424 research outputs found
Phra Maha Katsapa ro phop Phra Si-an na Kakutthabatkhiri
No full textThe author illustrates the legend of Phra Maha Katsapa -- one of Lord Buddha's important disciples-- and his retreat in the Mount Kakutthabat. Phra Maha Katsapa was believed to wait in a cave on that mountain until the time Phra Si-an would reincarnate and achieve nirvana. The author also refers to recent attempt of a British Buddhist monk in finding the location of the mountain in India
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in human lung microvascular endothelial cells controls oxidative stress, reactive oxygen-mediated cell signaling and inflammatory responses
No full textBackground: Perturbation of endothelial function in people with cystic fibrosis (CF) has been reported, which may be associated with endothelial cell expression of the cystic fibrosis transmembrane conductance regulator (CFTR). Previous reports indicate that CFTR activity upregulates endothelial barrier function, endothelial nitric oxide synthase (eNOS) expression and NO release, while limiting interleukin-8 (IL-8) release, in human umbilical vein endothelial cells (HUVECs) in cell culture. In view of reported microvascular dysfunction in people with CF we investigated the role of CFTR expression and activity in the regulation of oxidative stress, cell signaling and inflammation in human lung microvascular endothelial cells (HLMVECs) in cell culture.Methods: HLMVECs were cultured in the absence and presence of the CFTR inhibitor GlyH-101 and CFTR siRNA. CFTR expression was analyzed using qRT-PCR, immunocytochemistry (IHC) and western blot, and function by membrane potential assay. IL-8 expression was analyzed using qRT-PCR and ELISA. Nrf2 expression, and NF-κB and AP-1 activation were determined using IHC and western blot. The role of the epidermal growth factor receptor (EGFR) in CFTR signaling was investigated using the EGFR tyrosine kinase inhibitor AG1478. Oxidative stress was measured as intracellular ROS and hydrogen peroxide (H2O2) concentration. VEGF and SOD-2 were measured in culture supernatants by ELISA.Results: HLMVECs express low levels of CFTR that increase following inhibition of CFTR activity. Inhibition of CFTR, significantly increased intracellular ROS and H2O2 levels over 30 min and significantly decreased Nrf2 expression by 70% while increasing SOD-2 expression over 24 h. CFTR siRNA significantly increased constitutive expression of IL-8 by HLMVECs. CFTR inhibition activated the AP-1 pathway and increased IL-8 expression, without effect on NF-κB activity. Conversely, TNF-α activated the NF-κB pathway and increased IL-8 expression. The effects of TNF-α and GlyH-101 on IL-8 expression were additive and inhibited by AG1478. Inhibition of both CFTR and EGFR in HLMVECs significantly increased VEGF expression. The antioxidant N-acetyl cysteine significantly reduced ROS production and the increase in IL-8 and VEGF expression following CFTR inhibition.Conclusion: Functional endothelial CFTR limits oxidative stress and contributes to the normal anti-inflammatory state of HLMVECs. Therapeutic strategies to restore endothelial CFTR function in CF are warranted.<br/
CFTR limits F-actin formation and promotes morphological alignment with flow in human lung microvascular endothelial cells
No full textMicro- and macrovascular endothelial dysfunction in response to shear stress has been observed in cystic fibrosis (CF), and has been associated with inflammation and oxidative stress. We tested the hypothesis that the cystic fibrosis transmembrane conductance regulator (CFTR) regulates endothelial actin cytoskeleton dynamics and cellular alignment in response to flow. Human lung microvascular endothelial cells (HLMVEC) were cultured with either the CFTR inhibitor GlyH-101 (20 µM) or CFTRinh-172 (20 µM), tumor necrosis factor (TNF)-α (10 ng/ml) or a vehicle control (0.1% dimethyl sulfoxide) during 24 and 48 h of exposure to shear stress (11.1 dynes/cm2) or under static control conditions. Cellular morphology and filamentous actin (F-actin) were assessed using immunocytochemistry. [Nitrite] and endothelin-1 ([ET-1]) were determined in cell culture supernatant by ozone-based chemiluminescence and ELISA, respectively. Treatment of HLMVECs with both CFTR inhibitors prevented alignment of HLMVEC in the direction of flow after 24 and 48 h of shear stress, compared to vehicle control (both p < 0.05). Treatment with TNF-α significantly increased total F-actin after 24 h versus control (p < 0.05), an effect that was independent of shear stress. GlyH-101 significantly increased F-actin after 24 h of shear stress versus control (p < 0.05), with a significant (p < 0.05) reduction in cortical F-actin under both static and flow conditions. Shear stress decreased [ET-1] after 24 h (p < 0.05) and increased [nitrite] after 48 h (p < 0.05), but neither [nitrite] nor [ET-1] was affected by GlyH-101 (p > 0.05). CFTR appears to limit cytosolic actin polymerization, while maintaining a cortical rim actin distribution that is important for maintaining barrier integrity and promoting alignment with flow, without effects on endothelial nitrite or ET-1 production
