109,044 research outputs found
Breaking the stigma : redefining the architectural image of FET colleges in South Africa
No full textIncludes bibliographical references.The initial topic of this thesis focused on ways in which architecture can help to bridge the gap between education and employment; a very real need in South Africa's economy of today, as stated in the February 2011 State of the Province Address by Premier of the Western Cape, Helen Zille. My research into this topic soon revealed that there are already existing models in place that aim to close this gap, namely Further Education and Training (FET) College facilities. According to the FET Act of 2006, the aim of these colleges is to provide post-compulsory general education with a focus on vocational training, while preparing students for occupational fields and increasing employment opportunities (Act No. 16 of 2006). After visiting several of these colleges within the Cape Town area, and interviewing the Campus Managers, it became apparent that the system is currently not working at its full potential. There are many reasons for this, which will be discussed later. One of the most pressing issues, however, is related to the campuses themselves. Many of the colleges have been given old and unused school buildings, or have taken over older college buildings that were designed for different purposes. This has diminished the campus usability and relevance, which has ultimately created a negative image of FET Colleges in general
Narratives of women and murder in England, 1680-1760 ::deadly plots /
No full textArguing that the female criminal subject was central to the rise of the British novel, Kirsten T. Saxton provides insights into the complex ways in which categories of criminality, gender and fiction intersected in the long 18th century
Recommended from our members
Narratives of women and murder in England, 1680-1760 ::deadly plots /
No full textArguing that the female criminal subject was central to the rise of the British novel, Kirsten T. Saxton provides insights into the complex ways in which categories of criminality, gender and fiction intersected in the long 18th century
KRAS (Kirsten rat sarcoma viral oncogene homolog)
No full textReview on KRAS (Kirsten rat sarcoma viral oncogene homolog), with data on DNA, on the protein encoded, and where the gene is implicated
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Incidents in the Life of Kirsten T. Edwards: A Personal Examination of the Academic In-between Space
No full textThis paper investigates what happens when individuals do not fit into the ideological boxes established in a (post)colonial system, when they occupy a space of Academic "in-betweeness." The author asks, "How do these 'colonial contradictions' navigate this formerly colonized space we call the Academy?" Through conversations with three "Academic In-betweeners" as well as excerpts from the author's personal journal entries, this paper attempts to explore the following questions, "What do we do when our race or gender or personal values and beliefs do not coincide with the original design, with the underlining/historic values of the institution (Anderson, 1988; Solomon, 1985; Thelin, 2004)?" and "What do our navigational practices and understandings tell us about U.S. Higher Education?
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study
No full textResearchers worldwide with information about the Kirsten ras (Ki-ras) tumour genotype and outcome of patients with colorectal cancer were invited to provide that data in a schematized format for inclusion in a collaborative database called RASCAL (The Kirsten ras incolorectal-cancer collaborative group). Our results from 2721 such patients have been presented previously and for the first time in any common cancer, showed conclusively that different gene mutations have different impacts on outcome, even when the mutations occur at the same site on the genome. To explore the effect of Ki-ras mutations at different stages of colorectal cancer, more patients were recruited to the database, which was reanalysed when information on 4268 patients from 42 centres in 21 countries had been entered. After predetermined exclusion criteria were applied, data on 3439 patients were entered into a multivariate analysis. This found that of the 12 possible mutations on codons 12 and 13 of Kirsten ras, only one mutation on codon 12, glycine to valine, found in 8.6% of all patients, had a statistically significant impact on failure-free survival (P=0.004, HR 1.3) and overall survival (P=0.008, HR 1.29). This mutation appeared to have a greater impact on outcome in Dukes' C cancers (failure-free survival, P=0.008, HR 1.5; overall survival P=0.02, HR 1.45) than in Dukes' B tumours (failure-free survival, P=0.46, HR 1.12; overall survival P=0.36, HR 1.15). Ki-ras mutations may occur early in the development of pre-cancerous adenomas in the colon and rectum. However, this collaborative study suggests that not only is the presence of a codon 12 glycine to valine mutation important for cancer progression but also that it may predispose to more aggressive biological behaviour in patients with advanced colorectal cancer
Kirsten Boies "Heul doch nicht, du lebst ja noch": Geschichtsbewusstsein und Sinnpotential jugendliterarischen Erzählens über die frühe Nachkriegszeit
No full textRottschäfer N, Kersten M, Lucia T. Kirsten Boies "Heul doch nicht, du lebst ja noch": Geschichtsbewusstsein und Sinnpotential jugendliterarischen Erzählens über die frühe Nachkriegszeit. In: Ott C, Hübner R, Rémi C, eds. Kirsten Boie. Leseperspektiven und Lernpotentiale. DDG – Beiträge zur Didaktik der deutschsprachigen Gegenwartsliteratur. Trier: WVT; 2025
Block in the expression of differentiation markers of rat thyroid epithelial cells by transformation with Kirsten murine sarcoma virus.
No full textWell-differentiated epithelial cells, derived from primary cultures of normal rat thyroid glands (T-79 cells), as well as a cloned cell line also derived from normal rat thyroid glands (FRT-L cells) were infected with Kirsten murine sarcoma virus carrying outer coat of the helper Kirsten murine leukemia virus. Infected T-79 and FRT-L cells changed morphologically and began to proliferate rapidly, suggesting malignant transformation by the virus. Both cell lines can support the replication of both transformation-competent and transformation-incompetent viruses such as murine or rat leukemia viruses. Infected T-79 and FRT-L cells had a high colony-forming efficiency (68 and 64%, respectively) when grown in agar and formed tumors when transplanted s.c. into syngeneic rats. These tumors morphologically resemble undifferentiated adenocarcinomas, thus showing that Kirsten sarcoma virus carrying the outer coat of the helper Kirsten murine leukemia virus is able to transform differentiated epithelial cells. Transformed T-79 and FRT-L cells, in contrast to uninfected cells, neither secrete thyroglobulin concentrate iodide, two biochemical markers of differentiated thyroid function. Thus, expression of the differentiated phenotype is blocked as a consequence of cell transformation. The system described may be useful in studying epithelial cell carcinogenesis in terms of regulated expression of differentiated functions
La zone d'influence urbaine de Düsseldorf et Cologne à l'est du Rhin, d'après Gerd Kirsten
No full textMoreau Jean-Paul. La zone d'influence urbaine de Düsseldorf et Cologne à l'est du Rhin, d'après Gerd Kirsten. In: Annales de Géographie, t. 75, n°409, 1966. p. 340
- …
