13 research outputs found
Expression Of Advanced End Glycation Product in Diabetic And Non-Diabetic Patients Bladder Cancer Tissues And Relation Between Bladder Cancer And Advanced End Glycation Product And Endosplamic Reticulum Stress.
No full textTEZ11615Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 2019.Kaynakça (s. 75-88) var.x, 89 s. : res. (bzs. rnk.), tablo ; 29 cm.Amaç: Çalışmamızda, diyabetik ve diyabetik olmayan mesane kanserli hastalardan alınan transüretral rezeksiyon (TUR M) materyalinde AGE ekspresyonu ve akümülasyonu ile ER stresinin ilişkisinin gösterilmesi amaçlandı. Materyal ve Metod: Çukurova üniveristesi tıp fakültesi üroloji A.B.D’na başvuran ve mesane kanseri şüphesiyle patolojiye göndermek için biyopsi yapılan hastaların doku örnekleri alınıp -80°C de dondurulup ELISA deneylerinde kullanılmak üzere saklanmıştır. Doku örnekleri alınan hastaların patoloji sonucuna göre kanserli olanlar diyabetli ve normal olarak 2 gruba ayrılmıştır ve ELISA deneylerinde kullanılmak üzere homojenize edilmiştir. Patolojik materyalde 2 grupta ELISA yöntemiyle ortalama AGE, IRE1, PERK, ATF6 ekspresyon miktarlarına bakılıp gruplar arasındaki farklılık tespit edilmeye çalışıldı. Bulgular: Kliniğimizde, Mayıs 2016 ve Eylül 2018 tarihleri arasında mesane kanseri nedeniyle takip edilip transüretral mesane rezeksiyonu ( TURB) yapılan 17 hasta çalışmamıza dahil edildi. Ortalama yaşları 69,2 ± 9,41 (52-82) yıl olan 17 hastadan 9 (%53)’ü diyabetik 8 (%47)’i non-diyabetik idi. Diyabetik ve normal mesane kanserli hasta grubunda 4 ekspresyon miktarları student t testi ile değerlendirildiğinde istatistiksel olarak anlamlı fark izlenmedi (p=0,05?). Tartışma: Diyabet kanser ilişkisi, AGE birikimi ve ER stresinin kanser mekanizmasındaki rolü birçok çalışmada gösterilmiştir. Mesane kanseri gelişiminde de rolleri vardır.Objective: In our study, aim of this study was to investigate the relationship between ER stress and expression in diabetic and non-diabetic bladder cancer tissues expression of AGE in transurethral resection (TUR M) material Materials and Methods: Tissue samples were taken from the patients who were admitted to Çukurova University Medical Faculty Urology Department and sent to pathology for suspicion of bladder cancer. Tissue samples were taken and frozen at -80 ° C and stored for use in ELISA experiments. According to the pathology results of patients who received tissue samples, those with cancer were divided into 2 groups with diabetes and normally homogenized for use in ELISA experiments. In the pathological material, the mean AGE, IRE1, PERK and ATF6 expression levels were determined by ELISA method in two groups. Results: 17 patients who underwent transurethral bladder resection (TURB) between May 2016 and September 2018 for bladder cancer were included in our study. Of 17 patients with a mean age of 69.2 ± 9.41 (52-82) years, 9 (53%) were diabetic and 8 (47%) were non-diabetic. There were no statistically significant differences between the groups in the diabetic and normal bladder carcinoma patients (p < 0.05). Discussion: Diabetes cancer relationship, AGE accumulation and ER stress cancer the role in the mechanism has been shown in many studies. They also have a role in the development of bladder cancer.Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi tarafından desteklenmiştir. Proje No: TTU-2016-7124
Structural changes driven by e-petitioning technology: changing the relationship between the central government and local governments
No full texte-Petitioning is a type of information and communication technology for development that can be used by citizens to express their voices in society. Although much work is focused on government-citizen relationships, little is known about whether and, if so, how e-petitions technology might result in structural transformations in public administration. In this study, we investigated the effects of an e-petitioning system in the Turkish public administration from neo-institutional and transaction cost perspectives. In contrast to the expectation of reducing transaction costs due to ICTs use, the transaction costs increased. The changes have further strengthened the central government by transforming the current tutelary relationship into a more hierarchical structure. The change is not driven by lowering transaction costs; instead, the change mirrors the power structures. The use of technology changed the structures in such a way that political power structures are reinforced while empowering the citizens to make their voices heard.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Information and Communication Technolog
Public sector innovativeness and public values through information and communication technologies
No full textIn public administration (PA) literature, there are a number of big questions regarding institutional and organizational factors. Competency formation, availability of resources and citizen empowerment [1] are among them. The importance of big questions must not rely on instrumentality; rather should focus on how and whether they have consequences and value for society [2]. The literature also questions “the paradox of publicness” [3, 4] by referring the “special status of public organization” claim of [5] and “publicness theory” of [6]. Given that public organizations have different characteristics with regard to operational processes and organizational structures operating in a particularized environment [7:6], they pursue different ends [5]. Replying to these big questions, we put forward public sector innovation (PSI) and co-creation of public values (PVs) as particularly important when contextual and conditional indicators are at the table. PVs and innovations in government may serve the government to reorganize PA as a whole through producing holistic and long-term strategies to enhance public service delivery system in a multi-actor-environment. For this we need a functional mediator, thus we employ information and communication technologies (ICTs). Through ICT-led tools, various and differentiated stakeholders can meet on a continuous base to frame the collective ground. For governments, ICTs may well be used to realize collaboration, coordination, and co-creation values that would alleviate some of the issues addressed via the big questions.Information and Communication Technolog
