120 research outputs found
Clinical Research Authorships: Ethics and Problem-Solving
No full textThe article helps resolve the intricate authorship issue based on global organizations’ regulations. It draws a fine line between authorship and contributorship from the research ethics perspective.L’article aide à résoudre la question complexe de la paternité des oeuvres en se basant sur les réglementations des organisations mondiales. Il établit une distinction précise entre la paternité et la contribution du point de vue de l’éthique de la recherche
The impact of water vapor thermal therapy of the prostate (rezūm) on sexual functions: a narrative review
No full textBackground: Senile prostate enlargement is an age-related condition. Many sexually active patients fear formal prostate surgeries owing to their negative impact on sexual performance. Minimally invasive procedures, including prostate water vapor thermal therapy (Rezūm®), were devised to make ends meet. This study aims to present a comprehensive narrative synthesis about the impact of prostate water vapor therapy on sexual functions.
Methods: A narrative literature review was performed in May 2023, using MEDLINE, Cochrane Library, Ovid-Embase, Scopus, Science Direct, and Google Scholar; for the MeSH term “rezum AND sexual functions”. Selected reports were published articles from 2018 to date (the last 5 years). Only open-access journals in English were analyzed. Efforts were made to focus on the 2 main domains of sexual functions; erection and ejaculation.
Results: As per the concise MeSH term “rezum AND sexual functions”, a score of 207 hits appeared on the initial search. After eliminating duplicate and irrelevant papers, only 7 articles fulfilled the inclusion criteria and were subjected to analysis. The analyzed articles were critically appraised to point out the studies` strengths and limitations. The gathered data were found to be consistent with one another as no outliers were detected.
Conclusion: Water vapor thermal therapy of the prostate showed satisfying preservation of erectile function with minimal ejaculatory dysfunction
Research ethics challenges during the COVID-19 pandemic: what should and what should not be done
No full textThis article is directed primarily at how clinical trials can be ethically conducted in the midst of the current global COVID-19 pandemic. We explain why ethical issues are more complicated than they once were. Furthermore, we discuss the relevant parties` roles in protecting participants` rights and in keeping basic research ethics of justice, respect, equity, and beneficence strongly implemented on the ground.
References
Moorthy V, Restrepo H, Preziosi MP, Swaminathan S. Data sharing for novel coronavirus (COVID-19). Bull World Health Organ. 2020; 98: 150. http://dx.doi.org/10.2471/BLT.20.251561
Angus DC. Optimizing the trade-off between learning and doing in a pandemic. Epub ahead of print, 2020. https://doi.org/10.1001/jama.2020.4984)JAMA
Park YR, Koo H, Yoon YK, Park S, Lim Y-S, Baek S, et al. Expedited Safety Reporting to Sponsors Through the Implementation of an Alert System for Clinical Trial Management at an Academic Medical Center: Retrospective Design Study. JMIR Med Inform. 2020;8(2): e14379. https://doi.org/2196/14379.
Bae J, Lee J, Jang Y, Lee Y. Development of simulation education debriefing protocol with faculty guide for enhancement clinical reasoning. BMC Med Educ. 2019;19(1):197. https://doi.org/10.1186/s12909-019-1633-8.
Cox EM, Edmund AV, Kratz E, Lockwood SH, Shankar A. Regulatory Affairs 101: Introduction to Expedited Regulatory Pathways. Clin Transl Sci. 2020;13(3):451‐ https://doi.org/10.1111/cts.12745. Epub 2020 Feb 6.
Rivenbark JG, Ichou M. Discrimination in healthcare as a barrier to care: experiences of socially disadvantaged populations in France from a nationally representative survey. BMC Public Health. 2020;20(1):31. https://doi.org/1186/s12889-019-8124-z
Arsenijevic J, Tummers L, Bosma N. Adherence to Electronic Health Tools Among Vulnerable Groups: Systematic Literature Review and Meta-Analysis. J Med Internet Res. 2020;22(2): e11613. https://doi.org/2196/11613
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Deming D. Do extraordinary claims require extraordinary evidence? Philosophia (Ramat Gan). 2016;44(4):1319‐ https://doi.org/10.3389/fpsyg.2011.0011
Emphysematous epididymo-orchitis with involvement of the prostate, seminal vesicles, and the scrotum: a case report
No full textEmphysematous epididymo-orchitis is a rare clinical entity. Up until July 2020, only 9 cases have been reported in PubMed and Scopus platforms, one of which also had scrotal involvement. Therefore, we are reporting the second case with prostate, seminal vesicle, and scrotal involvement. The condition represents an aggressive form of infection caused by gas-forming microbes. The radiological detection of air within the organs involved in the characteristic diagnostic sign. The case we are reporting is a 47 years old diabetic, chronic renal failure patient on regular hemodialysis who had a fulminant emphysematous infection in the left testis, epididymis, spermatic cord, the prostate, seminal vesicles, and the scrotum. Emergency orchiectomy has been carried out. The most significant part of the case is the pictures showing ballooning scrotum and gas bubbles in abnormal anatomical locations
Measuring microfinance access : building on existing cross-country data
No full textGiven the acknowledged need for a new effort to expand the set of available data on direct access to financial services, including a focus on access by those at low income, Honohan provides a selective review of the diverse sources of data that exist and considers how best to build on them. He proposes a basic framework within which to consider the analysis of the interesting questions: (1) How does access affect poverty and productivity? and (2) What hinders access? The author discusses existing and potential contribution of household and business user surveys, surveys of providers and their regulators, and surveys of experts, and assesses their relative strengths.Banks&Banking Reform,Environmental Economics&Policies,Health Economics&Finance,Poverty Assessment,Governance Indicators
Primary testicular lymphoma in undescended testis of a middle-age man: a case report
No full textBackground: Primary testicular lymphoma (PTL) is an uncommon and aggressive form of extra-nodal non-Hodgkin lymphoma (NHL), accounting for <5.0% of testicular malignancies and 1.0% to 2.0% of NHL cases with a median age at diagnosis of 66 to 68 years. PTL accounts for 1–9% of testicular malignancies and 1–2% of NHLs. There are a handful of described lymphomas in the literature affecting normally positioned testis of aged men, yet none were reported in a cryptorchid middle-aged man. PTL is an extremely aggressive malignancy with poor progression-free survival and overall survival.
