105 research outputs found
Three Approaches to Psychoanalytic Psychotherapy in Aotearoa New Zealand
No full textThis paper discusses three styles of psychoanalytic psychotherapy commonly practiced in Aotearoa New Zealand. Judi Blumenfeld Hoadley writes on object relations, Gustavo Restivo on the Lacanian orientation, and Sarah Calvert on relational psychoanalysis and the relational movement. Each author discusses their specific orientation towards psychoanalytic psychotherapy in terms of the historical origins, seminal theorists, and philosophical views. They also articulate the key theoretical concepts, clinical techniques, and unique links to the therapeutic relationship. Finally, the authors point out the specific organisations, training, and conferences available in Aotearoa New Zealand
Design- Based Research Methods and Theory Building: A Case Study of Research with SpeakEasy
No full textDesign-based research methods are an emerging research paradigm that blends empirical research with design and implementation. This article discusses how a design-based research trajectory can help not only suggest and refine theories, but also permit their falsification. In a series of design-based research studies on an online discussion tool (called SpeakEasy), the author shows how a theory of socially relevant representations for learning was formed, applied, refined, and ultimately tested.,As described in the introductory article in this special issue, design-based research methods (DBRM) in education are an exciting, productive set of research methods that blend a desion stance with empirical research in context to advance our theoretical knowledge of learning, while simultaneously producing valued educational outcomes for learners in real settings 'Design-Based Research Collective, 2003; Kelly, 2003). In this article, 1 describe the development of an online discussion tool for learning, called SpeakEasy {Hoadlev, Hsi, & Berman, 1995a), and discuss how a long trajectory of design-based research not only allowed theory to inform design, but also enabled clesiqn to inform psychological theory Christopher M. Hoadley designs, builds, and studies ways for technolop to enhance collaboration and learning. He is currently Assistant Proiessor of Instructional Systems and o
Between curricula reforms and pedagogical practices: Ursula Hoadley and the “pedagogy in poverty”
No full textNesta entrevista, Ursula Hoadley, docente e pesquisadora da Universidade da Cidade do Cabo, África do Sul, discute algumas das ideias que desenvolve em seu livro Pedagogia na pobreza: lições de vinte anos de reformas curriculares na África do Sul, bem como salienta a potência explicativa da teoria de Basil Bernstein, sua principal referência nesta e em outras investigações no contexto sul-africano. A entrevistada comenta seus principais achados nessa pesquisa, que possibilitou descrever e analisar práticas docentes desenvolvidas por professoras dos anos iniciais do Ensino Fundamental, frente a um movimento de vinte anos de reformas curriculares, no contexto anterior e posterior ao apartheid. Suas reflexões não perdem de vista as especificidades de seu país, mas situam as reformas curriculares estudadas no cenário mais amplo de mudanças em países em desenvolvimento, o que as torna especialmente interessantes para os debates sobre o currículo da educação básica no Brasil.In this interview, Ursula Hoadley, a professor and researcher at the University of Cape Town, South Africa, discusses some of the ideas present in her book Pedagogy in Poverty: lessons from twenty years of curriculum reform in South Africa. The author highlights the explanatory power of Basil Bernstein’s theoretical framework, her main reference both in this and other investigations in the South-African context. The interviewee comments on her main findings in this research, which allowed her to describe and analyze teaching practices developed in the primary years of Elementary School – comprising a twenty-year period with intense curriculum reforms, in the context before and after the apartheid. While bearing the specificities of her country in mind, her considerations locate the aforementioned reforms in the wider context of developing countries – thereby becoming especially relevant to the debates about school curriculum in Brazil
The boundaries of care: education policy interventions for vulnerable children
No full textThis chapter interrogates a growing vision of schools as sites of care and support for vulnerable children, especially in the context of HIV/AIDS. The chapter is based on two research activities: a desk review of projects working in the area of schools in the context of HIV/AIDS and poverty; and documentation of a particular project in the Free State province of South Africa. The author also considers the South African policy framework for schools and vulnerable children. The chapter begins by sketching out some of the major education policies pertaining to vulnerable children, especially in the context of HIV and AIDS. It then offers three cautionary notes in relation to the thrust of these policies and those programmes attempting to implement them. The first is a consideration of the context of implementation - the schooling system. The second is the resourcing of these policies. The third considers policy visions of schools and teachers. How schools and teachers are conceptualised both in policies and programmes is problematised. The misalignment between the policies around schools and vulnerable children, the resourcing of these policies and their contexts of implementation as well as the implications for thinking about expanded roles for schools and teachers are brought into relief
Autonomy, Control, and Notation in Interactive Music
No full textThis paper proposes a conceptualization of notation for interactive musical environments. The notational approach describes the relationship between both human and non-human agents, instead of actions to be taken or sounds to be made. Of critical importance in contemporary networked culture is the degree to which technological devices and networks constrain (or control) the actions of their users. The author has developed a conception of interactivity and notational considerations which instead foreground the autonomous potential of participants and the computational systems. The author analyzes three case studies that demonstrate either a direct connection or a broader conceptual link to the described notational approach. The larger implication is a need for notational systems which do not constrain the identity of the users of interactive systems while also acknowledging and representing the agency of the systems themselves
Abstract PD1-03: Multivariate analysis of subtype and gene expression signatures predictive of pathologic complete response (pCR) in triple-negative breast cancer (TNBC): CALGB 40603 (Alliance)
No full textAbstract
Support: U10CA180821, U10CA180882
Background: The addition of either carboplatin (Cb) or bevacizumab (Bev) to standard neoadjuvant chemotherapy (NACT) increases pCR rates in TNBC overall and in the dominant subset of basal-like cancers (Sikov et al, JCO 2015; Sikov et al, SABCS 2014). Multigene expression signatures more accurately reflect tumor biology for response prediction and prognosis than individual gene expression. We evaluated the ability of multivariate analysis of gene expression signatures to create predictive models for achievement of pCR in TNBC.
