106 research outputs found
Meditsiinidoktor Priit Kampus
No full text20. juunil 2007 kaitses Tartu Ülikooli arstiteaduskonna kraadinõukogus doktoriväitekirja TÜ kardioloogiakliiniku ja TÜ biokeemia instituudi teadur Priit Kampus. Töö pealkirjaks oli „Põletiku, oksüdatiivse stressi ja vanuse seos arteriaalse süsteemi jäikuse ning unearteri sise- ja keskkesta paksusega“ („Impact of infl ammation, oxidative stress and age on arterial stiffness and carotid artery intima-media thickness“). Töö valmis prof Rein Teesalu ja prof Mihkel Zilmeri juhendamisel. Väitekirja oponeeris professor Thomas Hedner Göteborgi Ülikoolist Rootsis. Töö on üks esimesi Eesti endoteeluuringute keskuse(asutatud 2004. a) teadustööga seotud uurimusi.
Eesti Arst 2008; 87(7−8):57
Kodade virvendusarütmiaga patsientide hemodünaamiline ja biokeemiline profiil ning ≥65 aastaste kodade virvendusarütmiaga patsientide antikoagulantravi Eestis
No full textVäitekirja elektrooniline versioon ei sisalda publikatsiooneKodade virvendusarütmia (KVA) on sagedaseim rütmihäire maailmas, esinedes 2-4% täiskasvanud elanikest. Rütmihäire põhjustab patsiendi olulist elukvaliteedi häirumist ja suurendab kuni 5 korda ajuinsuldi riski. Teada on mitmeid selle rütmihäire riskifaktorid nagu hüpertensioon, diabeet ja uneapnoe aga ka ülekaal. Samas pole praeguseni selged selle rütmihäire kõik patofüsioloogilised ja hemodünaamikaga seotud mehhanismid. Kuna enamikel > 65 a patsientidel esineb kõrgenenud ajuinsuldi risk, siis trombi profülaktikaks on vajalik püsiv antikoagulantravi. Kui maailmas on uuringud näidanudantikoagulantravi alakasutust, siis Eesti kohta vastavad andmed puuduvad. Käesolevas doktoritöös uuriti nii KVA patsientide ja kontrollrühma vererõhu hemodünaamikaga seotud näitajaid, kui ka põletiku, oksüdatiivse stressi ja sidekoestumisega seotud biomarkereid . Selleks teostati rütmihäiretega patsientidel lisaks vereanalüüsidele vererõhu hemodünaamika määramine, et hinnata tsentraalse vererõhuga seotud muutusi ja arterite jäikust. Patsiente jälgiti 1 aasta jooksul rütmihäirete kordumise suhtes. Lisaks uurisime püsivat antikoagulantravi kasutamist üleriigiliselt ≥65 aastaste KVA patsientide seas hinnates ravimi kaetus väljakirutatud päevadoosidega. Leiti, et vaatamata sarnastele õlavarrelt mõõdetud vererõhkudele oli rütmihäirega patsientidel kõrgem tsentraalne vererõhk ja pulsilaine levikukiirus, mis viitab suuremale arterite jäikusele. Uuritavatel olid kõrgemad müeloperoksüdaasi, kõrgtundliku C-reaktiivse valgu, B-tüüpi natriureetilise propeptiidi N-fragmendi ja galektiin-3 väärtused. Kõrgenenud müeloperoksüdaas oli seotud KVA kordumise riskiga. Püsiv antikoagulantravi tarvitamine Eestis on äärmiselt madal ja ≥80% kaetus väljastatud antikoagulantravi retseptiga oli saavutatud vaid 57,4% 2019. aasta ja 44,5% 2020. aasta uuritavatest.Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide, affecting 2-4% of the adult population. This arrhythmia significantly impairs the patient's quality of life and increases the risk of stroke by up to 5 times. Several risk factors for this arrhythmia are known, such as hypertension, diabetes, sleep apnea, and obesity. However, the complete pathophysiological and hemodynamic mechanisms related to this arrhythmia are not yet fully understood. Since a heightened risk of stroke is present in most patients ≥65 years old, continuous anticoagulant therapy is necessary for thrombus prevention. While studies globally have indicated underutilization of anticoagulant therapy, specific data for Estonia is lacking. In this doctoral thesis, both indicators related to the hemodynamics of blood pressure and biomarkers associated with inflammation, oxidative stress, and fibrosis were examined in AF patients and a control group. In addition to blood tests, hemodynamics of blood pressure were measured in patients with arrhythmias to assess changes related to central blood pressure and arterial stiffness. Patients were monitored for 1 year for recurrence of arrhythmias. Furthermore, the nationwide use of continuous anticoagulant therapy among AF patients aged ≥65 was investigated, evaluating medication coverage based on prescribed daily doses. It was found that despite similar blood pressure measurements taken from the arm, patients with arrhythmias had higher central blood pressure and pulse wave velocity, indicating greater arterial stiffness. Study participants exhibited higher levels of myeloperoxidase, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, and galectin-3. Elevated myeloperoxidase levels were associated with a higher risk of AF recurrence. The utilization of continuous anticoagulant therapy in Estonia is extremely low, with only 57.4% of the studied patients in 2019 and 44.5% in 2020 achieving ≥80% coverage based on issued anticoagulant therapy prescriptions.https://www.ester.ee/record=b564546
Põletiku, oksüdatiivse stressi ja vanuse seos arteriaalse süsteemi jäikuse ning unearteri sise- ja keskkesta paksusega
No full textNooruse valuuta. „Noorkirjanik“ ja „rühmitus“ nullindatel / The Currency of Youth. The "Young Author" and the "Literary Group" in the 2000s
No full textThe article is focused on literary groups and the emergence of young authors in the 2000s. So far literary researchers have mainly studied the influential literary groups of the first third of the 20th century (Noor-Eesti, Siuru, Tarapita etc.). But literary groups have had a remarkable impact on contemporary Estonian literature as well. Many present-day well-known writers entered the literary scene through groups which were active in the 1990s (e.g. TNT and Erakkond). In the 2000s forming a literary group lost its appeal as young authors found more individual ways to introduce themselves to the public. At the beginning of the 2000s a couple of attempts were made to form new literary groups, but those groups were short-lived and unproductive (e.g. TNT! and !peatus).
