21 research outputs found
Charles Simeon Series: Carolyn Custis James
No full textCarolyn Custis James speaks on how we were created in the image of God for the Charles Simeon Series.
Carolyn Custis James (BA in Sociology, MA in Biblical Studies) is an award-winning author who thinks deeply about what it means to be a female follower of Jesus in a postmodern world. As a cancer survivor, she is grateful to be alive and determined to address the issues that matter most. Her speaking and writing ministry is dedicated to addressing the deeper needs which confront both women and men as they endeavor to extend God\u27s kingdom together in a messy and complicated world. Her books have been described as provocative, honest, and “ground-breaking
[George Washington Parke Custis, half-length portrait, three-quarters to the left, wearing white waistcoat]
No full textBuilder and original owner of Arlington House, later the Lee Mansion, Arlington (Va.); author, historian, artist (painter).Identification from The Atlas, August 26, 1849, p. 1.Scratched on back of plate: 207; Custis, G.W.P.Original served by appointment only.Produced by Mathew Brady's studio.Transfer; U.S. War College; 1920; (DLC/PP-1920:46153).Forms part of: Daguerreotype collection (Library of Congress)
Aerial View from John Hancock Building, Looking Northeast, Boston Common and Public Gardens, St. James Avenue and Arlington Street Church, State House in Background, 3:00 P.M.
No full texthttp://www.nps.gov/nr/travel/wash/dc68.htm
George Washington Parke Custis inherited the 1100-acre estate from his father, the only surviving son of Martha Washington. Like John Parke Custis, G.W.P. Custis was raised at Mount Vernon, and he dedicated much of his life to perpetuating the memory of George Washington.
He commissioned George Hadfield, the second architect of the US Capitol to design Arlington House. It was designed in 1818, and is the third representation of Greek Revival architecture in the United States. In 1803, Custis had constructed two wings, and Hadfield's design was erected between them. The house was constructed of locally made brick and its most prominent feature is the large 16' by 52' portico across the central section. The portico is formed by eight large stuccoed and marbleized brick Doric columns that support a massive central pediment. The house, sited prominently atop the hill, can be seen from many points in the District of Columbia.
Robert E. Lee, who was related to Custis's wife, was a frequent visitor to Arlington from childhood until his marriage to Custis's only daughter, Mary. For the next 30 years, the Lees considered Arlington their home. In the Lee bedroom on April 19, 1861, Lee made his fateful decision to resign his US Army commission rather than take up arms against his native state following Virginia's secession from the Union. On April 22, he left Arlington forever.
In 1863 Congress levied a tax on all confiscated properties, but payment was rejected for Arlington. It was put up for sale for non-payment of taxes in January of 1864 and purchased by the US government. In May 1864, Secretary of War Edwin Stanton ordered that a national cemetery be established at Arlington, and the first burials took place that month.
In 1928, following its authorization by Congress as a memorial to Lee, the house began to be restored by the War department. In 1933 the house and immediate grounds were transferred to the National Park Service. By that time, some structural changes made since 1861 had been reversed and many rooms had been partially furnished. Since, then further restoration has been completed.
Arlington House is located in Arlington, Va., just across Memorial Bridge from the Lincoln Memorial. Check with your ranger at the door to see if guided tours will be offered during your visit. In lieu of a free guided tour, self-guided tours and audio (cell phone) tours of the house will be available during your visit. Arlington House is open to visitors every day from 9:30 a.m. to 4:30 p.m., with the exception of January 1st and December 25th when the Arlington National Cemetery is also closed. Metro stop: Arlington Cemetery.full vie
Neutron production and transport at a medical linear accelerator
No full text2014 Summer.Includes bibliographical references.The Colorado State University Veterinary Teaching Hospital (VTH) uses a Varian Trilogy™ linear accelerator (linac) for radiation oncology treatment. The high-energy electron beam is used to treat superficial tumors (deep tissues are spared with this modality) or is accelerated against a target to produce high-energy photons that are used to treat deep seated tumors (skin is spared with this modality). Either application might exceed the neutron production threshold for various materials. This study evaluates neutron production and transport in the environment surrounding the VTH trilogy through MCNP modeling and physical measurements of the 10 MV photon and 18 MeV electron beam modalities. MCNP modeling was accomplished in two phases. The first phase involved simulating the linear accelerator and determining the relevant parameters for neutron production for both modalities. This was accomplished by using various target specifications and replicating the geometry of the machine. In the second phase, MCNP modeling of the accelerator vault as well as other locations of interest within the treatment suite was conducted. This phase determined measurable neutron fluence and dose rates at the test locations where physical measurements were taken. The MCNP results (for neutron energies