149 research outputs found
The evaluation of bacteriological quality parameters of natural spring water in Anatolian side of Istanbul Province
No full textThe main purpose of this study was to investigate the bacteriological quality parameters of drinking fountains found in the Anatolian side of Istanbul on an annual basis (2014 year/12 month) and their evaluation in terms of human health. Samples were taken monthly from 10 different public drinking fountains for bacteriological analysis for a year in 2014. Bacteriological analysis were carried on using the membrane filtration technique; Coliform bacteria, Escherichia coli, Fecal coliform and Enterococcus counting. 95 samples were collected in total and bacteriological analysis performed on these showed that 46 % of the samples were drinkable and 49 % of them were not drinkable according to the national and international standards for drinking water quality. Additionally, 47,4 % of the samples had Coliform bacteria, 27,4 % had Enterococcus, 17,9 % had Escherichia coli and 14,7 % had Fecal coliform which showed that they were out of the standards. On the other hand, 48,4 % of the samples were compatible with the values indicated in the standards
Effects of Chlorine Stress on Pseudomonas aeruginosa Biofilm and Analysis of Related Gene Expressions
No full textChlorine is deployed worldwide to clean waters and prevent water-originated illnesses. However, chlorine has a limited disinfection capacity against biofilms. Microorganisms form biofilms to protect themselves from biological threats such as disinfectant chemicals. Pseudomonas aeruginosa is an opportunistic pathogen and its biofilm form attaches to surfaces, living buried into exopolysaccharides, can be present in all watery environments including tap water and drinking water. This research aimed to study the biofilm trigger mechanism of the opportunistic pathogen P. aeruginosa PAO1 strain, which is known to form biofilm in water supply systems and human body, under chlorine stress levels. In addition to biofilm staining, certain genes that are relevant to the stress condition were selected for gene expression analysis. The bacteria cultures were grown under chlorine stress with concentrations of 0.5, 0.7 and 1 mg/l. Six gene regions were determined related to biofilm and stress response: rpoS, bifA, migA, katB, soxR, and algC. Biofilm formation was analyzed by basic fuchsin staining, and gene expressions were quantified by quantitative real-time PCR. According to the results, highest biofilm production was observed in P. aeruginosa PAO1 wild strain under no stress conditions. Higher biofilm amounts were observed for bacteria under 0.5 and 0.7 mg/l chlorine stress compared to 1 mg/l chlorine stress
Asteroseismic investigation of 20 planet and planet-candidate host stars
No full textCelik Orhan, Zeynep/0000-0002-9424-2339; KAYHAN, Cenk/0000-0001-9198-2289Planets and planet candidates are subjected to great investigation in recent years. in this study, we analyse 20 planet and planet-candidate host stars at different evolutionary phases. We construct stellar interiormodels of the host stars with the MESA e.volution code and obtain their fundamental parameters under influence of observational asteroseismic and non-asteroseismic constraints. Model mass range of the host stars is 0.74-1.55 M-circle dot. the mean value of the so-called large separation between oscillation frequencies and its variation about the minima shows the diagnostic potential of asteroseismic properties. Comparison of variations of model and observed large separations versus the oscillation frequencies leads to inference of fundamental parameters of the host stars. Using these parameters, we revise orbital and fundamental parameters of 34 planets and four planet candidates. According to our findings, radius range of the planets is 0.35-16.50 R-circle plus. the maximum difference between the transit and revised radii occurs for Kepler-444b-f is about 25 per cent