Cynicism as mediating variable between leadership support and emotional burnout: Administrative support staff in Turkish universities
No full textStudies in management and organization scholarship prefer to focus on personnel who constitute the core in institutions having bilateral employee status, academicians in the case of our research. Yet, organizational issues pertaining to administrative employees, as support personnel, seem understudied in the literature. Thus, in this study, we focus on issues experienced by administrative employees in Turkish universities. We have employed leader-member exchange theory as theoretical background, and conducted a field research through a questionnaire form to test the model. Organizational cynicism, emotional burnout and leadership support constitute the main dimensions of the research theme. We argue that leadership support affects emotional burnout through organizational cynicism. Analysis shows that administrative support personnel in universities suffer from emotional burnout, mainly sourcing from organizational cynicism on which leadership support is highly influential. Thus superiors in bilateral institutions are expected to support administrative employees to eliminate cynicism, otherwise they are in danger of emotional burnout.Information and Communication Technolog
E-Justice: A Review and Agenda for Future Research
No full textAs governments are increasingly adopting digitalization reforms to improve public services, the justice domain is no exception. Although not as rapidly grown as the other e-government initiatives, electronic justice or e-justice practices are developed and implemented to make justice services and their administration more open, accessible, effective, efficient, and less expensive for all actors. On the other hand, there are also specific challenges or risks involved in the digitalization of this area, such as the delicacy of the processes, legal restrictions, ensuring the independence of the judiciary, system design, and good user experience, and high interoperability. As a result of the relatively immature nature and the diversity of e-justice systems being used around the world, an integrated research framework outlining the specific areas and topics of research for e-justice and identifying future research directions is still lacking. In light of this gap, this chapter systematically reviews scholarly research on e-justice to present an integrated research framework. We identify 36 key research publications related to e-justice employing Web of Science and Google Scholar and review them to highlight what we know and do not know about e-justice. The study reveals four broad areas of foci about e-justice research in general: Identification of success and risk factors, assessment of the impact of e-justice implementation, examination of e-justice user satisfaction and experiences, and evaluation of judicial websites. For each of the research areas outlined, theoretical foundations, specific research aims, and main findings, and suggested directions for future research are summarized. A future research agenda informed by the results of the review is proposed. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG
The Effect of Manual Detorsion on Testicular Salvage Rates in Adult Testicular Torsion Patients: Single Center Experience
No full textAim: The aim of this study was to reveal the effect of manual detorsion on testicular salvage rates and the factors affecting the success of manual detorsion in adult testicular torsion.
Material and Methods: The records of patients who applied to the emergency department with pre-diagnosis of acute scrotum were examined. A total of 62 adult patients diagnosed with testicular torsion were included in the study. Manual detorsion was attempted in all patients before surgery. Demographic characteristics of the patients, time from onset of scrotal pain to hospital admission (<24 hours/>24 hours), physical examination and ultrasonography findings, type of surgery performed, and long-term results were evaluated. The data were statistically compared between patients with manual detorsion considered successful and unsuccessful.
Results: Manual detorsion was considered successful in 36 (58.1%) patients and unsuccessful in 26 (41.9%) patients. Orchiopexy was performed in 35 (97.2%) of the successful patients and in 11 (42.3%) of the unsuccessful patients (p<0.001). When subgroup analysis was performed, although there was no significant difference in pain duration between patients with and without successful manual detorsion for patients with pain duration of less than 24 hours (p=0.648), there was a statistically significant difference in testicular salvage rates. While the rate of orchiectomy was 1/35 (2.9%) in patients with successful manual detorsion, this rate was 8/19 (42.1%) in unsuccessful patients (p<0.001).
