3 research outputs found
A Systematic Study on Long-acting Nanobubbles: Current Advancement and Prospects on Theranostic Properties
No full textDelivery of diagnostic drugs via nanobubbles (NBs) has shown to be an emerging field of study. Due to their small size, NBs may more easily travel through constricted blood vessels and precisely target certain bodily parts. NB is considered the major treatment for cancer treatment and other diseases which are difficult to diagnose. The field of NBs is dynamic and continues to grow as researchers discover new properties and seek practical applications in various fields. The predominant usage of NBs in novel drug delivery is to enhance the bioavailability, and controlled drug release along with imaging properties NBs are important because they may change interfacial characteristics including surface force, lubrication, and absorption. The quick diffusion of gas into the water was caused by a hypothetical film that was stimulated and punctured by a strong acting force at the gas/water contact of the bubble. In this article, various prominent aspects of NBs have been discussed, along with the long-acting nature, and the theranostical aspect which elucidates the potential marketed drugs along with clinical trial products. The article also covers quality by design aspects, different production techniques that enable method-specific therapeutic applications, increasing the floating time of the bubble, and refining its properties to enhance the prepared NB’s quality. NB containing both analysis and curing properties makes it special from other nano-carriers. This work includes all the possible methods of preparing NB, its application, all marketed drugs, and products in clinical trials
DEVELOPMENT OF GUGGULSTERONE-LOADED PHYTOSOMES: A QUALITY BY DESIGN-BASED CHARACTERIZATION AND OPTIMIZATION STUDIES
No full textObjective: The primary objective of this study was to enhance drug delivery efficiency through the design and optimization of guggulsterone-pyrosomes, employing a 3-factor, 3-level box-behnken design.
Methods: The methodology involved a solvent evaporation technique utilizing guggulsterone and soy lecithin, with a systematic variation and optimization of critical factors such as soy lecithin and guggulsterone concentration, alongside temperature adjustments to refine the phytosome formulations. The characterizations of these formulations were extensive, with a particular emphasis on key quality attributes, notably percentage entrapment efficacy and drug release.
Results: The optimized guggulsterone-pyrosomes demonstrated impressive outcomes, showcasing a remarkable entrapment efficiency of 92.64% and a noteworthy drug release rate of 91.69% at 24 h. These formulations displayed heightened viability in selected cell lines, exhibiting cellular toxic c concentrations ranging from 253.39 to 330.44 µg/ml. Moreover, they exhibited stability under stressed conditions from a physicochemical perspective. The particle size was measured at 137.8 nm, with a zeta potential of-25.3 mV.
Conclusion: Significantly, the extended drug release from guggulsterone-pyrosomes adhered to first-order kinetics with Fickian diffusion. In summary, this study underscores the efficacy of the box-behnken design in crafting optimized guggulsterone-pyrosomes, showcasing their potential as promising drug delivery carriers. The enhanced drug delivery platform exhibits significant promise in amplifying antihyperlipidemic effects, attributed to the improved performance and stability of these innovative phytosome
Recent advances in green synthesized nanoparticles for bactericidal and wound healing applications
No full textFunding Information: The authors, Dr Sisubalan and Dr Gnanaraj, acknowledge the Bishop Heber College (Autonomous), Tiruchirappalli, Tamil Nadu, India, for providing physical facilities. Author Prof. Dr Varaprasad Kokkarachedu acknowledges the Fondecyt Regular 1211118, ANID and FIT, USS, Chile. Publisher Copyright: © 2023Nanotechnology has become an exciting area of research in diverse fields, such as: healthcare, food, agriculture, cosmetics, paints, lubricants, fuel additives and other fields. This review is a novel effort to update the practioneers about the most current developments in the widespread use of green synthesized nanoparticles in medicine. Biosynthesis is widely preferred among different modes of nanoparticle synthesis since they do not require toxic chemical usage and they are environment-friendly. In the green bioprocess, plant, algal, fungal and cyanobacterial extract solutions have been utilized as nucleation/capping agents to develop effective nanomaterials for advanced medical applications. Several metal salts, such as silver, zinc, titanium and other inorganic salts, were utilized to fabricate innovative nanoparticles for healthcare applications. Irrespective of the type of wound, infection in the wound area is a widespread problem. Micro-organisms, the prime reason for wound complications, are gradually gaining resistance against the commonly used antimicrobial drugs. This necessitates the need to generate nanoparticles with efficient antimicrobial potential to keep the pathogenic microbes under control. These nanoparticles can be topically applied as an ointment and also be used by incorporating them into hydrogels, sponges or electrospun nanofibers. The main aim of this review is to highlight the recent advances in the Ag, ZnO and TiO2 nanoparticles with possible wound healing applications, coupled with the bactericidal ability of a green synthesis process
