17 research outputs found
Male Breast Cancer: An Updated Review of Patient Characteristics, Genetics, and Outcome
No full textMale breast cancer (MBC) is a rare entity, underrepresented in population studies and clinical trials, resulting in management of MBC to be informed by current research on female breast cancer (FBC). A literature review was conducted by accessing relevant articles on 2 databases, by searching keywords “male breast cancer”. A total of 29 articles from year 2011 to 2022 were selected for this review. The authors found that male breast cancer generally occurs later in life with higher stage, higher grade, and more estrogen receptor (ER) positive tumours. Most of the studies noted the mean age for MBCs at the time of presentation as >60 years. Risk factors for male breast cancer include family history, obesity, lower physical activity, and syndromes like the Klinefelter syndrome. Positive family history is much higher in MBC compared to FBC (30.9 vs. 18.4%). BRCA 2 cancers constitute a higher proportion compared to FBCs. A lot of genetic mutations have been observed. Some show promise to assess disease-specific survival and proliferative rate like TWIST1 and RUNX3, among others. MBCs usually present with a palpable lump in central region, with a bigger size and chance of nodal involvement and metastasis compared to FBCs. They are mostly infiltrating ductal type and hormone receptor positive, with worse histological grade. Treatment usually follows the same principles as FBCs (systemic therapy, surgical excision, and radiotherapy), with poorer prognosis to same treatment approach, possibly owing to its advanced stage at presentation. This is a rare entity which requires further research to ascertain need for different management approach than FBCs
Speculum Quaestionum moralium, in universam Aristotelis philosophi summi Ethicen
No full textIoanne Caso Oxoniensi ... author
Prevalence and impact of endocrine disorders in advanced metastatic cancer patients undergoing cancer‐directed therapy: A prospective observational study
No full textAbstract Background Noncommunicable diseases (NCDs) contribute significantly to global morbidity and mortality, with cancer being one of the leading causes. In this prospective observational study, we aimed to investigate the prevalence and impact of endocrine disorders, specifically diabetes and thyroid dysfunction, in patients with advanced metastatic cancer undergoing cancer‐directed therapy. Methods Over 15 months, we recruited 100 histologically proven advanced metastatic cancer patients from the Department of Medical Oncology Haematology, All India Institute of Medical Sciences, Rishikesh, and conducted institutional‐based prospective observational study. All participants over 18 years of age, treatment‐naive, and potential candidates for systemic chemotherapy with an expected clinical survival of at least 6 months were included in the study. Patients with prior therapy, secondary neoplasms, and those unable to complete 3 months of palliative chemotherapy were excluded. Patients were assessed for diabetes and thyroid function at presentation, after 3 and 6 months of cancer‐directed standard therapy. These data were analyzed, processed, and presented as results. Results The mean age of participants was 50.45 years, with a near‐equal distribution of males and females. At baseline, 10% of the study population had preexisting endocrine disorders (2% hypothyroidism, 8% diabetes). By the end of 6 months, the prevalence increased to 18%, with females being more affected. Notably, the prevalence of new‐onset endocrine disorders during cancer‐directed therapy was only 3% for diabetes and 4% for thyroid dysfunction. Conclusion Analysis of sociodemographic and cancer‐related characteristics showed no significant association with changes in diabetic and thyroid status at 3 and 6 months. However, substance use, particularly smoking, was associated with an increased risk of diabetes development (p < .05). Cancer type and treatment regimen did not show statistically significant correlations with endocrine dysfunction. Implications Our study highlights the importance of considering endocrine disorders in advanced metastatic cancer patients undergoing therapy. The prevalence of diabetes and thyroid dysfunction increased during cancer‐directed therapy, particularly in females. Careful monitoring and timely intervention are essential to improve the quality of life for these patients. Further research is warranted to explore the long‐term effects of cancer‐directed therapy on endocrine health and develop tailored management strategies for this vulnerable population