Conclusion: Manual detorsion increases testicular salvage rates in adult patients diagnosed with testicular torsion, and it should be attempted especially in patients with pain duration less than 24 hours
Pressure-temperature phase diagram of Ti2O3 and physical properties in the golden Th2S3-type phase
No full textIn this paper, the pressure and temperature conditions of the synthesis of a recently discovered golden Th2S3-type phase of titanium sesquioxide (Ti2O3) are studied, along with its physical properties. In combined x-ray diffraction and Raman high-pressure studies at room-temperature we found signatures of an isostructural transition at pressures near similar to 8-10 GPa. This finding was addressed to the well-known isostructural semiconductor-semimetal transition that occurs at ambient pressure near 400-450 K. Above similar to 10 GPa the golden phase was synthesized under appropriate heating. Based on both in-situ high-pressure high-temperature (HP-HT) studies in diamond anvil cells and ex-situ studies on samples synthesized at HP-HT conditions in multianvil cells, we constructed a pressure-temperature phase diagram of Ti2O3 for the first time. The samples of the golden polymorph were examined by Raman, absorption, and reflectance spectroscopy as well as by measurements of electrical resistivity, Hall effect, thermoelectric power (Seebeck effect), and magnetoresistance. In addition, electronic band-structure calculations were performed. We established that at ambient conditions the golden polymorph of Ti2O3 behaves as a semiconductor with an energy gap of similar to 0.1-0.2 eV and determined its typical electronic band structure parameters.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000306409600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Physics, Condensed MatterSCI(E)16ARTICLE2null8
Structural stability of a golden semiconducting orthorhombic polymorph of Ti2O3 under high pressures and high temperatures
No full textAn orthorhombic polymorph of titanium oxide (Ti2O3) has been synthesized at high pressure-high temperature (HP-HT) conditions. It has been refined in the Pnma space group and the Th2S3 structural type with the unit cell parameters as follows: a = 7.8248(6) angstrom, b = 2.8507(4) angstrom, c = 8.0967(3) angstrom, V = 180.61(1) angstrom(3) and Z = 4. The samples of Pnma-Ti2O3 were of a golden colour, in contrast to the conventional black corundum-structured Ti2O3. The structural stability of this polymorph has been examined by simultaneous Raman and x-ray diffraction studies under high pressure over 70 GPa and high temperature over 2200 K. No phase transformations or chemical reactions have been established. The electrical resistivity of Th2S3-structured Ti2O3 samples showed a semiconducting behaviour and, at ambient conditions, was equal to 0.20-0.46 Omega cm. Conventional near-infrared absorption spectroscopy established the absence of energy gaps above 0.25 eV.Physics, Condensed MatterSCI(E)EI18ARTICLE37null2
High-pressure behavior of structural, optical, and electronic transport properties of the golden Th2S3-type Ti2O3
No full textInternational audienceRecently, a golden colored, dense polymorph of titanium sesquioxide, Ti2O3 with a Th2S3-type structure, has been synthesized at high-pressure high-temperature conditions. In this paper, we present results of investigations of structural, optical, and electronic transport properties of this unusual golden polymorph of Ti2O3 under high pressure. Several experimental techniques were used, including x-ray diffraction studies using synchrotron radiation, Raman spectroscopy, electrical resistivity, and thermoelectric power. The structural studies showed that the Th2S3-type lattice is conserved under pressure, while it is subjected to an isostructural phase transition with a ∼0.7% volume drop at 38.5 GPa.We speculated that this transition could be driven by the s → d electron transfer in the Ti atoms. For the Th2S3-type Ti2O3, we have established a bulk modulus value, B0 =258.3 GPa at B 0 =4.1. A full profile analysis of the diffraction patterns allowed us to discover anomalies in the compression behavior of the Th2S3-type structure. The bond valence sums method suggested that at ambient conditions the Ti cations have predominantly Ti3+ oxidation state, but applied pressure stimulates a partial charge disproportionation between the Ti1 and Ti2 sites achieving the maximal effect--reduction of the Ti1 cations to ∼Ti2.5+ and oxidation of the Ti2 ones to ∼Ti3.5+ near 14 GPa. Pressure evolution of Raman spectra across the above crossovers showed distinct changes corroborating the above findings. The high-pressure electronic transport studies confirmed that the Th2S3-type Ti2O3 remains semiconducting up to 21 GPa at ambient and low temperatures down to 4.2 K. These studies found additional features, e.g., in the activation energy curve near 7 GPa, that is accompanied by inversion of the dominant conductivity type from electron to hole. The intriguing high-pressure behavior of Ti2O3 with the Th2S3-type structure can contribute to better understanding of high-pressure properties of transition-metal sesquioxides
