1,720,970 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Many facets of CPEB proteins in neurons and beyond: expression, mRNA recognition and phosphorylation
Full text linkCPEBs are a family of evolutionary conserved auxiliary translational factors. They bind to CPEs in the 3’UTR of target mRNA and, by interacting with other members of the translational machinery, promote or decrease gene expression. Since the first description of CPEB protein as a key orchestrator of oocyte maturation in Xenopus Laevis, key functions of CPEBs in embryonic development, cellular senescence and synaptic plasticity have been described. Local, postsynaptic modulation of synaptic efficacy is the most studied function of CPEBs in the CNS. However, the expression of CPEBs is not restricted to neurons and even 7% of total brain mRNAs possesses CPEs. Moreover, specific mRNAs are enriched in functionally distinct subcellular regions, like dendritic spines of neurons or complex cellular processes of astrocytes, where they might be translationally regulated. Herein, I embarked on further elucidating the role of CPEB translational regulators family in selected cell populations in mouse brain. In the first part of the work, the target mRNA specificity of different CPEBs was tested. I argued with the hypothesis that CPEBs -3 and -4 require mRNA secondary structure (a stem-loop) for target recognition. I showed that despite differences in the RBD primary structure, CPEB-1 shows a considerable sequence specificity overlap with CPEB-3 (and possibly, due to sequence similarity, with CPEBs -2 and -4 as well). This holds true for neuronal (CaMKIIα) and astrocytic(β-catenin) CPEB targets. Additionally, RNAco-immunoprecipitation revealed two novel CPEB target mRNAs, encoding (1) an astrocytic gap junction protein (Connexin43) and (2) CPEB-3 protein itself. In the first part of the work, the target mRNA specificity of different CPEBs was tested. I argued with the hypothesis that CPEBs -3 and -4 require mRNA secondary structure (a stem-loop) for target recognition. I showed that despite differences in the RBD primary structure, CPEB-1 shows a considerable sequence specificity overlap with CPEB-3 (and possibly, due to sequence similarity, with CPEBs -2 and -4 as well). This holds true for neuronal (CaMKIIα) and astrocytic(β-catenin) CPEB targets. Additionally, RNAco-immunoprecipitation revealed two novel CPEB target mRNAs, encoding (1) an astrocytic gap junction protein (Connexin43) and (2) CPEB-3 protein itself. In the second part of the thesis, CPEBs 1-4 gene expression in microglia, NG2 cells and astrocytes was assessed at the mRNA and protein level, confirming the ubiquitous nature of the CPEB expression. A more detailed analysis of CPEB-3 mRNA revealed expression of only certain isoforms of the protein in ESdM cells. Each CPEB family member occurs in several splice variants. Hitherto, only a handful of reports are dealing with the significance of alternative splicing of CPEBs. Interestingly, regulation of expression of CPEBs in neurons may happen in an isoform-specific fashion. Seeing this as a highly intriguing phenomenon, I focused on CPEB-3, containing a putative kinase recognition site on the alternatively spliced exon 5. In a cell-free systems and in cultured cells, I showed that CPEB-3 is a target of PKA and CaMKII – both critical for LTP/LTD, and that exon 5 harbors a consensus sequence required for kinase recognition. In vivo, in a transgenic mouse overexpressing CPEB3 protein in principal neurons of the hippocampus, I founda significant decrease in GluR2 AMPA-R subunit protein levels. In view of the above, the stimulation-induced phosphorylation of CPEB-3 may very well be a novel mechanism of translational modulation of synaptic plasticity. In the final part of the thesis, I aimed at establishing a quality control method for Cre-mediated gene deletions. Using Cx30-/-;Cx43fl/fl mice with hGFAP-Cre recombinase driver, I developed a reliable immunoblot-based tool for post-hoc control of recombination variability in hGFAP-Cre transgenic mice
Instrumental Value of Knowledge and Knowledge-creation
Full text linkJohn Dewey’s pragmatic theory of knowledge supports the assertion that both the instrumental value of knowledge and knowledge-creation have common philosophical
underpinnings. An analysis of this issue can help bridge the gap between the typical economic approach to knowledge and those approaches that are represented by
contemporary epistemology and philosophy of science. The universal concept of the
value of knowledge that is proposed here allows one to carry out further research on
using contemporary epistemology in knowledge management practice.3249643Studia Metodologiczn
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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