198,493 research outputs found
Confidentiality of personal health information used for research
No full textMedical research has a long history in the United Kingdom and has generally enjoyed good public support. Researchers take confidentiality seriously and few breaches have been recorded. Concerns over research practices at Alder Hey hospital related to consent rather than confidentiality,1 but they tarnished the overall reputation of research. At much the same time, the Data Protection Act 1998 defined stricter criteria for handling personal data,2 supplementing the provisions in the UK common law of confidentiality. There is thus a legal and a moral impetus to ensure that research is conducted with the maximum respect for participants and their privacy, even if the research is not linked to clinical care. Many questions can be answered without the active participation of individuals, but researchers must strike a careful balance between their pursuit of health improvements for all and their obligation to maintain the privacy of individuals participating in research
Workshop on the EHCR
No full textThis deliverable provides a summary report of a workshop on Electronic Health
Records that was organised and delivered as the main focus of Workpackage 16 of
the Semantic Mining project.
The workshop was held as day three of a three-day series of events held in Brussels
in late November 2004, under the umbrella and with kind support of the
EUROREC organisation.
This report provides a brief summary of that event, and includes in Annex 1 the
complete delegate pack as printed and issued to all persons attending the event,
This delegate pack included printed copies of all slides and screenshots used
throughout the day.
The workshop was well attended, and in particular the organisers are pleased to
report that some very productive discussions took place that will act as the stimulus
for new threads of research collaboration between various Semantic Mining
partners, under the work plan of Workpackage 26.
The organisers are grateful for the support of the EUROREC organisation in
facilitating the organisation of this workshop and for lending their support to it
through their web site and a personal endorsement of the event
Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis
No full textNeuropeptide Y (NPY) produced in neurons in the arcuate nucleus and brain stem and released in the paraventricular nucleus (PVN) and surrounding areas is involved in stimulation of feeding in rats. We recently reported that gamma-aminobutyric acid (GABA) is coexpressed in a subpopulation of NPY neurons in the arcuate nucleus. To determine whether GABA is colocalized in NPY terminals in the PVN, the site of NPY action, light and electron microscopic double staining for NPY and GABA using pre- and postembedding immunolabeling was performed on rat brain sections. GABA was detected in NPY-immunopositive axons and axon terminals within both the parvocellular and magnocellular divisions of the PVN. These morphological findings suggested a NPY-GABA interaction in the hypothalamic control of feeding. Therefore, the effects of muscimol (MUS), a GABA(A) receptor agonist, on NPY-induced food intake were examined in sated rats. When injected intracerebroventricularly, both NPY and MUS elicited dose-dependent feeding responses that were blocked by the administration of 1229U91 (a putative Y1 receptor antagonist) or bicuculline (a GABA(A) receptor antagonist), respectively. Coadministration of NPY and MUS intracerebroventricularly amplified the feeding response over that evoked by NPY or MUS alone. Similarly, microinjection of either NPY or MUS into the PVN stimulated food intake in a dose-related fashion, and coinjection elicited a significantly higher response than that evoked by either individual treatment. These results suggest that GABA and NPY may coact through distinct receptors and second messenger systems in the PVN to augment food intake
Authors' Reply : Novel Biomarkers in CKD
No full textReply to : Liang B, Li FR, Liu L, Zhao JH. Novel Biomarkers in CKD. J Am Soc Nephrol. 2025 Sep 5. doi: 10.1681/ASN.0000000846. Epub ahead of print. PMID: 40911359.
Regarding : Onoja A, McDonnell T, Annessi I, Banks RE, Bergin M, Cockwell P, Dusaulcy R, Fraser SDS, Johnson T, Kalra PA, Lemaître B, Saleem M, Skroblin P, Soderberg M, Taal MW, Unwin RJ, Vuilleumier N, Wheeler DC, Geifman N. Biomarkers of Kidney Failure and All-Cause Mortality in CKD. J Am Soc Nephrol. 2025 Jun 20;36(12):2431–44. doi: 10.1681/ASN.0000000767. Epub ahead of print. PMID: 40540429; PMCID: PMC12677819. https://archive-ouverte.unige.ch/unige:186988</p
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Occurrence and stability of lone pair-π and OH-π interactions between water and nucleobases in functional RNAs
No full textWe identified over 1000 instances of water-nucleobase stacking contacts in a variety of RNA molecules from a non-redundant set of crystal structures with resolution ≤3.0 Å. Such contacts may be of either the lone pair-π (lp-π) or the OH-π type, in nature. The distribution of the distances of the water oxygen from the nucleobase plane peaks at 3.5 Å for A, G and C, and approximately at 3.1-3.2 Å for U. Quantum mechanics (QM) calculations confirm, as expected, that the optimal energy is reached at a shorter distance for the lp-π interaction as compared to the OH-π one (3.0 versus 3.5 Å). The preference of each nucleobase for either type of interaction closely correlates with its electrostatic potential map. Furthermore, QM calculations show that for all the nucleobases a favorable interaction, of either the lp-π or the OH-π type, can be established at virtually any position of the water molecule above the nucleobase skeleton, which is consistent with the uniform projection of the OW atoms over the nucleobases ring we observed in the experimental occurrences. Finally, molecular dynamics simulations of a model system for the characterization of water-nucleobase stacking contacts confirm the stability of these interactions also under dynamic conditions
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Managing healthcare transformation towards P5 medicine (Published in Frontiers in Medicine)
No full textHealth and social care systems around the world are facing radical organizational, methodological and technological paradigm changes to meet the requirements for improving quality and safety of care as well as efficiency and efficacy of care processes. In this they’re trying to manage the challenges of ongoing demographic changes towards aging, multi-diseased societies, development of human resources, a health and social services consumerism, medical and biomedical progress, and exploding costs for health-related R&D as well as health services delivery. Furthermore, they intend to achieve sustainability of global health systems by transforming them towards intelligent, adaptive and proactive systems focusing on health and wellness with optimized quality and safety outcomes.