Dose-dependent effects of endosulfan and malathion on adult wistar albino rat ovaries
No full textIn this sludy, histological effects and malondialdehyde (MDA) levels were investigated by endosulfan and malathion in adult female rat ovaries. An increase of MDA level in rat ovarium tissues due to endosulfan and malathion may be an indicator of the tree radicals occurred during the metabolism and their lipid peroxidative inducing damage. In this study in accordance with the biochemical findings, the study demonstrated that there are pronounced structural defects in histological examinations of ovarian tissues in rats which were administered endosulfan and malathion. It has been observed that the size of ovarian tissues of rats which were administered endosulfan and malalhion in different doses was decreased in various levels. There was a significant decrease healthy follicles and a significant increase atretic follicles in low dose of endosulfan and malathion (11 mg kg-1) treated rats The histologic observations of the ovary revealed the presence of less number of healthy follicles and more number of atretic follicles and corpus Intcums in high dose of endosulfan and malathion (33 mg kg-1} treated rats. Finally, a peroxidative damage occurs inavitably due lo endosulfan and malathion for ovarium tissues. The biochemical results (MDA levels) also showed such a damage, similar with the histological results. © 2009 Asian Network for Scientific Information
Edebî Türlerden Cenk-Nâme/Gazavat-Nâme Karşılaştırması ve Muhammed Hanefî-Tabut Cengi’nin Yeni Bir Nüshası
No full text“Cenk-nâme”, das durch die Zusammensetzung der Begriffe „Cenk“, das „kämpfen“ bzw. „schlagen“ bedeutet und „Nâme“, das „Erlass“ bzw. „Brief“ bedeutet, ist „der Name, der prosaischen und in Versform verfassten Werken gegeben wurde, in denen die Kriege während der Zeit der Expansion des Islams und Hz. Ali als Anführer und vorbildlicher Mensch in diesen Kriegen thematisiert werden“. In den Cenk-nâmes, die beim türkischen Volk sehr beliebt sind, auswendig gelernt wurden und ein Genre sind, das mit der Zeit eine anonyme Form annahm, wird nicht nur von Hz. Ali, sondern auch von den Heldentaten der Söhne Hz. Alis, Hasans, Huseyns und Muhammed Hanefîs erzählt. Cenk-nâmes, in denen Muhammed Hanefî der Hauptheld ist und die mit Namen wie Dâsitân-ı Muhammed Hanefî, Kitâb-ı Muhammed Hanefî, Menâkıb-ı Muhammed Hanefî und Hikâye-i Muhammed Hanefî geschrieben worden sind, waren sehr beliebt und wurden auswendiggelernt. Sie wurden in Begleitung der Langhalslaute (Saz) vorgetragen und haben sich mit der Zeit in anonyme Werke verwandelt, deren Autoren nicht bekannt sind. Das vorgestellte Werk befindet sich zwischen den Seiten 151-170 im Schriftexemplar mit der Nummer 06 Mil Yz A 3158-2. Es ist ein Mesnevi, dessen Metrik im Versmaß fâilâtün fâilâtün fâilün geschrieben wurde und aus 491 Versen besteht. Auch wenn beim Bibliothekseintrag als Autor des Werkes, das mit Naschī-Schrift geschrieben wurde, Isa angegeben wurde, konnten keine biographischen Informationen über den Autor gefunden werden. Das festgestellte Werk ist trotz von Zeit zu Zeit übersprungenen Versen und Metrikfehlern als neues Exemplar der Cenk-nâme Tradition wertvoll. Das erste bekannte Exemplar der Muhammed Hanefî-Tabut Cenk-Schrift gehört Tursun Fakih und Cenk-nâmes, die zum gleichen Thema geschrieben wurden, wurden in großem Maße vom Werk Tursun Fakihs beeinflusst, auch wenn ihre Autoren unterschiedlich sind. Nachdem im Artikel Informationen über die Genres Cenk-nâme und Gazavat-Nâme, die die Fortführung der türkischen Epos-Tradition darstellen, sowie über historische Entwicklungen gegeben wurden, wurde versucht, sowohl die Gründe zu erklären, wieso die beiden Genres sich vermischt haben, als auch die Unterschiede zu erläutern. Die akademischen Arbeiten zum Thema Muhammed Hanefî wurden aufgelistet. Für Leser aus anderen Fachgebieten wurde neben dem transkribierten Text der Muhammed Hanefî-Tabut Cenk-Schrift auch die ins heutige Türkisch übersetzte Prosaform beigefügt.