329 research outputs found
The death of justice?
No full textPriya Kale reflects on the apparent suicide of Ram Singh and what it means for justice in India
Why is child-rape on the rise in India?
No full textPriya Kale reflects on the current wave of reported child-rapes in India and asks why tougher rape laws have failed to stem the incidence of sexual assault
Petitioning for change: Indians turn to online petitions to protest Delhi gang rape
No full textOnline petitions calling for responses to gender-based violence and discrimination indicate that Indians have bucked the trend of apathy, writes LSE alumna Priya Kale
The impact of corruption on democracy in India
No full textPriya Kale argues that the 2G scam and ‘coal-gate’ signal a new trend in Indian corruption that threatens to undermine basic democratic tenets
Stalling a paradigm shift? The official response to the Justice Verma Committee report
No full textPriya Kale analyses what the Justice Verma Committee report – which recommends legislative reforms in the aftermath of the Delhi gang rape – and the government’s response mean for the future treatment of women in India
Patient treatment pathways of multidrug-resistant tuberculosis cases in coastal South India: Road to a drug resistant tuberculosis center
No full textDr Priya Rathi1, Dr Kalpita Shringapure2, Dr B Unnikrishnan1, Abhinav Pandey3, Abhirami Nair3 1. Kasturba Medical College, Department of Community Medicine, Manipal Academy of Higher Education, Mangalore, India, 575001 2. Medical College Baroda, Department Preventive and Social Medicine, Gujarat, India 3. Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, India 575001 Corresponding Author Dr Priya Rathi Department of Community Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, India 57500
Studies in the Bhaktirasa-Bodhini of Priya Dasa.
No full textThe present work consists of six chapters. The first chapter is an introduction comprising two parts: Part I deals with certain aspects of the commentary itself, its relation to the parent text, its title, date, metre, structure and narrative element; Part II is devoted to the author, about whom very little has been said in any history of Hindi literature, and it attempts to remove many misconceptions, one of which is the belief that Priya Dasa was a contemporary of Nabha Dasa, and to throw some light on his life, his other works, his preceptor, and his religious standpoint. The second chapter contains a description of the four manuscripts and a printed edition, with a full account of the Bodleian manuscript only, and includes a specimen of each manuscript. The 'Stemma codicum' both compares and groups the manuscripts, and is followed by a summary of the principles adopted in constituting the text. The third chapter presents the constituted text of the Bhaktirasa-Bodhini, verses 1-101, with textual notes. Appendices I and II contain the extra verses which are later interpolations. An annotated English translation of the Braj text is given in the fourth chapter. The fifth chapter is devoted to detailed notes on some technical terms and their contextual significance, on the author's statements requiring elucidation, and on the devotees mentioned in the text. All the legendary stories are traced back to their Sanskrit sources with their references, and where Priya Dasa refers to only a part of a legend or to only one of several incidents in a devotee's life, the details he omits have been supplied in the notes. The main sources are; the Mahabharata, the Ramayana, the Jaimini Bharata, the Bhagavata and other Puranas, and also the Ramacaritamanasa of Tulasi Dasa. Priya Dasa's version of a story is also compared with those of later commentators. The last chapter consists of a complete glossary with grammatical analysis and all the references for each word in the text
Nuclear organization of mouse Hox cluster paralogs during mouse embryonic stem cell differentiation to neural stem cell:
No full textIn this project we use Hox genes as a genetic tool to understand how nuclear architecture regulates cell differentiation during embryonic development. Hox genes come under the category of homeobox genes, a highly evolutionarily conserved group of genes with an important role during embryogenesis. Hox genes are located on 4 distinct chromosomes, in cluster paralogs (HOX A, B, C, D). Each individual cluster contains up to 13 homologous genes and corresponding genes on different clusters (e.g., HoxA13, HoxD13) exhibit varying degrees of functional redundancy. The position of a gene in the cluster is related to its spatiotemporal pattern of expression along the anterior-posterior axis of the embryo. The coordination of the spatiotemporal expression of equivalent paralog group genes on different clusters/chromosomes is coordinated is still not known. Our primary hypothesis is that nuclear architecture defines a regulatory framework of Hox cluster loci in the nucleus when the Hox cluster transcription is activated and maintained. We did a comparative analysis on the Hox cluster nuclear architecture in mouse embryonic stem cells (ESCs) and fibroblast growth factors (FGF) - induced differentiation to neural stem cells (NSC). We show for the first time that Hox gene expression is induced by FGF treatment in vitro simultaneously in the four Hox cluster. Using three-dimensional confocal fluorescence microscopy, FISH and computational techniques, we mapped the position of Hox gene cluster paralogs in individual nuclei of both cell types. We did not observe nuclear colocalization of Hox heterologous cluster in NSC. However, we observe that heterologous clusters tend to occupy similar nuclear domains in NSC, which may favor undetected long-range gene interactions. Nevertheless, our results indicate that Hox gene cluster nuclear three-dimensional organization is neither random nor correlated to the changes in nuclear volume and shape that parallel cell differentiation.M.S.Includes bibliographical references (p. 53-55)by Priya Panicke
Polymeric nanospheres for skin penetration enhancement: in vitro and in vivo assessment in skin models
No full textResearch and development in the field of topical and transdermal delivery has been particularly challenging due to the tough penetration barrier provided by the stratum corneum, the superficial skin layer. Nano-sized vesicles can potentially act as carriers to skin layers without causing the toxicity and irritation associated with chemical and physical skin penetration enhancers. In this study we have characterized the skin penetration potential of polymeric nanospheres made from amphiphilic ABA-triblock co-polymers that are biocompatible, biodegradable and bind efficiently to hydrophobic molecules. We evaluated the delivery of hydrophobic and poorly water soluble compounds via these nanospheres into different skin layers and found significant enhancement in their delivery to the epidermal-dermal junction and to the dermis. Thus, these nanospheres have tremendous potential for targeting diseases such as acne, psoriasis and eczema that have their origins in these layers. Formulation of the nanospheres in hydrophilic gels, alone and in combination with a chemical skin penetration enhancer significantly increased the penetration of complexed molecules in vitro in human skin and in vivo in porcine skin. We also evaluated the delivery profiles of these nanospheres in a bioengineered Human Skin Equivalent (HSE). The full thickness HSE was developed from a combination of human derived cells and extra-cellular components and cultured with a novel media cocktail to strengthen the permeability barrier. The HSE was characterized for the permeability profiles of agents with differing physiochemical properties and was found to be more permeable than human skin, but similar to the commercially available skin equivalent EpidermFT®. The HSE also served as an effective model for evaluation of phototoxicity of topically applied agents, and was able to correctly predict the phototoxic potential of compounds when evaluated against a validated in vitro cell-based method. When used for evaluation of the skin delivery potential of nanosphere formulations, the penetration enhancement ratios in the HSE were similar to those obtained in human skin and porcine skin, although the amount and depth of skin penetration of compounds was different. Thus, despite a weaker permeability barrier, the HSE can serve as a reproducible model for pre-screening of the skin delivery properties of formulations.Ph.D.Includes bibliographical references (p. 237-247)by Priya B. Bathej
2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
No full textIsaac Macwan (with Shrinivas Bhosale, Ashish Aphale, Miad Faezipour, Priya Bhosale, and Prabir Patra) is a contributing author Computer Assisted Detection of Liver Neoplasm (CADLN), pp.1510-1513
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