2,946 research outputs found
The influence of host factors on hepatic fibrosis and virolologic [virologic] response in chronic hepatitis C infection
No full textThe aims of this theses were to characterize host determinants of progressive fibrosis and assess virologic responses in a large cohort of CHC patients linked to an extensive and pedigreed biorepository. Our studies indicate that HLA class 1 allelic diversity has a relatively weak influence on disease severity and fibrosis progression compared to standard host factors such as age, gender and alcohol intake. However, steatosis is an important host variable that is associated with fibrosis, and also reduces both early and sustained virologic response to therapy in genotype-1 infected patients. Myeloperoxidase gene polymorphisms also appears to be associated with fibrosis severity, thus implicating oxidative stress in this regard. Non-invasive alternatives to a needle liver biopsy to stage and follow disease progression in CHC patients would be a useful clinical tool. We have developed and validated a serodiagnostic panel of matrix proteins to differentiate mild from moderate-to-severe stages of fibrosis that could provide an alternative to liver biopsy for binary disease staging in a proportion of CHC patients. At present, there are no reliable host, or viral, predictors of relapse following an end-of-treatment viral response. Our studies indicate that hepatic HCV RNA measurement has minimal clinical utility in following virologic responses to therapy, although residual intrahepatic virus may be present in a minority of patients that relapse following an apparent sustained virologic response. Whole blood extraction methods for viral detection also do not appear to provide any clinical benefit over conventional serum based assays during therapy, or in predicting relapse after an end-of-treatment response. Our ongoing studies will plan to better define the role of host immune response in hepatic injury, and develop accurate and reliable non-invasive markers of fibrosis.</p
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The IAAF’s hyperandrogenism regulations suspended
No full textOn 27 July, the Court of Arbitration for Sport (‘CAS’) delivered a landmark ruling on the regulation of gender in sport. The decision explores how the categorisation of sport on the basis of sex can be best reconciled with the “biological reality” that human sex cannot necessarily be divided so clearly. Dr. Seema Patel, Senior Lecturer at Nottingham Trent University, Deputy Director of the Centre for Sports Law and author of ‘Inclusion and Exclusion in Competitive Sport: Socio-Legal and Regulatory Perspectives,’ reviews the case and suggests that sport regulation must be cautious of traditional criteria to determine eligibility in sports
Author interview: Q and A with Dr Ian Sanjay Patel on we’re here because you were there: immigration and the end of empire
No full textIn this author interview, we speak to Dr Ian Sanjay Patel about his new book, We’re Here Because You Were There: Immigration and the End of Empire, which explores post-war immigration laws, the afterlives of British imperial citizenship and related attempts to reimagine and rejuvenate British imperialism after 1945. Contributing to transnational histories of decolonisation, the book also explores the interconnections between human rights, post-war migration and international diplomacy. Author Interview with Dr Ian Sanjay Patel, author of We’re Here Because You Were There: Immigration and the End of Empire. Verso. 2021
Effect of carbon dioxide on the performance of Spark Ignition Engine by Hydrogen Inject with Biogas Fuel
No full textMethane and carbon dioxide are the two main constituents of biogas. One of the reasons of poor combustion is the presence of carbon dioxide in the biogas. Biogas also has traces of nitrogen, hydrogen, oxygen and hydrogen sulphide. Because of a high investment cost and a heavy infrastructure, only fifty percent of the biogas production upgrades decrease CO2 by use of water scrubber. so the natural gas replacement is very low. This experiment is conducted on modified single cylinder 97.5cc petrol engine, to work it as a biogas hydrogen fuel spark ignition engine. Hydrogen added in small amounts by HHO generator hydroxy kit to decrease concentration of CO2 in biogas power and find out the effect of CO2 on the performance. The experimental results show that the large quantity of CO2 present in biogas lowers its calorific value, flame velocity and flammability range compared with natural gas. So it can be utilized in an IC engine with the hydrogen. Keyur D. Patel "Effect of carbon dioxide on the performance of Spark Ignition Engine by Hydrogen Inject with Biogas Fuel" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-4 , June 2018, URL: https://www.ijtsrd.com/papers/ijtsrd12839.pd
