1,506 research outputs found

    Correction: A case of novel DYT6 dystonia variant with serious complications after deep brain stimulation therapy: a case report

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    Following publication of the original article [1], the authors reported an error in author group. Author M. Zech should be affiliated to affiliations 6 and 7. The original article [1] has been updated

    An exile in Buenos Aires: The stroll in the Argentinean works of Paul Zech (1933-1946)

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    En 1933 el escritor alemán Paul Zech debe huir de Alemania y refugiarse en Buenos Aires, donde vivirá hasta su muerte en 1946. Allí tendrá una intensa actividad literaria, llevada adelante en difíciles condiciones de vida, tanto en cuanto a su condición misma de exiliado, como por sus cambiantes y conflictivos vínculos al interior de la colectividad alemana. En esta obra, una inclinación a la caminata por la ciudad nos muestra una imagen de la Argentina de la década de 1930 desde el novedoso punto de vista de un autor exiliado en estas tierras.En este trabajo nos preguntamos cómo se constituye en la obra argentina de Zech el paseo en el exilio (si acaso es posible el paseo en el exilio) y cómo se recorta, por sus particularidades, de los otros registros urbanos escritos «a pie» en su misma época (Benjamin, Kracauer).In 1933 the German writer Paul Zech had to flee from Germany and go into exile in Buenos Aires, where he would live until his death in 1946. There, he would have an intense literary activity, carried out under difficult living conditions, both because of his condition as an exile and because of his changing and con-flictive links within the German community. Within Zech’s works during these years, an inclination to walk around the city shows us an image of Argentina in the 1930s from the novel point of view of an author exiled in these lands.In this work we inquire how the strollin exile (whether it is possible to stroll in exile) is constituted in Zech’s Argentinean work and how it is cut out, due to its particularities, from the other urban records written «by foot» in his same period (Benjamin, Kracauer).Fil: Sufotinsky Reynoso, Eric Tomás. Universidad Nacional de Rosario. Facultad de Humanidades y Artes. Instituto de Estudios Críticos en Humanidades. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Estudios Críticos en Humanidades; Argentin

    Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

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    Extracellular ATP binds to and signals through P2X7 receptors (P2X7Rs) to modulate immune function in both inflammasome-dependent and -independent manners. In this study, P2X7-/- mice, the pharmacological agonists ATP-magnesium salt (Mg-ATP; 100 mg/kg, EC50 ≈ 1.32 mM) and benzoylbenzoyl-ATP (Bz-ATP; 10 mg/kg, EC50 ≈ 285 μM), and antagonist oxidized ATP (oxi-ATP; 40 mg/kg, IC50 ≈ 100 μM) were used to show that P2X7R activation is crucial for the control of mortality, bacterial dissemination, and inflammation in cecal ligation and puncture-induced polymicrobial sepsis in mice. Our results with P2X7-/- bone marrow chimeric mice, adoptive transfer of peritoneal macrophages, and myeloid-specific P2X7-/- mice indicate that P2X7R signaling on macrophages is essential for the protective effect of P2X7Rs. P2X7R signaling protects through enhancing bacterial killing by macrophages, which is independent of the inflammasome. By using the connexin (Cx) channel inhibitor Gap27 (0.1 mg/kg, IC50 ≈ 0.25 μM) and pannexin channel inhibitor probenecid (10 mg/kg, IC50 ≈ 11.7 μM), we showed that ATP release through Cx is important for inhibiting inflammation and bacterial burden. In summary, targeting P2X7Rs provides a new opportunity for harnessing an endogenous protective immune mechanism in the treatment of sepsis.-Csóka, B., Németh, Z. H., Töro, G., Idzko, M., Zech, A., Koscsó, B., Spolarics, Z., Antonioli, L., Cseri, K., Erdélyi, K., Pacher, P., Haskó, G. Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

    Do n-alkane biomarkers in soils/sediments reflect the δ 2-H isotopic composition of precipitation? A case study from Mt. Kilimanjaro and implications for paleoaltimetry and paleoclimate research

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    During the last decade compound-specific deuterium (2H) analysis of plant leaf wax-derived n-alkanes has become a promising and popular tool in paleoclimate research. This is based on the widely accepted assumption that n-alkanes in soils and sediments generally reflect δ2H of precipitation (δ2Hprec). Recently, several authors suggested that δ2H of n-alkanes (δ2Hn-alkanes) can also be used as a proxy in paleoaltimetry studies. Here, we present results from a δ2H transect study (∼1500 to 4000 m above sea level [a.s.l.]) carried out on precipitation and soil samples taken from the humid southern slopes of Mt. Kilimanjaro. Contrary to earlier suggestions, a distinct altitude effect in δ2Hprec is present above ∼2000 m a.s.l., that is, δ2Hprec values become more negative with increasing altitude. The compound-specific δ2H values of nC27 and nC29 do not confirm this altitudinal trend, but rather become more positive both in the O-layers (organic layers) and the Ah-horizons (mineral topsoils). Although our δ2Hn-alkane results are in agreement with previously published results from the southern slopes of Mt. Kilimanjaro [Peterse F, van der Meer M, Schouten S, Jia G, Ossebaar J, Blokker J, Sinninghe Damsté J. Assessment of soil n-alkane δD and branched tetraether membrane lipid distributions as tools for paleoelevation reconstruction. Biogeosciences. 2009;6:2799–2807], a re-interpretation is required given that the δ2Hn-alkane results do not reflect the δ2Hprec results. The theoretical framework for this re-interpretation is based on the evaporative isotopic enrichment of leaf water associated with the transpiration process. Modelling results show that relative humidity, decreasing considerably along the southern slopes of Mt. Kilimanjaro (from 78 % in ∼2000 m a.s.l. to 51 % in 4000 m a.s.l.), strongly controls δ2Hleaf water. The modelled 2H leaf water enrichment along the altitudinal transect matches well the measured 2H leaf water enrichment as assessed by using the δ2Hprec and δ2Hn-alkane results and biosynthetic fractionation during n-alkane biosynthesis in leaves. Given that our results clearly demonstrate that n-alkanes in soils do not simply reflect δ2Hprec but rather δ2Hleaf water, we conclude that care has to be taken not to over-interpret δ2Hn-alkane records from soils and sediments when reconstructing δ2H of paleoprecipitation. Both in paleoaltimetry and in paleoclimate studies changes in relative humidity and consequently in δ2Hn-alkane values can completely mask altitudinally or climatically controlled changes in δ2Hprec

