655 research outputs found
Nitrated proteome in human embryonic stem cells
No full textPost-translational modifications (PTMs) of proteins regulate self-renewal and differentiation in embryonic stem cells (ESCs). Nitration of tyrosine residues of proteins in ESCs modulates their downstream pathways, which can affect self-renewal and differentiation. However, protein tyrosine nitration (PTN) in ESCs has been rarely studied. We reviewed 23 nitrated sites in stem cell proteins. Functional enrichment analysis showed that these nitrated proteins are involved in signal transduction, cell adhesion and migration, and cell proliferation in ESCs. Comparison between the nitrated and known phosphorylated sites revealed that 7 nitrated sites had overlapping phosphorylated sites, indicating functional links of PTNs to their associated signaling pathways in ESCs. Therefore, nitrated proteome provides a basis for understanding potential roles of PTN in self-renewal and differentiation of ESCs. © 2016, Korean Society for Mass Spectrometry. All rights reserved11Nscopuskc
Fourier series of higher-order Daehee and Changhee functions and their applications
No full textAbstract In the paper, the author considers the Fourier series related to higher-order Daehee and Changhee functions and establishes some new identities for higher-order Daehee and Changhee functions
New type of degenerate Daehee polynomials of the second kind
No full textRecently, Kim and Kim (Russ. J. Math. Phys. 27(2):227–235, 2020) have studied new type degenerate Bernoulli numbers and polynomials by making use of degenerate logarithm. Motivated by (Kim and Kim in Russ. J. Math. Phys. 27(2):227–235, 2020), we consider a special class of polynomials, which we call a new type of degenerate Daehee numbers and polynomials of the second kind. By using their generating function, we derive some new relations including the degenerate Stirling numbers of the first and second kinds. Moreover, we introduce a new type of higher-order degenerate Daehee polynomials of the second kind. We also derive some new identities and properties of this type of polynomials. © 2020, The Author(s).Recently, Kim and Kim (Russ. J. Math. Phys. 27(2):227–235, 2020) have studied new type degenerate Bernoulli numbers and polynomials by making use of degenerate logarithm. Motivated by (Kim and Kim in Russ. J. Math. Phys. 27(2):227–235, 2020), we consider a special class of polynomials, which we call a new type of degenerate Daehee numbers and polynomials of the second kind. By using their generating function, we derive some new relations including the degenerate Stirling numbers of the first and second kinds. Moreover, we introduce a new type of higher-order degenerate Daehee polynomials of the second kind. We also derive some new identities and properties of this type of polynomials. © 2020, The Author(s)
Association of serum high-sensitivity C reactive protein with risk of mortality in an Asian population: the Health Examinees cohort
No full textOBJECTIVES: This study aimed to examine the association of high-sensitivity C reactive protein (hsCRP) with mortality risk and the attenuated effect of non-communicable disease history (NCD(history)) on the association. DESIGN: Prospective cohort study. SETTING: Health Examinees cohort. PARTICIPANTS: A total of 41 070 men and 81 011 women aged ≥40 years were involved (follow-up: 6.8 years). OUTCOME MEASURES: Data and cause of death occurring until 31 December 2015 were confirmed by death statistics from the National Statistical Office. We conducted advanced analysis after stratification by NCD(history) and sensitivity analysis after excluding death before 1 or 2 years from recruitment. Cox proportional hazard and restricted cubic spline models were used to assess the association. RESULTS: The association between serum hsCRP and risk of all-cause mortality was observed with strong linearity in both genders and was not influenced by NCD(history). The association of serum hsCRP with risk of cancer mortality was not observed in women with NCD(history), but the association with risk of cardiovascular disease (CVD) mortality was predominantly observed in men with NCD(history). CONCLUSIONS: This study suggests a dose–response association of hsCRP with mortality risk, including cancer and CVD mortality, in Koreans with low serum hsCRP, although the association with cancer and CVD mortality risk could be influenced by gender and NCD(history)
Some Explicit Expressions for Twisted Catalan-Daehee Numbers
No full textIn this paper, the author considers the twisted Catalan numbers and the twisted Catalan-Daehee numbers, which are arisen from p-adic fermionic integrals and p-adic invariant integrals, respectively. We give some explicit identities and properties for those twisted numbers and polynomials by using p-adic integrals or generating functions
Carbohydrate Intake and Hyperlipidemia among Population with High‐Carbohydrate Diets: The Health Examinees Gem Study
No full textScope The association between carbohydrate intake from low-, medium-, and high-glycemic index (GI) foods and hyperlipidemia among population with a high-carbohydrate diet is examined. Methods and results A total of 93,870 participants of the Health Examinees Study (HEXA) are included in this cross-sectional study. The odds ratio (ORs) and 95% confidence interval (CIs) are estimated using the logistic regression model. The mean (interquartile range) of % energy from carbohydrate intake is 72.05 (67.73-77.18)% per day. Increasing intake of carbohydrate replacing fat is associated with increasing prevalence of high triglyceride (TG) and low HDL-cholesterol, with stronger association for high-GI carbohydrates than low- or med-GI carbohydrates. ORs (95% CIs) comparing the highest with the lowest quintiles of high-GI carbohydrates are 1.27 (1.09, 1.48) among men and 1.51 (1.31, 1.74) among women for high TG; and 1.50 (1.24, 1.82) among men and 1.73 (1.54, 1.93) among women for low-HDL-cholesterol. High-GI carbohydrate intake replacing fat is inversely associated with the prevalence of high LDL- and total cholesterol. More pronounced associations in body mass index (BMI) <25 kg m(-2) than higher BMI are found. Conclusions Increasing low-quality carbohydrate intake is associated with increasing prevalence of high TGs and low HDL-cholesterol.N
