49 research outputs found
Development of radiolabeled probes for the prediction of therapeutic effects of EGFR-tyrosine kinase inhibitors
Get PDF金沢大学博士(創薬科学）博士論文 要旨Abstract/本文Full 以下に掲載：Molecule 25(2914) 2020. MDPI. 共著者：Muammar Fawwaz, Kenji Mishiro, Ryuichi Nishii, Izumi Sawazaki, Kazuhiro Shiba, Seigo Kinuya, Kazuma Ogawadoctoral thesi
Physiological Aspects of Filamentous Elongated Bacteria Induced by X-ray Irradiation
Get PDFSequences of cytological changes occurring in some bacteria following irradiation of X-ray have been described by many workers. It is known that, unless bacteria receive a considerable amount of irradiation, they continue to grow and become elongated, only their cell division being inbibited. In the present study, the author gave physiological aspects on the filamentous Salmonella typhi H901W elongated by culture following after X-ray irradiation (2000 r). 1. It was observed by Warburg's manometric technique that most of enzyme activities in the elongated cells were reduced. Especially, the induction of a adaptive enzyme for glucuronic acid could not be observed in the elongated cells. 2. In the post culture following after X-ray irradiation, protein and RNA increased as long as cell body elongates but DNA didn't increase. This result coincides with the finding that irradiated Salmonella typhi elongated without the increasing of number of nuclear apparatus. 3. In the studies on the agglutination reaction of the elongated cells, the author found that the agglutinability with antibody were reduced and moreover the isoelectric point moved slightly against to neutral pH
Synthesis of Benzoisoselenazolones via Rh(III)-Catalyzed Direct Annulative Selenation by Using Elemental Selenium
Get PDFThis is the accepted version of the following article: Xu-Xu Q.F., Nishii Y., Uetake Y., et al. Synthesis of Benzoisoselenazolones via Rh(III)-Catalyzed Direct Annulative Selenation by Using Elemental Selenium. Chemistry - A European Journal 27, 17952 (2021); which has been published in final form at https://doi.org/10.1002/chem.202103485. This article may be used for non-commercialpurposes in accordance with the Wiley Self-ArchivingPolicy [https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html]Isoselenazolone derivatives have attracted significant research interest because of their potent therapeutic activities and indispensable applications in organic synthesis. Efficient construction of functionalized isoselenazolone scaffolds is still challenging, and thus new synthetic approaches with improved operational simplicity have been of particular interest. In this manuscript, we introduce a rhodium-catalyzed direct selenium annulation by using stable and tractable elemental selenium. A series of benzamides as well as acrylamides were successfully coupled with selenium under mild reaction conditions, and the obtained isoselenazolones could be pivotal synthetic precursors for several organoselenium compounds. Based on the designed control experiments and X-ray absorption spectroscopy measurements, we propose an unprecedented selenation mechanism involving a highly electrophilic Se(IV) species as the reactive selenium donor. The reaction mechanism was further verified by a computational study
Stimuli‐Responsive Properties on a Bisbenzofuropyrazine Core: Mechanochromism and Concentration‐Controlled Vapochromism
No full textThis is the accepted version of the following article: Nakamura Shotaro, Okubo Kohei, Nishii Yuji, et al. Stimuli‐Responsive Properties on a Bisbenzofuropyrazine Core: Mechanochromism and Concentration‐Controlled Vapochromism. Chemistry – A European Journal, e202302605 (2023), which has been published in final form at https://doi.org/10.1002/chem.202302605. This article may be used for non-commercialpurposes in accordance with the Wiley Self-ArchivingPolicy [https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html]Stimulus-responsive organic materials with luminescence switching properties have attracted considerable attention for their practical applications in sensing, security, and display devices. In this paper, bent-type bisbenzofuropyrazine derivatives, Bent-H and Bent-sBu, with good solubilities were synthesized, and their physical and optical properties were investigated in detail. Bent-H gave three crystalline polymorphs, and they showed different luminescence properties depending on their crystal packing structures. In addition, Bent-H exhibited mechanochromic luminescence in spite of its rigid skeleton. Bent-sBu exhibited unique concentration-dependent vapochromic luminescence. Ground Bent-sBu was converted to blue-emissive, green-emissive, and green-emissive high-viscosity solution states at low, moderate, and high concentrations of CHCl3 vapor, respectively. This finding represents a concentration-dependent multi-phase transition with an organic solvent, which is of potent interest for application in sensing systems
睡眠障害を有する地域在住高齢者の身体機能・ 精神心理機能の特徴
Get PDF修士〔目的〕睡眠障害を有する地域在住高齢者を対象に、身体機能と精神心理機能の特徴を明らかにすることである。〔対象と方法〕対象は、60 歳以上の地域在住者189 名（男性45 名、女性144 名、平均年齢73.9 ± 6.9 歳）であった。測定項目は、基本属性、ロコモ度、身体機能、認知機能、精神心理機能、基本チェックリスト、睡眠状況とした。ピッツバーグ睡眠質問票の得点によって、睡眠障害あり群と睡眠障害なし群の2 群比較を行った。
〔結果〕睡眠障害あり群では有意にロコモ25 が高値、抑うつスコアが高値を示した。また、主観的健康感が低いこと、人との交流が少ないこと、主観的睡眠の質不良者が多いこととの関連性がみられた。
