566 research outputs found
Demographic and Clinical Findings of Patients with Refractory Epilepsy at Epilepsy Outpatient Clinic of Muğla Sıtkı Koçman University Faculty of Medicine
No full textObjectives:Demographic and clinical findings of patients with refractory epilepsy receiving treatment at the newly established epilepsy outpatient clinic of Muğla Sıtkı Koçman University Faculty of Medicine were evaluated.Methods:Records of patients treated at the epilepsy outpatient clinic between June 2014 and March 2016 were examined, and 60 patients with refractory epilepsy were included the study.Results:Mean age was 34.3 years. Of the total, 29 were men and 31 were women. Seizures of 50 patients were partial onset, while those of 3 were generalized. Fourteen patients had psychogenic seizures, and 1 patient was diagnosed with paroxysmal kinesigenic dyskinesia. The electroencephalogram (EEG) recording of 20 patients was normal. Partial epileptiform abnormalities were present in 24 patients, and generalized epileptiform abnormalities were seen in 1 patient. Treatment was modified in 45 patients. Four patients were seizure-free, 13 showed more than 50% reduction in seizure frequency, and 9 patients had less than 50% fewer seizures. It is thought that 34 patients have pharmacoresistant seizures. The cause of uncontrolled seizures was misdiagnosis in 5 patients, improper drug in 3 patients, and insufficient treatment dose in 5 patients.Conclusion:Accurate diagnosis and appropriate treatment with sufficient dose of drug selected according to type of seizure is important for patients with refractory epilepsy
Mustafa Kutlu hikâyelerinin Gerard Genette’in anlatı söylemi bağlamında incelenmesi Examination of Mustafa Kutlu’s stories in the context of Gerard Genette’s narrator discourse
No full textix, 107 sayfa29 cm. 1 CDÖZETHikâye ve deneme yazmaya günümüzde de devam eden Mustafa Kutlu, Türk edebiyatının önemli hikâye yazarlarından biridir. Yazarın hikâyeleri, anlatıbilimsel tekniklerle farklı şekillerde kurgulanmıştır. Bu çalışmada Gérard Genette’in Anlatının Söylemi adlı eserinden hareketle Mustafa Kutlu’nun Yoksulluk İçimizde, Uzun Hikâye ve Tirende Bir Keman adlı yapıtlarının anlatıbilimsel açıdan incelenmesi amaçlanmıştır. Mustafa Kutlu’nun farklı dönemlerde kaleme almış olduğu eserlerle ilgili incelemelerde zaman kurgusu, anlatıcının konumu ve işlevi, anlatı mesafesi ve perspektifinin nasıl inşa edildiği üzerinde durulmuştur. Gérard Genette’in ortaya koyduğu kuramsal çerçeve ve bu çerçeve kapsamında belirtilen teorik kavramlara ilişkin, inceleme nesnesi olan anlatılarda zamanın kurgulanış biçimineanalepsis ve prolepsislerle zamanın düzenlenişineözet, ara, eksilti ve sahne teknikleriyle zamanın şekillendirilmesine yönelik tespit ve çözümlemeler yapılmıştır.ABSTRACTMustafa Kutlu who continues writing stories and essays today, is one of the important story writers of Turkish Literature. The stories of the author have been fictionalized in different ways with narratological techniques. In this study, it is aimed to analyze the works of Mustafa Kutlu named Yoksulluk İçimizde, Uzun Hikâye and Tirende Bir Keman, based on Gérard Genette's The Discourse of Narrative, from a narratological point of view. In the examinations of the works written by Mustafa Kutlu in different periods, the time setup, the position and function of the narrator, the narrative distance and how the perspective is constructed are emphasized. The theoretical framework put forward by Gérard Genette and the theoretical concepts stated within the scope of this framework, the way time is constructed in the narratives that are the object of studythe arrangement of time with analepsis and prolepsissummary, intermediate, ellipse and scene techniques and the shaping of time have been determined and analyzed
Is it easy to switch antiepileptic treatment from valproate to others?