The outcome is a transformed health and wellness ecosystem combining the approaches of translational medicine, 5P medicine (personalized, preventive, predictive, participative precision medicine) and digital health towards ubiquitous personalized health services realized independent of time and location. It considers individual health status, conditions, genetic and genomic dispositions in personal social, occupational, environmental and behavioural context, thus turning health and social care from reactive to proactive. This requires the advancement communication and cooperation among the business actors from different domains (disciplines) with different methodologies, terminologies/ontologies, education, skills and experiences from data level (data sharing) to concept/knowledge level (knowledge sharing). The challenge here is the understanding and the formal as well as consistent representation of the world of sciences and practices, i.e. of multidisciplinary and dynamic systems in variable context, for enabling mapping between the different disciplines, methodologies, perspectives, intentions, languages, etc. Based on a framework for dynamically, use-case-specifically and context aware representing multi-domain ecosystems including their development process, systems, models and artefacts can be consistently represented, harmonized and integrated. The response to that problem is the formal representation of health and social care ecosystems through an system-oriented, architecture-centric, ontology-based and policy-driven model and framework, addressing all domains and development process views contributing to the system and context in question.
Accordingly, this Research Topic would like to address this change towards 5P medicine. Specifically, areas of interest include, but are not limited:
• A multidisciplinary approach to the transformation of health and social systems
• Success factors for sustainable P5 ecosystems
• AI and robotics in transformed health ecosystems
• Transformed health ecosystems challenges for security, privacy and trust
• Modelling digital health systems
• Ethical challenges of personalized digital health
• Knowledge representation and management of transformed health ecosystems
Table of Contents:
04 Editorial: Managing healthcare transformation towards P5
medicine
Bernd Blobel and Dipak Kalra
06 Transformation of Health and Social Care Systems—An
Interdisciplinary Approach Toward a Foundational
Architecture
Bernd Blobel, Frank Oemig, Pekka Ruotsalainen and Diego M. Lopez
26 Transformed Health Ecosystems—Challenges for Security,
Privacy, and Trust
Pekka Ruotsalainen and Bernd Blobel
36 Success Factors for Scaling Up the Adoption of Digital
Therapeutics Towards the Realization of P5 Medicine
Alexandra Prodan, Lucas Deimel, Johannes Ahlqvist, Strahil Birov,
Rainer Thiel, Meeri Toivanen, Zoi Kolitsi and Dipak Kalra
49 EU-Funded Telemedicine Projects – Assessment of, and
Lessons Learned From, in the Light of the SARS-CoV-2
Pandemic
Laura Paleari, Virginia Malini, Gabriella Paoli, Stefano Scillieri,
Claudia Bighin, Bernd Blobel and Mauro Giacomini
60 A Review of Artificial Intelligence and Robotics in
Transformed Health Ecosystems
Kerstin Denecke and Claude R. Baudoin
73 Modeling digital health systems to foster interoperability
Frank Oemig and Bernd Blobel
89 Challenges and solutions for transforming health ecosystems
in low- and middle-income countries through artificial
intelligence
Diego M. López, Carolina Rico-Olarte, Bernd Blobel and Carol Hullin
111 Linguistic and ontological challenges of multiple domains
contributing to transformed health ecosystems
Markus Kreuzthaler, Mathias Brochhausen, Cilia Zayas, Bernd Blobel
and Stefan Schulz
126 The ethical challenges of personalized digital health
Els Maeckelberghe, Kinga Zdunek, Sara Marceglia, Bobbie Farsides
and Michael Rigb
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