1,721,095 research outputs found
Replication Data for: Active mid-infrared ring resonators
No full textReplication dataset for "Active mid-infrared ring resonators" by Dmitry Kazakov, Theodore P. Letsou, Maximilian Beiser, Yiyang Zhi, Nikola Opačak, Marco Piccardo, Benedikt Schwarz, and Federico Capasso, accepted for publication in Nature Communications (NCOMMS-23-13724
Clinicopathological and molecular biologic characteristics of selected cutaneous epithelial and nonepithelial tumors
No full textThe doctoral thesis MD. Liubov Kastnerova (previous name Kyrpychova) is focused on the histomorphological and molecular biologic features of selected cutaneous epithelial and nonepithelial tumors and is structured as a commentary to the 20 articles published during four years, representing the completed scientific projects in the Ph.D. course. In eight papers, the author of the thesis is the first author, whereas she coauthored in the remaining 12 papers. The thesis is composed of the commented files of authors own publications and it is divided into cutaneous epithelial and nonepithelial tumors. The first section, «Cutaneous epithelial tumors», includes 14 articles that are subdivided into two parts: adnexal tumors (9 articles) and lesions of anogenital mammary-like glands (5 articles). Of the nine articles on adnexal tumors, there are 5 articles focused on various benign and malignant adnexal lesions with apocrine or eccrine differentiation. Novel findings in this part include the identification of hitherto unreported alterations of the MYBL1 gene in adenoid cystic carcinoma of the skin and lack of deletion of the 1p36 locus in this neoplasm; the lack of a correlation between cellular composition and the presence CRTC1-MAML2 fusions in hidradenoma, the absence of CRTC3-MAML2 fusions in this tumor,..
Klinickopatologické a molekulárně biologické charakteristiky vybraných kožních epiteliálních a neepiteliálních nádorů
Full text linkThe doctoral thesis MD. Liubov Kastnerova (previous name Kyrpychova) is focused on the histomorphological and molecular biologic features of selected cutaneous epithelial and nonepithelial tumors and is structured as a commentary to the 20 articles published during four years, representing the completed scientific projects in the Ph.D. course. In eight papers, the author of the thesis is the first author, whereas she coauthored in the remaining 12 papers. The thesis is composed of the commented files of authors own publications and it is divided into cutaneous epithelial and nonepithelial tumors. The first section, «Cutaneous epithelial tumors», includes 14 articles that are subdivided into two parts: adnexal tumors (9 articles) and lesions of anogenital mammary-like glands (5 articles). Of the nine articles on adnexal tumors, there are 5 articles focused on various benign and malignant adnexal lesions with apocrine or eccrine differentiation. Novel findings in this part include the identification of hitherto unreported alterations of the MYBL1 gene in adenoid cystic carcinoma of the skin and lack of deletion of the 1p36 locus in this neoplasm; the lack of a correlation between cellular composition and the presence CRTC1-MAML2 fusions in hidradenoma, the absence of CRTC3-MAML2 fusions in this tumor,...Disertační práce MD. Liubov Kastnerové (dříve Kyrpychova) se zaměřuje na histomorfologické a molekulárně biologické vlastnosti vybraných kožních epiteliálních a neepiteliálních nádorů. Je strukturována jako komentář k 20 článkům publikovaným v průběhu čtyř let, které představují dokončené vědecké projekty v Ph.D. studiu. V osmi článcích je autorka první autor, ve zbývajících 12 pracích je spoluautorem. Doktorská dizertační práce je prezentovaná ve formě komentovaného souhrnu vlastních publikací a je rozdělena na kožní epiteliální a neepiteliální nádory. První část, "Kožní epiteliální tumory", obsahuje 14 článků, které jsou členěny do dvou částí: adnexální tumory (9 článků) a léze z anogenitálních "mammary-like" žlázek (AGMLG) (5 článků). Z devíti článků týkajících se adnexálních nádorů je jich 5 zaměřeno na různé benigní a maligní adnexální léze s apokrinní nebo ekrinní diferenciací. Nové poznatky v této části zahrnují identifikaci dosud nepopsaných změn genu MYBL1 v adenoidně cystickém karcinomu kůže a absenci delece lokusu 1p36 v tomto nádoru. Dále prokazujeme chybění korelace mezi buněčným složením a přítomností fúzí CRTC1-MAML2 v hidradenomu, absenci fúzí CRTC3-MAML2 v tomto nádoru, a nové histopatologické znaky a translokace NFIX-PKN1 v primárním kožním sekrečním karcinomu. Také jsme provedli...Šiklův ústav patologieFaculty of Medicine in PilsenLékařská fakulta v Plzn
Genetic alterations of the skin adnexal tumours
No full text1. CYLD gene 1.7 Summary Our team discovered 19 new germinal mutations (22% of all known), with author participating on finding of seven of them. Particularly interesting is the discovery of new intronic mutation of CYLD gene and characterization of molecular biologic processes causing inactivation of the gene. Author also confirmed presence of LOH being the most frequent second inactivating hit. At the same time author found a group of patients with BSS/MFT phenotype carrying no mutation of CYLD gene suggesting that there might exist another gene participating in BSS/MFT pathogenesis. Furthermore genotype-phenotype analysis was performed resulting in no significant correlation. 2. Mismatch repair genes hMLH1, hMSH2, hMSH6 2.9 Summary In this study we have analyzed one patient with Muir-Torre syndrome (MTS) phenotype for causal mutation in mismatch repair (MMR) genes. Most patients with MTS carry mutations in MSH2 and MLH1 gene. Germline mutations in MSH6 are extremely rare, with only 3 cases reported thus far. Here we have described a germline mutation in MSH6 gene in three members of one family. This greatly extends previously published group of patients with MTS syndrome carrying mutation in MSH6 gene. 3. PRKAR1A gene 3.7 Summary In this study we have investigated patient with Carney complex for a..
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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