719 research outputs found
Sleep, executive functioning and behaviour in children and adolescents with type 1 diabetes
No full textAbstract not availableNicole C. Caruso, Branka Radovanovic, J. Declan Kennedy, Jennifer Couper, Mark Kohler, Phillip S. Kavanagh, A. James Martin, Kurt Lushingto
The dark side of love : love styles and the Dark Triad
No full textLittle work has examined the manner in which the Dark Triad may function in relationship contexts. In this online, international study (N = 302), we correlated the Dark Triad with love styles. Individuals who scored high on the Dark Triad appear to have a ludus – game playing – and a pragma – cerebral – love style. Game playing may allow these individuals to keep others at an emotional distance to maintain their short-term mating style. The Dark Triad composite partially mediated the gender difference in the adoption in the ludus love style, suggesting that the psychological systems that underlie this love style may relate to the adoption of an agentic social style. Similarly, loving with one’s head and not one’s heart may be an expression of the limited empathy/emotional systems characteristic of these individuals
DNA binding, cleavage and cytotoxicity of a novel dimetallic Fe(III) triaza-cyclononane complex
Full text linkA novel bimetallic Fe(III) complex with the bis(triaza-cyclononane) ligand 2,6-bis(1,4,7-triazacyclonon-1-ylmethyl)-4-methylphenol (bcmp) is reported. [Fe2{bcmp(-H)}(μ-OH)Cl2]Cl2 (2) contains two octahedral Fe(III) centers bound to the two triaza-cyclononane rings of bcmp. The coordination sphere is completed by one chlorine, one bridging phenolate oxygen and one bridging hydroxide group. The complex has been characterized by elemental analysis, Mössbauer spectroscopy, UV–Vis spectroscopy, pH potentiometric titration, ESI mass spectrometry and cyclic voltammetry. The complex hydrolyzes the DNA model bis(2,4-dinitrophenyl) phosphate (BDNPP) with a maximum activity a pH 7. Michaelis–Menten behavior is observed with kcat = 3.56 × 10−4 s−1 and Km = 0.56 mM (pH 7.0, 40 °C). The interaction of 2 with CT DNA was studied by electronic absorption spectroscopy and gel electrophoresis. Notably, the complex relaxes supercoiled pUC19 DNA into the nicked form at low micromolar concentration (10 μM) in the presence of an external reducing agent (ascorbic acid). Finally, the in vitro antiproliferative activity of 2 was assessed on a panel of human cancer cell lines and results revealed that the complex exhibited a significant cytotoxic effects in particular versus colon LoVo cancer cells, wih IC50 value 2.5 times lower than that shown by the reference metallodrug cisplatin (3.54 versus 8.53 μM).</p
The Dark Triad, schadenfreude, and sensational interests : dark personalities, dark emotions, and dark behaviors
No full textThis research examined the associations between the Dark Triad traits (i.e., narcissism, Machiavellianism, and psychopathy), sensational interests, and schadenfreude. One-hundred and eighty-six adults completed an online survey comprising the Dirty Dozen, the Sensational Interests Questionnaire Revised, and an author-generated measure of expressed schadenfreude. Higher levels of the Dark Triad were associated with higher levels of sensational interests and higher levels of schadenfreude; psychopathy was the most strongly related to both. These findings suggest a cluster of "dark" personalities, behaviors, and emotions. That is, those higher on the Dark Triad engage in more antisocial activities and experience greater satisfaction at the misfortune of others. Implications for future research are discussed
Book Review: Strategia: A Primer on Theory and Strategy for Students of War
Full text linkAuthor: Charles S. Oliviero
Reviewed by Phillip Dolitsky, master’s student at the School of International Service, American University
Strategia: A Primer on Theory and Strategy for Students of War poses the question “What is the true nature of war?” According to the author, even after studying war for 2,000 years, it is still misunderstood. Topics include war on land, war at sea, and war in the air. The reviewer notes that several relevant strategists names are noticeably absent from the work, including J. C. Wylie, Raymond Aron, Colin S. Gray, and Edward N. Luttwak, and even Thucydides.https://press.armywarcollege.edu/parameters_bookshelf/1022/thumbnail.jp
Defining indigenous plants: some problematic species from Norfolk Island
