262 research outputs found
The Neighbourhood of Infinity
No full textFanzine dedicated to the work of Mark E Smith and The Fall. Collaboration between myself and artists, Inge Marleen and David Powell. Sole author of text:
“And then I heard a voice say, ‘Hey, you’re lost in music.’
If #MeToo Came True: Author Marleen Barr and K-B Have a Chat
No full textThis is an interview with Marleen S. Barr which refers to her short fiction collection When Trump Changed: The Feminist Science Fiction Justice league Quashes the Orange Outrage Pussy Grabber
Marleen and Vickie Webb
No full textThis 1964 photograph shows Marleen and Vickie Webb, also known as the Waynesville Cousins singing. Founder and director of the Mountain Youth Jamboree, Hubert H. Hayes (1901-1964) auditioned and directed youth to perform in folk dance, music, and folk and ballad singing. The jamboree was held in the Asheville City Auditorium (now known as Thomas Wolfe Auditorium) from 1948 to 1973, and Hayes’ wife, Leona Trantham Hayes (1913-1989) continued to direct the program after his death in 1964. Hubert Hayes was an author, playwright, and alumni of Duke University
Feminist Sci-Fi Author Pens Fantasy Short Story Collection About Trump Post-Impeachment, In A Galaxy Far Far Away
No full textThis blog post contains a short story published in Marleen S. Barr\u27s WHEN TRUMP CHANGED: THE FEMINIST SCIENCE FICTION JUSTICE LEAGUE QUASHES THE ORANGE OUTRAGE PUSSY GRABBER
Dr. Barr Reporting for Duty!
No full textSpecial guest Dr. Marleen S. Barr joins the labsters and talks about her new book "The Feminist Science Fiction Justice League Quashes the Orange Outrage Pussy Grabber: Political Power Fantasy Fiction". Dr Barr is known for her pioneering work in feminist science fiction and teaches English at the City University of New York. She has won the Science Fiction Research Association Pilgrim Award for lifetime achievement in science fiction criticism. Barr is the author of Alien to Femininity: Speculative Fiction and Feminist Theory, Lost in Space: Probing Feminist Science Fiction and Beyond, Feminist Fabulation: Space/Postmodern Fiction, and Genre Fission: A New Discourse Practice for Cultural Studies. Barr has also edited many anthologies and co-edited the science fiction issue of PMLA. She is the author of the novels Oy Pioneer! and Feminist Planets: A Fake Memoir
Writing Artists’ Lives Across Nations and Cultures: Biography, Biofiction and Transnationality
No full textAs an introduction to the volume, this chapter explores recent developments relating to the study and practice of biography across nations and cultures, discussing key issues in the humanities that have significant implications for writing the lives of writers, musicians and visual artists. These include the resurgence in scholarly interest in artists’ biographies; the rise of biofiction and the ways in which this mode of writing is distinguished from biography; the death and return of the Author; and the prominence that transnationality has assumed in studies of life writing, challenging the traditional framework of the nation-state. It also outlines the aims and scope of the volume, and concludes with a one-paragraph summary of each of its chapters in turn
Corrigendum: Microbiota dynamics, metabolic and immune interactions in the cervicovaginal environment and their role in spontaneous preterm birth
No full textIn the published article, there was an error in the author list, and the consortium the PRECISE Network was not credited with authorship. The corrected author list appears below. Stanley Onyango1,2*, Jia Dai Mi3, Angela Koech2, Patricia Okiro1, Marleen Temmerman2, Peter von Dadelszen3, Rachel M Tribe3†, Geoffrey Omuse1†, and the PRECISE Network The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.</p
Screening accuracy of the parent-completed Ages and Stages Questionnaires – second edition as a broadband screener for motor problems in preschoolers with autism spectrum disorders
No full textChildren with autism spectrum disorders (ASD) are at risk for motor problems. However, this area is often overlooked in the developmental evaluation in autism diagnostic clinics. An alternative can be to identify children who should receive intensive motor assessment by using a parent-based screener. The aim of the present study was to examine whether the Ages and Stages Questionnaires (ASQ-2) may be used to identify gross and fine motor problems in children. High-functioning children with ASD (n=43, 22-54 m) participated in this study. Sensitivity (SE), specificity (SP), predictive values, areas under the ROC curve were calculated by comparing the ASQ-2 scores to the developmental evaluation of the Peabody Developmental Motor Scale (PDMS-2). Results revealed that both the ASQ-2 gross and fine motor domain may be used to identify children without motor problems. In contrast, sensitivity analyses revealed the likelihood of under screening motor problems in this population. The ASQ-2 met only the criteria of a fair to good accuracy to identify poor gross motor (SE 100%) and below average fine motor development (SE 71%) in this sample. Hence, the capacity of the ASQ-2 to identify motor problems in preschoolers with ASD appears to be limited. It is recommended to include a formal standardized motor test in the diagnostic procedure for all children with ASD.