“Cenkname”, formed of the words “cenk”, which means fighting, batting, and “name”, which means edict, letter, is “the name of prosaic and poetic texts that put forward the battles carried out during the spreading of Islam, and Ali as a leader and a role model in these battles”. “Cenkname”, a genre which was loved and memorized by Turkish people and became anonymous over time, describes not only Ali’s braveries, but also the braveries of his sons Hasan, Huseyin and Muhammed. “Cenknames”, named Dasitan-i Muhammed Hanefi, Kitab-i Muhammed Hanefi, Menakib-i Muhammed Hanefi, Hikaye-i Muhammed Hanefi, etc. in which Muhammed Hanefi is the main character, were loved and memorized, read accompanied with saz and over time turned into anonymous texts whose author is unknown. The text in question is a “mesnevi” (a poetic form) which consists of 491 couplets, written with a specific prosody pattern (“failatün failatün failün”) and found between 151-170. leaves of the edition numbered 06 Mil Yz A 3158-2. Although the information that the author of this text, written in a certain calligraphy without vowel marks, is Isa exists in the library records, there is no biographical information about him. The text in question is valuable in terms of being a new example of the “cenkname” tradition, despite some omitted couplets and prosody defects. The first known example of the Muhammed Hanefi-Tabut Battle belongs to Tursun Fakih and although the authors of the “cenknames” written on the same subject are different, they were greatly influenced by Tursun Fakih’s text. The paper gives information about the genres of “cenkname” and “gazavatname”, which are a continuation of the Turkish epic tradition, and their historical development, and afterwards it discusses the differences between the two genres and the reasons of their intertwining. The paper lists academic studies on Muhammed Hanefi and presents the text of Muhammed Hanefi-Tabut Battle translated into contemporary Turkish for the readers from different fields together with its transcription.“Savaşma, vuruşma” anlamına gelen cenk kelimesine, ferman mektup anlamındaki “nâme”nin eklenmesi ile oluşan cenk-nâme edebiyatta “İslamiyetin yayılma dönemi içerisinde yapılan savaşların ve bu savaşlar içerisinde de Hz. Ali’nin lider ve örnek insan olarak öne çıkarıldığı mensur ve manzum eserlere verilen ad”dır. Türk halkı tarafından çok sevilip ezberlenen ve zamanla anonim bir hâl alan bir tür olan cenk-nâmelerde yalnızca Hz. Ali değil Hz. Ali’nin oğulları Hasan, Hüseyin ve Muhammed Hanefî’nin kahramanlıkları da anlatılır. Muhammed Hanefî’nin başkahraman olduğu, Dâsitân-ı Muhammed Hanefî, Kitâb-ı Muhammed Hanefî, Menâkıb-ı Muhammed Hanefî, Hikâye-i Muhammed Hanefî gibi isimlerle yazılan cenk-nâmeler çok sevilip ezberlenmiş, saz eşliğinde okunmuş ve zamanla yazarı belli olmayan, anonim eserlere dönüşmüştür.Tanıtılan eser, 06 Mil Yz A 3158-2 numaralı yazma nüshanın 151-170. varakları arasında bulunan, aruzun fâilâtün fâilâtün fâilün vezni ile kaleme alınmış 491 beyitlik bir mesnevidir. Harekesiz nesih hatla yazılmış eserin yazarının İsa olduğu bilgisi kütüphane kaydında verilmişse de bu bilgi teyit edilemedi, yazar hakkında biyografik bilgi bulunamadı. Tespit edilen eser, zaman zaman atlanan beyitleri ve aruz kusurlarına rağmen cenk-nâme geleneğinin yeni bir örneği olması yönüyle kıymetlidir. Muhammed Hanefî-Tabut cenginin bilinen ilk örneği Tursun Fakih’e aittir ve aynı konuda yazılan cenk-nâmeler yazarları farklı olsa da Tursun Fakih’in eserinden büyük ölçüde etkilenmişlerdir. Makalede Türk destan geleneğinin devamı niteliğinde olan cenk-nâme ve gazavat-nâme türleri ve tarihi gelişimleri hakkında bilgi verildikten sonra, iki türün iç içe geçme sebepleri ve birbirinden farklı tarafları açıklanmaya çalışıldı. Muhammed Hanefî konusunda yapılan akademik çalışmalar sıralandı. Farklı alanlardan okuyucular için Muhammed Hanefî-Tabut Cengi’nin transkripsiyonlu metninin yanında günümüz Türkçesine çevrildiği nesir hâli de verildi
