1,721,142 research outputs found
A phantom study to create synthetic CT from orthogonal twodimensional cine MRI and evaluate the effect of irregular breathing.
Full text linkAn exciting innovation in radiotherapy is the use of real-time MRI for treatment adaptation. This study proposes an in-silico framework for the generation of 3D synthetic CT (sCT) from orthogonal interleaved 2D cine MRI data to overcome the lack of electron density information in MR images. The method uses pre-treatment data to build a patient breathing motion model. This model is then driven by surrogates extracted from cine MR images during the treatment. The effect of irregular breathing on the motion model is also evaluated by simulating different motion components related to uncorrelated diaphragm, chest and tumor motion. 3D sCT were successfully created for each of the 512 cine MRI pairs in the digital phantom study. The analysis showed that the diaphragm position was a good surrogate to rescale the 3D breathing motion for the current regular breathing phase. However, respiratory and tumor motion were correlated in only 59% of the phases, resulting in tumor position uncertainties of up to 3mm. The inclusion of additional chest and tumor motion information improved the accuracy for irregular changes in breathing pattern and enhanced the tumor position uncertainties to less than 1mm. This study successfully demonstrated a proof-ofprinciple for a digital phantom dataset based on patient parameters, providing a way to create real-time 3D electron density volumes and enhancing the need to account for irregular breathing pattern
Motion prediction in MRI-guided radiotherapy based on interleaved orthogonal cine-MRI
Full text linkIn-room cine-MRI guidance can provide non-invasive target localization during radiotherapy treatment. However, in order to cope with finite imaging frequency and system latencies between target localization and dose delivery, tumour motion prediction is required. This work proposes a framework for motion prediction dedicated to cine-MRI guidance, aiming at quantifying the geometric uncertainties introduced by this process for both tumour tracking and beam gating. The tumour position, identified through scale invariant features detected in cine-MRI slices, is estimated at high-frequency (25 Hz) using three independent predictors, one for each anatomical coordinate. Linear extrapolation, auto-regressive and support vector machine algorithms are compared against systems that use no prediction or surrogate-based motion estimation. Geometric uncertainties are reported as a function of image acquisition period and system latency. Average results show that the tracking error RMS can be decreased down to a [0.2; 1.2] mm range, for acquisition periods between 250 and 750 ms and system latencies between 50 and 300 ms. Except for the linear extrapolator, tracking and gating prediction errors were, on average, lower than those measured for surrogate-based motion estimation. This finding suggests that cine-MRI guidance, combined with appropriate prediction algorithms, could relevantly decrease geometric uncertainties in motion compensated treatments
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
OC-0409 Comparison of different strategies to derive time-resolved volumetric MRI in MRI-guided radiotherapy
No full text
Audiovisual biofeedback improves the correlation between surrogates and tumour motion for lung cancer
No full textA 4D CT/MRI digital phantom and its application in carbon-ion therapy of abdominal lesions
No full text- …