Young authors were very active in publishing both on paper and online. The emergence of new publishing channels is one of the reasons why young authors did not have the ambition or need to form groups. For example, in the 2000s literary debuts appeared in the web-based literary club POOGEN and the literary magazine Värske Rõhk (established in 2005). So the 2000s actually saw a new type of convergence: web-based literary clubs and forums. Unfortunately, many of the new channels of the 2000s are already out of reach: the web pages of KLOAAK, noortekas.delfi.ee, People&Poetry, Bahama Press and ThePression have been removed from the internet.
Debuts were welcomed by mainstream media eager to spot the next big thing, new rebels and rule breakers. Being “a young author” became a functioning brand, and youth became a form of currency for beginning writers
Kommentaar artikli „Magnetresonantstomograafiaga seotud riskid ja ohutuse tagamine” kohta
No full textEesti Arst 2020; 99(2):119–12
Atrial fibrillation is associated with increased central blood pressure and arterial stiffness
No full textAtrial fibrillation (AF) is the most common arrhythmia in clinical practice and beta blockers (BBs) are the drugs of choice for rate or rhythm control in these patients. The purpose of this study was to describe differences in arterial stiffness (AS), central blood pressure (cBP), and the role of BBs on cBP in patients with AF compared to healthy individuals. The authors included 76 patients with paroxysmal/persistent AF. Carotid-femoral pulse wave velocity (PWV) and cBP were measured and compared with data from 75 healthy individuals. Patients with AF had higher PWV (8.0 m/s vs. 7.2 m/s, p < .001), central systolic blood pressure (cSBP) (118 mm Hg vs. 114 mm Hg, p = .033), central pulse pressure (cPP) (39 mm Hg vs. 37 mm Hg, p = .035) and lower pulse pressure amplification (PPA) (1.24 vs. 1.30, p = .015), without differences in peripheral blood pressure (pBP) and heart rate (HR). AF patients had significantly increased PWV (beta= 0.500, p = .010, adjusted R-2 = 0.37) after adjustment for confounding factors. The use of BBs significantly reduced PPA (beta = -0.059, p = .017, adjusted R-2 = 0.30). AF patients have higher PWV, cSBP, cPP, and lower PPA, compared to healthy patients. These findings support the role of AS in the development of AF. Use of BBs is related to a potential adverse effect on cBP.Peer reviewe
Opportunities to Improve the Warehouse Efficiency on the Example of OÜ Pro Beauté
No full textLõputöös keskendus autor ettevõtte lao efektiivsuse tõstmise võimalustele. Töös kasutas autor struktureerimata intervjuud ja kvalitatiiv-kvantitatiivset küsimustikku, mida analüüsides selgitas välja ettevõtte laotoimingutes esinevad kitsaskohad. Autor tegi probleemide lahendamiseks omapoolsed parendusettepanekud, mida käsitletakse töö teoreetilises osas. Töö autori arvates on parendusettepanekute elluviimisel võimalik optimeerida ettevõtte laoprotsesse. Vabanenud ressursse on võimalik kasutada teisteks väärtust lisavateks toiminguteks.The author of the thesis focused on the opportunities to improve the company’s warehouse efficiency. Author conducted an unstructured interview and qualitative-quantitative survey which were analysed to identify the shortcomings in the company's warehousing operations. Author of the thesis made proposals which were discussed in the theoretical part of the paper to optimize the processes in the company. The author believes that company’s warehouse processes can be optimized by putting proposals into the practice. Unallocated resources can be used for other value-adding activities
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