1,720,975 research outputs found
Successful palliative chemotherapy for peristomal recurrence of laryngeal metastasis from colon adenocarcinoma.
No full textabstract not available
...Rare cases of metastasis of colon adenocarcinoma
to the larynx usually present with disseminated
disease. In view of the poor chances of long-term
survival only palliative laryngeal treatment aimed to
improve the patients’ quality of life is advised. In
palliative approaches to laryngeal metastases from
colon carcinoma, laser endoscopic resection of the
laryngeal lesion has been described as an ideal tool
for relieving airway obstruction without significant
morbidity [2]. Associated chemotherapeutic approaches
in patients with head and neck metastatic
colorectal cancer should also be considered. Considering
the therapy for metastatic colorectal cancer,
a recent review by Goldberg [3] showed that the
chemotherapeutic regimens FOLFOX (oxaliplatin/
5-fluorouracil/leucovorin) and FOLFIRI (irinotecan/
5-fluorouracil/leucovorin) consistently lead to
median overall survivals in the range of 1520
months. Combinations seemed to confer a 56
month advantage in median overall survival when
compared with single-agent chemotherapy. The
patients aged over 70 seemed to tolerate FOLFOX
regimen as well as younger patients. There are few
published data on the tolerability of first-line irinotecan-
based regimens in elderly patients [3]. Our
patient did not respond significantly to the FOLFOX
regimen; on the other hand, the FOLFIRI
regimen determined a good partial response of
peristomal recurrence and lung metastases
Simposio: L’impiego dei moderni biomarkers può rivoluzionare la diagnostica ed il trattamento dei carcinomi della testa e del collo?
No full textComplete response to weekly carboplatin-docetaxel chemotherapy in a 91-years old woman with anaplastic thyroid cancer.
No full textAnaplastic thyroid cancer (ATC) is an unusual tumor with the worst prognosis among
thyroid malignancies. Treatment of the patients diagnosed with ATC is not standardized
and the feasible options include surgery, radiotherapy and chemotherapy. ATC cannot be
regarded as a very chemo-sensitive tumor. Herein, we reported a case of a 91-year-old
woman with complete response after induction chemotherapy (weekly carboplatin and
docetaxel) that underwent subsequent radiotherapy
Tongue base metastasis from neuroendocrine endometrial small cell carcinoma.
No full textThe endometrial small cell carcinoma (ESCC) is a rare and aggressive malignancy with an estimated prevalence of less than 1% of endometrial carcinomas. Endometrial small cell carcinoma is frequently diagnosed at an advanced stage and has a poor prognosis. Although the most common presenting sign of ESCC is definitely a peri- or postmenopausal vaginal bleeding, we report for the first time the occurrence of tongue base bleeding as first manifestation of disseminated neuroendocrine ESCC. From a clinical viewpoint, tongue metastasis from primary endometrial carcinoma is a manifestation of widespread disease. Albeit, our patient underwent complete hysterectomy and postoperative chemotherapy, she died of disseminated disease 3 months after ESCC diagnosis
Advanced Medullary thyroid carcinoma: results of treatment in 35 patinets and crrelation to FDG PET-CT and 111 in Octotride imaging
No full textLate onset (22 years) of simultaneous tonsillar and cervical lymph-node metastases from breast ductal carcinoma.
No full textBreast cancer is the leading cause of cancer-related mortality in women worldwide; the most common metastatic sites are lymph nodes, lung, liver and brain. Tonsil metastases from breast cancer are extremely rare. Herein, we report a case of a 74-year-old woman with simultaneous occurrence of tonsillar and cervical lymph nodes metastases after a disease-free interval of 22 years
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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