3,179 research outputs found
Supplemental_materials-10292018 – Supplemental material for The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity
No full textSupplemental material, Supplemental_materials-10292018 for The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity by Xiaobin Huang, Leilei Zhong, Eefje van Helvoort, Floris Lafeber, Simon Mastbergen, Jan Hendriks, Janine N. Post and Marcel Karperien in CARTILAGE</p
CAPRI versus AGLINK-COSIMO: Two partial equilibrium models - Two baseline approaches
Get PDFThe agricultural modelling world has generated several models aiming at the analysis of the response of the sector to certain changes in exogenous mainly policy variables. Among those, the CAPRI modelling system developed by a consortium centred on the University of Bonn and the AGLINK-COSIMO model, a joint product of the OECD and the FAO, are well known and accepted as comprehensive tools. This analysis focuses on a qualitative comparison of both models and particularly on the process of setting up the baseline. The baseline is a medium-term projection of agricultural markets reflecting current policies and those already decided upon. This projection in turn serves as the base for comparisons when analyzing scenarios. It is shown that CAPRI uses generic and automatic procedures whenever possible for conducting the database and the baseline, while AGLINK-COSIMO puts more emphasis on expert knowledge in this process. Both approaches are shown to have certain advantages while the conclusion that a combination of them would potentially improve both models will be drawn from this analysis.CAPRI, AGLINK-COSIMO, Baseline process, Agricultural and Food Policy,
Osteoarthritis: Control of human cartilage hypertrophic differentiation. Research highlight van: Gremlin1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis
Get PDFDisruption of articular cartilage homeostasis is important in osteoarthritis (OA) pathogenesis, key to which is activation of articular chondrocyte hypertrophic differentiation. Healthy articular cartilage is resistant to hypertrophic differentiation, whereas growth-plate cartilage is destined to differentiate in this way: could genetics explain these differences and possibly lead to a better understanding of the pathophysiology of OA? Research by Marcel Karperien and colleagues now identifies the bone morphogenetic protein antagonist Gremlin 1 (GREM1), as well as Frizzled–related protein (FRZB) and Dickkopf-related protein 1 (DKK1)—two Wnt antagonists—as natural brakes on hypertrophic differentiation in healthy cartilage. Whole-genome expression microarray analysis of donor-paired healthy human articular and growth-plate cartilage revealed that expression levels of 35 genes differed more than 5-fold between the tissues. Most differentially expressed were GREM1, FRZB and DKK1—all overexpressed in articular cartilage compared with growth-plate cartilage—as confirmed by immunohistochemistry. Image courtesy of M. Karperien. Mouse tibiae (midsagittal sections) cultured for 7 days with recombinant Grem1, Frzb and Dkk1 have an increased resting zone.Next, the investigators showed that recombinant GREM1, FRZB or DKK1 could inhibit terminal hypertrophic chondrocyte differentiation and mineralization of chondrogenically-differentiating human mesenchymal stem cells, without affecting chondrogenesis. Also, Grem1, Frzb and Dkk1 inhibited endochondral ossification in mouse explanted tibiae. So, if GREM1, FRZB and DKK1 control hypertrophic chondrocyte differentiation in healthy articular cartilage are the genes encoding these proteins associated with OA risk? Associations between single nucleotide polymorphisms (SNPs) in or near GREM1 and DKK1 and radiographic hip or knee OA were investigated in two population-based cohorts. SNP-rs12593365, located in a genomic control region of GREM1, was associated with a 20% reduced risk of radiographic hip OA. “We succeeded in identifying specific markers to distinguish growth plate cartilage from articular cartilage and identified a mechanism likely to be involved in the regulation of articular cartilage homeostasis”, explains Karperien. “This new area of research may lead to new diagnostic markers for OA and hopefully new routes for therapeutic intervention.
