142,917 research outputs found

    World War I record of service survey for Simon Katz, signed 18 March 1926.

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    Questionnaire about Simon Katz's service in World War I, 1917-1919, signed by Katz on 18 March 1926.Questionnaire originally part of a survey of Norwich University alumni conducted by a “Norwich in the World War” committee consisting of Charles N. Barber (chairman), Carl V. Woodbury, K.R.B. Flint, and Gustaf A. Nelson. Data from these questionnaires may have been used in a chapter of "Vermont in the world war, 1917-1919" by Harold P. Sheldon (1928)

    Assessing stool quantities generated by three specific Kato-Katz thick smear templates employed in different settings.

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    BACKGROUND The Kato-Katz technique is recommended for the diagnosis of helminth infections in epidemiological surveys, drug efficacy studies and monitoring of control interventions. We assessed the comparability of the average amount of faeces generated by three Kato-Katz templates included in test kits from two different providers. METHODS Nine hundred Kato-Katz thick smear preparations were done; 300 per kit. Empty slides, slides plus Kato-Katz template filled with stool and slides plus stool after careful removal of the template were weighed to the nearest 0.1 mg. The average amount of stool that was generated on the slide was calculated for each template, stratified by standard categories of stool consistency (i.e. mushy, soft, sausage-shaped, hard and clumpy). RESULTS The average amount of stool generated on slides was 40.7 mg (95 % confidence interval (CI): 40.0-41.4 mg), 40.3 mg (95 % CI: 39.7-40.9 mg) and 42.8 mg (95 % CI: 42.2-43.3 mg) for the standard Vestergaard Frandsen template, and two different templates from the Chinese Center for Disease Control and Prevention (China CDC), respectively. Mushy stool resulted in considerably lower average weights when the Vestergaard Frandsen (37.0 mg; 95 % CI: 34.9-39.0 mg) or new China CDC templates (37.4 mg; 95 % CI: 35.9-38.9 mg) were used, compared to the old China CDC template (42.2 mg; 95 % CI: 40.7-43.7 mg) and compared to other stool consistency categories. CONCLUSION The average amount of stool generated by three specific Kato-Katz templates was similar (40.3-42.8 mg). Since the multiplication factor is somewhat arbitrary and small changes only have little effect on infection intensity categories, it is suggested that the standard multiplication factor of 24 should be kept for the calculation of eggs per gram of faeces for all investigated templates

    Quality control in the diagnosis of Trichuris trichiura and Ascaris lumbricoides using the Kato-Katz technique : experience from three randomised controlled trials

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    BackgroundAn accurate diagnosis of soil-transmitted helminthiasis is important for individual patient management, for drug efficacy evaluation and for monitoring control programmes. The Kato-Katz technique is the most widely used method detecting soil-transmitted helminth eggs in faecal samples. However, detailed analyses of quality control, including false-positive and faecal egg count (FEC) estimates, have received little attention.MethodsOver a 3-year period, within the frame of a series of randomised controlled trials conducted in Pemba, United Republic of Tanzania, 10% of randomly selected Kato-Katz thick smears were re-read for Trichuris trichiura and Ascaris lumbricoides eggs. In case of discordant result (i.e. positive versus negative) the slides were re-examined a third time. A result was assumed to be false-positive or false-negative if the result from the initial reading did not agree with the quality control as well as the third reading. We also evaluated the general agreement in FECs between the first and second reading, according to internal and World Health Organization (WHO) guidelines.ResultsFrom the 1,445 Kato-Katz thick smears subjected to quality control, 1,181 (81.7%) were positive for T. trichiura and 290 (20.1%) were positive for A. lumbricoides. During quality control, very low rates of false-positive results were observed; 0.35% (n¿=¿5) for T. trichiura and 0.28% (n¿=¿4) for A. lumbricoides. False-negative readings of Kato-Katz thick smears were obtained in 28 (1.94%) and 6 (0.42%) instances for T. trichiura and A. lumbricoides, respectively. A high frequency of discordant results in FECs was observed (i.e. 10.0-23.9% for T. trichiura, and 9.0-11.4% for A. lumbricoides).ConclusionsOur analyses show that the rate of false-positive diagnoses of soil-transmitted helminths is low. As the probability of false-positive results increases after examination of multiple stool samples from a single individual, the potential influence of false-positive results on epidemiological studies and anthelminthic drug efficacy studies should be determined. Existing WHO guidelines for quality control might be overambitious and might have to be revised, specifically with regard to handling disagreements in FECs

    Das Moment der Ressourcenaktivierung im Ansatz der Integrativen Kinder- und Jugendlichenpsychotherapie: eine theoretische Skizze

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    Es werden die theoretischen Prämissen, Arbeits-und Behandlungsmodelle der von Hilarion Petzold in Zusammenarbeit mit Bruno Metzmacher, Helmut Zaepfel und Nitza Katz-Bernstein entwickelten Integrativen Psychotherapie für Kinder und Jugendliche, unter ressourcenorientierten Gesichtspunkten skizziert. Dieser multimodale Ansatz verbindet tiefenpsychologische, leibtherapeutische, kognitiv-behaviourale und systemisch-lebensweltliche Perspektiven.The chapter outlines the theoretical premises, working and treatment models of integrative psychotherapy for children and adolescents as developed by Hilarion Petzold in collaboration with Bruno Metzmacher, Helmut Zaepfel and Nitza Katz-Bernstein, under resource-oriented aspects. This multimodal approach combines depth psychology, bodytherapeutic, cognitive-behavioral and systemic-life-world perspectives.https://www.fpi-publikation.de/polyloge/07-2019-zaepfel-h-metzmacher-b-katz-bernstein-n-ressourcenaktivierung-kinder-u-jugendliche/peerReviewedpublishedVersio

    Accuracy of the Kato-Katz method and formalin-ether concentration technique for the diagnosis of Clonorchis sinensis, and implication for assessing drug efficacy

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    Background: Clonorchiasis is a chronic neglected disease caused by a liver fluke, Clonorchis sinensis. Chemotherapy is the mainstay of control and treatment efficacy is usually determined by microscopic examination of fecal samples. We assessed the diagnostic accuracy of the Kato-Katz method and the formalin-ether concentration technique (FECT) for C. sinensis diagnosis, and studied the effect of diagnostic approach on drug efficacy evaluation. Methods: Overall, 74 individuals aged ≥18 years with a parasitological confirmed C. sinensis infection at baseline were re-examined 3 weeks after treatment. Before and after treatment, two stool samples were obtained from each participant and each sample was subjected to triplicate Kato-Katz thick smears and a single FECT examination. Results: Thirty-eight individuals were still positive for C. sinensis according to our diagnostic ‘gold’ standard (six Kato-Katz thick smears plus two FECT). Two FECT had a significantly lower sensitivity than six Kato-Katz thick smears (44.7% versus 92.1%; p <0.001). Examination of single Kato-Katz and single FECT considerably overestimated cure rates. Conclusions: In settings where molecular diagnostic assays are absent, multiple Kato-Katz thick smears should be examined for an accurate diagnosis of C. sinensis infection and for assessing drug efficacy against this liver fluke infection
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