No full text6th Congress of the European-Academy-of-Neurology (EAN) - MAY 23-26, 2020 - ELECTR NETWORKWOS: 000534616801421Europ Acad Neuro
The Relationship Between Illness Severity, Anxiety and Depressive Symptoms in Obstructive Sleep Apnea Syndrome Patients
No full textObjective:
Obstructive Sleep Apnea syndrome (OSAS) is a disease commonly seen in the community, causing labor loss and neuropsychiatric symptoms. The aim of the study is to compare the symptoms of depression and anxiety with those of healthy controls in patients with OSAS and to investigate the relationship between OSAS severity with anxiety and depression.
Materials and Methods:
Two hundred and thirteen patients with OSAS who underwent polysomnographic examination and 116 healthy controls were included in the study. The patient group was classified as mild, moderate and severe OSAS. Beck Anxiety and Beck Depression Scales were administered to the patients and healthy controls.
Results:
There was a significant difference between the patient group and the control group in the mean scores of Beck Depression and Beck Anxiety Scales. The mean scores of depression of the OSAS group were 11.16±8.87 (mild depression); 6.85±6.15 of the control group (p0.05).
Conclusion:
In our study; although there was a significant difference between depression and anxiety mean scores in patient and control group; there was no significant difference in anxiety and depression mean scores among mild, moderate and severe OSAS patients. Patients with OSAS were found to have mild anxiety and depressive symptoms. In these patients, there was no correlation between AHI values and depression and anxiety scores
Association between obstructive sleep apnea syndrome and waist-to-height ratio
No full textWOS: 000468613100013PubMed ID: 30238284Purpose Obesity is among the known risk factors for obstructive sleep apnea syndrome (OSAS). In this study, our aim was to investigate the correlation of waist-to-height ratio, an indicator of central obesity, with presence and severity of OSAS; to compare the use of this ratio with the use of waist circumference and body mass index (BMI); and to determine OSAS-related cutoff values. Methods The patient records were retrospectively analyzed for whom a polysomnography was conducted at our sleep. Sex, age, Apnea-Hypopnea Index (AHI), waist circumference, height, and BMI values of those patients were recorded. AHI scores were used to classify severity of OSAS. Results The study included 437 OSAS patients and 72 control cases. Out of the patient group, OSAS was severe in 208 (47%) patients, moderate in 124 (28%), and mild in 105 (24%) of them. In the group of OSAS patients, waist-to-height ratio, waist circumference, and BMI were higher compared to the control group with a further difference of all three parameters among severe, moderate, mild OSAS, and controls both in males and females. Cutoff values for OSAS of females were 95.5cm for waist circumference, 0.595 for waist-to-height ratio, and 27.75 for BMI whereas the cutoff values of males were 100.5cm, 0.575, and 27.75, respectively. Conclusions A high value of waist circumference, waist-to-height ratio, and BMI is associated with the presence and severity of OSAS. We have determined the cutoff values of the studied anthropometric measurements in both sexes for OSAS and severe OSAS
Restless Legs Syndrome in Patients with Epilepsy Under Levetiracetam Monotherapy
No full textObjective:
Restless Legs syndrome (RLS) is a frequent neurological disease. Levetiracetam (LEV) is an effective and broad-spectrum anticonvulsant drug. The aim of this study is to investigate the frequency of RLS in patients diagnosed with epilepsy who took LEV monotherapy.
Materials and Methods:
Two neurologists were reviewed the files of 1680 patients, who were followed in epilepsy outpatient clinic. One hundred seven patients under LEV monotherapy for at least six months and 120 healthy controls were included in the study. The criteria for the International Restless Legs Syndrome Study Group were taken into consideration for the assessment of RLS.