al-Rawiyat de Maha Hasan: métamorphose et réincarnation comme dernière tentative pour préserver la vie
No full textAl-Rawiyat (The Storytellers) is a metafictional novel written by Syrian author Maha Hasan in 2014. The text contains two intertwined levels: the first is the inner monologue of a woman who is writing a novel; the second is represented by the stories of the characters she creates and that become themselves storytellers. In this text Maha Hasan explores the art of storytelling through multiple stories and many female characters. Ḥasan’s storytellers often live in parallel and imaginary worlds, in a permanent state of metamorphosis and perpetual reincarnation. The stories they live and narrate represent their last attempt to preserve life in an inhuman time that changes at a spasmodic rhythm and generates simultaneous events with contradictory effects. This novel translates into fiction the rapid changes of the present period, which—as affirmed by Rosi Braidotti in her Metamorphoses—does not truncate the brutality of power relations, but at deeper view, intensifies them to their point of implosion
PERGOLAKAN IDEOLOGI DALAM NOVEL TERJEMAHAN YANG MAHA KECIL KARYA ARUNDHATI ROY: KAJIAN HEGEMONI GRAMSCI (Ideological Upheavel in Arundhati Roy’s Translated Novel Yang Maha Kecil: The Study of Gramsci’s Hegemony)
No full textPenelitian ini bertujuan untuk mengungkap dan mendeskripsikan formasi ideologi dalam novel terjemahan Yang Maha Kecil karya Arundhati Roy,serta melihat hubungannya dengan ideologi pengarang dengan menggunakan kajian teori hegemoni yang digagas Antonio Gramsci. Tinjauan teori hegemoni Gramsci dalam penelitian ini melihat praktik hegemoni ideologi dalam Yang Maha Kecil melalui negosiasi ideologi yang dilakukan pengarang sebagai aparatur hegemoni. Metode yang digunakan adalah metode kualitatif melalui pendekatan deskriptif dan pemahaman arti secara mendalam. Penelitian ini menghasilkan temuan berupa teridentifikasinya sejumlah ideologi, yaitu ideologi (1) ultraortodoks (2) komunis, (3) anglofilia, (4) rasialisme, dan (5) patriarki. Adapun ideologi yang dinegosiasi ditunjukkan oleh ideologi komunisme dan ultraortodoks. Simpulan dari penelitian ini adalah adanya pertentangan dalam cara pandang pengarang tentang ideologi komunis dan ultraortodoks yang dinegosiasikan. Dalam hal ini, pengarang melihat bahwa ideologi komunis maupun ideologi ultraortodoks (agama) yang mengajarkan kesetaraan manusia secara sosial maupun di mata Tuhan, ternyata sama sekali tidak mengubah sistem pembedaan manusia.(This research aims to disclose and describe the formation of ideology in translated novel Yang Maha Kecil written by Arundhati Roy, as well as to recognize its relationship with the author’s ideology using Antonio Gramsci’s theory of hegemony. Gramsci’s hegemony theory is used in this research to observe the practice of ideological hegemony in Yang Maha Kecil through ideological negotiations practiced by the author as a hegemony apparatus. The method used is the qualitative one using the descriptive approach and extensive comprehension of meaning. This research produced findings in the form of identifying a number of ideologies, namely ideology (1) ultra-orthodox, (2) communism, (3) anglophilia, (4) racism, and (5) patriarchy. The negotiated ideology is demonstrated by communism and ultra-orthodox ideology. The conclusion of this research is that there is conflict in the author's perspective on communism and ultra-orthodox ideologies that are negotiated. In this case, the author sees that both communism and the ultra-orthodox (religion), which promote human equality both socially and religiously, apparently fail to change the system of human discrimination.
Receptor-targeted nanocarriers for tumor specific treatment and imaging
No full textLung cancer is the leading cause of cancer death in the United States. The efficacy of chemotherapy in lung cancer is limited by the development of cancer cell resistance during the treatment, difficulties in the delivery of anticancer drugs specifically to lung tumors, and severe adverse side effects of high doses chemotherapy on healthy organs. The main objectives of the present research are: (1) to provide effective delivery of therapeutic and imaging agents to lungs, (2) to mitigate the above described resistance, (3) to enhance the efficacy of lung cancer chemotherapy and limit adverse side effects of the treatment. To achieve these goals, we developed, characterized, and evaluated in vitro and in vivo on orthotopic model of lung cancer using a novel multifunctional tumor-targeted Nanocarrier-based Drug Delivery System (NDDS) composed of (1) a carrier; (2) a synthetic analog of Luteinizing Hormone-Releasing Hormone (LHRH peptide) as a targeting moiety; (3) an anticancer drug or imaging agent; (4) suppressors of drug resistance. We tested and compared: linear polymer, dendrimers and liposomes as nanocarriers; antisense oligonucleotides or small interfering RNA targeted to MRP1 and BCL2 mRNA as suppressors of pump and nonpump cellular resistance respectively; near-infrared cyanine dye Cy5.5, rhodamine, or fluorescein isothiocyanate as imaging agents.
