59,242 research outputs found
Temperature- and cyclic nucleotide-induced phase transitions of Histoplasma capsulatum
No full textThe transition from yeast to mycelia of H. capsulatum could be accomplished by shifting the temperature of incubation from 37 to 25°C. It was accompanied by many changes in cellular metabolism, including changes in respiration, intracellular cyclic adenosine 3',5'-monophosphate (cAMP) levels, and activities of two enzymes specific for the yeast phase, cystine reductase (EC 1.6.4.1) and cysteine oxidase (EC 1.13.11.20). Even at 37°C, the yeast to mycelial transition could be induced by cAMP and agents which raise the intracellular levels of cAMP (theophylline, acetylsalicylic acid, prostaglandin E 1, and nerve growth factor). During this morphogenesis the same pattern of changes occurred as in the temperature-induced transition. Therefore, these changes were not simply dependent on a shift in temperatures, but rather were part of the process of the phase transition
Banach Fixed Point Theorem in Extended bv(s)-Metric Spaces
No full textWe define the class of extended bv(s)-metric spaces by replacing the real number s≥1 with a strictly increasing continuous function ϕ in the definition of a bv(s)-metric space. Also, we presented an example for this newly introduced space and exhibited that in a particular situation, the class of extended bv(s)-metric spaces reduces to the class of bv(s)-metric spaces. Afterwards, we establish a fixed point theorem which ensured the existence of a fixed point for the self-map satisfying the Banach contractive condition in the context of this newly defined space. Moreover, we compared the proved result with the existing fixed point theorems in the literature
Temperature Tolerant Rhizobium leguminosarum bv. viciae Strains with Plant Growth Promotion Traits
No full textRhizobacteria (PGPR) that promote the plant growth are essential component of sustainable agriculture. Pea (Pisum sativum L.) root nodule Rhizobium leguminosarum bv. viciae ten strains were cultured at two different temperatures (28°C and 45°C). Out of eight strains screened the three N25, N30 and N40 were temperature tolerant while only one strain (N40) showed tolerance to pH11. The growth of Rhizobium strain N40 at 45 °C was 96.8 percent as compared to the growth of the at 28°C. The temperature tolerant strain N40 produced maximum IAA and solubilized insoluble tri calcium phosphate compared to other strains and thus can be used microbial inoculant in biofertilizer technology
Complete genome sequence of Rhizobium leguminosarum bv. trifolii strain WSM1325, an effective microsymbiont of annual Mediterranean clovers
No full textRhizobium leguminosarum bv trifolii is a soil-inhabiting bacterium that has the capacity to be an effective nitrogen fixing microsymbiont of a diverse range of annual Trifolium (clover) species. Strain WSM1325 is an aerobic, motile, non-spore forming, Gram-negative rod isolated from root nodules collected in 1993 from the Greek Island of Serifos. WSM1325 is produced commercially in Australia as an inoculant for a broad range of annual clovers of Mediterranean origin due to its superior attributes of saprophytic competence, nitrogen fixation and acid-tolerance. Here we describe the basic features of this organism, together with the complete genome sequence, and annotation. This is the first completed genome sequence for a microsymbiont of annual clovers. We reveal that its genome size is 7,418,122 bp encoding 7,232 protein-coding genes and 61 RNA-only encoding genes. This multipartite genome contains 6 distinct replicons; a chromosome of size 4,767,043 bp and 5 plasmids of size 828,924 bp, 660,973 bp, 516,088 bp, 350,312 bp and 294,782 bp
Asymptotic behavior of <em>BV</em> functions and sets of finite perimeter in metric measure spaces
No full textAbstractIn this paper, we study the asymptotic behavior of BV functions in complete metric measure spaces equipped with a doubling measure supporting a 1-Poincaré inequality. We show that at almost every point x outside the Cantor and jump parts of a BV function, the asymptotic limit of the function is a Lipschitz continuous function of least gradient on a tangent space to the metric space based at x.We also show that, at co-dimension 1 Hausdorff measure almost every measure-theoretic boundary point of a set (Ε) of finite perimeter, there is an asymptotic limit set Ε∞ corresponding to the asymptotic expansion of Ε and that every such asymptotic limit (Ε)∞ is a quasiminimal set of finite perimeter. We also show that the perimeter measure of Ε∞ is Ahlfors co-dimension 1 regular. Abstract
In this paper, we study the asymptotic behavior of BV functions in complete metric measure spaces equipped with a doubling measure supporting a 1-Poincaré inequality. We show that at almost every point x outside the Cantor and jump parts of a BV function, the asymptotic limit of the function is a Lipschitz continuous function of least gradient on a tangent space to the metric space based at x.We also show that, at co-dimension 1 Hausdorff measure almost every measure-theoretic boundary point of a set (Ε) of finite perimeter, there is an asymptotic limit set Ε∞ corresponding to the asymptotic expansion of Ε and that every such asymptotic limit (Ε)∞ is a quasiminimal set of finite perimeter. We also show that the perimeter measure of Ε∞ is Ahlfors co-dimension 1 regular
Characterization of the compact operators on the class (bv,bvkθ)
No full textThe space bv, the set of all bounded variation sequences, has an important role in the summability theory. In recent study, this spaces has been extended to the space bvk? and some matrix class on this space has been characterized [2]. In the present paper, for 1 ? k ?, computing Hausdorff measure of non-compactness, we characterize compact operators in the class (bv, bvk?), where ? is a sequence of positive numbers. © 2019 Author(s)
A lower semicontinuity result for functionals on BV.