sj-pdf-1-jao-10.1177_03913988231213722 – Supplemental material for Microaxial mechanical circulatory support after orthotopic heart transplantation
No full textSupplemental material, sj-pdf-1-jao-10.1177_03913988231213722 for Microaxial mechanical circulatory support after orthotopic heart transplantation by Christopher Pritting, Danial Ahmad, Keyur Patel, Takuma Miyamoto, Taufiek K Rajab, Indranee N Rajapreyar, Howard T Massey and Vakhtang Tchantchaleishvili in The International Journal of Artificial Organs</p
Graceful BGP session shutdown
No full textIn the Operations and Management area, a «graceful shutdown» mechanism for BGP peering links is being standardized in collaboration with France Telecom -Orange, Internet Initiative Japan, and Cisco Systems. The draft capturing this work («Graceful BGP session shutdown», draft-ietf-grow-bgp-gshut-03), working group document of the GROW Working Group, describes operational procedures aimed at reducing the amount of traffic lost during planned maintenances of routers or links, involving the shutdown of BGP peering sessions. It also provides recommendations to router vendors for the support of a graceful shutdown mechanism that eases operational aspects of the solution. The authors are: Pierre Francois, Bruno Decraene, Cristel Pelsser, Keyur Patel and Clarence Filsfils.This draft describes operational procedures aimed at reducing the amount of traffic lost during planned maintenances of routers or links, involving the shutdown of BGP peering sessions.Internet Engineering Task Force (IETF)pu
Embedded in the Body: the Poetry, History and Politics of Migritude with Shailja Patel (2021-02-25)
No full textOnline discussion, reading and Q&A; Thursday, February 25 at 4:00PM CST; Shailja Patel is the bestselling author of Migritude, taught in over 100 colleges and universities worldwide. Patel's poems have been translated into 17 languages, and been featured in the Smithsonian. The Nobel Women's Initiative honored her with a Global Feminist Spotlight. She is currently a Research Associate at Five College Women's Studies Research Center.Women, Gender & Sexuality Studies program; Alworth Institute for International Studies; Department of Anthropology, Sociology & Criminology; English program; Writing Studies programPatel, Shailja. (2021). Embedded in the Body: the Poetry, History and Politics of Migritude with Shailja Patel (2021-02-25). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/220654
The Patel trials: further evidence of the need to reform the Griffith Codes
No full textThis article argues that the two trials of Dr Jayant Patel for criminal medical negligence under s 288 of the Criminal Code 1899 Act (Qld) highlight the inadequacies of the duty provisions in the Griffith Codes of Queensland and Western Australia. The difficulties with these duty provisions extend beyond causation and go to the heart of the construction of the Griffith Codes. The fundamental problem lies in the wording of s 23 of both the Queensland and
the Western Australia Codes, the principal section dealing with criminal responsibility, which allows a prosecution for criminal negligence under two alternative routes with different standards of proof, and the importation of
common law criminal negligence into the duty provisions in the absence of a specified fault element in the relevant Code sections. It is further contended that other criminal law jurisdictions in Australia, such as the Criminal Code
1995 (Cth), offer a better model for the prosecution of criminal negligence cases that flow from breach of a specified duty. The article has greatly benefited from comments provided to the author by Justice HG Fryberg, who
conducted the second Patel trial
sj-xlsx-2-pdp-10.1177_10935266241230600 – Supplemental material for Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge
No full textSupplemental material, sj-xlsx-2-pdp-10.1177_10935266241230600 for Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge by Fouad El Dana, Sofia Alexandra Garces Narvaez, Nader K. El-Mallawany, Jennifer E. Agrusa, ZoAnn E. Dreyer, Andrea N. Marcogliese, Mohamed Tarek Elghetany, Jyotinder N. Punia, Chi Young Ok, Keyur P. Patel, Dolores H. Lopez-Terrada, Kevin E. Fisher and Choladda V. Curry in Pediatric and Developmental Pathology</p
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