The proposed multivalent NDDS exhibited preferential accumulation in the lungs, increased the sensitivity and specificity of tumor imaging, enhanced cancer treatment, and limited adverse side effects of the treatment on healthy organs. Targeting of nanocarriers to tumor specific receptors minimizes the influence of the architecture, composition, size, and molecular mass of nanocarriers on the efficacy of imaging and cancer treatment.
Local intratracheal administration sustained higher concentration of NDDS and its payload in the lungs and substantially limited their accumulation in other organs. Moreover, intratracheal local delivery of NDDS led to the more efficient treatment of lung cancer when compared with the intravenous administration of NDDS or free drugs. Simultaneous suppression of pump and nonpump resistance dramatically enhanced the cytotoxicity of the anticancer drug leading to a substantial increase in apoptosis induction.Ph.D.Includes bibliographical references
Gereja Hati Yesus Yang maha Kudus - Katedral (sejarah Gereja Katolik di Sulawesi Selatan dan Tenggara)
No full textThe Hati Yesus yang Maha Kudus Church is the oldest Catholic church in Makassar. Built in 1898, the church later became the cathedral church in Makassar. In this paper, the author makes the church as the object of research using the method of archaeological descriptions. This study aims to find out how the application of building styles in gothic churches and its changes to date. Through the embodiment of the visual elements of the oldest Catholic church in Makassar, the gothic style and other artistic styles of the buildings the church shows an interesting and unique blend of architecture. The shape of windows, doors, and curved roofs is part of the Gothic style that was the influence of the Dutch colonial period. Although the style and forms of this church have a resemblance of form with the later Christian church, the Christian church of Immanuel Makassar, the Hati Yesus yang Maha Kudus Church has become part of the Roman Catholic church structure which has many historical values, both in Makassar's local history, as well as Indonesian national history.
Keywords: Church of the Most Sacred Heart of Jesus, Catholic, history, Architecture, Makassar.

Gereja Hati Yesus yang Maha Kudus merupakan gereja Katolik tertua di Makassar. Dibangun pada tahun 1898, gereja ini kemudian men-jadi gereja Katedral di Makassar. Dalam tulisan ini, penulis menjadi¬kan gereja Hati Yesus yang Maha Kudus sebagai objek penelitian dengan menggunakan metode deskripsi arkeologis. Penelitian ini bertujuan untuk mengetahui bagaimana penerapan gaya bangunan pada gereja gotik dan perubahannya hingga saat ini. Melalui perwujudan unsur-unsur visual pada gereja Katolik tertua di Makassar tersebut, gaya gotik dan gaya artistik lainnya dari bangunan memperlihatkan perpaduan arsitektur yang menarik dan unik. Bentuk jendela, pintu, dan atap melengkung adalah bagian dari corak gotik yang merupakan pengaruh dari masa kolonial Belanda. Meskipun gaya dan bentuk gereja ini memiliki kemiripan bentuk dengan gereja Kristen yang muncul kemudian, yaitu gereja Kristen Immanuel Makassar, Gereja Hati Yesus yang Maha Kudus, menjadi bagian dari struktur gereja Katolik Roma yang memiliki banyak nilai-nilai sejarah, baik sejarah lokal Makassar, bahkan sejarah nasional Indonesia umumnya. 
Kata Kunci: Gereja Hati Yesus yang Maha Kudus, Katolik, sejarah, Arsitektur, Makassar.</jats:p
Erratum: Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals
No full textThe original version of this Article contained an error in the spelling of the author Maha Al-Asmakh, which was incorrectly given as Al-Asmakh Maha. This has now been corrected in the PDF and HTML versions of the Article.Scopu
On m-Regular Rings
No full textAs a generalization of regular rings, we introduce the notion, of m-regular rings, that is for all , there is a fixed positive integer m such that is a Von-Neumann regular element. Some characterization and basic properties of these rings will be given. Also, we study the relation-ship between them and Von-Neumann regular rings, -regular rings, reduced rings, locally rings, uniform rings and 2-primal rings
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