Methods: RNA sequencing was successful on 389 pretreatment samples from patients with available pCR data, and used to assign PAM50 subtype and calculate gene signatures scores for 489 published expression signatures. Elastic net, a penalized regression model for high dimensional variable selection, was used to select features associated with pCR in all TNBC and in the basal-like subset. Models were derived in a training set (2/3 of samples) and validated in a separate test set (1/3). A separate model was derived using 196 TNBC samples from patients treated only on the standard NACT +/- Cb arms for application to external TNBC neoadjuvant data sets not treated with Bev.
Results: Consistent with our prior partial data set, 343 (88%) of the cancers were classified basal-like, in whom the in breast pCR rate was 54%; the remainder were classified normal-like (n=32) or HER2-enriched (n=14) with a non-basal pCR rate of 56%. Elastic Net analysis in all TNBC generated a model of 23 signatures and treatment assignment with 68% sensitivity and 64% specificity. The area under the curve was 0.64 (p-value=0.0019). Nineteen modules, including immune cell signatures (Th1, NK, IgG), immunoglobulin variable region expression, addition of Cb and Bev and expression of genes at regions 15q25, 17p11.2-13.3, and 8p22 were positively associated with response. The latter two regions are associated with aggressive breast cancer, and while not part of the 17p13 signature, this region contains TP53, a gene important in TNBC. Six modules were associated with resistance, including luminal progenitor, TGFB, NOTCH, FOS/JUN, 8p amplicon, and eosinophil signatures. When limited to basal-like samples, a model including 32 modules and addition of Cb and Bev was generated, with 62.3% sensitivity and 59.1% specificity. Seventeen features were selected in both models. Omitting Bev-treated patients, a model using just the gene expression signatures was developed. The predictive value of this model will be assessed using an external cohort of TNBC patients treated with neoadjuvant docetaxel and Cb (NCT01560663) and results presented.
Conclusions: Multivariate analysis of gene expression signatures derived from pretreatment samples enabled the construction of models to predict achievement of pCR in TNBC. These models performed well on our test set, and will be assessed for their predictive ability in other TNBC data sets. If validated by future analyses, this could help us identify patients likely to achieve pCR with standard NACT and may benefit from the addition of agents such as Cb or Bev.
ClinicalTrials.gov Identifier: NCT00861705.
Citation Format: Hoadley KA, Hyslop T, Fan C, Berry DA, Hahn O, Tolaney SM, Sikov WM, Perou CM, Carey LA. Multivariate analysis of subtype and gene expression signatures predictive of pathologic complete response (pCR) in triple-negative breast cancer (TNBC): CALGB 40603 (Alliance) [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr PD1-03.</jats:p
SEMAPHORE: Cross-Domain Expressive Mapping with Live Notation
No full textThis paper describes research, investigations, creative experiments and performances undertaken by the author in collaboration with practitioners in different creative and performance domains. The research focuses on the translation of expression between these domains and its implementation using technology. This paper focuses primarily on the role of notation in this process. The domains involved include music (audio and notation), movement (dance) and text (poetry). The data arising from performers' movements are collected and investigated; consideration is given to the use of image and graphics enabling elementary algorithmically generated dance notation
Abstract P3-16-01: Using the new pan-cancer clinical data resource (TCGA-CDR) to identify breast cancer genomic correlates associating with different survival outcome endpoints
No full textAbstract
Introduction The Cancer Genome Atlas (TCGA) generated abundant high quality molecular data, however its relatively short-term patient follow-up limited its immediate clinical utility. We led a PanCanAtlas effort to systematically collate, integrate, and quality check the large body of acquired clinicopathologic data, generated 4 primary clinical outcome endpoints for each case, and created a new Pan-Cancer Clinical Data Resource (TCGA-CDR) for public use. We report here on the utility and validity of this TCGA-CDR in relating breast cancer (BC) genomic information to survival endpoints.
Methods Clinicopathologic data from all data files were integrated and processed. Overall survival (OS), disease-specific survival (DSS, an approximation), progression-free interval (PFI), and disease-free interval (DFI)were derived.Tests of the adequacy of the follow-up intervals for each endpoint were performed, and quality evaluation of these endpoints was established by their comparison with different clinical features. As a case study we compared each survival endpoint for significant association (FDR &lt;0.2) with chromosomal aneuploidy.