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by a foundation Marguerite-Marie Delacroix grant (Tienen, Belgium) to M. Vanvuchelen
Joodse gemeenschappen in Noordoost-Italie: op zoek naar sporen van het Jiddisch
No full textThe Dutch language has inherited several words and expressions from the Yiddish language spoken by Ashkenazic Jews who settled in the Low Countries in the early seventeenth century. Amsterdam especially had a major Ashkenazic community, which in the nineteenth century encompassed up to thirteen percent of the city’s population. At that time, however, segments of the Ashkenazic population ceased using Yiddish as their dominant vernacular, giving rise to a Jewish ethnolect of Dutch. Yiddish and Jewish Dutch have left an important legacy to the Dutch language, especially in its informal registers. The question addressed by the present study is: did the Yiddish language leave any traces in Italy as well? After sketching the rise and development of Yiddish, the author describes the historical context of the Jewish presence in Italy. Yiddophone Ashkenazic populations settled only in Northern Italy, particularly in the North-East. In the rest of Italy, Yiddish was a completely unknown language. The northern Jewish-Italian dialects, which died out at the end of the nineteenth century, have retained some sporadic traces of their former Yiddish-speaking communities. More importantly, the Jewish dialects in Northern Italy included aspects of language use which are clear reminders of the attitude of Yiddish speakers worldwide towards their language
Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers
No full textBlockade of the inhibitory PD-1/PD-L1 immune checkpoint axis is a promising cancer treatment. Nonetheless, a significant number of patients and malignancies do not respond to this therapy. To develop a screen for response to PD-1/PD-L1 inhibition, it is critical to develop a non-invasive tool to accurately assess dynamic immune checkpoint expression. Here we evaluated non-invasive SPECT/CT imaging of PD-L1 expression, in murine tumor models with varying PD-L1 expression, using high affinity PD-L1-specific nanobodies (Nbs). We generated and characterized 37 Nbs recognizing mouse PD-L1. Among those, four Nbs C3, C7, E2 and E4 were selected and evaluated for preclinical imaging of PD-L1 in syngeneic mice. We performed SPECT/CT imaging in wild type versus PD-L1 knock-out mice, using Technetium-99m (99mTc) labeled Nbs. Nb C3 and E2 showed specific antigen binding and beneficial biodistribution. Through the use of CRISPR/Cas9 PD-L1 knock-out TC-1 lung epithelial cell lines, we demonstrate that SPECT/CT imaging using Nb C3 and E2 identifies PD-L1 expressing tumors, but not PD-L1 non-expressing tumors, thereby confirming the diagnostic potential of the selected Nbs. In conclusion, these data show that Nbs C3 and E2 can be used to non-invasively image PD-L1 levels in the tumor, with the strength of the signal correlating with PD-L1 levels. These findings warrant further research into the use of Nbs as a tool to image inhibitory signals in the tumor environment.sponsorship: This research was performed with the financial support of the Agency of Innovation by Science and Technology (IWT-SBO) and "Kom op tegen Kanker". Broos K. and Renmans D. are funded via an IWT-SB fellowship. Lecocq Q. is funded via an 'Emmanuel van der Schueren' fellowship. Keyaerts M. is a senior clinical investigator of the Research Foundation-Flanders. Escors D. is funded by a "Miguel Servet" Fellowship (CP12/03114) from the Instituto de Salud Carlos III (ISCIII), Spain. Part of the work was funded by the ISCIII (FIS. PI14/00579 project grant) and the Government of Navarre (BMED 033-2014). (Agency of Innovation by Science and Technology (IWT-SBO), Kom op tegen Kanker, IWT-SB fellowship, 'Emmanuel van der Schueren' fellowship, Instituto de Salud Carlos III (ISCIII), Spain|CP12/03114, ISCIII|FIS. PI14/00579, Government of Navarre|BMED 033-2014)status: Publishe
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