1,721,045 research outputs found
Nanoparticle of the core-shell type suitable for delivering therapeutic oligonucleotides to target tissues and the use thereof for the preparation of a medicament for treating duchenne muscular distrophy
No full textA nanoparticle of the core-shell type is described, which is suitable for delivering therapeutic oligonucleotides into muscle fibers, particularly antisense oligoribonucleotides capable of restoring, in all or in part, the expression of the dystrophin protein by the exon skipping mechanism, and thus effective in the treatment of Duchenne muscular dystrophy. Moreover, a nanoparticle/oligonucleotide complex effective in the treatment of Duchenne muscular dystrophy is described
Photoactive spherical colloids for opal photonic crystals
No full textThe synthesis and characterization of submicrometersized
polymer particles, functionalized by different
techniques with fluorescent dyes and featuring tunable
surface charges, are described. Dyes with a polymerizable
moiety were incorporated during emulsifier-free
or seeded emulsion polymerization, whereas nonpolymerizable
dyes were included into preformed
nanoparticles by a swelling and deswelling process.
The particle surface charge was controlled through the
choice of suitable initiators. All the nanoparticles were
successfully used to grow high optical quality opal
photonic crystals by the vertical deposition technique.
Optical characterization of such photonic crystals
pointed out the presence of the optical stop band and
the high-energy van Hove-like structures, both scaling
with the particle diameter according to the scaling
laws of photonic crystals and possessing the expected
angular dispersion. These results are indicative of the
high size uniformity and of the surface quality of the
nanospheres independently on the synthetic method
adopted. Preliminary data seem to suggest some effect
of the opal photonic band structure on the dye fluorescence
spectra
DISPOSITIVO FOTOVOLTAICO A CONCENTRAZIONE IBRIDA – HYBRID CONCENTRATED PHOTOVOLTAIC DEVICE
No full textHybrid concentrated photovoltaic device comprising: (i) at least one luminescent solar concentrator (LSC) having the shape of a polygonal, circular, or elliptical plate, comprising at least one photoluminescent compound having a spectral range of absorption and a spectral range of emission ; (ii) at least one micrometric or sub-micrometric dielectric photonic structure, optically coupled to said luminescent solar concentrator (LSC), said micrometric or sub-micrometric dielectric photonic structure being able to induce diffusion and/or diffraction of sunlight, preferably diffraction, within said luminescent solar concentrator (LSC), in a spectral range where there is no absorption of said photoluminescent compound; (iii) at least one photovoltaic cell positioned on the outside of at least one side of said luminescent solar concentrator (LSC). The aforementioned hybrid concentrated photovoltaic device may advantageously be incorporated in buildings and dwelling (for example, in photovoltaic windows, both indoor and outdoor). Moreover, said hybrid concentrated photovoltaic device may also be used advantageously as a functional element in urban and transport contexts (for example, in photovoltaic noise barriers, in photovoltaic wind breaks)
IN VITRO AND IN VIVO ANTINEOPLASTIC EFFECTS OF A NOVEL PLATINUM BIOCONJUGATE USING A BIOCOMPATIBLE POLYMERIC MATRIX.
No full textPoly(methylmetacrylate) (PMMA) core-shell nanospheres act as efficient pharmacophores for the antiproliferative [PtCl3(NH3)]- complex by forming ionic couples.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