    Astronomy and astrophysics abstracts: author and subject indexes to volumes 1-10, literature 1969-1973

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    Astronomy and Astrophysics Abstracts, which has appeared in semi-annual volumes since 1969, is devoted to the recording, summarizing and indexing of astronomical publications through­ out the world. It is prepared under the auspices of the Interna­ tional Astronomical Union (according to a resolution adopted at the 14th General Assembly in 1970). Astronomy and Astrophysics Abstracts aims to present a com­ prehensive documentation of literature in all fields of astronomy and astrophysics. Volume 15/16 contains author and subject indexes of volumes 1 - 10, covering the literature from 1969 to 1973. It is a pleasure to express our warmest thanks to Miss Helga Ballmann, Mrs. Monika Betz, Dr. Siegfried B6hme, Mrs. Karola Gud6, Miss Lore Kiefert, and Mrs. Ingrid Wolf for their kind support in the preparation of the indexes. Heidelberg, June 1976 Ute Esser Inge Heinrich Frieda Henn Dietlinde Krahn Hans Scholl Gert Zech v Introduction The Author Index contains 110 180 references to publications initial letter following the first names. of 28654 different authors. The Subject Index contains 38145 An effort has been made to cite Russian names according to references to 7170 different key words. the following transliteration: The main characteristics of the concept of Astronomy and r Astrophysics Abstracts, Author and Subject Indexes may be A a P p a summarized briefly

    On the V ariability of the Family Names of C zech Migrants’ Descendants in the N orthern Caucasus and Western Siberia

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    This paper deals with the systems of family names characteristic for the communities of C zech migrants living in Russia in several villages near Novorossiysk and Anapa in the N orthern Caucasus and in the M iddle Irtysh area in Omsk Region which emerged in the 1860s and in the early 20th century respectively, as a result of migration of two different groups of C zech peasants. The article also takes into account, though selectively, family names of the Polish dialect speakers living in the Republic of K hakassia in Russia. The author points out that both Czech groups preserve unofficial local family names typical of the community’s initial Czech dialectal zones, southwestern in the first case and northeastern in the second. These unofficial names seem to be opposed to Russified official family names which are used in communication with the world outside the community. The semantic base of local, “internal” family names coming, in general, from possessive adjectives, is built on the expression of belonging to a family or to a house, these meanings being particularly important in female family names which display some notable parallels between the observed groups of C zech and Polish migrants in Russia.В статье рассматриваются системы фамильных именований внутриобщин потомков чешских переселенцев, живущих в России: в нескольких деревнях под Новороссийском и Анапой на Северном Кавказе и в С реднем Прииртышье, на территории Омской области. Эти общины возникли в результате переселения на указанные территории двух разных групп чешских крестьян соответственно в конце 1860-х гг. и в начале XX в. Для сравнения выборочно привлекаются также фамильные именования носителей переселенческого польского говора в Республике Хакасия. Автор показывает, что у северокавказских и среднеприиртышских чехов хорошо сохраняются неофициальные внутриобщинные фамилии, характерные для исходных чешских диалектных ареалов, юго-западного в первом и северо-восточного во втором случае. Им противопоставлены подвергшиеся русификации официальные фамилии, воспринимаемые их носителями как «внешние». Семантической базой комплекса внутриобщинных фамилий, восходящих в основном к притяжательным прилагательным, является выражение принадлежности к дому или семье. Особенно значима эта семантика для женских фамильных именований, в отношении которых прослеживаются примечательные параллели между рассматриваемыми группами потомков чешских и польских переселенцев в России

    Coupling delta H-2 and delta O-18 biomarker results yields information on relative humidity and isotopic composition of precipitation - a climate transect validation study

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    The hydrogen isotopic composition (δ2H) of leaf waxes, especially of n-alkanes (δ2Hn-alkanes), is increasingly used for paleohydrological and paleoclimate reconstructions. However, it is challenging to disentangle past changes in the isotopic composition of precipitation and changes in evapotranspirative enrichment of leaf water, which are both recorded in leaf wax δ2H values. In order to overcome this limitation, Zech M. et al. (2013) proposed a coupled δ2Hn-alkanes–δ18Osugar biomarker approach. This coupled approach allows for calculating (i) biomarker-based "reconstructed" δ2Hδ18O values of leaf water (δ2Hδ18Oleaf water), (ii) biomarker-based reconstructed deuterium excess (d-excess) of leaf water, which mainly reflects evapotranspirative enrichment and which can be used to reconstruct relative air humidity (RH) and (iii) biomarker-based reconstructed δ2Hδ18Oprecipitation values

    Symptomkontrolle und spezielle Therapieprobleme

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