between 0.2 to 10 MeV) were compared with the physical measurements. Physical measurements were performed with a BF3 detector (responsive to energies between 0.2 and 10 MeV) and taken at the same test locations. For both modalities, MCNP and physical measurements demonstrated neutron production. Large uncertainties were associated with the physical measurements for both modalities. For the photon mode, MCNP modeling resulted in neutron equivalent doses per photon Gy up to 0.112 mrem/photon Gy, and physical measurements up to 0.133 mrem/photon Gy. For the electron mode, MCNP modeling resulted in measureable neutron equivalent doses per electron Gy up to 14.88 mrem/electron Gy, and physical measurements up to 3.83 x 10-04 mrem/electron Gy. Taking the entire neutron spectrum into account, MCNP results showed neutron doses up to 347.81 mrem/ photon Gy at the isocenter for the photon beam, and up to 1.77 x 105 mrem/electron Gy at the isocenter for the electron beam. These numbers could not be compared to the physical measurements because the BF3 detector used in this experiment only responded to neutron energies between 0.2 and 10 MeV. The conclusion made from this research is that neutrons are generated at various locations in and outside the room. For the photon modality, the neutron dose to the patient can be considered negligible when compared with the treatment dose. Neutron production does not appear to exceed the tolerance for workers in appropriate locations surrounding the VTH linac vault. Further research is recommended for an accurate analysis of both modalities
18世紀アメリカに関するエフェメラ : ワシントン・受領証・手形
No full textThis paper investigates several interesting aspects of 18th century America utilizing a little over fifteen historical ephemera privately owned by the author. First, as an introduction, the section 1 of the chapter 1 deals with three items concerning George Washington (GW) in their historical contexts: a pocket watch, a medal, and a cameo. An analysis of GWʼs pocket watches from his portraits is an epilogue of the former three articles written by the author in this bulletin on GWʼs timepieces. Historical meanings of a famous memorial medal (“Comitia Americana medal”) issued by the U.S. government in 1780s and dedicated to GW, and a precious “Berlin casting” iron cameo, on which the bust of GW is engraved and had been owned by a descendant of William Floyd, a revolutionary general (now owned by the author) are also analyzed. The section 2 of the chapter 1 treats three valuable ephemera written by relatives of GW: a receipt issued in 1769 by John Washington, a distant relative of GW and an overseer of the Dismal Swamp Company, a check issued in 1839 by Lawrence Lewis, GWʼs favorite nephew, and a check issued in 1846 by George Washington Parke Custis, GWʼs adopted grandson and the original owner of Arlington House. The section 1 of the chapter 2 is an analysis of the “texture” (physical characteristics) of the seventeen ephemera dealt with in this article and other historical documents dealt with in the former articles, which induces interesting facts on the size-system of documents used at that time. The section 2 of the chapter 2 analyzes the text itself of fourteen ephemera such as receipts, promissory notes, and bills of exchange including a receipt for the repayment by Thomas Penn, a son of William Penn, the founder of the colony of Pennsylvania.p.37の史料1、史料2およびp.38-39は都合により掲載しておりませ
18世紀アメリカに関するエフェメラ : ワシントン・受領証・手形
No full text2014-03-31This paper investigates several interesting aspects of 18th century America utilizing a little over fifteen historical ephemera privately owned by the author. First, as an introduction, the section 1 of the chapter 1 deals with three items concerning George Washington (GW) in their historical contexts: a pocket watch, a medal, and a cameo. An analysis of GWʼs pocket watches from his portraits is an epilogue of the former three articles written by the author in this bulletin on GWʼs timepieces. Historical meanings of a famous memorial medal (“Comitia Americana medal”) issued by the U.S. government in 1780s and dedicated to GW, and a precious “Berlin casting” iron cameo, on which the bust of GW is engraved and had been owned by a descendant of William Floyd, a revolutionary general (now owned by the author) are also analyzed. The section 2 of the chapter 1 treats three valuable ephemera written by relatives of GW: a receipt issued in 1769 by John Washington, a distant relative of GW and an overseer of the Dismal Swamp Company, a check issued in 1839 by Lawrence Lewis, GWʼs favorite nephew, and a check issued in 1846 by George Washington Parke Custis, GWʼs adopted grandson and the original owner of Arlington House. The section 1 of the chapter 2 is an analysis of the “texture” (physical characteristics) of the seventeen ephemera dealt with in this article and other historical documents dealt with in the former articles, which induces interesting facts on the size-system of documents used at that time. The section 2 of the chapter 2 analyzes the text itself of fourteen ephemera such as receipts, promissory notes, and bills of exchange including a receipt for the repayment by Thomas Penn, a son of William Penn, the founder of the colony of Pennsylvania.p.37の史料1、史料2およびp.38-39は都合により掲載しておりませんdepartmental bulletin pape
Influence of adipose-derived mesenchymal stromal cells on osteosarcoma minimal residual disease