No full textDefining indigenous species may at first appear straight forward; most botanical texts provide similar definitions. The consistent requirement of such definitions is the lack of human intervention in the occurrence of the species within the area under consideration. Islands around the world have been invaded by plant species brought to their shores by humans. They are also places where self-introduced species can be continually arriving, as they have done for millennia. Scrutiny of the situation on Norfolk Island (1200 km east of Australia) finds that the distinction between indigenous and introduced taxa is sometimes unclear. There is also inconsistency regarding the acceptance of self-introduced species as indigenous. This paper explores these issues and notes that they are more important than idle botanical curiosity, because control of introduced (weed) species is a major area of activity in managing protected natural areas
Basic values and the Dark Triad traits
No full textIn samples from America, Brazil, and Hungary (N = 937), we examined the associations between the Dark Triad traits (i.e., narcissism, psychopathy, and Machiavellianism) and individual differences in excitement(i.e., valuing personal enjoyment), promotion (i.e., valuing achievements), existence (i.e., valuing physical survival), suprapersonal (i.e., valuing abstract ideas), interactive (i.e., valuing social relationships), and normative (i.e., valuing cultural norms) values. The traits were associated with the values of excitement and promotion, psychopathy was associated with a diminished emphasis on existence, psychopathy and Machiavellianism were associated with limited interactive or normative values, whereas narcissism was associated with a greater emphasis on suprapersonal, interactive, and normative values. We also found that sex differences in psychopathy were mediated by individual differences in the existence and normative values. Results are discussed from a life history framework
Education, safe drinking practices and fetal alcohol spectrum disorder in the Kimberley region of Western Australia
No full textThere are alarming rates of fetal alcohol spectrum disorder (FASD) in the Kimberley region of Western Australia despite numerous international studies demonstrating the links between alcohol consumption during pregnancy and FASD. The aim of this research was to help determine factors that may be associated with correct knowledge about safe drinking practices during pregnancy, with these factors used to help inform future interventions
Strategy for identification of novel fungal and bacterial glycosyl hydrolase hybrid mixtures that can efficiently saccharify pretreated lignocellulosic biomass
No full textWe have applied a rational four-step strategy to identify novel bacterial glycosyl hydrolases (GH), in combination with various fungal enzymes, in order to define an efficient enzyme cocktail to hydrolyze pretreated lignocellulosic biomass. The fungal cellulases include cellobiohydrolase I (CBH I; GH family 7A), cellobiohydrolase II (CBH II; GH family 6A), endoglucanase I (EG I; GH family 7B) and ß-glucosidase (ßG; GH family 3). Bacterial endocellulases (LC1 and LC2; GH family 5), ß-glucosidase (LßG; GH family 1), endoxylanases (LX1 and LX2; GH family 10) and ß-xylosidase (LßX; GH family 52) from multiple sources were cloned, expressed and purified as well. Enzymatic hydrolysis for various enzyme combinations was performed on Ammonia Fiber Expansion (AFEX) treated corn stover at various total protein loadings (30, 15 and 10 mg enzyme/g glucan). The optimal mass ratio of enzymes necessary for obtaining high glucan and xylan yields was determined using a suitable mixture design of experiments. The optimal hybrid enzyme mixtures contain fungal cellulases (78% of total protein loading), which include CBH I (loading ranging between 9-51% of total enzyme load), CBH II (9-51%), EG I (10-50%), and bacterial hemicellulases (22% of total protein loading) comprising of LXl (13%) and LßX (9%). The hybrid mixture works effectively at 50 °C and pH 4.5 to efficiently saccharify AFEX treated corn stover giving as high as 95% glucan and 65% xylan conversion, respectively. This strategy of screening enzyme mixtures on pretreated lignocellulose will ultimately help develop enzyme cocktails that can hydrolyze plant cell walls efficiently and economically to produce cellulosic ethanol.The final publication (Version of Record) is available at Springer via http://dx.doi.org/10.1007/s12155-009-9066-
Mass photometry enables label-free tracking and mass measurement of single proteins on lipid bilayers
Full text linkData for the manuscript ''Mass photometry enables label-free tracking and mass measurement of single proteins on lipid bilayers" (collected between September 2019 and May 2021). The data were collected using the AcquireMP software (Refeyn Ltd) and processed using custom Python software, which is required to read and process the data (available on request to the corresponding author of the manuscript: [email protected]). The data is split into individual .zip files each of which contain a spread sheet titled 'Raw_data_guide.xlsx' that links each folder and data set to the corresponding figure in the manuscript
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