) CROM device was used for proprioception assessment.Results: The result shows the participants in neck pain group displayed lower Cervical Range of Motion (CROM) values than without neck Pain Group. Similarly, the Craniovertebral Angle (CVA) was smaller in the neck Pain Group (mean difference of − 6.3°), indicating a more forward head posture. Neck pain resulted in a mean difference of − 4.5° in proprioception accuracy. This indicates that neck pain affects CROM, CVA, and proprioception in car drivers.Conclusion: Car driving significantly impacts cervical parameters in individuals with neck pain, reducing cervical range of motion, altered craniovertebral angle, and diminished proprioceptive accuracy. These findings emphasize the need for ergonomic interventions and proprioceptive training tailored for drivers. Future research should broaden demographic parameters and consider potential confounders to provide a holistic understanding of the relationship between car driving and neck health.Keywords: car driving, cervical range of motion, craniovertebral angle, proprioception, neck pai
Neck Health Metrics and Quality of Life: A Comparative Study in Bike Drivers with and without Neck Pain
No full textAafreen Aafreen,1 Abdur Raheem Khan,1 Ashfaque Khan,1 Ausaf Ahmad,2 Abdullah Hussain Alzahrani,3 Abdullah Ibrahim Alhusayni,3 Abdulaziz H Alameer,4 Ramzi Abdu Alajam,4 Bhuvanesh Babu Mondey Ganesan,4 Mohammad Abu Shaphe4 1Department of Physiotherapy, Integral University, Lucknow, India; 2Department of Community Medicine, Integral University, Lucknow, India; 3Department of Health Rehabilitation Sciences, College of Applied Medical Sciences, Shaqra University, Shaqra, Saudi Arabia; 4Department of Physical Therapy, College of Applied Medical Sciences, Jazan University, Jazan, Saudi ArabiaCorrespondence: Abdur Raheem Khan, Department of Physiotherapy, Integral University, Lucknow, India, Tel +9616739965, Email [email protected]: Neck pain is a prevalent musculoskeletal issue among bike drivers, often resulting from extended static postures, repetitive head movements, and exposure to vibrations. This study aims to assess the connection between cervical ROM, neck proprioception, CVA, and QOL in bike drivers with neck pain compared to those without neck pain so that the targeted interventions can be developed to enhance their well-being.Methods: A cross-sectional study involving 100 bike drivers aged 20– 50 years was conducted, split into two groups: those with neck pain (n=50) and those without neck pain (n=50). Cervical ROM was measured using a smartphone, neck proprioception was assessed through a head repositioning test, and CVA was determined using lateral-view photographs with a plumb line. The Short Form-36 (SF-36) questionnaire was employed to evaluate QOL. Data analysis was conducted using independent t-tests and Pearson’s correlation coefficient.Results: Bike drivers with neck pain exhibited significantly reduced cervical ROM (p-value=< 0.001), impaired neck proprioception (p-value=< 0.001), and decreased CVA (p-value=< 0.001) compared to their counterparts without neck pain. A strong negative correlation was found between neck pain and QOL, with lower scores in all eight domains of the SF-36. Cervical ROM, neck proprioception, and CVA showed moderate correlations with various QOL domains (p-value=< 0.05).Conclusion: Neck pain in bike drivers is linked to decrease cervical ROM, compromised neck proprioception, and reduced CVA. These factors correlate with a lower quality of life, both physical and mental domains. Interventions addressing these aspects may enhance the quality of life for bike drivers experiencing neck pain.Keywords: cervical range of motion, neck proprioception, craniovertebral angle, quality of life, neck pain, bike driver
To Study and Compare Postural Sway by Romberg Test in Diabetic and Non-Diabetic Subjects
No full textBackground: Diabetes is a silent disorder leading to disabling and fatal complications. The long-term complications of diabetes affect almost every system in the body. Balance impairment and postural instability is also observed in people having chronic diabetes which is a result of diabetic peripheral neuropathy, diabetic retinopathy, and vestibular dysfunctions.
Objective: The objective of this study is to find out the effect of chronic diabetes on postural sway by Romberg’s test and thereby finding effects of diabetes on balance and stability.
Method: 60 participants both male and female between 40 to 60 years of age were included. The participants were divided into diabetic and non-diabetic group (n=30). All the participants performed Romberg’s test. Their postural sway was observed and subsequently Romberg’s sign was noted. The procedure is repeated again two more times to find out average Romberg’s sign.
Results: The data shows a significant difference in postural sway between diabetic and non-diabetic subjects. The chi-square value computed for this comparison was 5.406, yielding a p-value of 0.020. The p-value was below the conventional significance threshold of 0.05, indicating a statistically significant association between diabetes status and the presence of postural sway. Diabetic individuals were significantly more likely to exhibit signs of impaired balance compared to non-diabetic individuals, as evidenced by the highly significant chi-square test result. This finding highlights the impact of diabetes on balance and stability.
Conclusion: The study demonstrated that postural sway and instability was more common in diabetic subjects as compare to non-diabetic subjects between 40 to 60 years of age. Additionally, this study suggested that patients having diabetes should take measures to prevent postural instability, balance impairments and other complications of diabetes
Broad band low noise amplifier for wireless application using double order gain flatting technique
No full textTo Study and Compare Postural Sway by Romberg Test in Diabetic and Non-Diabetic Subjects
No full textBackground: Diabetes is a silent disorder leading to disabling and fatal complications. The long-term complications of diabetes affect almost every system in the body. Balance impairment and postural instability is also observed in people having chronic diabetes which is a result of diabetic peripheral neuropathy, diabetic retinopathy, and vestibular dysfunctions.