Results The 4 endpoints were derived for 1097 TCGA BC cases having a median follow-up time of 27.7 months. Median times to events/censorship for OS, DSS, PFI, and DFI were 41.8/25.0, 32.6/26.0, 26.0/25.0, and 25.4/25.0 months respectively. PFI and DFI passed tests for adequate follow-up times; OS and DSS partially passed the same tests signaling some caution with their use in genomic associations.
Using the endpoints, outcomes of patients with ER+ and ER- tumors were compared, along with those of patients with low (I&II) and high (III&IV) stage breast tumors. Univariate analyses suggested patients with ER+ tumors had significantly better survival than patients with ER- tumors when using PFI (p=0.005), DFI (p=0.001), and DSS (p=0.009), with OS not reaching significance (p=0.09). Patients with low stage tumors showed significantly better outcomes than patients with high stage tumors for each endpoint (p&lt;0.001). The 4 endpoints were also evaluated for their significant associations with chromosomal arm aneuploidy. Adjusted for patient age and AJCC stage, tumors with a loss of 8q and 8p (p=0.019, FDR=0.37) had worse PFI; and those with loss of 8q, 20q, and 8p had worse DFI. Tumors with gain of 11q or loss of 14, 7q, 12q, 18q, 20q, 3p, 7p, 8p, 18p, and 20p had worse OS. In contrast, tumors with loss of 16q had better DSS, while those with loss of 3q, 12q, 17q, 18q, 19q, 20q, 3p, 8p, 12p, 18p, 19p, and 20p had worse DSS. The finding that 8p loss associated with worse survival for all 4 endpoints, while 18p loss associated with worse OS and DSS, agrees with literature reports.
Conclusion These findings confirm that PFI and DFI, as extracted from the TCGA-CDR, are valid and appropriate BC survival endpoints, while OS and DSS may be recommended with some caution when employing TCGA data to evaluate new relationships between breast cancer genomic abnormalities and clinical outcomes.
The views expressed in this article are those of the author and do not reflect the official policy of the Department of Army/Navy/Air Force, the Department of Defense, or U.S. Government.
Citation Format: Liu J, Lichtenberg T, Hoadley KA, Cherniack A, Poisson L, Kovatich AJ, Benz C, Thorsson V, TCGA PanCanAtlas Research Network, Shriver CD, Hu H. Using the new pan-cancer clinical data resource (TCGA-CDR) to identify breast cancer genomic correlates associating with different survival outcome endpoints [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P3-16-01.</jats:p
United States Promotion of GM Foods in Mexico: An Application of a Public Diplomacy Model
No full textThe Mexican government’s policy of genetically modified (GM) foods has moved from a precautionary approach to the promotion and commercialization of agricultural biotechnology, possibly at the risk of narrowing Mexico’s biodiversity. The approval of the Law of Biosafety of Genetically Modified Organisms in 2005 allowed the cultivation of GM food crops. Subsequently, in accordance with the North America Free Trade Agreement, Mexico liberalized all agricultural product imports, including GM foods in 2008. In this thesis, I argue that the GM food policy change in Mexico can be explained by studying the US diplomatic and commercial efforts to promote GM foods. How US agencies, biotechnology companies, and NGOs have interacted with Mexican officials and other stakeholders, and how they have influenced this change of GM food policy, will be analyzed at length in this thesis. Through an adaptation of a public diplomacy model, and the conduct of documentary analysis and in-depth interviews, in this thesis I examine the state and non-state actors along with the public diplomacy activities involved in the Mexico’s GM food policy change. I describe how state actors such as the US Department of State and the Department of Agriculture have implemented programs that promote American agricultural products, including GM foods, and have applied diplomatic instruments, which in parallel with biotechnology corporations’ initiatives, appear to have been effective in influencing Mexican policy-makers. Non-state actors such as biotechnology companies and non-governmental organizations (NGOs) have also played important roles in changing Mexico’s GM food policy. My research found that biotechnology companies, as a result of their greater resources, have been more influential than NGOs, but NGO participation in public diplomacy activities has been relevant in raising GM food awareness among general audiences that in turn influenced policy-makers to exercise caution. Nevertheless, it is hypothesized that while the decision to liberalize GM food imports was a Mexican government decision, Mexican officials and legislators were influenced in that decision by US agencies and biotechnology corporations’ representations. How that influence was initiated, manifested, institutionalized, and received, analyzed by this author through the lens of a public diplomacy model, is the subject of this thesis
NOTATION AS TEMPORAL INSTRUMENT
No full textInternational audienceIn this paper the author proposes a descriptive musico-logical framework built on the notion of notation as temporal instrument in today's context of electronic music. The principal goal is to discuss a research categorization of musical notation that consider the performative character of musical writing in electronic music performance. In the intentions of the author, this framework could resume the multiple enhancement of the temporal dimension of notation implied by the new means of performance in electronic music
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