1,720,989 research outputs found
Cellular and Molecular Mechanisms that Distinguish the Effects of Progestorone and Medroxyprogesterone Acetate on Neuroprotection
No full textKaur, Paramjit. Cellular and Molecular Mechanisms That Distinguish the Effects of Progesterone and Medroxyprogesterone Acetate on Neuroprotection., Doctor of Philosophy, (Pharmacology and Neuroscience), July, 2006, 203 pp., 5 illustrations, 20 figures and bibliography. Women have a higher prevalence for Alzheimer’s disease (AD) than men, suggesting that the precipitous decline in gonadal hormone levels following the menopause may contribute to the risk of developing AD. However, principal results from the Women’s Health Initiative concluded that women taking conjugated equine estrogens combined with medroxyprogesterone acetate (MPA, tradename: Prempro) incurred more harmful than beneficial outcomes versus the placebo group (Rossouw et al., 2002). This dissertation was aimed at determining if the discrepancy between basic science reports and these clinical studies could have been due to the synthetic progestin, MPA. I hypothesized that P4 and MPA differed in their ability to protect against the excitotoxic/oxidative insult, glutamate. Further, I proposed that this difference in neuroprotective potential would be reflected in the difference in the ability of these hormones to elicit key effectors of two neuroprotection-associated signaling pathways, the ERK/MAPK and P13-Kinase pathways. Finally, studies were initiated to evaluate the potential importance of BDNF (brain-derived neurotrophic factor) in mediating the protective effects of P4. I used organotypic explants of the cerebral cortex, and found that both P4 and MPA elicit the phosphorylation of ERK and Akt, two signaling pathways implicated in neuroprotection, with maximal phosphorylation occurring at a concentration of 100 nM. Interestingly, P4 protected against glutamate- induced toxicity however, while an equimolar concentration of MPA (100nM) did not. Further, P4 resulted in an increase in BDNF, while MPA did not. Our data bring into question the relevance of using MPA as a component of hormone therapies in postmenopausal women, and instead, argue that the relevant progestin for use in treating brain-related disorders is progesterone. Collectively, the data presented here suggest that P4 is protective via multiple, and potentially related mechanism, and importantly, its neurobiology is different from the clinically used progestin, MPA
Management of mites with homemade neem fruit aqueous extract in capsicum under protected cultivation
No full textBhullar, Manmeet Brar, Kaur, Paramjit, Kumar, Sanjeev, Sharma, Rakesh Kumar, Kumar, Rajinder, Kumari, Suman, Singh, Vinay, Kaur, Arshdeep, Kaur, Jagdeep, Sharma, Urvi, Kaur, Jasjinder (2021): Management of mites with homemade neem fruit aqueous extract in capsicum under protected cultivation. Persian Journal of Acarology 10 (1): 85-94, DOI: 10.22073/pja.v10i1.61968, URL: https://www.mendeley.com/catalogue/f143dbd7-151b-317f-a54c-e05015597a71
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Health behaviour of school-aged children in Punjab, India
No full textAim. To analyze the profile health behaviour in school aged children in Punjab, India. Objectives. To analyze the profile health behaviour (nutrition, low physical activity, smoking, use of alcohol and perceived health evaluation by gender; To compare and analyze health behaviour of school children in urban and rural schools in Punjab. To compare the profile of lifestyle of students in Punjab with students of other countries (seven reference HBSC network countries). Methods. The data on health behaviour analysed below were collected in a school-based, cross-sectional, anonymous survey conducted during December 2016 in 2 different schools in Punjab (India). the sample of students covered 6 to 10 grade students (5 classes) in one public school in the rural area (n=150) and in one private school (n=150) in urban area. in total 300 students aged 13 to 17 years took part in the survey. questionnaire forms were distributed by the author of this research to students in each classroom. it was explained shortly to respondent’s methodology of filling in the questionnaire forms. questionnaire comprised 45 questions regarding respondents the main demographical data (gender, age, place of residence) and health behaviours – perceived health, illness and health complaints, unhealthy behaviours (smoking, alcohol)eating habits, physical activity, leisure time, injury behaviour, relations with family and peers, school related behaviour. Results.Majority of school children from Punjab state, India, aged 13-17 years reported good and excellent their perceived health condition. boys have demonstrated better perceived health scores than girls (91.5% vs. 77, 4%, respectively, p0.05). in overall, boys reported eating fruits less frequently in comparison to girls (22.6% vs. 34.6%, respectively, p<0.05). girls reported higher frequency of sweets use, but boys showed higher consumption of soft drinks on every day basis (p<0.05). data showed that boys were more physically active than girls. only few percent of school-aged boys and girls have reported smoking and alcohol drinking behaviour in Punjab. it was established that urban students were less likely to eat breakfast everyday (71.6% and 85.8%, p<0.05) in comparison with rural students. urban students consumed more fruits but less vegetables every day (p<0.05). study showed that urban students (85.6 %) reported good and excellent health more frequently than rural (77,4%) school children (p<0.05). comparison of health behaviour of students aged 13-17 years in Punjab and seven selected HBSC countries (Lithuania, Sweden, Italy, Spain, Wales, Canada, Scotland) showed that some relatively small differences exist between school students in Punjab and HBSC countries. Conclusions. The general profile of health behaviour in school-aged children aged 13-17 years in Punjab, India, presented by this study. small percentage of alcohol users and weekly smokers was established among students in Punjab. Relatively small differences were demonstrated between school students in Punjab and students in seven HBSC countries (2014 survey data compared)
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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