101,540 research outputs found

    Pradyumna P. Karan, Sikkim Himalaya. Development in Mountain Environment

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    Dupuis Jacques. Pradyumna P. Karan, Sikkim Himalaya. Development in Mountain Environment. In: Annales de Géographie, t. 96, n°535, 1987. pp. 383-384

    Pradyumna P. Karan, Sikkim Himalaya. Development in Mountain Environment

    No full text
    Dupuis Jacques. Pradyumna P. Karan, Sikkim Himalaya. Development in Mountain Environment. In: Annales de Géographie, t. 96, n°535, 1987. pp. 383-384

    Wool coat

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    Coat of red wool; high rounded neck; no collar; knee-length; modified kimono sleeve; coat seams keep armhole close-fitting; 5 hidden hook and eye closures at CF; darts in front and back start at neckline and extend to hip; unlined. Designer Label: Donna Karan / New Yor

    Letter, [Author unclear] to Paulina T. Merritt

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    Handwritten letter to Paulina Merritt from an unknown author, October 1, 1876.

    Detection of Single Nucleotide Polymorphism by T-ARMS PCR of Cross Bred Cattle Karan Fries for A1, A2 Beta Casein Types

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    “Detection of Single nucleotide Polymorphism by T-ARMS PCR of cross bred cattle Karan Fries for A1, A2 beta casein types” to distinguish between A1 and A2 type containing beta-casein and genotyping of hundred Karan Fries cross breed cattle. Casein is the main milk protein where it accounts for 80% of bovine milk protein and contains four fractions (alpha S1-CN, alpha S2-CN, beta-CN and k-CN). Beta casein contributes 25-35% of milk protein and many variants are reported (A1, A2, A3, B, C, D, E, F, G, H1, H2 and I) in different breeds of cattle. The beta casein variants A1 and A2 differs in the 67th amino acid position, the substitution of proline in A2 type with Histidine (in A1) is mainly due to a replacement of “C” nucleotide with “A” nucleotide in that corresponding nucleotide position. One hundred Karan Fries cross breed cattle were selected for genotyping of A1, A2 beta casein gene from the genomic DNA. The beta casein gene was amplified by Multiplex Tetra-Primer Amplification (T-ARMS-PCR). T-ARMS touchdown PCR and subsequent agarose gel electrophoresis could differentiate between the A1, A2 types of beta casein genes in these animals. The screening result showed three genotypes of animal in these 100 animals. The number of A2A2, A1A2 and A1A1 animals are 73, 19 and 8 respectively. The frequency of A2 and A1 alleles are 0.825 and 0.175 respectively

    Supplemental Material - Post-Traumatic High-Flow Priapism: Accessory Pudendal Origin of Cavernosal Artery From External Iliac Artery - A Case Report

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    Supplemental Material for Post-Traumatic High-Flow Priapism: Accessory Pudendal Origin of Cavernosal Artery From External Iliac Artery - A Case Report by Karan Visanji Dedhia, DNB, S. Vignesh, MD, PDCC, T. Mukuntharajan, DMRD, N. Karunakaran, DMRD, DNB(RD), and Ganesh Rajagopal, DMRD, DNB(RD), FRCR in Vascular and Endovascular Surgery</p

    Handwritten biographical information on Paulina T. McClung Merritt

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    A handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.

    Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.

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    IFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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