Objective: The objective of this study is to find out the effect of chronic diabetes on postural sway by Romberg’s test and thereby finding effects of diabetes on balance and stability.
Method: 60 participants both male and female between 40 to 60 years of age were included. The participants were divided into diabetic and non-diabetic group (n=30). All the participants performed Romberg’s test. Their postural sway was observed and subsequently Romberg’s sign was noted. The procedure is repeated again two more times to find out average Romberg’s sign.
Results: The data shows a significant difference in postural sway between diabetic and non-diabetic subjects. The chi-square value computed for this comparison was 5.406, yielding a p-value of 0.020. The p-value was below the conventional significance threshold of 0.05, indicating a statistically significant association between diabetes status and the presence of postural sway. Diabetic individuals were significantly more likely to exhibit signs of impaired balance compared to non-diabetic individuals, as evidenced by the highly significant chi-square test result. This finding highlights the impact of diabetes on balance and stability.
Conclusion: The study demonstrated that postural sway and instability was more common in diabetic subjects as compare to non-diabetic subjects between 40 to 60 years of age. Additionally, this study suggested that patients having diabetes should take measures to prevent postural instability, balance impairments and other complications of diabetes
Leukemic stem cell signatures in Acute myeloid leukemia- targeting the Guardians with novel approaches
No full textAcute myeloid leukemia is an aggressive hematopoietic stem cell malignancy with poor outcomes despite the available treatment options including standard chemotherapy, selective targeted therapy and stem cell transplantation. Approximately ∼30-40% of AML patients are refractory to initial therapy or succumb to relapse. Induction failure result from inherent resistance to chemotherapy, which is primarily driven by the chemo-resistant residual leukemic stem cells (LSC) that lead to disease progression and recurrence. The rarity and lack of universal surface markers for the identification and isolation of AML LSC renders a major challenge. Therefore, a perpetual quest for novel markers to characterize LSC and design anti-LSC therapies is ongoing. The evolving technologies from high-throughput bulk cell sequencing to high-dimensional single cell analysis has begun to decode the cellular hierarchies and dysregulated transcriptional networks in AML. These inherent properties of LSC as well as cross-talk with the extrinsic bone marrow microenvironmental milieu induce a conducive environment for leukemogenesis by secretion of various cytokines, chemokines and growth factors that shield LSC against conventional chemotherapy. To overcome these barriers, novel approaches of intratumoural delivery that focus on immune-mediated eradication by inducing microenvironmental changes within the tumour as well as avoid systemic toxicity seem encouraging. Selective targeting of LSC and their protective bone marrow niche holds immense potential as a promising therapeutic strategy for AML. Novel multimodal anti-LSC therapies are being explored that can overcome chemo-resistance and immune escape combined with reduced toxicity and sustained delivery may improve remission and survival rates in AML patients and decrease relapse
Are Thalamocortical Circuits Implicated in Focal Epilepsy? A Rare Case of Focal Non-Convulsive Status Epilepticus in A Comatose Patient With Unilateral Thalamic Infarct And No Ipsilateral Cortical Deficit
No full textAutophagy in acute myeloid leukemia: A paradoxical role in chemoresistance
No full textAutophagy is a lysosomal degradation pathway that is constitutively active in almost every cell of our body at basal level. This self-eating process primarily serves to remove superfluous constituents of the cells and recycle the degraded products. Autophagy plays an essential role in cell homeostasis and can be enhanced in response to stressful conditions. Impairment in the regulation of the autophagic pathway is implicated in pathological conditions such as neurodegeneration, cardiac disorders, and cancer. However, the role of autophagy in cancer initiation and development is controversial and context-dependent. Evidence from various studies has shown that autophagy serves dual purpose and may assist in cancer progression or suppression. In the early stages of cancer initiation, autophagy acts as a quality control mechanism and prevents cancer development. When cancer is established and progresses to a later stage, autophagy helps in the survival of these cells through adaptation to stresses, including exposure to anti-cancer drugs. In this review, we highlight various studies on autophagic pathways and describe the role of autophagy in cancer, specifically acute myeloid leukemia (AML). We also discuss the prognostic significance of autophagy genes involved in AML leukemogenesis and implications in conferring resistance to chemotherapy
Disability evaluation in patients with Guillain-Barre syndrome and SARS-CoV-2 infection
No full textObjective: Several cases of Guillain-Barre syndrome (GBS) associated with SARS-CoV-2 infection have been described. This study illustrated the demographic, clinical, and neurophysiological characteristics of patients with GBS and COVID-19, as well as associated factors with disability at discharge. Materials and methods: A retrospective analytical observational study was conducted. It included patients diagnosed with GBS admitted in a national reference center in Peru between 2019 and 2021. Epidemiological, clinical, neurophysiological, and cerebrospinal fluid data were analyzed. A multivariate analysis, using the generalized linear model, was performed, considering the presence of disability at discharge as the dependent variable. Results: Eight-one subjects diagnosed with GBS were included. The mean age was 46.8 years (SD: 15.2), with a predominance of males (61.73%). The most frequent clinical presentation was the classic sensory-motor form in 74 cases (91.36%) with AIDP (82.35%) as the most frequent neurophysiological pattern in the group with COVID-19, while AMAN pattern predominated (59.26%) in those without COVID-19 (p = <0.000). The disability prevalence ratio at discharge between subjects with COVID-19 and those without COVID-19 was 1.89 (CI 1.06–3.34), p = 0.030, adjusted for age, sex, and neurophysiological subtype. Conclusion: The neurophysiologic subtype AIDP, and a higher disability were associated with the presence of COVID-19.The authors thank Aafreen Khan for English language support