Simon Vigor face aux catholiques zélés : le gallicanisme radical du début du xviie siècle
No full textLe présent article analyse la position du juriste et magistrat Simon Vigor (1556-1624) à l'égard de la doctrine romaine et théocratique, telle que le cardinal Bellarmin l'avait en son temps formulée dans ses Disputationes de controversiis christianae fidei (1586-1593) et dans son De potestate Summi Pontificis in rebus temporalibus (1610). En suivant les théories d'Edmond Richer, l'auteur fameux d'un De ecclesiastica et politica potestate liber unus (1611) qui avait provoqué un immense scandale lors de sa publication, Simon Vigor défend en définitive un gallicanisme radical qui rappelle le De Republica ecclesiastica de Marc 'Antonio De Dominis, archevêque apostat réfugié à la cour du roi Jacques Ier d'Angleterre.This article analyzes the position of the jurist and magistrate Simon Vigor (1556-1624) regarding Roman and theocratic doctrine as formulated by Cardinal Bellarmin in his Disputationes de controversiis christianae fidei (1586-1593) and in his De potestate Summi Pontificis in rebus temporalibus (1610). Following the theories of Edmond Richer, the famous author of the De ecclesiastica et politica potestate liber unus (1611) that had provoked a tremendous scandal when it was published, Simon Vigor ultimately defends a radical Gallicanism reminiscent of the De Republica ecclesiastica of Marc Antonio De Dominis, an apostate archbishop who had fled to the court of James I of England
Managing Intertextuality in Ennodius’ Corpus: The Case of 1V. (= dict. 1H.) Dictio Ennodi diaconi in natale Laurenti Mediolanensis episcopi
No full text‘There is too much literature between reality and him’, said Labriolle: this seems such an adequate statement for Ennodius‘ corpus, since it is normal to stumble upon references or quotations by other authors, either pagan or Christian ones. This paper takes into account Ennodius 1V. (= dict. 1H.) as a case study and aims at examining in detail which works and authors Ennodius uses in order to arrange one dedication. The declamation has been divided in five thematic sections; each shows a different percentage of intertextual categories such as clear reference, self-quotation, altered reference and word collocation. Through statistical evidence, the author of this paper has thought back on Ennodius‘ overall technique in making rhetorics: a good way of paying homage to the summi and the minores, or the easiest way to bundle up quotes and so to earn an entire piece of literature
Francisci de Verulamio, summi Angliae cancellarii : Instauratio magna. Multi pertransibunt et augebitur scientia
No full textFirst edition of Bacon\u27s Novum organum, the second part of his intended multivolume work on the scientific method. Published in 1620 in London by Apud Joannem Billium, Typographia Regium. The Nouum organum is followed by a sketch of the third part, which the author calls "Parasceve, ad historiam natvralem, et experimentalem", and a "Catagvs historiarvm paricvlarivm, secundum capita". Works which represent the first and third part were published later; of the fourth and fifth parts only prefaces were written
Learning-Based Orchestration for Dynamic Functional Split and Resource Allocation in vRANs
No full textOne of the key benefits of virtualized radio access networks (vRANs) is
network management flexibility. However, this versatility raises
previously-unseen network management challenges. In this paper, a
learning-based zero-touch vRAN orchestration framework (LOFV) is proposed to
jointly select the functional splits and allocate the virtualized resources to
minimize the long-term management cost. First, testbed measurements of the
behaviour between the users' demand and the virtualized resource utilization
are collected using a centralized RAN system. The collected data reveals that
there are non-linear and non-monotonic relationships between demand and
resource utilization. Then, a comprehensive cost model is proposed that takes
resource overprovisioning, declined demand, instantiation and reconfiguration
into account. Moreover, the proposed cost model also captures different routing
