1,721,061 research outputs found
Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity
No full textCdk10 is a Cdc2-related kinase that may play a role in regulating the G2/M phase of the cell cycle. However little is known about the proteins that interact with this putative kinase and contribute to its function in the cell. We report in this study that Cdk10 interacts with the N-terminus of the Ets2 transcription factor, which contains the highly conserved Pointed domain and transactivation domain. The Pointed domain has been implicated in protein-protein interactions and we find that Ets2 requires an intact Pointed domain to bind Cdk10. The Pointed domain of Ets1 is highly similar to Ets2, however Cdk10 does not recognize Ets1 in a two-hybrid assay thereby demonstrating significant binding specificity on the part of Cdk10. We find that Cdk10 binds full length Ets2 in vitro and in vivo and inhibits Ets2 transactivation in mammalian cells
H. Kasten, M. Tullii Ciceronis Scripta. Fase. 18. Oratio pro Murena
No full textVan den Bruwaene Martin. H. Kasten, M. Tullii Ciceronis Scripta. Fase. 18. Oratio pro Murena. In: L'antiquité classique, Tome 31, fasc. 1-2, 1962. pp. 355-356
H. Kasten, M. Tullius Cicero. Fasc. 19. Oratio pro Sulla. Oratio pro Archia
No full textDepret Elsy. H. Kasten, M. Tullius Cicero. Fasc. 19. Oratio pro Sulla. Oratio pro Archia. In: L'antiquité classique, Tome 37, fasc. 1, 1968. pp. 295-296
Current understanding of AIDS pathogenesis
No full textFrom the mid 1990s, considerable progress has been achieved in understanding the biology of the human immunodeficiency virus type 1 (HIV-1), and the pathogenesis of the acquired immunodeficiency syndrome (AIDS). However, these achievements are still not sufficient to indicate the reasons for failure of the host immune response in suppressing HIV-1 infection and why the immune system collapses at the end of the clinical latency period, followed by progression to the terminal course of the disease. A more complete view of the dynamics of AIDS pathogenesis may greatly facilitate the development of novel and ambitious therapeutic interventions, that are needed to counteract the onset of HIV-1 variants resistant to current antiretroviral treatments, to ensure affordable therapy programs for developing countries, and, in the long term, to eradicate the virus from patients and to confer protective immunity to HIV-1 infection
The RB family of cell cycle regulatory factors
No full textThe intense investigation of the retinoblastoma 'tumor suppressor family' members, pRb, pRb2/p130, and p107, has revealed impressive mechanisms evolved to safeguard development and homeostasis in higher eukaryotes. Members of the retinoblastoma family are involved in implementing and controlling three major aspects of cellular life: (1) proliferative growth, (2) differentiation, and (3) apoptosis. The activities of these proteins are highly regulated, enabling them to precisely establish control. The pRb protein is well understood in its regulatory abilities and is considered a classical tumor suppressor. The role of pRb2/p130 protein in growth suppression and its potential as a tumor suppressor have been established during the last few years. The p107 protein, structurally and functionally similar to, but yet distinctive from, pRb2/p130, is characterized at a more rudimentary level. In this report, we review the latest data on the retinoblastoma protein family and its web of regulatory mechanisms
pRb and the cdks in apoptosis and the cell cycle
No full textApoptosis is a fundamental biological process present in metazoan cells. Linking apoptosis to the cell cycle machinery provides a mechanism to maintain proper control of cell proliferation in a multicellular organism, pRb and the cyclin-dependent kinases may have dual roles as integral components of the cell cycle and regulators of apoptosis. In many instances manipulation of the cell cycle through these molecules can induce or inhibit apoptosis. Recent studies also identify pRb as a substrate for an apoptotic protease; however, other cell cycle components are not known substrates. While it is clear that many common molecules can affect cell proliferation and cell death, the universality of any one cell cycle molecule in apoptosis has yet to be determined
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Interaction of polymorphonuclear leukozytes with cartilage in vitro - catabolic effects of serine protease and oxygen radicals
No full textBurkhardt H, Rehkopf E, Kasten M, Rauls S, Heimann P. Interaction of polymorphonuclear leukozytes with cartilage in vitro - catabolic effects of serine protease and oxygen radicals. Scand J Rheumatol. 1988;17(3):183-195
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