No full textIncludes bibliographical references.2015 Summer.Introduction: Mesenchymal stromal cells (MSCs) have been shown to improve bone integration and healing in several preclinical studies and have therapeutic potential in limb salvage following massive bone loss due to tumor resection. However, MSCs have also been shown to promote primary and pulmonary metastatic tumor growth when injected in the presence of gross tumor or when co-injected with tumor cells in rodent models. While these results raise concerns about the safety of using MSCs in sarcoma patients, MSCs are unlikely to be utilized in a clinical setting when gross tumor is present. The objective of this dissertation project was to develop murine models of minimal residual osteosarcoma following primary tumor removal then to utilize these models to determine whether the administration of adipose-derived MSCs with or without chemotherapy treatment in a minimal residual disease setting would promote either pulmonary metastatic osteosarcoma progression or local disease recurrence. We hypothesized that surgical site or intravenous administration of MSCs will influence either osteosarcoma pulmonary metastatic burden or local disease recurrence in a minimal residual disease setting. Materials & Methods: Two syngeneic, orthotopic models of luciferase-expressing osteosarcoma were developed. In the first model, tumor-bearing mice underwent a coxofemoral amputation and were followed to assess development of pulmonary metastases. In the second model, a femorotibial amputation was performed in order to develop a model of consistent local tumor recurrence. In this model, all gross tumor was removed, however, microscopic tumor remained at the surgical margin. In this dissertation project, three principle projects were completed to test our hypothesis. The first project explored the use of MSCs delivered either to the surgical site or intravenously to ascertain their influence on pulmonary disease burden. A follow-on pilot explored concurrent MSC and chemotherapy treatment on development of pulmonary disease. The second project evaluated the use of MSCs delivered either to the surgical site or intravenously on local recurrence of osteosarcoma at the surgical site. Gross recurrent tumor size was measured for comparison between treatment groups. The third project examined the use of cisplatin and MSCs on survival of mice following removal of primary osteosarcoma. Data were expressed in mean +/- SD or median with 95% CI. ANOVA test, Kruskal-Wallis test, Fisher’s Exact test, Welch’s test, t-test, and Mann Whitney test were used for statistical analysis. Significance was set at p<0.05. Results: Mice treated with intravenous MSCs had a faster time to first pulmonary metastatic disease detection than mice treated with MSCs injected into the surgical site or control mice (no MSCs) (p=0.022). No treatment effect was seen between groups with respect to time to tumor recurrence or size of recurrent tumor in the second study. Survival curves were significantly different when comparing cisplatin, cisplatin and MSC treatment, MSC alone treatment and untreated mice (p<0.001) as well as in pairwise comparisons. Mice treated with MSCs had a 73% chance of earlier death than untreated controls. Discussion/Conclusion: Intravenous administration of MSCs in a minimal residual osteosarcoma environment resulted in a faster time to first detection of pulmonary disease and in a higher chance of earlier death compared to untreated mice. However, administration of MSCs locally in a surgical site following sarcoma excision appears to be safe, even in the setting of known residual microscopic disease. Further, the use of cisplatin treatment appeared to ameliorate the effects of intravenous MSCs on survival. Based on these results, further study is warranted to evaluate the influence of intravenously administered MSCs on minimal residual pulmonary metastatic disease
Computational investigation of biological dose-volume outcome predictors in 29 canine nasal tumor patients treated with stereotactic radiation therapy
No full text2012 Summer.Includes bibliographical references.The ability to mathematically model biological response to radiation dose in the tumors of cancer patients is a significant goal for the medical physics community. Although much work has been done in this area, novel treatment approaches are challenging the current knowledge of the radiation biology and oncology communities. In particular, doses five to ten times higher than traditional treatments are prescribed in stereotactic radiation therapy. These new treatment techniques are thought to have different mechanisms that cause cell death in comparison to classical treatments. These extraordinarily high doses are made possible by using advanced imaging, treatment planning, linear accelerator capabilities and immobilization to precisely target cancer while sparing healthy normal tissue. Biologically guided radiation therapy (BGRT) and biologically based treatment planning (BBTP) methods offer the next attractive step forward in radiation therapy. To examine the capabilities of biological based dose parameters, a mature data set of 29 canine nasal tumor patients was analyzed using the generalized equivalent uniform dose (gEUD) and the dose to a relative volume.Over one hundred individual predictors were inspected, with greater than five thousand individual tests, in search of optimal indicators of patient outcome.Testing showed that high negative gEUD values and the minimum dose to the tumor were highly significant predictors in the outcome of the patients. However, more robust techniqes need to be added to the analysis in order to validate these results