Utilizing real-time location data for performance monitoring in healthcare systems:
No full textAlthough both public and private healthcare expenditures have been very high in the US when compared to other wealthy and industrialized nations; the quality and reach of services provided have constantly been in dispute. For that reason, improving the efficiency of healthcare services has emerged to be an important goal. However, the unpredictable and complex nature of the healthcare environments makes this goal difficult to achieve. Recently industrial engineering methods started being applied to improve hospital efficiencies. In addition, the utilization of technological advancements such as RFID based real time location systems (RTLS) in the healthcare sector provides an additional opportunity to apply industrial engineering methods to healthcare.
In this thesis, a data transformation and analysis framework is developed to be employed as part of a RTLS schema in a hospital unit. This framework consists of a software agent that is capable of monitoring, analyzing and predicting the performance of a process from RTLS data. The software agent performs its task by means of several statistical methods customized for specific purposes. It can identify steady state behavior, changes in the mean and transient states such as learning curves. Its main purpose is to detect the effects of modifications on the system and forecast the future performance level. A simulation model is built to produce tracking data of entities in a hypothetical hospital unit to be fed into the software agent via a database structure. This completes the framework and enables the testing of the developed agent using realistic data.
RTLSs typically suffer from accuracy issues which result in imperfect tracking data. This makes performance monitoring very infeasible or even impossible. To overcome this issue, a data cleaning algorithm is developed which can be fully integrated with the developed performance agent. The algorithm utilizes a Bayesian approach in a sliding window analysis. Testing of the data cleaning algorithm is performed for various scenarios.M.S.Includes bibliographical references (p. 60-61)by Cenk Demi
Using proteomics, q-PCR and biochemical methods complementing as a multiapproach to elicit the crucial responses of zebrafish liver exposed to neonicotinoid pesticide
No full textPesticides enter the environment through runoff and leaching and this raises public concern about effects on non-target organisms.
Imidacloprid (IMI) a synthetic pesticide, has an unstable half-life, metabolized in minutes to weeks in the water. To evaluate the effects
of IMI on the zebrafish liver, we conducted proteomic, molecular and biochemical analysis in a multi-level approach, to highlight the
complementary features regarding the results of each method. Adult zebrafish were exposed to 60 mg/L IMI for 48 hours and were
evaluated using nLC-MS/MS for proteins, q-PCR analysis for expression of cat, gpx, pxr, ache, along with CAT and AChE enzyme
activities and GSH and MDA assays. Based on proteomics, the regulation of antioxidant and immune responses, as well as gene
transcription were significant processes affected. Apoptosis and ER stress pathways were upregulated and there was a down-regulation
of cat and gpx genes. There was also elevated CAT activity and GSH and decreased MDA. Additionally, elevated AChE activity and
up regulation of ache expression was observed. The multi-approach results included regulators of antioxidant, xenobiotic response and
neuro-protective related proteins (genes and enzymes), which overall reflected harmful effects of IMI. Consequently, this study
highlights the effects of IMI on zebrafish liver and reveals new potential biomarkers. In this respect, evaluated outcomes reveal the
complementary features emphasizing the importance of studying chemicals using several methods. Our study provides deeper insights