Case presentation: A 47-year-old man presented to the urology clinic complaining of multiple painless swellings in the neck and groins. He also complains of back pain, drenching night sweats, a swollen right lower limb, constipation, anorexia, weight loss, and occasional vomiting. The illness\u27s duration is 2 months. He had a right inguinal testis. Histology examination of the excised testis and lymph nodes revealed an advanced “diffuse large beta-cell lymphoma” in both. The patient was referred for oncology care.
Conclusion: It is an extremely rare case of Diffuse Large B-Cell Lymphoma (DLBCL) in the undescended testis of a middle-aged man. To the best of our knowledge, this is the first published case of its kind about the tumor\u27s type, testis anomaly, and patient\u27s age
A massive benign prostate delivered intact: a case report
No full textBackground: Benign prostatic enlargement (BPH) is an age-related condition. Males above the age of 40 years commonly experience lower urinary tract symptoms (LUTS) related to the progressively growing prostate. BPH is coined by a deterioration in the quality of the patient`s life. Medicines along with advanced surgical procedures may not be suitable for treating oversized prostate glands.
Case presentation: A 84-years-old man presented to the urology clinic with severe LUTS that are getting worse over 2 years. He was never catheterized. Medicinal treatments failed to alleviate the symptoms. He has no past medical or surgical history of significance. Prostate ultrasonography revealed a huge prostate of 340cc. He underwent open prostatectomy and enjoyed an uneventful post-operative hospital stay. Histology showed a benign nodular prostatic hyperplasia.
Conclusion: This case presents one of the largest prostates reported in the literature
Interleaved Multilevel Boost Converter With Minimal Voltage Multiplier Components for High-Voltage Step-Up Applications
No full textIn this article, a new interleaved multilevel boost converter (interleaved-MBC) is suggested with minimal voltage multiplier (VM) cells for high-voltage step-up applications. The interleaved-MBC is derived in such a way that the maximum utilization of the VM circuit operation can be achieved by the interleaved structure. Furthermore, compared to existing multilevel interleaved converters, the reduced number of capacitors and diode with equal voltage rating makes it more attractive. Similar to the existing multilevel converter, the feature of the interleaved-MBC provides the extension of the number of levels to achieve the necessary voltages just by adding similar capacitor-diode stages (single capacitor and single diode are required to increase the stage by one). The features like continuous input current, low-input ripples, high voltage conversion ratio, and reduced stress on devices make the proposed converter more suitable for the voltage step-up applications, such as dc link, hybrid distribution systems, hybrid photovoltaic systems, etc. The detailed analysis of the converter is carried out by considering the nonidealities in the power circuit. The operation of the interleaved-MBC is presented for continuous and discontinuous conduction modes with boundary conditions. The components selection criterion and the comparison of converters are presented with suitable discussions. The converter is experimentally tested, and the obtained results validate its performance and functionality.Manuscript received October 5, 2019; revised January 11, 2020 and March 20, 2020; accepted April 20, 2020. Date of publication May 5, 2020; date of current version July 31, 2020. This work was supported in part by the Qatar National Library, Doha, Qatar, and in part by the Qatar National Research Fund, Qatar Foundation, under NPRP Grant X-033-2-007. Recommended for publication by Associate Editor Y. Siwakoti. (Corresponding author: Atif Iqbal.) Mohammad Meraj, Atif Iqbal, and Nasser Al-Emadi are with the Department of Electrical Engineering Qatar University, Doha, Qatar (e-mail: Meraj@ qu.edu.qa; [email protected]; [email protected]).Scopu
Optimization of Kiln Feed Yield through an Analysis of Drilling and Blasting Parameters in a Quarry
No full textBlasting and drilling serves as an essential element for a mining operation to excel. Optimization of this operational aspect, requires consideration of various parameters that can be controllable or uncontrollable. To overcome the tediousness of analyzing each element selectively, some major parameters are outlined, and each blast is rendered relative to the other, by organizing the data from each blast design and integrating it in an empirical model called Kuz-Ram Model, which further can be used for predicting the impact of these parameters on fragmentation. Image analysis aids in validating the model credibility for using it as step forward for proposing alterations to the current practices in drilling and blasting area. Each image is processed with the help of Unmanned Aerial Vehicle, for safety and coverage of complete muck-pile. The study involves in depth focus on the impact of rock mass characteristic over fragmentation as well. Discontinuities, fractures, joint orientation and fillings are considered in designating each rock zone to specific class with the help of a geo-mechanical classification system called, Rock Mass Rating. To test the theory, an exercise is performed by separating two zones of variable rock mass properties and then the procedure is followed with empirical calculation, image analysis and supported by preferential loading to acquire a broad image of each zone fragmentation profile. Suggesting the variation in particle size distribution due to rock mass influence. The collected data and analyses shall serve as supporting tools for changes to blast design for obtaining desired fragmentation, which is synonymous to increasing the feed of kilns.Applied Earth Sciences | European Mining Cours
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