After the Addendum: Author Rights Management and/as Library Service
No full textThis report presents the findings from a qualitative study of Rice University faculty attitudes and practices around author rights conducted by Marcel LaFlamme, a graduate student in the Department of Anthropology, during his tenure as a Fondren Fellow. This project was supervised by Shannon Kipphut-Smith, Fondren Library’s scholarly communications liaison
Ruskin traduzido: Sesame and Lilies por Proust e Catalán
Get PDFTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Literatura, Florianópolis, 2009.Este trabalho parte da análise das traduções da obra Sesame and Lilies, de John Ruskin, para o francês e para o castelhano para fazer um exame de questões ligadas ao gênero ensaístico, à tradução de ensaios e à autoria. Para isso, analisarei a tradução de Marcel Proust para o francês e seu paratexto e a tradução para o castelhano feita por Miguel Catalán e o respectivo paratexto.This study analises the translations of Sesame and Lilies, by John Ruskin, into French and Spanish in order to examine issues related to the essay as a literary genre, to the translation of essays and to authorship. This exam will be carried out by analising the translation into French by Marcel Proust and its paratext and the translation into Spanish by Miguel Catalán, accompanied by its paratext
Jean-Marcel Jeanneney à l'OFCE - Fondations et contributions (1981-1989).
Get PDFJean-Marcel Jeanneney était un économiste rare, à la fois théoricien, empiriste et praticien. C’est son aventure à la tête de l’OFCE que ce livre raconte, ou plutôt qu’il laisse l’auteur lui-même conter au travers d’articles écrits depuis le premier jour de son premier mandat de Président de notre institution. Ce recueil s’ouvre sur une introduction qui rappelle l'attachement du fondateur de l’OFCE au « libéralisme intellectuel», cette indépendance vis-à-vis des idées reçues qu’il jugeait indispensable à la conduite de politiques publiques raisonnables. Il est ensuite structuré en trois parties dont les titres font écho à une oe uvre marquante de Jean-Marcel Jeanneney : Vouloir le débat public en économie, Une mémoire au service de la prospective et Écoute le monde qui vient : intégration globale et unification européenne. Ce volume est un hommage à la mémoire de Jean-Marcel Jeanneney mais plus encore à sa présence. Les textes rassemblés ici par Jean-Paul Fitoussi et Éloi Laurent nous rappellent l’actualité des enseignements les plus précieux de Jean-Marcel Jeanneney : honnêteté, courage et espérance.
Aggregation and Gelation Behavior of Stereocomplexed Four-Arm PLA-PEG Copolymers Containing Neutral or Cationic Linkers
Get PDFPoly(lactide) (PLA) and poly(ethylene glycol) (PEG)-based hydrogels were prepared by mixing phosphate buffer saline (PBS, pH 7.4) solutions of four-arm (PEG-PLA)2-R-(PLA-PEG)2 enantiomerically pure copolymers having the opposite chirality of the poly(lactide) blocks. Dynamic Light Scattering, rheology measurements, and fluorescence spectroscopy suggested that, depending on the nature of the linker R, the gelation process followed rather different mechanisms. In all cases, mixing of equimolar amounts of the enantiomeric copolymers led to micellar aggregates with a stereocomplexed PLA core and a hydrophilic PEG corona. Yet, when R was an aliphatic heptamethylene unit, temperature-dependent reversible gelation was mainly induced by entanglements of PEG chains at concentrations higher than 5 wt.%. When R was a linker containing cationic amine groups, thermo-irreversible hydrogels were promptly generated at concentrations higher than 20 wt.%. In the latter case, stereocomplexation of the PLA blocks randomly distributed in micellar aggregates is proposed as the major determinant of the gelation process
Some Marks in Marcel Iancu’s Creation
Get PDFThe paper emphasises some aspects of Marcel Iancu’s creation during his dadaist period in Zürich and after his return in Romania where he was one of avant-garde movement leaders and author of some important theoretical articles
Data for: Author Ranking Evaluation at Scale
No full textThis data consists of two test data sets of researchers that have (1) received one or more prestigious prizes for the long-lasting and high impact contribution to their fields (596 data entries) and (2) author names of ACM fellows (1000 data entries).Each author in the data sets is matched to the corresponding ACM author profileID and multiple Microsoft Academic Graph author entity IDs (name disambiguated). It also includes citation counts, publication counts, download counts from various sources (ACM Digital Library, Google Scholar, Microsoft Academic)
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