97,494 research outputs found
Joshua Davis: Author of Spare Parts
Full text linkCitation: K-State First (2016). Joshua Davis: Author of Spare Parts [Flier]. Manhattan, Kansas: K-State First.Flyer advertising Joshua Davis's author talk at Kansas State University
Nanovesicles Delivery Systems Containing Doxorubicin Hydrochloride and Paclitaxel for the Treatment of Breast Cancer
No full text2023Breast cancer is a type of cancer that can metastasize to distant organs of the body if left untreated, causing significant morbidity. The use of chemotherapeutic agents, one of the most employed approaches, possesses several shortcomings, including low tissue availability, short circulation time, and toxicity to healthy cells. To overcome these shortcomings, this study aimed to develop and characterize nanovesicles loaded with doxorubicin hydrochloride and paclitaxel, hypothesizing that combining both drugs in a single nanovesicle would enhance targeting to tumor cells, reduce drug dosing and toxicity resulting in improved patient compliance. The study developed and validated an UPLC method for the simultaneous detection and quantitation of both drugs in aqueous solutions. The UPLC method was validated for linearity, precision, sensitivity, and accuracy. Standard curves developed for both drugs were linear over a concentration range of 3.13 µg/mL through 50 µg/mL. The retention time of doxorubicin hydrochloride and paclitaxel were 1.53 minutes, and 4.06 minutes, respectively.
Thin-film hydration method was used to formulate blank, drug-loaded liposomes, transfersomes, and niosomes. The nanovesicles were physiochemically characterized for particle size, polydispersity index, zeta potential, drug loading, encapsulation efficiency, and drug release. The particle size for blank and drug-loaded nanovesicles ranged from 150 nm-250 nm, and PDI and zeta potential varied from 0.14-0.20 and -0.56 mV - +0.54 mV, respectively. The results indicated that 2.0-2.5% of doxorubicin hydrochloride and 7.0-7.5% of paclitaxel were successfully loaded in the formulations, with high encapsulation efficiency observed for both drugs.
Drug release studies using dialysis membranes with a molecular weight cut-off of 10,000 showed sustained release of drugs from the nano vesicular drug delivery systems for up to 72 hours. Both blank and drug-loaded nanovesicles were physically stable for a minimum of seven days when stored at room temperature and 4⁰C. The cytotoxicity of both drugs, blank nanovesicles, as well as drug-loaded nanovesicles, was investigated through MTT cytotoxicity assay and apoptosis study using flow cytometry. The liposomes, transfersomes, and niosomes developed in the study demonstrated potent and efficient cytotoxicity and apoptotic cell death against the MDA-MB 231 breast cancer cell line, requiring lower doses than their individual drug solutions.
In conclusion, the study developed and characterized three nanovesicles loaded with doxorubicin hydrochloride and paclitaxel, demonstrating their potential as an effective drug delivery system for the treatment of breast cancer
Steven Johnson Author Talk Poster
No full textK-State Book NetworkA poster advertising an author talk by Steven Johnson at Kansas State University on September 3, 2014. Steven Johnson's book "The Ghost Map" was the 2014-2015 common book
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Expanding “Communities and Collections” in the K-State Research Exchange (K-REx) to benefit the K-State Community and Beyond
No full textKansas State University has used its institutional repository, the K-State Research Exchange (K-REx), to store and share its first year experience program, K-State First, and notably its common reading program, K-State First Book. We have done so with the aim that the accessibility and preservation of these documents ensures program stability, promotes engagement with first year programming, and provides the ability to foster growth,educational opportunities, and community building outside of K-State. Moving away from research concentrated repositories and taking a more holistic approach to scholarship, especially when realizing the pedagogical significance of collaborative campus programming, institutions can showcase, discover, preserve, and grow programs that shape campus communities and engagement.
This session will provide an overview of K-REx and spotlight the digital archive of the university’s first year experience program and common reading program, K-State First Book. We will discuss the benefits and challenges to expanding the purview of your repositories. We talkthrough the types of materials we decide to host in our repository and why we share what we do. We will also provide recommendations on new ways to evaluate what belongs in institutional repositories and how this diversity can benefit your program, your institution, the community, and others
Microencapsulated bait: Does it work with red imported fire ants, Solenopsis invicta (Hymenoptera: Formicidae)?
No full textReady Player One Program Event Poster
No full textK-State Book NetworkA poster advertising an author talk by Ernest Cline at Kansas State University on October 10, 2013. Ernest Cline's book "Ready Player One" was selected as the 2013-2014 common book
Simplified approaches to determine the attractant preference of Solenopsis invicta (Hymenoptera: Formicidae)
No full textDepolarization and decreased surface expression of K+ channels contribute to NSAID-inhibition of intestinal restitution
No full textNon-steroidal anti-inflammatory drugs (NSAIDs) contribute to gastrointestinal ulcer formation by inhibiting epithelial cell migration and mucosal restitution; however, the drug-affected signaling pathways are poorly defined. We investigated whether NSAID inhibition of intestinal epithelial migration is associated with depletion of intracellular polyamines, depolarization of membrane potential (Em) and altered surface expression of K+ channels. Epithelial cell migration in response to the wounding of confluent IEC-6 and IEC-Cdx2 monolayers was reduced by indomethacin (100μM), phenylbutazone (100μM) and NS-398 (100μM) but not by SC-560 (1μM). NSAID-inhibition of intestinal cell migration was not associated with depletion of intracellular polyamines. Treatment of IEC-6 and IEC-Cdx2 cells with indomethacin, phenylbutazone and NS-398 induced significant depolarization of Em, whereas treatment with SC-560 had no effect on Em. The Em of IEC-Cdx2 cells was: −38.5±1.8mV under control conditions; −35.9±1.6mV after treatment with SC-560; −18.8±1.2mV after treatment with indomethacin; and −23.7±1.4mV after treatment with NS-398. Whereas SC-560 had no significant effects on the total cellular expression of Kv1.4 channel protein, indomethacin and NS-398 decreased not only the total cellular expression of Kv1.4, but also the cell surface expression of both Kv1.4 and Kv1.6 channel subunits in IEC-Cdx2. Both Kv1.4 and Kv1.6 channel proteins were immunoprecipitated by Kv1.4 antibody from IEC-Cdx2 lysates, indicating that these subunits co-assemble to form heteromeric Kv channels. These results suggest that NSAID inhibition of epithelial cell migration is independent of polyamine-depletion, and is associated with depolarization of Em and decreased surface expression of heteromeric Kv1 channels.ID: S0006295207001931; M3: Article; Accession Number: S0006295207001931; Author: L.C. Freeman (b); Author: D.F. Narvaez (a); Author: A. McCoy (a); Author: F.B. von Stein (c); Author: S. Young (b); Author: K. Silver (a); Author: S. Ganta (b); Author: D. Koch (b); Author: R. Hunter (b); Author: R.F. Gilmour (c); Author: J.D. Lillich (a, ⁎); Affiliation: Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, United States; Keyword: Non-steroidal anti-inflammatory drugs; Keyword: Intestinal epithelial cells; Keyword: Membrane potential; Keyword: Potassium channels; Number of Pages: 12; Language: English;Source type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=edselp&AN=S0006295207001931&site=eds-live&scope=sit
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