Some Identities on the Twisted <i>q</i>-Analogues of Catalan-Daehee Numbers and Polynomials
No full textIn this paper, the author considers twisted q-analogues of Catalan-Daehee numbers and polynomials by using p-adic q-integral on Zp. We derive some explicit identities for those twisted numbers and polynomials related to various special numbers and polynomials
Associations between Physical Activity and Incidence of Cancer among Overweight Adults in Korea: Results from the Health Examinees-G Study
No full textAlthough the protective effects of physical activity against several cancers are well established, evidence is inconsistent concerning Asian populations. Therefore, we assessed the association between the characteristics of physical activity and overall and type-specific cancer incidence in Koreans and examined the differences in association according to obesity status. Using prospective data from 112,108 parti-cipants in the Health Examinees study-G from 2004 to 2013, we evaluated the association between leisure-time physical activity (LTPA) and the incidence of overall and type -specific cancers using the Cox proportional hazards model. Self-reported LTPA participation, duration per week, inten-sity, type, and diversity were assessed. The incidence of overall and type-specific cancers, including colorectal, gas-tric, lung, breast, and prostate cancer and 13 obesity-related cancers, was identified using the Korea Central Cancer Registry from 1999 to 2018. Analyses were also stratified according to obesity status. In overweight males, participa-tion in vigorous LTPA [HR, 0.84; 95% confidence interval (CI), 0.72-0.97] and walking (HR, 0.84; 95% CI, 0.72-0.98) were associated with a lower risk of cancer overall. Regarding cancer types, climbing was marginally associated with a lower risk of colorectal cancer in overweight males (HR, 0.61; 95% CI, 0.37-1.00). In normal-weight females, although there was an increased risk in those performing recreational activities, this risk was attenuated when those diagnosed with thyroid cancer were excluded. In the analysis for 13 obesity-related cancers, consistent associations were found. These findings suggest the need for greater public awareness regarding physical activity among overweight individuals within the Asian population. Prevention Relevance: Overall cancer risk is associated with leisure-time physical activity such as duration, intensity, type, and diversity in overweight males, but not in the general population. The decreased risk was most noticeable for colorectal cancer. Our results suggest that physical activity may reduce the risk of cancer among overweight Asian males.Y
Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer
No full textMammalian cells have cytoplasmic and mitochondrial aminoacyl-tRNA synthetases (ARSs) that catalyze aminoacylation of tRNAs during protein synthesis. Despite their housekeeping functions in protein synthesis, recently, ARSs and ARS-interacting multifunctional proteins (AIMPs) have been shown to play important roles in disease pathogenesis through their interactions with disease-related molecules. However, there are lacks of data resources and analytical tools that can be used to examine disease associations of ARS/AIMPs. Here, we developed an Integrated Database for ARSs (IDA), a resource database including cancer genomic/proteomic and interaction data of ARS/AIMPs. IDA includes mRNA expression, somatic mutation, copy number variation and phosphorylation data of ARS/AIMPs and their interacting proteins in various cancers. IDA further includes an array of analytical tools for exploration of disease association of ARS/AIMPs, identification of disease-associated ARS/AIMP interactors and reconstruction of ARS-dependent disease-perturbed network models. Therefore, IDA provides both comprehensive data resources and analytical tools for understanding potential roles of ARS/AIMPs in cancers.1120Nsciescopu
Multi-Grain Rice Diet Decreases Risk of Breast Cancer in Korean Women: Results from the Health Examinees Study
No full textAlthough a number of studies explain the association between dietary patterns, which take into account that foods are eaten in combination, and breast cancer risk, the findings are inconsistent. We examined the association between dietary patterns and multi-grain rice intake, and the risk of breast cancer in a large-scale prospective cohort study in Korean women. A total of 93,306 women aged 40–69 years from the Health Examinees-Gem (HEXA-G) study (2004 and 2013) were included. We obtained Information on cancer diagnosis via linkage to the Korea Central Cancer Registry. Factor analysis was conducted to obtain dietary patterns, and Cox proportional models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CI) for breast cancer risk. For 494,490 person-years, 359 new cases of breast cancer occurred. We identified three major dietary patterns, that explained 23.9% of the total variance based on daily total food intake (g/day) from 37 food groups: the meat dietary pattern (higher intake of bread and red meat), the white rice dietary pattern (higher intake of white rice and lower intake of multi-grain rice), and the other pattern. Women who had higher white rice dietary pattern scores had a 35% higher risk of breast cancer, than did women with lower white rice dietary pattern scores (multivariable HR 1.35; 95% CI 1.00–1.84 for the highest vs. lowest quartile of the white rice dietary pattern scores, p for trend = 0.0384). We found that women who consumed three or more servings of multi-grain rice per day had 33% lower risk of breast cancer than did those who consumed one or less multi-grain rice serving per day among women under 50 years of age (multivariable HR 0.67; 95% CI 0.45–0.99, p for trend = 0.0204). Our study suggests that a multi-grain rice diet may be associated with lower risk of breast cancer in Korean women
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