Results:
The mean age of patient group was 38.26±17.39 years, while the mean age of healthy controls was 39.17±16.12 years. There were no statistically significant differences in terms of age and sex between each two groups. The mean duration of LEV usage was 28.34 months. The LEV usage dose was between 500-3000 mg/day. RLS was seen in 7 (5.83%) healthy controls, whereas 4 patients (3.73%) had RLS in patient group before LEV treatment. The symptom of RLS in two patients disappeared after LEV treatment started and this rate decreased to 1.87%. The biochemical parameters were normal in all patient groups, after LEV treatment, peripheral neuropathy was detected in one patient whose symptoms were not relieved.
Conclusion:
LEV may have therapeutic effect on RLS. It may be preferred especially in comorbid situations where epilepsy and RLS are seen together. Longitudinal and prospective studies are needed to manifest better the therapeutic effects of LEV on RLS
Demographic and Clinical Findings of Epilepsy Patients who Underwent Follow-up at the Newly Established Clinic of the Muğla Sıtkı Koçman University Faculty of Medicine
No full textObjectives:The aim of the present study was to evaluate demographic and clinical findings of patients who underwent follow-up at the newly established epilepsy outpatient clinic of the Muğla University Faculty of Medicine.Methods:Included were 208 patients who underwent follow-up at the clinic between March 2014 and September 2015.Results:Mean age was 29.42±15.86, with a range of 5–84 years. Eighty-three patients were men (39.9%); 125 were women (60.1%). The most common risk factors included head trauma, febrile convulsion, and family history of epilepsy. Seizures of 155 patients (75.5%) were partialonset, those of 22 (10.6%) were generalized, and those of 9 (4.3%) were unclassified. Sixty-seven patients (37.2%) had normal electroencephalogram, 96 patients (53.3%) had partial, and 10 patients (5.6%) had generalized epileptiform abnormalities. Of the 172 patients (28.5%) to whom antiepileptic drugs had been administered, 49 were resistant to medical treatment. Of the patients with modified therapy, 22 (41.5%) were seizure-free, 7 (13.2%) experienced >50% reduction in seizure frequency, and 8 experienced <50% reduction. Seizure frequency of 16 patients (30.2%) did not change.Conclusion:Regular monitoring of patients in certain centers significantly increases compliance, success of treatment, seizure-free rate, and the monitoring of side effects
Sudden Unexpected Death in Epilepsy: A Case Report
No full textSudden unexpected death in epilepsy (SUDEP) is a serious problem, and its importance has increased in recent years. It is responsible for the death of 17% of epilepsy patients. As the age of onset rises, the risk increases. Patients with refractory epilepsy are particularly at risk. Likewise, male gender, early age of onset, polytherapy, nocturnal seizures, generalized tonic-clonic seizures (GTCS) are also among the risk factors. Respiratory, cardiac, autonomic and brain stem related pathologies are held to be responsible for its pathophysiology
Response to: Obstructive sleep apnea syndrome and obesity: screening ability
No full textWOS: 000499987000001[No abstract available
Do mentalization skills affect the perception of stigma in patients with epilepsy?
No full textWOS: 000450110100008PubMed ID: 30241053Purpose: We aimed to study the relationship between the mentalizing ability and stigma in patients with epilepsy. Methods: Patients with epilepsy were administered the following battery of tests: Mini-International Neuropsychiatric Interview (MINI) form, Reading the Mind in the Eyes Test (Eyes Test), Stigma Scale of Epilepsy (SSE), Internalized Stigma of Mental Illness (ISMI) Scale, Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Results: Assessment of an association between the Eyes Test score, ISMI Scale total score, and subscale scores revealed a negative significant correlation of Eyes Test scores with approval of stereotypes, perceived discrimination, stigma resistance, and total score. Eyes Test score and BDI scores appears to be significant predictor of internalized stigma among the clinical variables that were studied. A positive significant correlation was detected between BDI score and alienation, perceived discrimination, and total score. Conclusion: The presence of a correlation between the mentalization and stigma perception in our study demonstrates that these two concepts are connected and that this connection needs further study. In particular, mentalization-based therapy can have an effect on the reduction of the stigma perceptions and in this way can improve the course of the disease, potentially improving the patients' quality of life. (C) 2018 Elsevier Inc. All rights reserved
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