and computing costs for each split. Motivated by our measurement insights and
cost model, LOFV is developed using a model-free reinforcement learning
paradigm. The proposed solution is constructed from a combination of deep
Q-learning and a regression-based neural network that maps the network state
and users' demand into split and resource control decisions. Our numerical
evaluations show that LOFV can offer cost savings by up to 69\% of the optimal
static policy and 45\% of the optimal fully dynamic policy.Comment: This paper has been accepted in Proc. of The 2022 Joint European
Conference on Networks and Communications (EuCNC) & 6G Summi
Prognostic value of the combination of serial APACHE II with serum lactate for predicting post-operative mortality in gastrointestinal perforation peritonitis: a prospective cohort study
No full textAbstract Background Gastrointestinal perforation peritonitis is a life-threatening surgical emergency with high mortality. Early identification of patients at increased risk of poor outcomes is critical for optimizing care. In this study, we aimed to evaluate the prognostic value of combining serial Acute Physiology and Chronic Health Evaluation II (APACHE II) scores and serial serum lactate levels in predicting 30-day postoperative mortality among patients undergoing emergency laparotomy for gastrointestinal perforation peritonitis. Methods In this prospective cohort study, 120 adult patients diagnosed with gastrointestinal perforation peritonitis and undergoing emergency laparotomy were enrolled after obtaining ethical approval and informed consent. APACHE II scores and serum lactate levels were recorded at three time points: preoperatively (baseline), 6 h postoperatively, and 24 h postoperatively. The primary objective of this study was a combination of serial APACHE II and serial serum lactate level (baseline, 6 h and 24 h post-operatively) and its correlation with post-operative mortality in emergency laparotomy for hollow viscus perforation peritonitis. Data were analysed to compare clinical variables between survivors and non-survivors. Receiver operating characteristic (ROC) curves and area under the curve (AUC) analyses were used to assess the predictive performance of individual and combined markers. Results The 30-day postoperative mortality rate was 35%. Significant differences in age, serial APACHE II scores, and serial serum lactate levels were observed between survivors and non-survivors. A serum lactate level of ≥ 1.88 mmol/L had a sensitivity of 81% and specificity of 69.2% (AUC: 0.817; p = 0.0001). APACHE II scores of ≥ 11.16 yielded a sensitivity of 76.2% and specificity of 91% (AUC: 0.915; p = 0.0001). Both serial lactate levels and APACHE II scores were independent predictors of 30-day mortality. The combination of serial APACHE II scores and serum lactate (cutoff ≥ 11.95) had a sensitivity of 85%, specificity of 82%, and an AUC of 0.919 (p = 0.0001), making it the preferred predictor for 30-day post-operative mortality. Conclusions The combination of serial APACHE II scores and serial serum lactate levels provides superior prognostic accuracy for predicting 30-day postoperative mortality in patients undergoing emergency laparotomy for gastrointestinal perforation peritonitis. This approach may facilitate early identification of high-risk patients and guide clinical decision-making. Trial registration Not applicable
GIOVANNI PIETRO ARRIVABENE POESIS
No full textWith this brief study, first the author deals with the poetry by Giovanni Pietro Arrivabene. In fact, for the first time he has published a long Latin poem of the poet preserved in a single manuscript in Pienza, in the library, which was of Pio II. The poet, who lived during the Renaissance, had a very careful preparation at the school of Francesco Filelfo, the most appreciated humanist after Enea Silvio Piccolomini. With the Carmen in Pii Pontificis laudem… Arrivabene hoped to enter in the courtyard of the Pope; but Pius II, even though he appreciated the poem, written on fine parchment, didn’t take the young poet into account, who was only twenty years. The scholar, on the one hand, thought back to the formation and the aspirations of the young poet, on the other the cultural character of his age, in which Giovanni Pietro Arrivabene spent his life. Short, but useful hints are devoted to the wonderful court of Mantua, where the poet spent