〔結語〕地域在住者では、睡眠障害を有する者はロコモ25 スコアの悪化、抑うつスコアの増大が示唆された。articl
Stimuli‐Responsive Properties on a Bisbenzofuropyrazine Core: Mechanochromism and Concentration‐Controlled Vapochromism
Get PDFThis is the accepted version of the following article: Nakamura Shotaro, Okubo Kohei, Nishii Yuji, et al. Stimuli‐Responsive Properties on a Bisbenzofuropyrazine Core: Mechanochromism and Concentration‐Controlled Vapochromism. Chemistry – A European Journal, e202302605 (2023), which has been published in final form at https://doi.org/10.1002/chem.202302605. This article may be used for non-commercialpurposes in accordance with the Wiley Self-ArchivingPolicy [https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html]Stimulus-responsive organic materials with luminescence switching properties have attracted considerable attention for their practical applications in sensing, security, and display devices. In this paper, bent-type bisbenzofuropyrazine derivatives, Bent-H and Bent-sBu, with good solubilities were synthesized, and their physical and optical properties were investigated in detail. Bent-H gave three crystalline polymorphs, and they showed different luminescence properties depending on their crystal packing structures. In addition, Bent-H exhibited mechanochromic luminescence in spite of its rigid skeleton. Bent-sBu exhibited unique concentration-dependent vapochromic luminescence. Ground Bent-sBu was converted to blue-emissive, green-emissive, and green-emissive high-viscosity solution states at low, moderate, and high concentrations of CHCl3 vapor, respectively. This finding represents a concentration-dependent multi-phase transition with an organic solvent, which is of potent interest for application in sensing systems
Arrhythmia management after device removal
No full textAbstractArrhythmic management is needed after removal of cardiac implantable electronic devices (CIEDs). Patients completely dependent on CIEDs need temporary device back-up until new CIEDs are implanted. Various methods are available for device back-up, and the appropriate management varies among patients. The duration from CIED removal to implantation of a new CIED also differs among patients. Temporary pacing is needed for patients with bradycardia, a wearable cardioverter defibrillator (WCD) or catheter ablation is needed for patients with tachyarrhythmia, and sequential pacing is needed for patients dependent on cardiac resynchronization therapy. The present review focuses on arrhythmic management after CIED removal
Enzymatic Properties of Candida (I)
Get PDFPart I O(2) Uptake of the Fresh Cells Using Candida albicans, C. krusei, C. parakrusei and C. tropicalis, the author studied the O(2) uptakes of the organisms at the expense of various carbon compounds or amino acids as substrate and the environmental factors to this. The following results were obtained. 1) The endogenous respiration of each strain was fairly high, and this respiration tended to decrease by the shaking of cell suspension without addition of substrates. Since prolonged shaking of the cell suspension may cause the inactivation of enzyme activity, the most advantage were given on the cell suspension that was previously shaken for 1-2 hrs. in order to study the enzymatic properties of the organisms. 2) Generally, the O(2) uptakes of Candida were high at the expense of glucose, acetate and citrte. Besides this, the O(2) uptake of C. albicans was also high at the expense of lactate and pyruvate. 3) As a whole, it could say that the greater enzyme activity was found on the cells of shorter cultivation compared with that of longer cultivation. And the organism cultured by shaking method showed more accelerated O(2) uptake at the oxidation of lactate, pyruvate and acetate than the cultured in still-standing method, this fact possibly implied that the metabolism of the former organism was carried out very satisfactory. Part II Properties of Freezing-dried Cell Preparation andFraction of Ground Fresh Cell As in the previous report, part I, using 4 strains of Candida, C. albicans, C. krusei, C. krusei, C. parakrusei and C. tropicalis, the author prepared the freezing-dried cell preparation and the fractions of ground fresh cells, studied O(2) uptake, catalase activity and action of inhibitors to these. The results obtained were following. 1) The freezing-dried cells showed an catalase activity in a same extent as the living cells, and a large amount of O(2) uptake with glucose, lactate, citrate and succinate; while a marked decrease of O(2) uptakes were found with pyruvate and acetate. 2) The supernatant fraction obtained from ground fresh cell at 40,000 rpm showed greater catalase activity, and greater oxidative capacity for pyruvate, acetate and citrate, and also accelerated endogenous respiration. On the other hand, the sediment separated by centrifugation at 40,000 rpm had no catalase activity; but revealed specifically much greater oxidative capacity for lactate and succinate. 3) It was confirmed that the action of inhibiter was more effective on the freezing-dried cells and the cell free extract than on the intact living cells; by an addition of KCN the O(2) upteak was not affected on the living cells, but was serionsly inhibited on the freezing-dried cells and the cell free extract