for future work in ecotoxicological studies regarding IMI and contribute to existing toxicity literature
Miyokard infarktüsünde angiotensin dönüştürücü enzim (ADE) gen polimorfizminin biyokimyasal temelleri
No full textGelişmiş ülkelerde en başta gelen morbidite ve mortalite nedeni miyokard infarktüsü ve koroner arter hastalıklarıdır. Miyokard infarktüsü ABD'de ve diğer birçok gelişmiş ülkede tüm nedenlere bağlı ölümlerin yaklaşık yarısından sorumludur. Son zamanlarda miyokard infarktüsü oluşumundan sorumlu olabilecek bazı genetik risk faktörleri üzerinde çalışmalar artmıştır. Bunların arasında en popüler olanlarından biri Angiotensin Dönüştürücü Enzim (ADE) genindeki I/D polimorfizmi ve miyokard infarktüsünün ilişkisini araştıran çalışmalardır. Miyokard infarktüsü ve koroner arter hastalıklarına yol açan genetik belirteçlerin saptanması, bu hastalıkları önleme ve tedavi çalışmalarında kolaylık sağlayabilecektir. Bu genetik belirteçlerin önceden saptanması durumunda klinik belirtiler ve kardiyovasküler komplikasyonlar ortaya çıkmadan yüksek risk grubundaki kişiler belirlenebilecekler ve uygun tedavi için takibe alınabileceklerdir. Tüm bu çalışmalar ADE gen polimorfizminin kardiyovasküler riskin tahmininde, yüksek risk gruplarındaki hastalara erken ve etkili tedavinin planlanması ve Önceden belirlenmesinde ışık tutabileceği düşüncesinden hareketle sürdürülmektedir.Myocardial Infarction (MI) is the most important reason of mortality and morbidity in developed countries. It is detected that about half of the deaths, no matter what reason is, in the USA is sourced from MI. In recent years, a lot of scientific studies have increased on some genetic risk factors responsible from the formation of MI. One of the most popular of these is searching for the relations between the I/D polymorphism in the ACE gene and MI. In this study, it is assumed that ACE I/D gene polymorphism is a useful indicator in the detection of the risk of cardiovascular disease, the better control of the people in high risk group and the optimal cure to start at an earlier stage. By the help of these studies the risk factors of genetic origin, using the genetic indicators and new risk factors, and supporting the information by some easily performed biochemical experiments would supply great easiness in diagnosis and cure and save life
New micromegas for axion searches in CAST
No full textYıldız, Süleyman Cenk (Dogus Author)Micromegas detectors have been taking data in the CAST experiment since 2002, occupying one opening (out of the two looking for sunrise axions) of the magnet and showing good performance and stability. Currently, three of the four X-ray detectors used in the experiment are micromegas. The new detectors are of the Microbulk technology, which have attracted a lot of attention because of the advantages they present, among them the low-material construction, high radiopurity and good energy resolution. Here, their performance during the last year will be commented. In particular, the low background levels reached in some detectors have triggered a set of studies in order to understand the effect
Deletion of macro domain containing 2(MACRO D2) associated with transient hydrops fetalis
No full textCilingir, I. Uzun (Trakya Author)
Sayin, Niyazi Cenk (Trakya Author)
Gurkan, H.(Trakya Author)
Ciftdemir, N. A. (Trakya Author)
Atli, E. (Trakya Author)
Inan, C. (Trakya Author)
Erzincan, S. (Trakya Author)
Sutcu, H. (Trakya Author)
Vatansever, U. (Trakya Author)
Varol, Fusun (Trakya Author)Macro Domain Containing 2 (MACRO D2) gene is a gene from macro family which is highly expressed in the ventriculer zone of the brain during embryonic development. Association between Autism spectrum disorders and MACRO D2 gene polymorphisms has been reported before [1] . Deletion in MACRO D2 gene has also been associated with Kabuki Syndrome which is a well described congential anomaly syndrome [2]
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