twenty years at the service of the cardinal Francesco Gonzaga.Per breuem et luculentam uestigationem auctor primus de Ioannis Petri Arriuabeni poesi agit. Poeta enim illa floruit aetate, qua per doctissimos uiros humanae litterae sunt funditus renouatae. In doctissimis illis uiris fuit et Ioannes Petrus Arriuabenus, qui, cum duo scripsisset carmina, postremis his saltem temporibus, minime poeta memoratur. Auctor, innumeris inquisitionibus perfectis, duo tantum Ioannis Petri Arriuabeni inuenit carmina, quorum alteri In Pii summi Pontificis Laudem, Gonzagis titulus est alteri. Poeta uero, cum in Pontificis familiam ascisci uellet, magistro fortasse hortante atque opitulante, longum contexuit carmen, cui epistolam poeticam, imparibus modis confectam, haud fortuito praemisit. Auctoris sententia, nullum est dubium, quin Franciscus Philelphus, apud quem Ioannis Petrus Arriuabeni doctrinam sibi atque eruditionem comparauit, uel epistolam uel carmen, antequam pontifici traderentur, legerit atque emendauerit. Quod, ut par est, ex quibusdam eiusdem Philelfi epistolis cogitur. De quibus epistulis et notitiis alias
Status of the poet and question of eternity in the Odes of Horace, between greek heritage and romanity
No full textPlusieurs odes réflexives (Odes I, 1, II, 20, III, 30 ou encore IV, 3) se font le miroir du projet poétique d’Horace. Le poète y définit clairement son dessein : être reconnu comme le premier poète de Rome à avoir adapté en latin la lyrique lesbienne du VIe siècle avant J.-C. et voir son nom inscrit dans la chaîne éternelle des uates lyrici, des poètes lyriques inspirés. L’imitation est un geste incontournable à Rome : tout auteur qui souhaite s’illustrer dans un genre particulier doit se mesurer à ses prédécesseurs grecs, selon le double principe de l’imitatio-aemulatio. Toutefois, le projet d’Horace est ambitieux : la lyrique grecque archaïque est une poésie de l’occasion, de la performance, contextes que la Rome augustéenne ignore. De plus, cette lyrique, Horace la connaît au travers de sa réception hellénistique, plus livresque. Mais que nous dit précisément le poète de ses modèles ? Et comment réussit-il à conjuguer l’imitation de ses différents héritages et influences à une inspiration profondément romaine, empreinte de morale et ancrée dans le saeculum augustum ? La création d’une telle lyrique – qui a acquis une légitimité en tant que poésie civique – va permettre à Horace de faire entrer dans l’éternité non seulement les objets les plus humbles, mais aussi les summi uiri de Rome. Or, comment parvenir à faire du plus important d’entre eux, Auguste, le princeps, un fragment d’éternité ? Et que peut retirer le poète – qui revendique de façon jamais ouïe jusqu’alors que ses vers offriront l’immortalité à leur créateur – d’une telle entreprise ? C’est à ces questions que nous nous proposons, dans notre thèse, d’apporter des éléments de réponse.Several reflexive odes (Odes I, 1, II, 20, III, 30 and IV, 3) are the mirror of Horace’s poetic project. The poet clearly defines his aim : to be recognized as the first poet in Rome to have adapted into Latin the lesbian lyric of the 6th century B.C. and to see his own name inscribed in the eternal chain of uates lyrici, of inspired lyric poets. Imitation is an inevitable gesture in Rome : any author wishing to excel in a particular genre has to confront his Greek predecessors according to the double principle of imitatio-aemulatio. However, Horace’s project is an ambitious one : archaic Greek lyric is a poetry of occasion, of performance, contexts that Augustan Rome is not familiar with. What’s more, Horace knows this lyric through its Hellenistic, more book-based reception. But what does the poet precisely tell us about his models ? And how does he manage to combine the imitation of various heritages and influences with a profoundly Roman inspiration, imbued with morality and rooted in the saeculum augustum ? The creation of such a lyric – which has acquired legitimacy as civic poetry – will enable Horace to bring into eternity not only the humblest objects, but also the summi uiri of Rome. But how can he turn the most important of them, Augustus, the princeps, into a fragment of eternity ? And what’s in it for the poet – who claims in a way never heard before that his verses will bring immortality to their creator ? It is to these questions that we propose, in our thesis, to provide some answers