No full textIn this work the author deals with some very important problems in the calculus of variations related to the functional|
that can be considered as the natural extension to BV(Ω) of the functional
f(x,u,Du)dx, u ∈ W1,1(Ω) [see G. Dal Maso, Manuscripta Math. 30 (1979/80), no. 4, 387–416; MR0567216]. The author generalizes her results from another paper [Boll. Un. Mat. Ital. B (7) 5 (1991), no. 2, 291–313] and proves that F is lower semicontinuous, along sequences bounded in BV(Ω), relative to the strong topology of L1(Ω). The interest of the result is based on two facts: (i) the integrand f(x,s,p) is dependent on x, while in the above-mentioned paper by the author it was not so; (ii) the integrand f (x, s, p), which was supposed in Dal Maso’s paper [op. cit.] to be lower semicontinous relative to s, is not so in the present paper
Lopsided Blood-thinning Drug Increases the Risk of Internal Flow Choking and Shock Wave Generation Causing Asymptomatic Stroke
No full textLopsided Blood-thinning Drug Increases the Risk of Internal Flow Choking and Shock Wave Generation Causing Asymptomatic Stroke
Author Block: V R SANAL KUMAR, ISRO; S.K.Choudhary, AIIMS; P.K.Radhakrishnan, GU; Suresh Menon, GT; Vrishank Raghav, AU; K.K.N Namboodiri, Sapna E.Sreedharan, SCTIMST; Bharath R.S, Nichith C, C.Oommen, IISc; V.Sankar, IITK; A.Sukumaran, KCT; Arun K, DHMMC; A.Pal, Tharikaa R.K, AU, Abhirami R, AIMS.
Introduction
Consequence of lopsided blood-thinning-drug, lowering blood-viscosity (BV), is bleeding and very frequently asymptomatic-hemorrhage (AH) and the acute-heart-failure (AHF) happen. V.R.S.Kumar et al. (2020) reported that such asymptomatic episodes are due to the internal flow choking in the cardiovascular system (CVS) at a critical blood-pressure-ratio (BPR), which is regulated by biofluid/blood heat capacity ratio (BHCR).
Methods
The closed-form-analytical-methodology is used for correlating BV, BPR, BHCR, vessel geometry and ejection fraction (EF). In vitro method is used for the BHCR estimation of healthy subjects. In silico method is used for demonstrating the Sanal flow choking.
Results
The analytical models reveal that the relatively high and low BV are risk factors of internal flow choking. In vitro study shows that N2, O2, CO2 & Ar gases are predominant in fresh-blood samples of the healthy subjects at a temperature range of 37-400 C (98.6-1040 F), which increases the risk of flow-choking. In silico results demonstrated the Sanal flow choking followed by the shock wave generation and pressure-overshoot in a simulated artery with the divergent/bifurcation region.
Conclusions
An overdose of blood-thinning drug reduces BV and increases Reynolds number causing high-turbulence leading to the Sanal flow choking. Asymptomatic stroke could be diminished by concurrently lessening the BV and flow turbulence by rising thermal tolerance level in terms of BHCR or by decreasing the BPR. In conclusion, BPR must always be lower than 1.8257 as dictated by the lowest BHCR of the evolved gas for prohibiting asymptomatic stroke
Sulfhydryl induced respiratory "shunt" pathways and their role in morphogenesis in the fungus, Histoplasma capsulatum.
No full textWhen the mycelial to yeast transition of the dimorphic fungus Histoplasma capsulatum is induced by a temperature shift from 25 to 37 degrees C, the activities of the cytochrome system and the alternate oxidase decrease in parallel over the first 24 to 40 h (stage 1 of the transition). The decrease in activity of the cytochrome system is correlated with extensive decreases in the amounts of cytochromes b, c, and aa3, assayed spectrophotometrically. After 40 h, the cells enter a dormant phase (stage 2 of the transition) and cysteine or other sulfhydryl-containing compounds are required to reactivate mitochondrial respiration. This reactivation is due to the establishment of shunt pathways which bypass blocked segments of the electron transport system. The "shunt" pathways operate normally in mycelia grown at 25 degrees C, but are shut down during the transition, possibly because of depletion of intracellular cysteine. The longstanding observation that cysteine is required to progress beyond the initial stages of the morphological transition may be due, at least in part, to the reactivation of these "shunt" pathways
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